Catalog No.
Product Name
Application
Product Information
Citations
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HLA-B7-Derived Peptide
Allotrap 07 is a synthetic peptide derived from residues 75-84 of the HLA-B7 molecule, a class I major histocompatibility complex (MHC) protein. This peptide is known for its ability to promote donor-specific tolerance in rat cardiac allografts when used in conjunction with Cyclosporin A, leading to a significant extension of graft survival. Allotrap 07 is a valuable tool for researchers exploring mechanisms of immune tolerance and transplant biology. -
HLA-Cw*1601 Binder
BAGE (2-10) is a nonapeptide encoded by the BAGE gene that specifically binds to the HLA-Cw*1601 molecule. This interaction facilitates the formation of an antigen recognized by autologous cytotoxic T lymphocytes, making BAGE (2-10) useful in studies related to melanoma. Its ability to elicit an immune response positions it as a valuable tool for research in cancer immunotherapy and antigen presentation. -
MHC Peptide
SEIDLILGY is a nonapeptide that acts as a ligand for major histocompatibility complex class I (MHC) molecules, derived from mouse sources. This compound is primarily used to stimulate sensory neurons expressing the vomeronasal receptor V2rf2, facilitating studies in neural signaling and sensory processing. Its unique properties make it an invaluable tool for research in neurobiology and immunology. -
T-Helper Epitope
TpD is a chimeric T-helper epitope designed to elicit robust immune responses via targeted binding to various human MHC class II molecules, predominantly HLA-DRB1. Facilitating cleavage by cathepsins, TpD effectively promotes long-term CD4+ T-cell responses, making it a valuable tool in immunization strategies. Its ability to bind to multiple HLA alleles, including DRB3, DRB4, DRB5, DP, and DQ, enhances its utility in optimizing peptide vaccine efficacy and advancing research in immunology and vaccine development. -
Melanoma Antigen-Derived Peptide
VLPDVFIRCV is a melanoma antigen-derived peptide that targets MHC-I class molecules. It has been shown to induce cytotoxic T lymphocytes (CTLs) capable of specifically lysing T2 cells pre-loaded with this peptide in chromium release assays. While VLPDVFIRCV does not activate immune responses against natural tumor cells, it is valuable for vaccine design research and studies focused on immune modulation in melanoma. -
Inhibitor Of The Binding Of DQ8 Peptide To MHC Class II Molecule
D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. By occupying a pocket in the DQ8 peptide binding groove, D-α-Methyl DOPA disrupts the presentation of DQ8 peptides to CD4+ T cells. This inhibition may play a role in modulating the immune response, potentially slowing the development or progression of type 1 diabetes and celiac disease. This compound is valuable in immunological research focused on T cell activation and autoimmune disease mechanisms. -
e14a2 Junctional Sequence
GFKQSSKAL is an e14a2 junctional sequence that specifically binds to HLA-B8. This binding interaction is relevant for investigating T cell responses and immunological applications in chronic myeloid leukemia (CML) research. GFKQSSKAL can be utilized in studies focused on cancer immunotherapy and the mechanisms of immune evasion in hematological malignancies. -
MHC class II Antigen Presentation Modulator
Ac-YR-NH2 is a small molecule that modulates MHC class II antigen presentation. By influencing peptide binding to MHC class II, Ac-YR-NH2 can alter immune responses, making it a valuable tool for studying immune system dynamics. This compound is particularly useful in research applications focused on autoimmune diseases and vaccine development, where modulation of antigen presentation is critical. -
MHC II Antigen Loading Catalyst
AdCaPy is an MHC II antigen loading catalyst that facilitates the efficient loading of peptide antigens onto MHC II molecules. By enhancing the presentation of antigens to CD4+ T cells, AdCaPy plays a crucial role in modulating immune responses. This reagent is valuable for research applications in immunology, vaccine development, and therapeutic strategies targeting T cell activation. -
MR1 Antigen
Photolumazine III is an MR1 (MHC class I-related molecule 1) antigen, which plays a crucial role in the immune response by presenting antigenic metabolites to T cells. This compound exhibits biological activity related to the activation of MR1-restricted T cell responses, thus serving as a valuable tool for studying immune mechanisms and developing immunotherapies. Research applications include the investigation of microbial and tumor-associated antigens, as well as the modulation of immune responses in various disease models. -
