Kinesin

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  1. Kinesin-5 Inhibitor

    NSC-80141 is a selective inhibitor of kinesin-5, targeting the human kinesin-5 (HsEg5) with an IC50 of 9.4 μM, while exhibiting weaker inhibition against Plasmodium kinesin-5 (PvEg5) at an IC50 of 27.3 μM. This compound is valuable for research applications focused on differentiating human kinesin-5 from its Plasmodium counterpart, making it a useful tool for studying cellular transport mechanisms and potential therapeutic interventions in parasitic infections.
  2. Kinesin-5(KIF11) inhibitor

    Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. Monastrol blocks mitosis (IC5N/A = 14 μM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity.
  3. Microtubule Associated inhibitor

    CW069 is an allosteric, and selective inhibitor of microtubule motor protein HSET with IC50 of 75 uM, significant selectivity over KSP.
  4. Eg5 mitotic motor protein inhibitor

    ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor.
  5. Mps1 inhibitor

    MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1
  6. Kinesin Eg5 inhibitor

    Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM.
  7. Kinesin Eg5 inhibitor

    K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM.
  8. Kinesin inhibitor

    EMD534085 is a kinesin inhibitor currently in clinical development.
  9. TTK (Mps1) and CLK2 dual inhibitor

    CC-671 is a potent and selective dual inhibitor of TTK (Mps1) and CLK2.
  10. MPS1 kinase inhibitor

    BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM.
  11. MPS1 kinase inhibitor

    Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM.
  12. Mps1 inhibitor

    Empesertib (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
  13. MPS1 inhibitor

    NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
  14. MPS1 inhibitor

    CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.
  15. mitosis-specific kinesin Eg5 inhibitor

    Litronesib is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity.
  16. dual Mps1/Plk1 inhibitor

    Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.
  17. Kif15 inhibitor

    Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.
  18. Kif15 inhibitor

    Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.
  19. HSET/KIFC1 inhibitor

    AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.
  20. kinesin Eg5 inhibitor

    Litronesib (Racemate) is the racemate of litronesib. Litronesib is a selective, allosteric inhibitor of kinesin Eg5.
  21. kinesin Eg5 inhibitor

    Eg5 Inhibitor V, trans-24 is a potent and specific kinesin Eg5 inhibitor with an IC50 of 0.65 μM, and can be used in the research of cancer.
  22. MPS1 checkpoint inhibitor

    BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM.
  23. KSP inhibitor

    ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.

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