Catalog No.
Product Name
Application
Product Information
Citations
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Purine Nucleoside Analog
2-Thiothymidine is a purine nucleoside analog with significant antitumor activity specifically targeting indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is suitable for studies focused on elucidating mechanisms of tumorigenesis and evaluating therapeutic strategies in lymphoid cancers. -
Thymidine Analog
5-Methyl-2'-O-methyl-uridine is a thymidine analog that exhibits insertional activity within replicated DNA. This modified nucleoside plays a significant role in cellular labeling and tracking of DNA synthesis processes. Naturally occurring in tRNA from rabbit liver, 5-Methyl-2'-O-methyl-uridine is valuable in various biochemical research applications, particularly in studies involving nucleic acid dynamics and cellular metabolism. -
Adenosine Analog
2'-O-Methyladenosine 5'-monophosphate triethylammonium is an adenosine analog that primarily targets adenosine receptors. It exhibits significant biological activity, functioning as a smooth muscle vasodilator while also demonstrating potential for inhibiting cancer progression. This compound is valuable for research applications focusing on cardiovascular studies and cancer biology. -
Purine Nucleoside Analog
Raluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are primarily mediated through the inhibition of DNA synthesis, leading to cell cycle arrest and the induction of apoptosis. This agent serves as a valuable tool in cancer research, facilitating studies aimed at understanding tumor biology and developing novel therapeutic strategies. -
Oxidation Product of 5-Hydroxykynuramine
4,6-Dihydroxyquinoline is an oxidation product of 5-hydroxykynuramine, primarily known for its role in influencing biological pathways through redox reactions. This compound exhibits notable biological activity as an antioxidant, which can contribute to the understanding of oxidative stress in cellular systems. Its applications in research include studies on neuroprotection, inflammation, and potential therapeutic interventions for various neurodegenerative diseases. -
Nucleoside
L-Inosine is an L-configured purine nucleoside primarily involved in cellular metabolism as a product of adenosine catabolism. It exhibits anti-inflammatory, antinociceptive, immunomodulatory, and neuroprotective properties, making it a valuable tool in research. L-Inosine can be applied in studies of neurodegenerative diseases, immune response modulation, and pain management, providing insights into its therapeutic potential in various biological contexts. -
Purine Nucleoside Analog
5-(Aminomethyl)uridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic development. -
Purine Nucleoside Analog
2′-Bromo-2′-deoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is commonly utilized in research aimed at understanding cancer biology and developing therapeutic strategies for lymphoid cancers. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-4-thiouridine is a purine nucleoside analogue that exhibits potent antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and the development of nucleoside-based therapeutics. -
Nucleoside Analog
DMT-OMe-rA(Bz) is a nucleoside analog that functions by mimicking natural nucleosides, thereby influencing nucleic acid metabolism. This compound exhibits key biological activities such as incorporating into RNA and potentially interfering with RNA polymerase activity. DMT-OMe-rA(Bz) is primarily utilized in research applications focusing on RNA synthesis, gene expression modulation, and the development of antiviral therapeutics. -
Nucleobase
9-Ethylguanine is a modified nucleobase that serves as a valuable tool for studying nucleobase interactions and DNA alterations. This compound is particularly useful in exploring the antitumor activity of organometallic complexes. Its role in cancer research may contribute to a deeper understanding of nucleotide behavior and potential therapeutic applications. -
Ricin toxin A-chain (RTA) Substrate
DNA-GAGA is a specific substrate for Ricin toxin A-chain (RTA), exhibiting a slow depurination rate. Upon interaction, RTA cleaves a single adenylate at the GAGA stem-loop region of eukaryotic 28S RNA, highlighting its role as a potent ribosome-inactivating toxin. This compound is valuable for studying the mechanisms of RNA targeting and the toxic effects of ricin in cellular models. -
Guanosine Nucleoside Derivative
N-Isobutyryl-2',3'-Acetyl-Guanosine is a guanosine nucleoside derivative that serves as a substrate or inhibitor for various enzymatic reactions involving RNA metabolism. This compound is significant in studies investigating nucleoside signaling pathways and the modulation of guanosine-related biological processes. Its use can facilitate research into therapeutic strategies for diseases related to nucleoside metabolism. -
