Dantrolene-13C3 is a stable isotope-labeled analog of Dantrolene, a muscle relaxant that non-competitively inhibits human erythrocyte glutathione reductase, with Ki and IC50 values of 111.6 μM and 52.3 μM, respectively. As a ryanodine receptor antagonist, Dantrolene-13C3 plays a critical role in stabilizing Ca2+ signaling. This reagent is suitable for research applications related to muscle spasticity, malignant hyperthermia, Huntington's disease, and neuroleptic malignant syndrome.
Dantrolene-13C3 is a stable isotope-labeled analog of Dantrolene, a muscle relaxant that non-competitively inhibits human erythrocyte glutathione reductase, with Ki and IC50 values of 111.6 μM and 52.3 μM, respectively. As a ryanodine receptor antagonist, Dantrolene-13C3 plays a critical role in stabilizing Ca2+ signaling. This reagent is suitable for research applications related to muscle spasticity, malignant hyperthermia, Huntington's disease, and neuroleptic malignant syndrome.
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