Catalog No.
Product Name
Application
Product Information
Citations
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dTTP Precursor
dUDP disodium is a nucleotide that serves as a key precursor for the synthesis of dTTP. Composed of a uracil base, ribose, and two phosphate groups, dUDP disodium is utilized as a substrate for deoxyuridine triphosphate nucleotide hydrolase, facilitating the conversion of dUDP to dUMP, the direct precursor for dTTP synthesis. This compound is integral to DNA synthesis and is applicable in diverse biochemical analyses and research applications focused on nucleotide metabolism. -
Purine Nucleoside Analog
5'-Deoxy-5'-iodouridine is a purine nucleoside analog known for its antitumor activity against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and induction of apoptosis, making it a valuable compound in cancer research. This reagent is applicable in studies focused on the mechanisms of tumor cell proliferation and therapeutic resistance. -
DNA-binding agent
Centanamycin is a novel DNA-binding agent that exhibits significant cytotoxic activity, demonstrated by an average GI50 of 34 nM in the NCI-60 cancer cell line panel. Its mechanism targets DNA, making it a valuable compound for research in cancer biology and therapeutic development. Centanamycin can be utilized to explore DNA-interactive processes and the underlying mechanisms of action in cellular responses to DNA damage. -
Adenosine Analog
DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenosine analog designed for use in oligonucleotide synthesis. This compound functions as a building block for the incorporation of 2'-O-methyl modifications into RNA sequences. Its primary biological activity enables researchers to explore the effects of modifications on RNA stability, structure, and function, making it valuable for studies in molecular biology and therapeutic development. -
Purine Nucleoside Analog
7’-OH-N-trityl morpholinothymine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis, making it valuable in cancer research. Its application in studies focusing on nucleoside metabolism and tumor biology provides essential insights into therapeutic strategies for lymphoid cancers. -
Uridine Analog
2'-C-methyluridine is a uridine analog that interacts with various biological pathways. It exhibits potential anticonvulsant and anxiolytic effects, making it valuable for studying epilepsy and anxiety disorders. Additionally, it can be explored for the development of novel antihypertensive agents, contributing to research in cardiovascular health. -
Nucledside Analogue
2'-Deoxy-β-L-uridine is a nucleoside analogue that serves as a specific substrate for the viral enzyme, demonstrating no stereospecificity against herpes simplex virus type 1 (HSV1) thymidine kinase. This compound exhibits antiviral activity through the interaction of its 5'-triphosphate form with viral DNA polymerase, thereby inhibiting viral replication. It is a valuable tool in studying HSV1 and other viral infections, as well as in developing antiviral therapies. -
Purine Nucleoside Analog
2-Hydrazinyl-adenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanism primarily involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for research aimed at understanding and treating various cancers. This reagent is suitable for studies focused on cancer biology and the development of novel therapeutic strategies. -
Nucleoside Analogue
2,3-O-Isopropylidene-D-ribonolactone is a nucleoside analogue that serves as an acetonide derivative of D-ribonolactone. It is primarily utilized as an intermediate in organic synthesis, formed through the acid-catalyzed acetalization of D-ribonolactone with acetone. This compound plays a critical role in the production of 1,5-dideoxy-1,5-imino-D-ribitol and 1,5-dideoxy-1,5-imino-L-arabinitol, making it valuable for various biochemical applications and research endeavors. -
Purine Nucleoside Analog
5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite is a purine nucleoside analog that targets DNA synthesis pathways. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. The compound's mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and drug development. -
Nucleoside Analog
2′,3′-Di-O-acetylguanosine is a nucleoside analog that mimics natural guanosine. It exhibits potential as an antiviral agent and is utilized in biochemical research to study nucleoside metabolism and cellular processes. This compound is relevant for exploring mechanisms of RNA synthesis and functions, making it a valuable tool in molecular biology and therapeutic development research. -
Adenosine Analog
