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DNA-GAG

Catalog No.: A55322
Ricin toxin A-chain (RTA) Substrate
DNA-GAG is a specialized substrate for Ricin toxin A-chain (RTA), functioning as a slow-reacting compound. It facilitates the depurination of a specific adenylate within the GAGA stem-loop structure of eukaryotic 28S RNA, highlighting RTA's mechanism of action. This substrate is valuable in studying the biochemical pathways and toxicological effects associated with ricin exposure, aiding research in molecular biology and therapeutic applications.
DNA-GAG 54230-76-1 Ricin toxin A-chain (RTA) Substrate
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDNA-GAG is a specialized substrate for Ricin toxin A-chain (RTA), functioning as a slow-reacting compound. It facilitates the depurination of a specific adenylate within the GAGA stem-loop structure of eukaryotic 28S RNA, highlighting RTA's mechanism of action. This substrate is valuable in studying the biochemical pathways and toxicological effects associated with ricin exposure, aiding research in molecular biology and therapeutic applications.
Product Information
Catalog NumA55322
FormulaC30H37N15O15P2
Molecular Weight909.65
CAS Number54230-76-1
SMILESO=C1C(N=CN2[C@H]3C[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)C[C@@H]4OP(OC[C@H]7O[C@@H](N(C=N8)C9=C8C(NC(N)=N9)=O)C[C@@H]7O)(O)=O)(O)=O)[C@@H](CO)O3)=C2N=C(N)N1
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DNA Damage > Nucleoside Antimetabolite/Analog