Finerenone-d3 is a deuterium-labeled form of finerenone, a selective, orally active nonsteroidal mineralocorticoid receptor (MR) antagonist with an IC50 of 18 nM. This compound exhibits remarkable selectivity against glucocorticoid, androgen, and progesterone receptors, with over 500-fold selectivity. Finerenone-d3 is valuable for studying cardiorenal diseases, including type 2 diabetes mellitus and chronic kidney disease, enabling detailed metabolic and pharmacokinetic investigations in research settings.
Finerenone-d3 is a deuterium-labeled form of finerenone, a selective, orally active nonsteroidal mineralocorticoid receptor (MR) antagonist with an IC50 of 18 nM. This compound exhibits remarkable selectivity against glucocorticoid, androgen, and progesterone receptors, with over 500-fold selectivity. Finerenone-d3 is valuable for studying cardiorenal diseases, including type 2 diabetes mellitus and chronic kidney disease, enabling detailed metabolic and pharmacokinetic investigations in research settings.
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