Catalog No.
Product Name
Application
Product Information
Citations
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Antibacterial agent
FtsZ-IN-9 is an antibacterial agent targeting the essential protein FtsZ, which is critical for bacterial cell division. By specifically inhibiting the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ), FtsZ-IN-9 disrupts bacterial proliferation. This compound is valuable for research focused on developing novel antimicrobial therapies and understanding bacterial cell division mechanisms. -
Bacterial Inhibitor
BPH-651 is a bacterial inhibitor that targets dehydrosqualene synthase, an essential enzyme involved in bacterial terpenoid biosynthesis. This compound exhibits potent antibacterial activity by binding to multiple sites on the enzyme, revealing structural insights into the mechanism of action and inhibition of head-to-head prenyltransferase. BPH-651 is useful for research focused on designing new antibacterial agents and studying bacterial resistance mechanisms. -
Bacterial Inhibitor
Antistaphylococcal agent 1 functions as a bacterial inhibitor, specifically targeting Staphylococcus species. This compound exhibits significant antimicrobial activity, making it a valuable tool in the study of bacterial infections and resistance mechanisms. Its application can aid in the development of novel therapeutic strategies against staphylococcal infections. -
Anti-Bacterial Agent
Furanomycin is an anti-bacterial agent that exhibits broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria. This compound inhibits the bacteriophage of Escherichia coli and acts as a competitive antagonist of L-isoleucine, making it a valuable tool for exploring bacterial resistance mechanisms and characterizing amino acid transport pathways. Its diverse biological activity supports a range of research applications in microbiology and antibiotic discovery. -
Anti-bacterial Agent
8-Br-GTP is a GTP analog that serves as a competitive inhibitor of FtsZ polymerization and GTPase activity, exhibiting a Ki value of 31.8 μM. This compound demonstrates antibacterial properties and can be utilized for nucleic acid modification in various research applications, particularly in the study of bacterial cell division and antibiotic resistance mechanisms. -
Antibacterial Agent
ATD-3169 is an antibacterial agent that functions by enhancing endogenous reactive oxygen species (ROS), including superoxide radicals. This mechanism of action effectively inhibits the growth of Mycobacterium tuberculosis (Mtb). ATD-3169 is a valuable tool for research applications aimed at understanding and combating tuberculosis infections. -
Bacterial Inhibitor
(Rac)-DNDI-8219 is a bacterial inhibitor with demonstrated efficacy against Leishmania species. This compound exhibits potent antituberculosis and anti-leishmanial activities, showcasing significant effectiveness in both the Leishmania donovani mouse model and the Leishmania infantum hamster model. Interestingly, the R-6 candidate form of (Rac)-DNDI-8219 offers excellent oral bioavailability and efficacy in the hamster model, making it a valuable tool for research focused on treating leishmaniasis and tuberculosis. -
Antibacterial Agent
CYP3A4 enzyme-IN-1 is a potent antibacterial agent that specifically targets and inhibits bacterial growth, demonstrating a minimum inhibitory concentration (MIC) of 1 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Additionally, this compound exhibits low to moderate inhibitory effects on various cytochrome P450 enzymes, including CYP1A2, CYP2E1, CYP2D6, and CYP3A4. It serves as a valuable tool for studying antibacterial mechanisms and exploring potential therapeutic applications in infectious diseases. -
Antibacterial Agent
Armeniaspirol A is an antibacterial agent that targets the cell membranes of Helicobacter pylori. It induces membrane permeabilization, leading to cytoplasmic leakage and effectively inhibits or eradicates biofilm formation. This compound shows promise for research related to H. pylori infections and contributes to understanding strategies for combating this pathogen. -
Antibacterial Agent
Jinflexin D is a dimeric phenanthrene natural product that functions as a potential antibacterial agent. Its unique seven-membered ring structure enhances its biological activity, although it does not exhibit inhibitory effects against methicillin-resistant Staphylococcus aureus (MRSA). Extracted from the methanol extract of the roots of Juncus inflexus, Jinflexin D may have applications in the development of novel antibacterial therapies. -
Antibacterial Agent