CD8 T Cell Epitope
TYVPANASL is a MHC I-binding CD8 T cell epitope derived from the HER2/neu protein. This nine-amino-acid peptide plays a crucial role in stimulating CD8 T cell responses, making it valuable in immunological studies and vaccine development. TYVPANASL can be utilized in the preparation of J-LEAPS vaccines, contributing to cancer immunotherapy research. -
MHC Class II Restriction Antigen
InsB (9-23) is an MHC class II-restricted peptide derived from the insulin B-chain, encompassing amino acid residues 9-23. This peptide is a critical antigen for HLA-DQ8, facilitating T cell recognition and activation, leading to the release of IFN-γ and various cytokines. InsB (9-23) has been shown to activate CD4 T cells associated with the pathogenesis of type 1 diabetes and autoimmune diabetes. It serves as an essential tool for research investigating the immunological mechanisms underlying these diseases. -
LAG-3/MHCII and LAG-3/FGL1 PPI Inhibitor
SA-15-P is a potent inhibitor of the LAG-3/MHCII and LAG-3/FGL1 protein-protein interactions, with IC50 values of 4.21 μM and 6.52 μM, respectively. By disrupting these interactions, SA-15-P serves as a valuable tool in immunotherapy research, providing insights into immune regulation and the potential enhancement of anti-tumor responses. Its application facilitates the exploration of therapeutic strategies targeting LAG-3 in various disease contexts. -
LAG-3 D1 Ligand
Z3071585108 is a small molecule inhibitor of the LAG-3 D1 domain, exhibiting Kd values of 59.2 μM and 56.1 μM through MST-TRIC channel and spectral shift detection, respectively. This compound partially inhibits the interaction between LAG-3 and MHC class II molecules, with an EC₅₀ value of 42.9 μM. Z3071585108 is valuable for research on small molecule immunotherapies targeting the LAG-3 pathway, contributing to the understanding of immune modulation in various diseases. -
Bioactive Peptide
OVA-T4 Peptide (SIITFEKL) is a bioactive peptide variant of the ovalbumin epitope (OVA (257-264)), known for its binding to H-2Kb MHC class I molecules. This peptide exhibits comparable binding strength to H-2Kb but demonstrates significantly reduced affinity for the OT-I TCR. OVA-T4 Peptide is useful in research focused on T cell responses and MHC-TCR interactions, making it valuable for the study of immunological mechanisms and peptide-MHC complex dynamics. -
Peptide
OVA peptide is a class I (Kb)-restricted peptide epitope derived from ovalbumin, associated with the major histocompatibility complex (MHC) molecule H-2Kb in mice. This peptide plays a crucial role in immune response studies, particularly in allergy research, where it serves as a model antigen. Its ability to elicit specific T cell responses makes OVA peptide a valuable tool for understanding immune mechanisms and developing therapeutic strategies in allergy and immunology. -
Polypeptide
Gp100 (25-33), human is a polypeptide fragment comprising amino acids 25-33 of the human melanoma antigen. This 9-amino acid epitope is restricted by MHC class I H-2Db and elicits a specific T cell response due to its immunogenic properties. Gp100 (25-33), human is valuable for cancer research, particularly in studies focused on melanoma and T cell-mediated immune responses. -
Bioactive Peptide
CFP10 (71–85) is a bioactive peptide that stimulates the production of interferon-gamma (IFN-γ) and enhances cytotoxic T lymphocyte (CTL) activity in both CD4+ and CD8+ T cells. It is particularly effective in individuals expressing various MHC class II and class I molecules. This peptide is valuable for research applications focused on immune response modulation and T cell activation. -
CLIP Fragment
CLIP (86-100) is the amino acid fragment of the class II-associated invariant chain peptide, comprising residues 86 to 100. This small self-peptide is a cleavage product that resides within the HLA-II antigen binding groove, playing a pivotal role in the assembly and transport of MHC class II alphabetaIi complexes. It interacts with the class II peptide-binding site, making it essential for understanding MHC class II functionality in immunological research and potential therapeutic applications. -
Graft Protective Agent
N-Octanoyl dopamine is a graft protective agent that enhances contractile function in heart transplant recipients, particularly those from brain-dead donors. This compound functions by inhibiting cytokine production in activated T-cells, along with reducing MHC class II expression and adhesion molecules in interferon-gamma-stimulated endothelial cells. Its unique properties support research into transplant immunology and cardiac preservation. -
