Catalog No.
Product Name
Application
Product Information
Citations
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5-HT3 Antagonist
Palonosetron is a selective 5-HT3 antagonist that effectively prevents acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition to its primary application in oncology, Palonosetron demonstrates moderate activity against flaviviruses and exhibits potent antiviral effects against Zika virus in mammalian cells. Furthermore, this compound has been associated with antidepressant properties, making it a valuable tool for diverse research applications in both oncology and virology. -
5-HT3 Antagonist
Palonosetron hydrochloride is a selective 5-HT3 receptor antagonist that primarily functions to prevent acute and delayed nausea and vomiting associated with chemotherapy. Beyond its primary application, Palonosetron hydrochloride demonstrates moderate activity against flaviviruses, including potent efficacy against the Zika virus in mammalian cells. Additionally, this compound has been associated with antidepressant effects, expanding its potential therapeutic applications in neurological research. -
Stable Isotope
Palonosetron-d3 hydrochloride is a deuterium-labeled derivative of Palonosetron hydrochloride, functioning primarily as a 5-HT3 receptor antagonist. It is widely utilized in research to investigate mechanisms of chemotherapy-induced nausea and vomiting and is known for its ability to prevent both acute and delayed episodes. Additionally, Palonosetron hydrochloride demonstrates moderate activity against flavivirus and potent efficacy against Zika virus in mammalian cells, contributing to its relevance in virology studies. Its potential antidepressant properties also make it a compound of interest in neuropharmacology research. -
Flaviviruse Inhibitor
Flaviviruses-IN-3 is a potent inhibitor specifically targeting flaviviruses. This compound demonstrates significant activity by reducing West Nile virus (WNV) protease activity, achieving an impressive inhibition rate of 54%. Flaviviruses-IN-3 is applicable for research into therapeutic strategies against flavivirus-related diseases and contributes to the understanding of viral protease functions. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-5 is an allosteric inhibitor targeting the NS2B/NS3 protease of Dengue Virus Serotype 2 (DENV2) and Zika Virus (ZIKV). It demonstrates effective inhibitory activity with IC50 values of 0.67 µM against ZIKV and 4.38 µM against DENV2 NS2B/NS3 proteases. This compound presents significant potential for research applications in virology, specifically in the development of antiviral therapies targeting these flavivirus proteases. -
MTase Inhibitor
NSC 288387 is a pan-flavivirus methyltransferase (MTase) inhibitor that targets the S-adenosylmethionine (SAM) binding pocket. It demonstrates significant antiviral activity, inhibiting Zika virus (ZIKV) replication with an IC50 of 0.2 μM. This compound is useful in research applications focused on flavivirus infections and the mechanisms of viral replication. -
Flaviviruses Inhibitor
Flaviviruses-IN-2 is a potent inhibitor targeting flavivirus proteases, particularly effective against the West Nile virus (WNV). This compound significantly reduces WNV protease activity, achieving an inhibition level of 56%. Flaviviruses-IN-2 is primarily utilized in research applications focused on understanding flaviviral pathogenesis and developing antiviral therapeutics. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-4 is an allosteric inhibitor targeting the NS2B/NS3 protease of dengue virus serotype 2 (DENV2) and Zika virus (ZIKV). It demonstrates IC50 values of 0.69 µM for DENV2 and 1.04 µM for ZIKV proteases, highlighting its potent enzymatic inhibition. This compound serves as a valuable tool in antiviral research, particularly for elucidating mechanisms of viral replication and developing therapeutic strategies against flavivirus infections. -
NS2B/NS3 Inhibitor
NS2B/NS3-IN-6 is an allosteric inhibitor targeting the NS2B/NS3 protease of Dengue virus (DENV) and Zika virus (ZIKV). It exhibits IC50 values of 2.23 µM and 25.2 µM against ZIKV and DENV proteases, respectively. This compound is valuable for research applications focused on developing antiviral therapies and understanding the enzymatic mechanisms of flavivirus proteases. -
RdRp Inhibitor
