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DNA-GAGA

Catalog No.: A55306
Ricin toxin A-chain (RTA) Substrate
DNA-GAGA is a specific substrate for Ricin toxin A-chain (RTA), exhibiting a slow depurination rate. Upon interaction, RTA cleaves a single adenylate at the GAGA stem-loop region of eukaryotic 28S RNA, highlighting its role as a potent ribosome-inactivating toxin. This compound is valuable for studying the mechanisms of RNA targeting and the toxic effects of ricin in cellular models.
DNA-GAGA 110138-50-6 Ricin toxin A-chain (RTA) Substrate
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Size Price Stock Qty
100mg
$240.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDNA-GAGA is a specific substrate for Ricin toxin A-chain (RTA), exhibiting a slow depurination rate. Upon interaction, RTA cleaves a single adenylate at the GAGA stem-loop region of eukaryotic 28S RNA, highlighting its role as a potent ribosome-inactivating toxin. This compound is valuable for studying the mechanisms of RNA targeting and the toxic effects of ricin in cellular models.
Product Information
Catalog NumA55306
FormulaC40H49N20O20P3
Molecular Weight1222.86
CAS Number110138-50-6
SMILESO=C1C(N=CN2[C@H]3C[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)C[C@@H]4OP(OC[C@H]7O[C@@H](N(C=N8)C9=C8C(NC(N)=N9)=O)C[C@@H]7OP(O)(OC[C@H]%10O[C@@H](N(C=N%11)C%12=C%11C(N)=NC=N%12)C[C@@H]%10O)=O)(O)=O)(O)=O)[C@@H](CO)O3)=C2N=C(N)N1
Useful Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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DNA Damage > Nucleoside Antimetabolite/Analog