Antibacterial Agent 47 acts primarily as an antibacterial compound, enhancing the efficacy of established antibiotics such as Ceftazidime. This agent significantly lowers the minimum inhibitory concentration (MIC) of Ceftazidime, promoting greater antibacterial activity against susceptible strains. Antibacterial Agent 47 is suitable for research focused on developing combination therapies and investigating mechanisms of antibiotic resistance. -
Antibacterial Agent
Daldinone A is an antibacterial agent isolated from Nigrospora oryzae, targeting a range of microbial pathogens. Notably, Daldinone A exhibits significant antimicrobial activity against Pseudomonas aeruginosa, making it a valuable compound for research in antimicrobial resistance and drug development. Its potential applications extend to exploring new therapeutic strategies for treating bacterial infections. -
Antibacterial Agent
Hexahydrohippuric acid is an antibacterial agent derived from the microbial metabolism of shikimic acid in liver and kidney tissues. This compound consists of cyclohexane carboxylic acid and glycinamide, exhibiting significant antibacterial activity. Its unique properties make it a valuable tool for research into antibacterial mechanisms and potential therapeutic applications. -
Antibacterial Agent
(+)-Thienamycin is a potent broad-spectrum antibacterial agent and β-lactamase inhibitor derived from Streptomyces cattleya. It demonstrates significant activity against various Gram-positive and Gram-negative bacteria, making it a valuable tool for research in antimicrobial resistance and antibiotic development. Its ability to inhibit β-lactamase enzymes enhances the efficacy of β-lactam antibiotics, facilitating studies on bacterial pathogenesis and therapeutic strategies. -
Antibacterial Agent
RWJ-416457 is an orally bioavailable antibacterial agent that targets 23S rRNA within the ribosome. This compound exhibits potent activity against Gram-positive bacterial infections, making it a valuable tool for researchers studying antibiotic mechanisms and bacterial resistance. Its specific action on ribosomal components positions RWJ-416457 as an important candidate for further exploration in antimicrobial research. -
Bacterial
FCE 22250 is a 3-azinomethylrifamycin that targets bacterial infections, demonstrating long-term in vivo persistence and effective oral absorption. It exhibits potent antimicrobial activity across a broad spectrum, particularly against mycobacteria, making it a valuable reagent for research applications focused on bacterial resistance and treatment strategies. -
Antibacterial Drug
Curcapicycloside (Pilosidine) is a norlignan glucoside that exhibits antibacterial activity primarily targeting Escherichia coli. This compound has potential applications in antibacterial drug development and pharmacological studies aimed at understanding its mechanisms of action against bacterial infections. It serves as a valuable tool for researchers investigating novel antibacterial agents. -
Antibacterial Agent
Mucrolidin is an eudesmane-type sesquiterpenoid with antibacterial activity. Isolated from the aerial parts of Homalomena occulta, Mucrolidin demonstrates modest efficacy against bacterial strains. This compound can be used in research applications focusing on the development of new antibacterial agents and the study of natural product pharmacology. -
Bacterial Inhibitor
Acaterin is a bacterial inhibitor derived from Pseudomonas, known for its role in antimicrobial activity. Research indicates that its biosynthesis is regulated through a complex gene cluster, with studies highlighting its associated biosynthetic pathway. Comparative transcriptomics further demonstrates the compound's formation is intricately linked to bacterial regulatory networks, making it valuable for studies in bacterial physiology and the development of new antimicrobial strategies. -
Antibacterial Agent
Antibacterial Agent 102 is a potent antibacterial compound that exhibits significant in vitro and in vivo activity against Staphylococcus aureus, with minimum inhibitory concentrations (MICs) below 0.5 μg/mL. Additionally, it moderately inhibits the cytochrome P450 enzyme CYP3A4, with an IC50 value of 6.148 μM. This compound has demonstrated efficacy in reducing Methicillin-resistant Staphylococcus aureus (MRSA) loads in infected mice models, making it valuable for research into antibiotic resistance and therapeutic interventions. -
Antibacterial Agent
