Catalog No.
Product Name
Application
Product Information
Citations
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Prp8 intein Inhibitor
Antifungal agent 151 is a selective inhibitor of the Prp8 intein, targeting its self-splicing mechanism and disrupting the maturation of the Prp8 protein. This compound demonstrates significant in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 is valuable for research applications focused on cryptococcal pneumonia and related fungal infections. -
Antifungal Agent
Sclerodione is a metabolite derived from the Scleroderris canker fungus, Gremmeniella abietina, exhibiting potent antifungal properties. This compound functions as a lipase inhibitor, demonstrating a half-maximal inhibitory concentration (IC50) of 1 μM. Sclerodione is valuable for research applications focused on fungal pathogenesis and the study of enzyme inhibition mechanisms. -
Pentanorlanostane Derivative
Cladosporide D is a pentanorlanostane derivative, isolated from the strain of Cladosporium sp. IFM 49191. While it lacks antifungal activity, Cladosporide D serves as an important compound for research in the exploration of natural products and their derivatives. Its unique structure may facilitate studies in biochemistry and pharmacology related to sterol biosynthesis pathways. -
Fungicide
Furalaxyl is a potent fungicide targeting fungi within the order Peronosporales. Its high selectivity towards these pathogens makes it an effective choice for managing various fungal diseases in agricultural applications. Furalaxyl inhibits fungal growth, offering a targeted approach to disease control and improving crop health. -
Antifungal Agent
6-Prenylindole is a potent antifungal agent derived from the genus Streptomyces. It exhibits significant activity against various fungal strains, making it a valuable compound for antifungal research. Its efficacy in inhibiting fungal growth positions it as a useful tool for studies related to fungal infections and the development of new antifungal therapies. -
Antifungal Agent
Indole-3-thio carboxamide is an antifungal agent that functions as a biotransformation product of Camalexin. It has been identified in the context of interactions with the plant pathogenic fungus Botrytis cinerea. This compound is of interest for research applications focusing on antifungal mechanisms and the biochemical pathways involved in plant-fungal interactions. -
Antimicrobial Agent
2-n-Heptyl-4-quinolinol is an antimicrobial agent effective against a range of pathogenic organisms, including Candida albicans, Staphylococcus aureus, and Vibrio species (V. anguillarum and V. harveyi). This compound demonstrates significant antibacterial and antifungal properties, making it a valuable tool for research in microbiology and infectious disease studies. Its mechanism of action involves disruption of microbial membrane integrity and function, contributing to its efficacy as a broad-spectrum antimicrobial reagent. -
Fungal
Tolciclate is an antifungal agent targeting dermatophytes, demonstrating significant in vitro inhibitory activity at concentrations between 0.01 to 0.1 μg/mL. This compound is characterized by its colorless appearance and solubility in various excipients, with enhanced lipophilicity compared to Tolnaftate. Tolciclate is primarily utilized in research focused on antifungal infections, aiding in the exploration of effective treatments and mechanisms of action against fungal pathogens. -
Anthraquinone Derivative
Neobulgarone F is an anthraquinone derivative derived from Neobulgaria pura HA A07-97, a member of the ascomycetes class of fungi. This compound effectively inhibits the formation of appressoria in Magnaporthe grisea, a key pathogenic fungus in rice. Additionally, Neobulgarone F demonstrates low levels of cytotoxicity while exhibiting no significant antifungal, antibacterial, or phytotoxic effects, making it a valuable tool for research in microbial pathogenesis and plant-fungal interactions. -
Antifungal Agent
Radulone A is a secondary metabolite with antifungal properties, derived from the wood-decomposing fungus Granulobasidium vellereum. This compound effectively inhibits spore germination of notable fungi, including Phlebiopsis gigantea, Coniophora puteana, and Heterobasidion occidentale, at concentrations of 10 µM, 500 µM, and 100 µM, respectively. Radulone A is valuable for research applications related to mycology and the development of antifungal agents. -
Antifungal Agent