Linker
UnyLinker 12 is a universal linker designed for the synthesis of oligoribonucleotides. It facilitates the conjugation of ribonucleotides, enabling researchers to construct diverse RNA sequences for various applications. Its versatility makes it an essential tool in nucleic acid chemistry, including the development of RNA therapeutics and molecular probes. -
Nucleotide Analog
2'-F-Ac-C (N-Acetyl-2′-deoxy-2′-fluorocytidine) is a nucleotide analog that serves as a building block for the synthesis of oligoribonucleotides. Its incorporation into nucleic acid sequences can modulate biological activity and enhance stability. This reagent is valuable for research in nucleic acid chemistry, gene expression studies, and therapeutic applications involving RNA interference and antisense oligonucleotides. -
Adenosine Analog
N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'CE-phosphoramidite is an adenosine analog that serves as a key building block for the synthesis of modified nucleotides. This compound exhibits smooth muscle vasodilatory activity and demonstrates potential in inhibiting cancer progression. Its applications in research include the development of therapeutic agents targeting adenosine pathways and investigations into nucleic acid functionality. -
Uridine Analog
5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite is a uridine analog that serves as a key substrate for nucleic acid synthesis. This compound exhibits potential anticonvulsant and anxiolytic properties, making it useful for studies in epilepsy and anxiety disorders. Additionally, its unique structure supports research focused on the development of novel antihypertensive agents. -
Oligonucleotide
2'-O-(2-Methoxyethyl)-cytidine is a synthetic modified nucleotide targeting oligonucleotides. It exhibits enhanced hybridization properties and improved stability, making it suitable for applications in oligonucleotide-based therapeutics. This reagent serves as a valuable tool for researchers studying oligonucleotide chemotherapeutic agents and their potential in nucleic acid modifications. -
Dinucleotide Derivative
UU ((3′,5′)-Uridylyluridine) is a dinucleotide derivative primarily involved in RNA-related processes. This compound serves as a substrate or building block in the synthesis and analysis of RNA, facilitating research in areas such as RNA folding, stability, and enzymatic activity. Its unique structure enables investigation into the biochemical roles of ribonucleotides in cellular functions and molecular interactions. -
Nucleoside Analog
Biotin-7-GMP (5'-Biotin-G-monophosphate) is a nucleoside analog that serves as a versatile building block for nucleic acid synthesis. This compound is particularly useful in the preparation of biotinylated nucleotides, enabling applications in molecular biology such as the labeling of DNA and RNA for detection, purification, and various bioconjugation strategies. Biotin-7-GMP facilitates innovative research in areas such as gene expression analysis and nucleic acid interactions. -
Nucleotide Analog
3'-NH2-CTP is a nucleotide analog featuring an amino group substitution at the 3' position of cytidine triphosphate (CTP). This modification allows it to engage in specific biochemical interactions, making it valuable for studies involving nucleic acid synthesis and metabolism. Its unique properties facilitate research in molecular biology, particularly in the design of nucleotide-based experiments and the assessment of enzymatic activity. -
Purine Nucleoside Analog
2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]-beta-D-arabinouridine is a purine nucleoside analog that primarily inhibits DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting cellular proliferation. Its utility in cancer research enhances the understanding of therapeutic strategies targeting nucleoside metabolism in malignancies. -
Guanosine Analog
3’-O-Me-G(iBu)-2’-phosphoramidite is a guanosine analog designed to activate immunostimulatory pathways. It has been shown to induce type I interferons in various animal models, contributing to its antiviral effects. The mechanism of action is primarily through the activation of Toll-like receptor 7 (TLR7), making it valuable in research applications involving immune response modulation and viral infection studies. -
Purine Nucleoside Analog
3'-O-Me-C(Bz)-2'-phosphoramidite is a purine nucleoside analog that serves as an important reagent for nucleic acid research. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through its mechanisms of inhibiting DNA synthesis and inducing apoptosis. It is primarily utilized in the synthesis of modified oligonucleotides for various applications in cancer research and therapeutic development. -
