Fig. 1 · Structure
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DNA-GAGA
Ricin toxin A-chain (RTA) Substrate
DNA-GAGA is a specific substrate for Ricin toxin A-chain (RTA), exhibiting a slow depurination rate. Upon interaction, RTA cleaves a single adenylate at the GAGA stem-loop region of eukaryotic 28S RNA, highlighting its role as a potent ribosome-inactivating toxin. This compound is valuable for studying the mechanisms of RNA targeting and the toxic effects of ricin in cellular models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 110138-50-6 |
| Applications | Ricin toxin A-chain (RTA) Substrate |
| Formula | C40H49N20O20P3 |
| Molecular Weight | 1222.86 |
| SMILES | O=C1C(N=CN2[C@H]3C[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)C[C@@H]4OP(OC[C@H]7O[C@@H](N(C=N8)C9=C8C(NC(N)=N9)=O)C[C@@H]7OP(O)(OC[C@H]%10O[C@@H](N(C=N%11)C%12=C%11C(N)=NC=N%12)C[C@@H]%10O)=O)(O)=O)(O)=O)[C@@H](CO)O3)=C2N=C(N)N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.