Torvoside C is a natural compound derived from Solanum torvum, exhibiting potent antifungal activity. This compound demonstrates a broad spectrum of efficacy against various fungi, including Alternaria brassicicola, Alternaria geophila, and Aspergillus flavus, with inhibition zones and minimum inhibitory concentrations ranging from 33.4% to 87.4% and 31.25 to 250 µg/mL, respectively. Torvoside C also effectively inhibits the production of harmful mycotoxins, specifically aflatoxin B1 and fumonisin B1. Its unique properties make it a valuable reagent for research in antifungal infections and mycotoxin-related studies. -
Antifungal Agent
Antifungal Agent 105 is a potent antifungal compound that targets fungal cells, disrupting their integrity and function. It exhibits both protective and curative effects against a variety of fungal pathogens. This agent is useful in research applications focused on mycology, antifungal drug development, and the study of fungal resistance mechanisms. -
Fungal Inhibitor
13-Hydroxy-9-octadecenoic acid is a hydroxy unsaturated fatty acid (HUFA) that functions as a fungal inhibitor. This compound exhibits notable antifungal properties, making it valuable in the study of fungal growth and pathogenicity. It is suitable for research applications focused on fungal diseases and the development of antifungal therapies. -
Botanical Fungicide
4-Propylphenol is a plant-derived phenolic compound that functions as a botanical fungicide. It induces reactive oxygen species (ROS) production in Fusarium graminearum, resulting in DNA and cell membrane damage that effectively inhibits mycelial growth. Additionally, 4-Propylphenol exhibits growth inhibitory effects against walnut pathogenic fungi, such as Colletotrichum gloeosporioides and Alternaria alternata, with an EC50 ranging from 29.11 to 31.89 mg/L, and inhibits spore germination with an EC50 of 55.04-71.85 mg/L. This compound is valuable for research into fungal diseases affecting walnuts and wheat, particularly Fusarium head blight. -
Anti-Fungal Agent
Phoslactomycin A is an anti-fungal agent that exhibits potent activity against fungal pathogens. While it demonstrates limited effectiveness against Gram-positive bacteria, its primary application lies in the treatment and study of fungal infections. This compound can be utilized in research focused on understanding fungal biology and developing antifungal therapies. -
Fungicide
Benalaxyl is a systemic fungicide that inhibits the biosynthesis of fungal cell wall components. It is particularly effective against blue mould caused by Peronospora tubacina, making it a valuable tool in agricultural research aimed at managing this pathogen. Benalaxyl's activity is primarily due to its ability to disrupt fungal growth, providing a basis for studies in plant pathology and disease control strategies. -
Antifungal Agent
AFK-108 is a potent antifungal agent that specifically targets and inhibits the activity of 14 alpha-demethylase. By disrupting ergosterol synthesis, AFK-108 effectively impairs fungal cell membrane integrity, leading to cell death. This compound is suitable for research applications aimed at understanding antifungal mechanisms and developing new therapeutic strategies against fungal infections. -
Fungicide
Pyrazophos is a systemic fungicide primarily targeting powdery mildew pathogens in crops and cereals. It demonstrates effective biological activity against various fungal species, including Erysiphe spp., Sphaerotheca spp., Leveillula spp., and Oidium spp. This reagent is commonly utilized in agricultural research to develop sustainable disease management strategies and enhance crop health. -
Antifungal Agent
Antifungal Agent 146 (Compound 19l) is a broad-spectrum antifungal compound targeting various fungal pathogens. It exhibits significant inhibitory activity against major dermatophytes responsible for onychomycosis, including Trichophyton rubrum and Trichophyton mentagrophytes, as well as other fungi such as Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, with minimum inhibitory concentration (MIC) values ranging from 16 to 64 μg/mL. This compound is primarily utilized in research focused on fungal infections and their treatment. -
Antimicrobial Agent
5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione functions as an antimicrobial agent. It demonstrates significant activity against various bacteria, including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and Salmonella typhi, with minimum inhibitory concentrations ranging from 4.5 to 9.9 μM/mL. Additionally, it exhibits antifungal properties, effectively inhibiting Aspergillus niger and Candida albicans at a minimum inhibitory concentration of 4.99 μM/mL. This compound is useful for research in antimicrobial drug discovery and development. -