N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine is an adenosine analog that primarily targets adenosine receptors. It exhibits significant vasodilatory effects by relaxing smooth muscle and has demonstrated potential in inhibiting cancer progression. This compound is valuable in biomedical research, particularly in studies focused on cardiovascular health and cancer therapy. -
Thymidine Analog
1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog serving as an important tool in molecular biology research. It exhibits insertional activity towards replicated DNA, making it useful for labeling cell populations and monitoring DNA synthesis. This compound has applications in studies of nucleic acid metabolism and cell proliferation. -
Purine Nucleoside Analog
2'-Deoxyisoguanosine is a purine nucleoside analog that demonstrates potential inhibitory effects on tumor cell growth. It acts by targeting telomerase, a critical enzyme for cellular immortality in cancer cells. Although exhibiting low potency and specificity, it serves as a valuable tool for research in cancer biology and the study of telomerase function. -
Purine Nucleoside Analog
3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound operates primarily through the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. Its unique mechanisms make it a valuable tool for research in cancer biology and therapeutic development. -
Purine Nucleoside Analog
Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily through the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. Its ability to mimic natural nucleosides allows for the exploration of therapeutic strategies targeting tumor cells. -
Purine Nucleoside Analog
8-Methyl-2’-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology. This compound is suitable for studies aimed at exploring therapeutic strategies involving purine metabolism and nucleoside analogs. -
Adenosine Nucleoside
8-Methyladenosine is a modified adenosine nucleoside that exerts its effects through methylation at the 8-position. This modification imparts resistance to five classes of antibiotics that target the ribosomal peptidyl transferase center, making it a valuable tool in research on antibiotic-resistant bacterial infections. Its unique properties make it essential for understanding the mechanisms of resistance and developing strategies to counteract such infections. -
Nucleoside Antimetabolite/Analog
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is a nucleoside antimetabolite and analog that serves as a valuable intermediate for synthesizing oligodeoxynucleotides with 3'-S-phosphorothiolate linkages. This compound is instrumental in studying enzyme-catalyzed cleavage processes within DNA, aiding in the investigation of nucleic acid interactions and mechanisms. Its structural features enhance its utility in various genetic and molecular biology research applications. -
Purine Nucleoside Analog
N6-Ethyl-2’-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism includes the inhibition of DNA synthesis, which plays a crucial role in inducing apoptosis. This compound is valuable for research applications aimed at investigating cancer biology and developing therapeutic strategies for lymphoid malignancies. -
Purine Nucleoside Analog
5-Iodouridine is a purine nucleoside analog that primarily targets dihydroorotase, exhibiting an inhibition constant (Ki) of 340 µM. This compound has been shown to notably enhance the cytotoxic effects of gamma irradiation. Its applications in research extend to investigating herpes simplex virus type 1 (HSV-1) infection and leukemia, providing valuable insights into therapeutic mechanisms and potential treatment strategies. -
Nucleoside
L-Guanosine is a purine nucleoside that primarily targets nucleoside metabolism. It exhibits anti-herpesvirus activity, making it a valuable tool for studying viral infections. Additionally, L-Guanosine can be utilized in the preparation of supramolecular hydrogels, which have potential applications in drug delivery and tissue engineering. -
Uridine Analog
N3-Methyl-2’-O-methyluridine is a uridine analog that targets diverse biological processes. It has been investigated for its potential anticonvulsant and anxiolytic effects, contributing to research in neurological disorders. Additionally, this compound is valuable in the exploration of new antihypertensive agents, making it a versatile tool in chemical research. -
Purine Nucleoside Analog
2’-Chloro-N6-(3-methoxy)benzyl adenosine is a purine nucleoside analog that exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound demonstrates significant biological activity against indolent lymphoid malignancies, making it a valuable tool in cancer research. Its mechanisms of action are beneficial for studies focusing on therapeutic strategies for various malignancies. -
Purine Nucleoside Analog