Active Compound
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine serves as an active compound primarily utilized for the silyl protection of ribonucleosides. This reagent is essential for enhancing the stability and reactivity of nucleosides during chemical synthesis. Its robust protective functionalities facilitate the development of various nucleotide-based applications in biochemical research and drug discovery. -
Nucleotide Analogue
3'-NH2-TTP is a nucleotide analogue featuring an amino modification at the 3' end of thymidine triphosphate (TTP). This compound can serve as a substrate for DNA polymerases, enabling the study of nucleic acid synthesis and editing processes. Its incorporation into DNA can be used to investigate the effects of amino group modifications on nucleic acid structure and function, making it a valuable tool in molecular biology and genetic research applications. -
Ricin toxin A-chain (RTA) Substrate
DNA-GAG is a specialized substrate for Ricin toxin A-chain (RTA), functioning as a slow-reacting compound. It facilitates the depurination of a specific adenylate within the GAGA stem-loop structure of eukaryotic 28S RNA, highlighting RTA's mechanism of action. This substrate is valuable in studying the biochemical pathways and toxicological effects associated with ricin exposure, aiding research in molecular biology and therapeutic applications. -
Nucleotide Derivative
DMT-OMe-rC(Ac) (N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine) is a nucleotide derivative designed for oligoribonucleotide synthesis. This compound features protective groups that enable efficient polymerization while maintaining compatibility with various synthetic protocols. DMT-OMe-rC(Ac) is essential for researchers exploring RNA biology and developing RNA-based therapeutics. -
Purine Nucleoside Analog
5-Methoxycarbonylmethyl-2-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological efficacy is attributed to mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable in cancer research for its potential therapeutic applications and in studies focused on nucleoside metabolism and treatment resistance. -
Guanosine Analog
2′-O-2-Propyn-1-ylguanosine is a guanosine analogue with notable immunostimulatory properties. It has been shown to induce type I interferons in various animal models, thereby exhibiting antiviral effects. The functional activity of this compound is linked to the activation of Toll-like receptor 7 (TLR7). Additionally, 2′-O-2-Propyn-1-ylguanosine serves as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
Purine Nucleoside Analog
4′-Thiouridine is a purine nucleoside analog that functions as a thio derivative of thymidine. It exhibits significant antiviral and anticancer properties, making it useful for the synthesis of 4'-thionucleosides. Additionally, 4′-Thiouridine is applicable in RNA-sequencing studies, facilitating the exploration of RNA molecular biology. -
Nucleoside Analog
5-F-UTP (5-Fluorouridine-5'-triphosphate) is a nucleoside analog that functions as a substrate for RNA polymerases during nucleic acid synthesis. This compound is utilized in research applications involving RNA synthesis, allowing for the incorporation of fluorine into RNA molecules, which can aid in the study of RNA structure and function. Its unique properties make it valuable for developing RNA-based therapeutics and molecular probes. -
Adenosine Analog
8-Chloro-2'-deoxyadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits significant biological activity as a potential vasodilator and has demonstrated inhibitory effects on cancer progression. It is useful in various research applications, particularly in studying the pharmacological effects of adenosine and its derivatives in cardiovascular and oncology research. -
Purine Nucleoside Analog
5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves inhibition of DNA synthesis and induction of apoptosis, making it a valuable tool in cancer research. This compound can be utilized for studying the effects of nucleoside metabolism and the development of targeted therapies in oncology. -
Purine Nucleoside Analog
3′-Chloro-3′-deoxythymidine is a purine nucleoside analog that exhibits potent antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis in targeted cancer cells. This compound is primarily utilized in cancer research to explore therapeutic strategies for lymphoid malignancies and to further understand nucleoside analog mechanisms of action. -
Adenosine Analog
2-Methoxy-2'-deoxyadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory effects on smooth muscle and has demonstrated potential in inhibiting cancer progression, making it relevant for various research applications, including cardiovascular studies and oncology. Its structural similarity to adenosine allows for exploration in drug development targeting related pathways. -
