Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day.
Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day.
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