1,10-Decanediol-d20 is the deuterated version of 1,10-decanediol, a diol compound known for its role in the formation of polymeric microparticles (paKG MPs) upon reaction with α-ketoglutarate (aKG). These microparticles facilitate the sustained release of aKG, promoting immunosuppressive responses by modulating dendritic cell metabolism, including reduced glycolysis and mitochondrial respiration. This modulation impacts the expression of key surface markers such as MHC-II and CD86 and influences the frequency of regulatory T cells and T-helper subsets in vitro. 1,10-Decanediol-d20 serves as a critical tool in immunometabolism research and is also useful as a surfactant or stabilizer in nanomaterial synthesis.
1,10-Decanediol-d20 is the deuterated version of 1,10-decanediol, a diol compound known for its role in the formation of polymeric microparticles (paKG MPs) upon reaction with α-ketoglutarate (aKG). These microparticles facilitate the sustained release of aKG, promoting immunosuppressive responses by modulating dendritic cell metabolism, including reduced glycolysis and mitochondrial respiration. This modulation impacts the expression of key surface markers such as MHC-II and CD86 and influences the frequency of regulatory T cells and T-helper subsets in vitro. 1,10-Decanediol-d20 serves as a critical tool in immunometabolism research and is also useful as a surfactant or stabilizer in nanomaterial synthesis.
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