Enasidenib-d6 is a deuterated analogue of Enasidenib, a potent, reversible inhibitor selectively targeting mutant IDH2 enzymes. It exhibits IC50 values of 100 nM for IDH2R140Q and 400 nM for IDH2R172K, demonstrating significant biological activity in modulating the pathways associated with these mutations. This stable isotope-labeled compound is useful in research applications such as metabolic studies, pharmacokinetic profiling, and elucidation of IDH2-related cellular mechanisms.
Enasidenib-d6 is a deuterated analogue of Enasidenib, a potent, reversible inhibitor selectively targeting mutant IDH2 enzymes. It exhibits IC50 values of 100 nM for IDH2R140Q and 400 nM for IDH2R172K, demonstrating significant biological activity in modulating the pathways associated with these mutations. This stable isotope-labeled compound is useful in research applications such as metabolic studies, pharmacokinetic profiling, and elucidation of IDH2-related cellular mechanisms.
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