Catalog No.
Product Name
Application
Product Information
Citations
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Antiviral Agent
Antiviral agent 67 (compound PC6) is a potent inhibitor of the dengue virus (DENV) NS5 RNA-dependent RNA polymerase, exhibiting a Ki value of 1.12 nM. It demonstrates significant antiviral activity, making it a valuable tool for research focused on DENV replication and antiviral drug discovery. This compound is suitable for studies aimed at understanding the mechanisms of antiviral action and evaluating potential therapeutic strategies against dengue virus infections. -
Antitumor Antibiotic
2-Hydroxyaclacinomycin A is an anthracycline antibiotic that exerts its antitumor effects through the inhibition of RNA and DNA synthesis. It demonstrates potent cytotoxic activity against leukemia L-1210 cells, with IC50 values of 0.10 μg/mL and 0.95 μg/mL for RNA and DNA synthesis, respectively. This compound is valuable for research focused on cancer therapeutics and the cellular mechanisms of anthracycline antibiotics. -
Antitumor Antibiotic
1-Hydroxyoxaunomycin is an antitumor antibiotic that targets cellular proliferation. It effectively inhibits U210 cell growth, demonstrating IC50 values of 0.0005 μg/mL for cell growth, 1.00 μg/mL for DNA synthesis, and 0.76 μg/mL for RNA synthesis. This compound is primarily utilized in cancer research to explore mechanisms of action related to nucleic acid synthesis and cellular function. -
Antibacterial Agent
DV-7751A is a fluoroquinolone antibiotic that primarily inhibits the supercoiling activity of DNA gyrases. This compound demonstrates significant antimicrobial activity against a range of bacterial strains, including Streptococcus pneumoniae, Streptococcus pyogenes, and Peptostreptococcus species. Additionally, DV-7751A exhibits a rapid bactericidal effect against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, making it a valuable reagent for research in antibacterial therapeutics. -
Antibiotic
Erythromycin glutamate is a macrolide antibiotic that primarily targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis by blocking transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity against various bacterial pathogens. In addition to its antibiotic properties, erythromycin glutamate has shown potential antitumor and neuroprotective effects, making it valuable for diverse research applications in microbiology, oncology, and neurobiology. -
AntibioticAgent
GSK299423 is an antibiotic agent primarily targeting DNA gyrase. It exhibits potent inhibition of supercoiling in Staphylococcus aureus with an IC50 of 14 nM and in Escherichia coli with an IC50 of 100 nM. This compound is suitable for research applications focused on antibacterial mechanisms and the evaluation of DNA-targeting therapies. -
Antibiotic
Viquidacin is an antibiotic that primarily targets topoisomerase IV and DNA gyrase. It demonstrates significant antibacterial activity against gram-positive bacteria, particularly Staphylococcus aureus, by inhibiting supercoiling, decatenation, and relaxation processes. Viquidacin also exhibits activity against Escherichia coli and shows a minimum inhibitory concentration (MIC) range of 2-128 mg/L against wild-type and mutant strains of S. aureus, making it a valuable reagent for antibacterial research applications. -
Antibiotic
Erythromycin hydrochloride is a macrolide antibiotic that acts as a protein synthesis inhibitor, targeting bacterial ribosomes. It demonstrates broad-spectrum activity against both Gram-positive and some Gram-negative bacteria, making it effective in treating various bacterial infections, including respiratory and skin infections. Additionally, erythromycin hydrochloride has been implicated in the inhibition of mammalian mRNA splicing, indicating potential roles in research related to gene expression and cellular function. This compound is widely utilized in biomedical research for its antibacterial properties and mechanisms. -
Anti-HIV Agent
3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analog that serves as an anti-HIV agent by acting as a chain terminator. Incorporated into the nascent DNA strand by HIV reverse transcriptase, AZddCTP halts DNA synthesis due to its lack of a 3'-hydroxyl group, effectively inhibiting viral replication. With IC50 values of 15.6 μM against wild-type HIV and 160.8 μM for AZTR HIV, 3′-Azido-2′,3′-dideoxy-CTP demonstrates significant antiviral activity, making it a valuable tool in HIV research. -
Insecticide/Antibacterial Agent
Satranidazole is an orally active insecticide and antimicrobial agent that primarily targets DNA through the formation of reduced nitro intermediates. By inducing helix instability and strand breakage, it exhibits notable antitrichomonal activity against organisms such as Trichomonas vaginalis and Trichomonas foetus, as well as antiamoebic effects in rodent models of hepatic and caecal amoebiasis. Additionally, Satranidazole has been shown to inhibit the replication of bacteriophage φX174 DNA. This compound is valuable for research exploring caecal amoebiasis, trichomoniasis, and anaerobic bacterial infections. -
Anticancer Agent
Endusamycin is an anticancer agent that inhibits protein and nucleic acid synthesis in Ehrlich ascites carcinoma cells. This selective activity contributes to its efficacy as a potential therapeutic for cancer research, while exhibiting no antibacterial or antifungal effects. Endusamycin is suitable for studies aimed at understanding cancer cell metabolism and the development of new cancer treatment strategies. -
Antibacterial/anti-inflammatory Agent
Sinapaldehyde is a methoxyphenol that primarily functions as a selective COX-2 inhibitor with an IC50 of 47.8 µM. This compound exhibits notable antibacterial and anti-inflammatory properties, demonstrating efficacy against both Gram-positive and Gram-negative bacteria. Additionally, Sinapaldehyde possesses antioxidant activity through its ability to scavenge DPPH free radicals, with an IC50 of 172 μM, making it a valuable reagent for research in inflammation and microbial resistance. -
Antibacterial Agent
1-Tetradecanol is a straight-chain saturated fatty alcohol that serves as an effective antibacterial agent. Isolated from Myristica fragrans, it exhibits notable antibacterial and anti-inflammatory properties, particularly in the context of periodontitis. This compound can be utilized in research applications focusing on antimicrobial activity and the modulation of inflammatory responses. -
Antibacterial Agent
