NSC-80141 is a selective inhibitor of kinesin-5, targeting the human kinesin-5 (HsEg5) with an IC50 of 9.4 μM, while exhibiting weaker inhibition against Plasmodium kinesin-5 (PvEg5) at an IC50 of 27.3 μM. This compound is valuable for research applications focused on differentiating human kinesin-5 from its Plasmodium counterpart, making it a useful tool for studying cellular transport mechanisms and potential therapeutic interventions in parasitic infections.
NSC-80141 is a selective inhibitor of kinesin-5, targeting the human kinesin-5 (HsEg5) with an IC50 of 9.4 μM, while exhibiting weaker inhibition against Plasmodium kinesin-5 (PvEg5) at an IC50 of 27.3 μM. This compound is valuable for research applications focused on differentiating human kinesin-5 from its Plasmodium counterpart, making it a useful tool for studying cellular transport mechanisms and potential therapeutic interventions in parasitic infections.
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