TNH

Catalog No.: A54762
Kinesin Activator
TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that activates kinesins, facilitating the targeted recruitment of proteins to cellular structures. This compound responds to light signals, enabling the dynamic interaction with kinetochores by either recruiting or releasing proteins, particularly CENP-E (kinesin-7). TNH is a valuable tool for studying protein dynamics in mitosis and investigating the mechanisms of cellular transport and division.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that activates kinesins, facilitating the targeted recruitment of proteins to cellular structures. This compound responds to light signals, enabling the dynamic interaction with kinetochores by either recruiting or releasing proteins, particularly CENP-E (kinesin-7). TNH is a valuable tool for studying protein dynamics in mitosis and investigating the mechanisms of cellular transport and division.
Product Information
Catalog NumA54762
FormulaC39H57ClN6O13
Molecular Weight853.36
CAS Number2137895-00-0
SMILESO=C(OCC1=CC(OC)=C(OCCOCCOCCOCCOCCCCCCCl)C=C1[N+]([O-])=O)NCCCOC2=C(OC)C=C(CC3=CN=C(N)N=C3N)C=C2OC
SynonymsTMP-NVOC linker-Halo
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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