Adenosine-2-carboxamide is a purine nucleoside analog that primarily targets cellular proliferation pathways. It exhibits significant antitumor activity against indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable research tool for investigating cancer treatment strategies and understanding purine metabolism in cancer cells. -
Uridine Analog
6-Methyluridine is a uridine analogue that serves as an important tool in neurological research. Its structure allows for the exploration of potential antiepileptic effects, making it useful in studies focused on anticonvulsant and anxiolytic activities. Additionally, this compound may assist in the development of novel antihypertensive agents, contributing to advancements in treatments for hypertension. -
Wobble Modification in tRNA
Mnm5s2U is a wobble modification present in the anticodon of lysine and glutamate tRNAs. This compound plays a crucial role in stabilizing codon-anticodon pairing, thereby enhancing translation fidelity and efficiency. Mnm5s2U is essential for studying tRNA modifications and their impact on protein synthesis, making it a valuable reagent for research in molecular biology and genetics. -
Nucleotide Prodrug
Fostroxacitabine bralpamide is an orally active nucleotide prodrug that targets cancerous cells through the cytotoxic effects of Troxacitabine. Upon conversion within the body, it exhibits potent antitumor activity, making it a valuable tool for cancer research. Its application in studies focused on cancer metabolism and therapeutic efficacy positions it as a significant compound in the development of innovative cancer treatments. -
Purine Nucleoside Analog
9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine is a purine nucleoside analog that primarily targets nucleic acid synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA synthesis and induction of apoptosis. It serves as a valuable tool for research into cancer therapeutics and the development of nucleoside-based treatments. -
Purine Nucleoside Analog
2’,3’-Dideoxy-3’-fluorocytidine is a purine nucleoside analogue that inhibits DNA synthesis, making it a valuable compound in cancer research. This reagent exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and interfering with cellular proliferation. Its application in preclinical studies supports investigations into novel therapeutic strategies for treating various cancers. -
Purine Nucleoside Analog
4',5'-Didehydro-5'-deoxyuridine is a purine nucleoside analog known for its significant antitumor activity against indolent lymphoid malignancies. Its mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound serves as a critical reagent for studies aimed at understanding cellular responses to nucleoside analogs and their potential therapeutic applications in oncology. -
Purine Nucleoside Analog
Dihydrodeoxyuridine (H2dUrd) is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve inhibition of DNA synthesis and the induction of apoptosis. H2dUrd is a valuable reagent for research focused on cancer biology and therapeutic developments targeting nucleoside metabolism. -
Pain Inhibitor
Brivoligide (AYX1) is a double-stranded, unprotected oligonucleotide composed of 23 base pairs, functioning as a pain inhibitor. It has demonstrated efficacy in reducing acute post-surgical pain through its ability to mimic the DNA sequence typically bound by the transcription factor EGR1 on chromosomes. This unique mechanism makes Brivoligide a valuable tool for research applications focused on pain management and therapeutic interventions in pain-related conditions. -
Purine Nucleoside Analog
5′-Azido-5′-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. As a versatile click chemistry reagent, 5′-Azido-5′-deoxyadenosine contains an azide group that readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN moieties, making it suitable for various chemical biology applications. -
Adenosine Analog
3’-O-(2-Methoxyethyl)adenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator. This compound has demonstrated potential in inhibiting cancer progression, making it a valuable tool for oncological research. Its properties enable the exploration of adenosine signaling pathways and may contribute to the development of novel therapeutic strategies in cardiovascular and cancer research. -
Guanosine Analog
8-Nitroguanosine is a guanosine analog that exerts immunostimulatory activity. It has been shown to induce type I interferons in various animal models, leading to notable antiviral effects. The biological activity of 8-Nitroguanosine is primarily mediated through the activation of Toll-like receptor 7 (TLR7), making it a valuable tool for research in antiviral response and immune modulation. -
Uridine Analog