Terminolic acid is a pentacyclic triterpene glycoside that acts as an antibacterial agent. It exhibits significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) ranging from 64 to 256 μg/mL. Terminolic acid also demonstrates the ability to inhibit pro-inflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6, contributing to a reduction in IL-8 levels. This compound is utilized in research targeting colon cancer and inflammatory conditions. -
HIV-Ⅰ Inhibitor
HIV-IN-6 is an inhibitor of HIV-1 viral replication, specifically targeting Src family kinases (SFKs) that associate with the viral Nef protein, including Hck. This compound has demonstrated significant antiviral activity by disrupting the functional interactions necessary for viral pathogenesis. Its application in research includes the study of HIV infection mechanisms and the exploration of novel therapeutic strategies against HIV-1. -
Antitumor Antibiotic
Herbimycin B is an ansamycin antibiotic targeting Src family tyrosine kinases. It exhibits significant antitumor activity by inhibiting cell proliferation in various cancer cell lines, including HeLa and Ehrlich cells. Additionally, Herbimycin B demonstrates a herbicidal effect on both monocotyledons and dicotyledons and can inhibit the tobacco mosaic virus (TMV), making it relevant for studies in plant pathology and cancer research. -
Antibacterial Agent
Antibacterial Agent 69 is a novel antimicrobial compound that targets and inhibits the growth of multidrug-resistant bacteria. With a reported minimum inhibitory concentration (MIC) of 2.978 μM, it demonstrates significant antibacterial activity. This agent is primarily employed in research focused on combating antibiotic resistance and developing new therapeutic strategies against challenging bacterial infections. -
Antibiotic
Methicillin is a narrow-spectrum β-lactam antibiotic that targets and inhibits penicillin-binding proteins (PBPs). Its efficacy is primarily observed against Staphylococcus aureus and Staphylococcus epidermidis strains that exhibit resistance to other penicillins. Methicillin is utilized in research investigating various conditions, including skin infections, osteomyelitis, and endocarditis. -
Antibiotic
Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis. Effective against Staphylococcus aureus and Staphylococcus epidermidis, particularly strains resistant to other penicillins, it is utilized in researching conditions such as skin infections, osteomyelitis, and endocarditis. -
Stable Isotope
Loratadine-d4 is a deuterated form of Loratadine, a selective inverse agonist of peripheral histamine H1 receptors. With an IC50 greater than 32 μM, Loratadine demonstrates significant anti-dengue virus (DENV) activity and can inhibit the immunologic release of inflammatory mediators. This stable isotope is valuable in pharmacokinetic studies and for the development of analytical methods in chemical research. -
Anti-inflammatory/Antioxidant/Antibacterial Agent
Eukovoside is a cinnamic acid derivative that primarily exerts anti-inflammatory, antioxidant, and antibacterial effects. This compound shows potential in the study of hyperglycemic diseases and is useful for investigating various inflammatory conditions, including eye inflammation and respiratory tract disorders. Additionally, Eukovoside may contribute to research focused on allergic responses such as hay fever and conjunctivitis, as well as infections like colds, influenza, and sinusitis. -
Stable Isotope
Loratadine-d4-1 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral H1-histamine receptors. With an IC50 value exceeding 32 μM, Loratadine exhibits significant biological activity, including anti-dengue virus (DENV) effects and the inhibition of immunologic release of inflammatory mediators. This stable isotope reagent is valuable for mechanistic studies, pharmacokinetic evaluations, and research applications in allergy and inflammatory response investigations. -
BTK/MNK Dual Inhibitor
QL-X-138 is a selective dual inhibitor of Bruton's tyrosine kinase (BTK) and MAPK-interacting kinase (MNK), demonstrating potent covalent binding to BTK and non-covalent binding to MNK. It exhibits IC50 values of 9.4 nM for BTK, and 107.4 nM and 26 nM for MNK1 and MNK2, respectively. Additionally, QL-X-138 displays antiviral activity against dengue virus serotype 2, with an IC50 of 3.5 μM. This compound is valuable for research involving B-cell malignancies and related therapeutic investigations. -
Fluoroquinolone antibiotic
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens. -
Antifungal compound
Amorolfine hydrochloride, is a morpholine antifungal reagent that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. -
HIV Protease inhibitor
Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). -
HIV Protease inhibitor
Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). -
Protein synthesis inhibitor
Azomycin(2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica, which is active against aerobic Gram-positive and Gram-negative bacteria. -
HIV-1 integrase inhibitor
BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.
- Cefditoren pivoxil is a third-generation cephalosporin antibiotic for oral use.
- Levofloxacin is a fluoroquinolone antibiotic. It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively).
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nitroimidazole antibiotic medication
Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. - Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.
- Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal; acts as a depolarizing neuromuscular blocking agent.
- Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain.
- Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).
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HIV Protease inhibitor
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. -
HIV reverse transcriptase inhibitor
Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. - Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.
- Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171.
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Antiinfective Agent
SMAP-29, a promising antiinfective agent, is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide. SMAP-29 acts by permeabilizing bacterial membranes and inducing remarkable changes in the surface morphology of susceptible microorganism. -
HIV replication inhibitor
Feglymycin is a HIV replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus). -
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against, bacteria, fungi, and protozoa at micromolar concentration.
- Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities.
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6-Diazo-5-oxo-L-nor-Leucine is a glutamine antagonist that shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells.