TGR5 Agonist
Cholic acid 7-sulfate is a selective agonist for the TGR5 receptor with an EC50 of 0.17 μM. This compound enhances GLP-1 secretion in enteroendocrine L cells, leading to improved glucose tolerance through TGR5 activation. Additionally, as an endogenous ligand for MHC class I-related protein (MR1), it supports the survival of mucosal-associated invariant T (MAIT) cells and influences their development and function by modulating homeostatic gene expression. Cholic acid 7-sulfate is valuable in studies related to diabetes and MAIT cell-mediated immune regulation. -
Stable Isotope
Cholic acid 7-sulfate-d4 is a deuterium-labeled derivative of cholic acid 7-sulfate, a selective agonist for the TGR5 receptor with an EC50 of 0.17 μM. This compound plays a crucial role in stimulating GLP-1 secretion and enhancing glucose tolerance through its action on enteroendocrine L cells. Additionally, cholic acid 7-sulfate-d4 serves as an endogenous ligand for MHC class I-related protein (MR1), influencing the development and function of mucosal-associated invariant T cells (MAIT). It is primarily utilized in research focused on diabetes and immune regulation related to MAIT cells. -
ERAP1 Inhibitor
ERAP1 modulator-2 is a potent inhibitor of the enzyme ERAP1, exhibiting an IC50 value of less than 100 nM. This compound effectively modulates the activity of ERAP1, influencing peptide trimming and presentation in the context of antigen processing. It is valuable for research applications focused on immune regulation, inflammation, and the modulation of major histocompatibility complex (MHC) class I-mediated responses. -
LXR Agonist
DMHCA is a potent and selective liver X receptor (LXR) agonist that specifically activates the cholesterol efflux pathway while avoiding the stimulation of triglyceride synthesis. This compound exhibits anti-inflammatory properties, making it a valuable tool for research in cholesterol homeostasis and diabetes. DMHCA's selective mechanism provides insight into the role of LXR modulation in metabolic disorders. -
Endogenous Metabolite
p60 (217–225) is a subdominant epitope derived from Listeria monocytogenes, recognized by H-2Kd MHC class I molecules. This peptide plays a crucial role in the immune response to Listeria infection, facilitating T cell recognition and activation. p60 (217–225) is essential for studying antigen presentation and T cell immunity in infectious disease research and vaccine development. -
Endogenous Metabolite
NC1153 is a Mannich base that targets and inhibits IL-2-induced JAK3 activation, subsequently preventing the activation of downstream substrates such as STAT5a/b. This compound has been shown to effectively extend the survival of kidney transplants in both MHC and non-MHC mismatched rat models. Additionally, NC1153 provides comprehensive protection against toxicity for recipients when used in conjunction with cyclosporine A (CsA), demonstrating a synergistic effect to enhance graft survival while avoiding nephrotoxicity, myelotoxicity, and lipotoxicity. -
TRP-2 Derived Peptide
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from tyrosinase-related protein 2, corresponding to residues 181-188. This peptide contains the primary reactive epitope recognized by anti-B16 cytotoxic T lymphocytes (CTLs) and is designed to conform to the MHC class I H2-Kb binding motif. TRP-2 (181-188) is essential for studies in immunology and cancer research, particularly in the context of melanoma and anti-tumor immune responses. -
Immunoproteasome Activator
Immunoproteasome Activator 1 is a selective activator of the immunoproteasome that enhances the presentation of MHC-I-bound peptides by over 100-fold. This compound functions by binding to the proteasome structural subunit PSMA1, facilitating the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes. Its significant biological activity makes it valuable for research focused on immune response modulation and antigen processing. -
Hapten
1-Adamantaneethanol is a hapten that modifies peptide binding to Major Histocompatibility Complex Class II (MHC II) molecules. This compound is utilized in immunological research to study T cell activation and the role of haptens in immune response modulation. Its ability to alter peptide presentation makes it a valuable tool for investigating MHC-related pathways and autoimmune conditions. -
Stable Isotope