Antibacterial Agent 201 is an antibacterial compound that disrupts membrane integrity in target organisms. It demonstrates significant efficacy against Staphylococcus aureus strain RN4220, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa strain PA01, and Escherichia coli strain ANS1, with minimum inhibitory concentrations (MIC99) of 2.0, 1, 8.1, and 2.2 μg/mL, respectively. This reagent is suitable for research applications focused on studying bacterial resistance mechanisms and evaluating antibacterial properties. -
Antibacterial Agent
Antibacterial Agent 48 is a potent antibacterial compound that enhances the efficacy of the beta-lactam antibiotic Ceftazidime by significantly reducing its minimum inhibitory concentration (MIC). This synergy suggests its potential utility in combating antibiotic-resistant bacterial strains and improving treatment outcomes. It is a valuable reagent for research focused on developing novel antibacterial therapies and exploring resistance mechanisms. -
Antimycobacterial Agent
Antimycobacterial agent-1 selectively targets Mycobacterium tuberculosis (M. tuberculosis) H37Ra and exhibits potent antimycobacterial activity with a minimum inhibitory concentration (MIC) of 1 μg/ml. This compound demonstrates relatively low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg/ml in Vero cells. Its efficacy and safety profile make it a valuable tool for research focused on tuberculosis and antimycobacterial drug development. -
Antibacterial Agent
Antibacterial Agent 94 is a potent antibacterial compound that demonstrates significant activity against MRSA persisters. This agent disrupts bacterial membrane integrity and interferes with the synthesis of phosphatidylglycerol (PG). Its mechanism of action makes it a valuable tool in the research of antibacterial therapies and the exploration of drug resistance in pathogenic bacteria. -
Bacterial
Berninamycin A is a cyclic thiopeptide antibiotic that targets Gram-positive bacteria by inhibiting protein biosynthesis through specific binding to ribosomal subunits. Initially isolated from Streptomyces bernensis, this compound also induces the transcriptional activator TipA in Streptomyces, highlighting its role in antimicrobial research. Berninamycin A is valuable for studies involving antibiotic resistance mechanisms and the development of new antibacterial agents. -
Antibacterial Agent
Asperglaucin B is an alkylated salicylaldehyde derivative derived from the fungus Aspergillus chevalieri SQ-8, recognized for its antibacterial properties. This compound exhibits potent antibacterial activity against plant pathogens, specifically Pseudomonas syringae pv actinidae and Bacillus cereus, with a minimum inhibitory concentration (MIC) of 6.25 μM. Asperglaucin B serves as a valuable tool in research focused on plant disease control and the development of novel antibacterial agents. -
Bacterial Inhibitor
8-Epidiosbulbin E acetate is a furanoid compound derived from Dioscorea bulbifera L. It functions as a bacterial inhibitor, demonstrating broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. Additionally, it has been noted to induce liver injury in murine models, highlighting its potential impact on liver function. This compound is valuable for research involving antibiotic resistance and bacterial pathogenicity. -
Bacterial Inhibitor
FtsZ-IN-10 is a bacterial division inhibitor that targets the assembly of FtsZ, a critical protein involved in bacterial cytokinesis. By binding specifically to Bacillus subtilis FtsZ monomers, FtsZ-IN-10 disrupts their polymerization, ultimately hindering the formation of the Z ring and inhibiting cell division. This compound has demonstrated efficacy against antibiotic-resistant clinical isolates, including Staphylococcus aureus and Enterococci, making it a valuable tool in microbiological research and antibiotic development. Additionally, FtsZ-IN-10 may stimulate nucleotide-free archaeal FtsZ to form structured polymers, contributing to its versatile applications in studying bacterial growth and division mechanisms. -
Metallo-β-Lactamase Inhibitor
EBL-3183 is a potent inhibitor of metallo-β-lactamases (MBLs) that targets the NDM-1 enzyme. This indole-2-carboxylate compound exhibits reversible, non-covalent, and competitive inhibition characterized by a pIC50 value of 7.7. EBL-3183 is valuable for research applications focused on combating antibiotic resistance and exploring mechanisms of MBL inhibition. -
β-lactamase Inhibitor
Xeruborbactam methoxy acetoxy methyl ester is a boronic acid derivative specifically designed as a β-lactamase inhibitor. This compound effectively inhibits the enzymatic activity of β-lactamases, which are responsible for antibiotic resistance in various bacterial strains. It is primarily utilized in research applications aimed at understanding β-lactamase mechanisms and developing novel antimicrobial therapies. -