Anticancer nucleosides
4'-Ethynyl-2'-deoxycytidine is an anticancer nucleoside that selectively targets DNA replication pathways. This compound exhibits significant efficacy against various malignancies, including acute lymphoblastic leukemia and diffuse large B-cell lymphoma. It provides a valuable tool for research focused on cancer cell kinetics and therapeutic resistance. -
Nucleoside Metabolite
6-Acetamido-2-oxohexanoate primarily interacts as a nucleoside metabolite within biological systems. It serves as an important intermediate in metabolic pathways associated with nucleotide synthesis and breakdown. Research applications include studies on nucleoside metabolism, enzymatic activity, and potential therapeutic targets related to nucleic acid metabolism. -
Purine Nucleoside Analog
N4-Benzoyl-2'-deoxy-5-iodocytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound is valuable for research focused on understanding cancer biology and developing therapeutic strategies for hematological malignancies. -
Purine Nucleoside Analog
3'-β-Amino-2',3'-dideoxy-5'-O-methoxy trityluridine is a purine nucleoside analog that effectively inhibits DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its pharmacological mechanisms include the induction of apoptosis and disruption of cellular proliferation, making it valuable for research in cancer biology and therapeutic development. -
Purine Nucleoside Analog
2’,3’-Bis(O-t-butyldimethylsilyl)-2-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research focused on understanding the therapeutic potential of purine nucleoside analogs in oncology. -
Purine Nucleoside Analog
2'-O-(2-Azidoethyl)adenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily driven by the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent due to its azide functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing alkyne, DBCO, or BCN groups. It is a valuable tool for bioconjugation applications in chemical biology and medicinal chemistry. -
Purine Nucleoside Analog
4′,5′-Didehydro-5′-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in the study of indolent lymphoid malignancies. This compound is suitable for research applications focused on cancer biology and therapeutic development. -
Purine Nucleoside Analog
4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine functions as a purine nucleoside analog, exhibiting significant antitumor activity against indolent lymphoid malignancies. This compound operates through various mechanisms, including the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research, facilitating the exploration of therapeutic strategies against lymphoid tumors. -
Adenosine Analog
N-(2-Phenoxyacetyl)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits smooth muscle vasodilatory effects and has demonstrated potential in inhibiting cancer progression. It serves as a valuable tool in cancer research and studies related to vascular biology. -
Purine Nucleoside Analog
3'-Azido-3'-deoxy-5-fluoro-beta-L-uridine is a purine nucleoside analog that demonstrates significant antitumor activity, primarily against indolent lymphoid malignancies. Its mechanisms of action involve inhibition of DNA synthesis and induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, including those with DBCO or BCN groups. These properties make it a valuable tool for various biochemical research applications. -
Purine Nucleoside Analog
4’-Methyladenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications. This compound is essential for studying the effects of nucleoside analogs in various oncological contexts. -
Purine Nucleoside Analog
Methyl 2,3,5-tri-O-benzyl-D-ribofuranoside is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. The compound functions primarily by inhibiting DNA synthesis and inducing apoptosis in target cells, making it a valuable tool for cancer research. Its unique mechanism of action facilitates investigations into therapeutic strategies for malignancies associated with purine metabolism. -
Purine Nucleoside Analog
9-(3-Deoxy-3-fluoro-beta-D-ribofuranosyl)-9H-Purine is a purine nucleoside analog known for its antitumor activity. This compound primarily targets indolent lymphoid malignancies by inhibiting DNA synthesis and inducing apoptosis, thereby contributing to its potential therapeutic effectiveness in cancer research. Its applications extend to studying mechanisms of tumor cell proliferation and apoptosis in various models. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-alpha-D-arabinoguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound serves as a valuable tool in cancer research, contributing to studies aimed at understanding the effects of purine synthesis inhibition and the development of novel therapeutic strategies.
