Fig. 1 · Structure
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5′-Azido-5′-deoxyadenosine
Purine Nucleoside Analog
5′-Azido-5′-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. As a versatile click chemistry reagent, 5′-Azido-5′-deoxyadenosine contains an azide group that readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN moieties, making it suitable for various chemical biology applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 737-76-8 |
| Applications | Purine Nucleoside Analog |
| Formula | C10H12N8O3 |
| Molecular Weight | 292.25 |
| SMILES | O[C@@H]1[C@@H](CN=[N+]=[N-])O[C@@H](N2C(N=CN=C3N)=C3N=C2)[C@@H]1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.