Antimicrobial Agent
Epicorazine A is an antimicrobial agent that exhibits potent activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE), with minimum inhibitory concentrations (MICs) ranging from 12.5 to 25 μg/mL. Additionally, Epicorazine A demonstrates efficacy against Candida albicans, with an MIC of 25 μg/mL. This compound is suitable for research applications focused on antibacterial and antifungal agents. -
Secondary Metabolites
Byssochlamic acid is a secondary metabolite derived from fungal biosynthetic pathways. This compound exhibits notable biological activity, particularly in antifungal and cytotoxic assays. Its unique properties make it a valuable tool for research in mycology and the investigation of fungal metabolite functions. -
Anti-fungal Agent
2-Ethylbenzimidazole is an anti-fungal agent targeting various fungal species. It effectively inhibits the growth of both unicellular and filamentous fungi, making it a valuable tool in the study of fungal infections. This compound is utilized in research applications aimed at understanding the mechanisms of antifungal activity and developing therapeutic strategies against fungal pathogens. -
CYP51 Inhibitor
Pipercroside B is a potent inhibitor of CYP51, an essential enzyme in sterol biosynthesis. Isolated from Piper crocatum Ruiz & Pav, this compound exhibits significant antifungal activity, making it valuable for research into antifungal therapeutics. Its role in modulating CYP51 provides insights into fungal metabolism and potential treatment strategies against fungal infections. -
Fungal
Benthiavalicarb isopropyl is a fungicide that targets specific fungal pathogens, particularly effective against downy mildew and blight. This compound is utilized in agricultural research to explore alternative strategies for managing serious threats to plant health, especially in potato cultivation. Its application is critical for controlling fungal diseases that are resistant to conventional methods, while studies indicate that environmental and human exposure risks are minimal. -
Anti-Fungal Agent
Crocacin A is an anti-fungal agent that demonstrates inhibitory effects against yeast and filamentous fungi. Additionally, it has the capacity to inhibit the proliferation of mouse fibroblast cell line L929. Mechanistically, Crocacin A disrupts the bc1 complex of the electron transport chain in calf heart microsomes, resulting in a noticeable redshift in the 569 nm peak of the cytochrome B reduction spectrum. This compound is useful for researching fungal infections and exploring mitochondrial function and pathology. -
Antifungal Agent
Antifungal agent 139 targets Colletotrichum gloeosporioides through the inhibition of CgSfu1 and CgRidA. It demonstrates potent antifungal activity by completely blocking mycelial growth, spore germination, and appressorium formation, with an EC50 of 18 μg/mL. This compound effectively prevents the pathogen's infection in susceptible host plants, including linden and cypress trees. Antifungal agent 139 is a valuable tool for research into plant-fungal interactions and disease management strategies. -
Antifungal Compound
Nikkomycin Lz is a nucleoside peptide antifungal compound that selectively inhibits fungal cell wall synthesis by targeting chitin. It exhibits potent antifungal activity against Candida albicans, making it a valuable tool in antifungal research. This compound is particularly useful for studying chitin biosynthesis and evaluating potential antifungal therapies. -
Marker For B. cinerea Quantification
1,5-Dimethylnaphthalene is a volatile organic compound utilized as a biomarker for the quantification of Botrytis cinerea in various agricultural studies. Its presence is significantly correlated with infection levels in Chardonnay berries, making it an essential tool for assessing disease severity. This compound aids in the monitoring and management of fungal infections, facilitating research in plant pathology and related fields. -
Anthraquinone Derivative
Neobulgarone A is an anthraquinone derivative derived from Neobulgaria pura HA A07-97, a species of the ascomycetes class. This compound effectively inhibits the formation of appressorium in Magnaporthe grisea, a key pathogenic fungus. Notably, Neobulgarone A exhibits weak cytotoxicity and lacks significant antifungal, antibacterial, or phytotoxic effects, making it a valuable reagent for studying fungal developmental processes. -
Antifungal Agent