4'-C-Azidouridine is a uridine analog that functions as a click chemistry reagent. It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. This compound is instrumental in the investigation of uridine's potential anticonvulsant and anxiolytic properties and may aid in the development of novel antihypertensive agents. Its unique reactivity and biological relevance make it a valuable tool for chemical biology research. -
Purine Nucleoside Analog
α-Cytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is utilized in studies focused on elucidating the molecular pathways underlying tumorigenesis and developing novel therapeutic strategies. -
Adenosine Analog
9-(β-D-Xylofuranosyl)adenine is an adenosine analog that primarily acts as a vasodilator by targeting adenosine receptors. This compound has demonstrated significant biological activity, including the inhibition of cancer progression. It is particularly useful for researchers exploring the mechanisms of vasodilation and the therapeutic potential of adenosine-related pathways in cancer biology. -
Purine Nucleoside Analog
2-Chloro-9-(beta-D-ribofuranosyl)purine functions as a purine nucleoside analog. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. This compound is valuable for research applications focused on cancer treatment and the underlying mechanisms of nucleoside analogs in therapeutic contexts. -
Adenosine Analog
2'-Fluoro-2'-deoxy-ara-A(Bz)-3'-phosphoramidite is an adenosine analog that functions primarily as a smooth muscle vasodilator. This compound demonstrates significant biological activity by potentially inhibiting cancer progression. It is widely utilized in research focused on nucleoside metabolism, therapeutic development, and the exploration of adenosine pathways in various physiological and pathological contexts. -
Purine Nucleoside Analog
2’-Deoxy-5,N4-dimethylcytidine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is useful for studying the molecular pathways involved in tumor cell proliferation and can aid in the development of targeted therapies. -
Dinucleotide Derivative
Cytidylyl-(3′,5′)-uridine is a dinucleotide derivative that plays a crucial role in nucleotide metabolism. It serves as an important component for the investigation of RNA synthesis and degradation pathways. This compound is utilized in various research applications, including studies on enzymatic activity and cellular signaling processes associated with nucleotide functions. -
Purine Nucleoside Analog
DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite is a modified purine nucleoside analog that plays a critical role in the field of cancer research. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. It is a valuable reagent for studies focusing on anticancer mechanisms and the development of therapeutic strategies. -
Purine Nucleoside Analog
Alpha-Guanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include inhibition of DNA synthesis and induction of apoptosis in cancer cells, making it a valuable reagent for cancer research. This compound can aid in investigations focused on understanding nucleoside metabolism and the development of novel therapeutic strategies in oncology. -
Purine Nucleoside Analog
2’-Deoxy-N3-methylcytidine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is utilized in various studies aimed at understanding its effects on cancer cell proliferation and survival pathways. -
Purine Nucleoside Analog
2-Amino-9-β-D-ribofuranosylpurine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is useful in biochemical research focusing on cancer therapeutics and the exploration of nucleoside analog mechanisms in tumor biology. -
Purine Nucleoside Analog
5-Methoxycarbonyl methyl uridine is a purine nucleoside analog that exhibits significant antitumor activity. It operates through mechanisms including the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for studying indolent lymphoid malignancies. This compound is utilized in cancer research to explore its potential therapeutic effects and understand the underlying molecular pathways. -
Purine Nucleoside Analog
N4-Methyl-2’-O-methyl-cytidine functions as a purine nucleoside analog with significant antitumor activity, particularly effective against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic development. This compound is suitable for studies exploring nucleoside analogs in cancer treatment strategies. -
Nucleoside Analogue
1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose is a nucleoside analogue that acts as a structural mimic of ribonucleosides. This compound exhibits potential antiviral properties and can be utilized in research focused on nucleoside metabolism and the development of antiviral therapeutics. Its unique modifications provide valuable insights for studies involving nucleic acid synthesis and enzymatic interactions in cellular systems.