HeE1-2Tyr is a pyridobenzothiazole compound that serves as an inhibitor of RNA-dependent RNA polymerases (RdRp) in flavivirus. It demonstrates significant inhibitory activity against West Nile, Dengue, and SARS-CoV-2 RdRps, with an IC50 value of 27.6 μM in vitro. HeE1-2Tyr is valuable for research investigating viral replication and potential therapeutic strategies targeting RNA polymerase activity. -
WNV Protease Substrate
DEPN-8 is a substrate specifically designed for West Nile Virus (WNV) protease. Its primary application lies in the development of inhibitors targeting the protease of the dengue virus. This compound is crucial for advancing research in antiviral drug discovery and understanding proteolytic processes associated with flavivirus infections. -
Antiviral Agent
DN59 is a 33 amino acid peptide that targets dengue virus type 2 by mimicking the E stem region. It exhibits potent antiviral activity against all four serotypes of the dengue virus, with an IC50 ranging from 2 to 5 μM, and also acts against other flaviviruses. By interacting directly with viral particles, DN59 facilitates the release of genomic RNA, making it a valuable tool in virology research and the development of antiviral strategies. -
NS2B-NS3 Inhibitor
NS2B/NS3-IN-9 is a non-competitive inhibitor targeting the NS2B-NS3 protease of Orthoflavivirus, demonstrating broad-spectrum antiviral activity. It exhibits IC50 values of 2.4 μM, 7.2 μM, and 1.9 μM against the Dengue virus DENV2, West Nile virus WNV, and Zika virus ZIKV, respectively. Additionally, NS2B/NS3-IN-9 shows cellular EC50 values of 4.1 μM for DENV2, 4.9 μM for WNV, and 5.0 μM for ZIKV, while exhibiting minimal toxicity to host cells. This compound is suitable for research applications focused on inhibiting Orthoflavivirus infections. -
NS2B·NS3 Protease Inhibitor
CN-716 dihydrochloride is a reversible covalent inhibitor targeting the NS2B·NS3 protease of flaviviruses, demonstrating significant antiviral activity. This compound effectively impedes the replication of dengue virus (DENV2), West Nile virus (WNV), and Zika virus (ZIKV), with IC50 values of 0.066 μM, 0.11 μM, and 0.25 μM, respectively. Additionally, CN-716 dihydrochloride exhibits Ki values of 0.051 μM, 0.082 μM, and 0.04 μM against the same proteases. It serves as a valuable tool for investigating the infection mechanisms associated with dengue fever, West Nile fever, and Zika virus infection. -
NS2B-NS3 Inhibitor
Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate designed to probe the NS2B-NS3 cleavage site. This reagent includes a readily hydrolyzable para-nitroanilide at the P1’ position, enhancing its reactivity. It is primarily used in studies of dengue virus type 2 and other flavivirus infections, facilitating the exploration of viral protease activity and potential therapeutic interventions. -
NS2B-NS3 Protease Inhibitor
NS2B/NS3-IN-3 is a potent inhibitor of the Flavivirus NS2B-NS3 protease, which plays a critical role in viral polyprotein processing. This compound demonstrates significant antiviral activity, making it a valuable tool for research investigating Flavivirus infections and potential therapeutic strategies. Applications include studies on protease inhibition mechanisms and the development of antiviral drugs targeting flavivirus-related diseases. -
Flavivirus NS2B-NS3 Inhibitor
NS2B/NS3-IN-3 hydrochloride is a potent inhibitor of the Flavivirus NS2B-NS3 protease, crucial for the viral replication cycle. This compound selectively disrupts the protease activity, demonstrating significant antiviral efficacy. It serves as a valuable tool for research applications focused on understanding Flavivirus pathogenesis and developing new antiviral therapies. -
DENV Inhibitor
(-)-JNJ-A07 is a potent and selective inhibitor of Dengue Virus (DENV) with an EC50 value of 31 nM. It demonstrates significant antiviral activity, making it a valuable tool for research in virology and the study of DENV pathogenesis. This compound is suitable for investigations into potential therapeutic strategies for dengue fever and other flavivirus-related diseases. -
Yellow Fever Virus Inhibitor
RCB16007 is a selective inhibitor of the Yellow Fever Virus (YFV). It demonstrates effective antiviral activity against the West Nile virus, with an EC50 value of 7.9 μM and a CC50 of 17 μM. This compound serves as a valuable tool for studies related to flavivirus infections and can aid in the development of therapeutics targeting RNA viruses. -