1,10-Decanediol-d20 is the deuterated version of 1,10-decanediol, a diol compound known for its role in the formation of polymeric microparticles (paKG MPs) upon reaction with α-ketoglutarate (aKG). These microparticles facilitate the sustained release of aKG, promoting immunosuppressive responses by modulating dendritic cell metabolism, including reduced glycolysis and mitochondrial respiration. This modulation impacts the expression of key surface markers such as MHC-II and CD86 and influences the frequency of regulatory T cells and T-helper subsets in vitro. 1,10-Decanediol-d20 serves as a critical tool in immunometabolism research and is also useful as a surfactant or stabilizer in nanomaterial synthesis. -
Stable Isotope
Pristane-d40 is a deuterium-labeled derivative of Pristane, which is a naturally occurring hydrocarbon found in various plants and marine organisms. This stable isotope is utilized in biological research to trace metabolic pathways and investigate lipid dynamics. Pristane has been shown to induce MHC class II-restricted, arthritogenic T cells in rat models, making this compound valuable for studies related to autoimmunity and immunological response. -
Insecticide
Furathiocarb is a carbamate pro-insecticide that primarily targets insect nervous systems. It exhibits significant biological activity by inducing the proliferation of MHC II-positive B cells in auricular lymph nodes and promoting the production of Th1 cytokines, including IL-2, TNF-γ, and IFN-γ. Furathiocarb has applications in contact allergy research, demonstrating no respiratory allergy induction in mice. After dermal absorption in isolated rats, it is fully metabolized to carbofuran, with skin permeation rates for emulsifiable concentrate and wettable powder formulations exceeding those of the parent compound. -
Immunological Adjuvant
Pristane is a naturally occurring hydrocarbon oil that functions as an immunological adjuvant. It is used to induce MHC class II-restricted, arthritogenic T cells in experimental models, particularly in rat studies. Pristane's unique properties make it valuable for research applications focused on immune response modulation and the study of autoimmune conditions. -
Anticancer Agents
Hericenone A is an isoindoline compound derived from the fruiting bodies of Hericium erinaceum. Exhibiting potent anticancer activity, it effectively inhibits the growth of SMMC-7221 and MHCC-97H cell lines at a concentration of 20 μg/mL. This compound is of particular interest in cancer research for its potential therapeutic applications. -
Hapten
AdBeSA is a hapten that modulates peptide binding to MHC class II molecules. This structural analog can alter immune responses by impacting antigen presentation. Its primary application is in the study of T-cell activation and the design of peptide-based vaccines. AdBeSA serves as an important tool for researchers investigating immune system interactions and therapeutic strategies targeting autoimmune diseases. -
MHC class II epitope antigen
M30 peptide is an MHC class II epitope antigen that plays a crucial role in initiating T cell responses. This peptide is particularly valuable in cancer nanovaccine research, facilitating the development of targeted immunotherapies. By enhancing antigen presentation, M30 peptide supports investigations into adaptive immune responses against tumors. -
MHC class I epitope antigen
M27 peptide is an MHC class I epitope antigen that plays a crucial role in immune response modulation. Its primary application lies in cancer nanovaccine research, facilitating the development of targeted immunotherapies. By presenting specific antigenic sequences, M27 peptide aids in the identification and activation of T lymphocytes, contributing to enhanced anti-tumor immune responses. -
Multiple Sclerosis Immune Modulator
Glatiramer acetate is a synthetic analogue of myelin basic protein that functions primarily as an immune modulator for the treatment of multiple sclerosis. Its mechanism involves inhibiting experimental autoimmune encephalomyelitis (EAE) by competing with myelin antigens for binding to MHC molecules, which subsequently modulates T cell response. Additionally, glatiramer acetate promotes the induction of T helper 2 (Th2) cells, which migrate to the central nervous system and facilitate localized immunosuppression. This compound serves as a valuable tool for research into autoimmune disorders and therapeutics for multiple sclerosis. -
Hapten
J10-1 is a hapten that enhances peptide exchange among various DR alleles, including DR1, DR2, and DR4 (specifically DRB1*0401). This compound facilitates the binding of peptides to MHC class II molecules, making it a valuable tool for investigating immune regulation and responses. Its utility in research applications can aid in the understanding of T cell activation and autoimmune diseases.
