NC1153 is a Mannich base that targets and inhibits IL-2-induced JAK3 activation, subsequently preventing the activation of downstream substrates such as STAT5a/b. This compound has been shown to effectively extend the survival of kidney transplants in both MHC and non-MHC mismatched rat models. Additionally, NC1153 provides comprehensive protection against toxicity for recipients when used in conjunction with cyclosporine A (CsA), demonstrating a synergistic effect to enhance graft survival while avoiding nephrotoxicity, myelotoxicity, and lipotoxicity.
NC1153 is a Mannich base that targets and inhibits IL-2-induced JAK3 activation, subsequently preventing the activation of downstream substrates such as STAT5a/b. This compound has been shown to effectively extend the survival of kidney transplants in both MHC and non-MHC mismatched rat models. Additionally, NC1153 provides comprehensive protection against toxicity for recipients when used in conjunction with cyclosporine A (CsA), demonstrating a synergistic effect to enhance graft survival while avoiding nephrotoxicity, myelotoxicity, and lipotoxicity.
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