Antibacterial Agent
Mycolic acid IIa is a key structural lipid of the mycobacterial cell wall, primarily sourced from Mycobacterium bovis BCG. This compound plays a crucial role in modulating membrane permeability and stability, making it a valuable tool for research on Mycobacterium tuberculosis infections. Its antibacterial properties support studies aimed at understanding mycobacterial pathogenesis and developing new therapeutic approaches. -
Bacterial Inhibitor
Ianthelliformisamine C ditrifluoroacetate is a bacterial inhibitor that enhances the activity of antibiotics against resistant Gram-negative bacteria. This compound has been shown to significantly improve the efficacy of doxycycline against Pseudomonas aeruginosa. Its mechanism of action involves inducing ATP efflux and causing membrane depolarization in bacterial cells. Ianthelliformisamine C ditrifluoroacetate is synthesized using peptide coupling, resulting in high chemical yields ranging from 27% to 91%, making it a valuable tool for research in combating antibiotic resistance. -
Antibacterial Agent
Ilicicolin C is an antibacterial agent with demonstrated efficacy against Pseudomonas syringae, exhibiting an IC50 of 28.5 µg/mL. Additionally, it has shown weak inhibitory effects on acetylcholinesterase and β-glucuronidase, with IC50 values ranging from 30 to 43 µg/mL. The compound also displays weak cytotoxicity in human lung fibroblasts, with IC50 values of 64 to 120 µg/mL. Furthermore, Ilicicolin C influences seed germination and root tip growth in lettuce, indicating potential implications in plant research. -
Bacterial Inhibitor
Protactin is a pentapeptide lactone that targets bacterial growth, derived from the Streptomyces cucumeris strain L703-4 (ATCC 53784). This compound demonstrates significant antioxidant properties and can be converted to actinomycin Zp through ferrocyanide oxidation, which displays potent antibacterial activity in vitro. Additionally, actinomycin Zp has been shown to possess substantial antitumor effects against P-388 leukemia in murine models, making it a valuable reagent for cancer research and microbiological studies. -
Antibacterial Agent
Olamufloxacin is an orally active fluoroquinolone antibacterial agent that exerts its effect by targeting bacterial DNA gyrase and topoisomerase IV. This compound demonstrates broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and effectively inhibits the growth of extracellular Legionella species as well as intracellular Legionella pneumophila. Olamufloxacin also mitigates cytotoxicity associated with Legionella pneumophila and has been shown to increase survival rates and decrease lung bacterial burden in infected guinea pig models. This reagent is valuable for research focused on legionnaires’ disease and its underlying pathogenic mechanisms. -
Bacterial Inhibitor
Cyclo(Leu-Ala) is a cyclic dipeptide with demonstrated antimicrobial properties targeting bacterial pathogens. This compound exhibits significant inhibitory activity against various plant pathogens, making it a valuable tool in studies involving plant-microbe interactions and the development of novel antimicrobial agents. Its potential applications include agricultural research and the investigation of natural products for controlling plant diseases. -
Antibacterial Agent
Syringopicroside is a natural compound derived from Syringa oblata Lindl. It exhibits significant antibacterial activity, making it a valuable tool for research into microbial infections and potential therapeutic applications. This compound is of interest for studies exploring the mechanisms of action against a variety of bacterial strains. -
Bacterial Inhibitor
Haplopine is a bacterial inhibitor that exhibits photo-activated antimicrobial properties. It demonstrates the ability to bind to DNA, making it a valuable tool for research applications focused on bacterial infections and microbial resistance. This compound is beneficial in studies investigating the mechanisms of antimicrobial action and the potential development of novel therapeutic strategies. -
Antibacterial Agent
8,9-Dehydro-7,9-diisobutyryloxythymol is a derivative of thymol that exhibits antibacterial properties. This compound demonstrates selective inhibitory activity against Gram-positive bacteria, notably Bacillus cereus, while showing no detectable cytotoxicity against human cancer cell lines in vitro. 8,9-Dehydro-7,9-diisobutyryloxythymol is valuable for research applications focused on bacterial infections and developing antibacterial agents. -
