5-Iodouridine is a purine nucleoside analog that primarily targets dihydroorotase, exhibiting an inhibition constant (Ki) of 340 µM. This compound has been shown to notably enhance the cytotoxic effects of gamma irradiation. Its applications in research extend to investigating herpes simplex virus type 1 (HSV-1) infection and leukemia, providing valuable insights into therapeutic mechanisms and potential treatment strategies.
5-Iodouridine is a purine nucleoside analog that primarily targets dihydroorotase, exhibiting an inhibition constant (Ki) of 340 µM. This compound has been shown to notably enhance the cytotoxic effects of gamma irradiation. Its applications in research extend to investigating herpes simplex virus type 1 (HSV-1) infection and leukemia, providing valuable insights into therapeutic mechanisms and potential treatment strategies.
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