NS5 RdRp/NS2B-NS3pro Inhibitor
LabMol-301 is a potent inhibitor of both NS5 RNA-dependent RNA polymerase (RdRp) and NS2B-NS3 protease, with IC50 values of 0.8 μM and 7.4 μM, respectively. This reagent demonstrates cytoprotective properties by effectively preventing cell death induced by the Zika virus (ZIKV). LabMol-301 is valuable for research applications focusing on antiviral drug development and the mechanistic study of flavivirus pathogenesis. -
Anti-virus Agent
XA-E is a purified compound derived from a methanol-ethyl acetate extract of A. keiskei, targeting viral replication. This compound exhibits potent anti-Zika virus activity, with an IC50 value of 22.0 µM. XA-E is suitable for research applications focusing on antiviral drug development and the mechanistic study of flavivirus infections. -
STT3A-mediated Mega Protein Complex Assembly Inhibitor
NSC-323241 is an STT3A-mediated mega protein complex assembly inhibitor that effectively disrupts the endoplasmic reticulum (ER) mega complex essential for dengue virus (DENV) and Zika virus (ZIKV) infection. By targeting the interaction between the STT3A subcomplex, viral nonstructural proteins (e.g., NS2B, NS3), and host translocon proteins, NSC-323241 impedes the establishment of the viral replication microenvironment. This compound is valuable for investigating the mechanisms of flavivirus infections, including dengue fever and Zika virus. -
Flavivirus inhibitor
Flaviviruses-IN-1 is a potent inhibitor of various viruses within the Flaviviridae family, acting primarily by modulating the host cell immune response to viral infection. This compound has demonstrated significant efficacy in preventing viral replication and infection, making it a valuable tool in virology research. Flaviviruses-IN-1 was identified through high-throughput screening as a promising candidate for therapeutic development against flavivirus infections, offering new avenues for intervention in related diseases. -
Flaviviru Inhibitor
TYT-1 is a sulfonamide-thiourea compound that targets flavivirus replication. It demonstrates potent inhibitory activity against West Nile virus, with a 50% effective concentration of 0.7 µM, effectively blocking a post-entry, pre-assembly step in the viral life cycle. This compound is valuable for research applications focused on understanding flavivirus pathogenesis and developing antiviral strategies. -
Rna Virus Inhibitor
Galidesivir dihydrochloride is a broad-spectrum RNA virus inhibitor targeting various RNA viruses, including Ebola and yellow fever viruses. This compound exhibits potent antiviral activity against tick-borne encephalitis virus (TBEV) and inhibits the proliferation of several other medically significant flaviviruses. Its efficacy makes Galidesivir a valuable tool for research applications focused on viral pathogenesis and antiviral drug development. -
ZIKV NS2B-NS3 Protease Inhibitor
IRBM-Z-2 is an orally active, non-competitive inhibitor targeting the Zika virus (ZIKV) NS2B-NS3 protease, demonstrating IC50 values of 0.04 μM for the wild-type and 3.1 μM for the I156T mutant strains. This compound exhibits broad-spectrum activity against flaviviruses, with IC50 values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus serotype 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-2 effectively inhibits ZIKV replication and mitigates virus-induced cytopathic effects, making it a valuable tool for research on ZIKV infection and the study of flavivirus-related diseases. -
Antiviral Agent
Helioxanthin is an antiviral agent with demonstrated in vitro activity, exhibiting an effective concentration (EC50) of 1 μM against hepatitis B virus (HBV). Additionally, Helioxanthin shows efficacy against flaviviruses, making it a valuable compound in antiviral research. It is suitable for studies focusing on the development of treatments for viral infections. -
IRF3 Activator
KIN1400 is a potent IRF3 activator that stimulates the expression of IRF3-dependent antiviral genes, including RIG-I, MDA5, IFIT1, and Mx1, as well as IFN-β production. This compound effectively inhibits the replication of West Nile Virus (WNV) and Dengue Virus (DV), both of which are mosquito-borne flaviviruses, as well as Hepatitis C Virus (HCV). KIN1400 activates innate antiviral immunity via the MAVS-IRF3 signaling pathway, making it a valuable tool for research focused on antiviral responses and immune modulation.