Bacterial Inhibitor
Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day. -
Antibacterial Peptide
Acetyl-Adhesin (1025-1044) amide is a 20-peptide fragment derived from the cell surface adhesin of Streptococcus pyogenes, functioning as an antibacterial peptide. This compound specifically inhibits the interaction between adhesin and salivary receptors, thereby preventing the recolonization of Streptococcus pyogenes. Its potential applications include studies in microbial pathogenesis and the development of novel antimicrobial strategies. -
Antibacterial Agent
Antibacterial Agent 96 (compound 4k) is a potent antibacterial compound that targets Mycobacterium tuberculosis, demonstrating significant antitubercular activity against both drug-susceptible and multidrug-resistant strains. This agent is valuable for research applications focused on tuberculosis treatment, particularly in the face of emerging resistance. However, it is important to note that Antibacterial Agent 96 exhibits toxicity to HepG2 and Vero cell lines. -
Antibacterial Agent
3,4-Seco-mansumbinoic acid is an antibacterial agent isolated from the oleo-resin of *Commiphora molmol*. This compound demonstrates significant in vitro anti-staphylococcal activity, particularly against the multidrug-resistant strain *Staphylococcus aureus* SA-1199B, with a minimum inhibitory concentration (MIC) of 4 μg/mL. Additionally, 3,4-Seco-mansumbinoic acid shows weak potentiation of Ciprofloxacin and Tetracycline against *Salmonella enterica* serovar Typhimurium strains. This compound is valuable for research focused on multidrug-resistant bacterial infections. -
Bacterial Inhibitor
Glyasperin D is a flavonoid derived from Glycyrrhiza uralensis that demonstrates antibacterial properties, specifically as a bacterial inhibitor against Helicobacter pylori. Its biological activity suggests potential applications in research focused on bacterial infections and the development of antibacterial agents. This compound may serve as a valuable tool in studying H. pylori-related diseases and exploring flavonoid mechanisms in bacterial inhibition. -
Antibacterial Agent
LAB 149202F is an acylanilide antibacterial agent that exerts inhibitory effects on bacterial strains exhibiting formyl and phosphate resistance. This compound demonstrates significant antimicrobial activity, making it a valuable tool for research into antibiotic resistance mechanisms and the development of new therapeutic strategies. Its application in various biological assays supports the exploration of bacterial pathogenesis and antibiotic efficacy. -
Antibacterial Agent
Desethylene Ciprofloxacin hydrochloride functions as an antibacterial agent, derived from the metabolism of Ciprofloxacin. It acts primarily as a topoisomerase IV inhibitor, contributing to its antibacterial properties. This compound is suitable for research applications focused on antibacterial mechanisms and the study of bacterial resistance. -
Antibacterial Agent
Antibacterial Agent 130 is a 1,1-diarylthiogalactoside that specifically targets the lectin LecA from Pseudomonas aeruginosa. It exhibits a high affinity for LecA, with a Kd of 1 μM, demonstrating effective antibiofilm activity. Although it does not possess bactericidal properties, it is valuable for research into bacterial adhesion and biofilm formation, making it a useful tool in studies of Pseudomonas aeruginosa virulence and infection mechanisms. -
Bacterial Inhibitor
JM 1397 is a potent antibacterial agent with a primary mechanism of action against bacterial pathogens. It demonstrates significant antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC90) of 1 μg/mL. This compound is valuable for research in antibiotic resistance and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Gyramide A is a bacterial inhibitor that targets bacterial topoisomerases. It has been shown to exhibit a unique mechanism of action distinct from other topoisomerase inhibitors, highlighting its potential in studies related to bacterial resistance. Gyramide A is valuable for research applications aimed at understanding the protective effects of Qnr proteins on bacterial enzymes and developing novel antibacterial strategies. -
Antibacterial Agent
Vaneprim is an antibacterial agent that exhibits broad-spectrum activity against various bacterial strains. Its mechanism involves the inhibition of bacterial cell wall synthesis, leading to cell lysis and death. This reagent is valuable for research applications involving the study of bacterial resistance mechanisms and the development of new antibacterial therapies.