MoTPS1-IN-1 is a specific inhibitor of MoTPS1, targeting the fungal enzyme involved in the pathogenicity of Magnaporthe oryzae. By interacting with Glu396 in MoTPS1, this compound effectively disrupts the biosynthesis pathways critical for fungal growth and survival. MoTPS1-IN-1 has demonstrated significant antifungal activity, making it a valuable tool for research into fungal infections and potential therapeutic applications in plant pathology. -
Antifungal Antibiotic
Scytalidin is a terpenoid antibiotic that primarily targets fungal pathogens. It exhibits significant antifungal activity, making it particularly useful in research focused on fungal infections and their treatments. This compound serves as a valuable tool for studying antifungal mechanisms and developing potential therapeutic interventions against resistant fungal strains. -
Antifungal Antibiotic
Pradimicin T2 is an antifungal antibiotic that targets a range of filamentous and yeast-like fungi. It exhibits significant biological activity against various fungal pathogens, making it a valuable reagent for studying fungal infections and evaluating antifungal drug development. This compound is useful in research applications focused on elucidating the mechanisms of antifungal resistance and developing innovative therapeutic approaches. -
Pyruvate Kinase Inhibitor
PKR-IN-1 is an inhibitor of pyruvate kinase, demonstrating potent antifungal activity with an EC50 of 0.21 μg/mL against Rhizoctonia solani. Its primary mechanism involves the inhibition of glycolytic metabolism, which is crucial for fungal growth and survival. This compound is valuable for research applications focused on the development of antifungal strategies and the study of metabolic pathways in fungi. -
Phytotoxic Metabolite
Alternaric acid is a phytotoxic metabolite that functions as a host-specific toxin produced by certain plant fungi. This compound enhances the phosphorylation of His-tagged cytosolic kinase RiCDPK2 in the presence of Ca2+ and Mg2+, highlighting its role in plant-fungal interactions. Alternaric acid is useful for studying plant defense mechanisms and signaling pathways in response to pathogenic attacks. -
Anthraquinone Derivative
Neobulgarone B is an anthraquinone derivative derived from the ascomycete fungus Neobulgaria pura HA A07-97. This compound is primarily known for its ability to inhibit the formation of appressoria in the plant pathogenic fungus Magnaporthe grisea, which is crucial for understanding fungal infection processes. Additionally, Neobulgarone B exhibits weak cytotoxicity while showing no significant antifungal, antibacterial, or phytotoxic effects, making it a valuable tool for research in fungal biology and plant pathology. -
Antifungal Agent
Isoconazole is a broad-spectrum antifungal agent primarily targeting Candida albicans. This azole compound exhibits significant antimicrobial activity and is valuable in research focused on dermatomycoses and fungal infections. Its effectiveness makes it suitable for various studies involving the treatment and understanding of superficial fungal diseases. -
Intermediate of Antifungal Agents
Echinocandin B nucleus is a key intermediate in the synthesis of semi-synthetic antifungal agents, generated through the enzymatic action of Echinocandin B deacylase. This compound is integral for the development of antifungal therapeutics, offering a scaffold for modifications that enhance potency and activity against fungal pathogens. Research applications include studying the structure-activity relationship and optimizing antifungal efficacy. -
Fungus Metabolite
Cladospirone bisepoxide is a fungal metabolite known for its selective antibiotic properties against various bacteria and fungi. This compound exhibits notable activity in inhibiting the germination of Lepidium sativum at low concentrations, making it relevant for studies in microbial resistance and plant growth regulation. Its unique mechanism provides valuable insights into fungal biology and potential applications in agricultural and ecological research. -
Antifungal Agent
27-O-Demethylrapamycin, a derivative of Rapamycin, functions primarily as an antifungal agent. It demonstrates significant inhibitory activity against Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum. This compound is valuable for research applications focusing on antifungal mechanisms and the exploration of novel therapeutic strategies against fungal infections. -
Antifungal Agent
Cytochalasin R is a cytochalasin analogue derived from the endophytic fungus Phomopsis sp. xz-18. This compound exhibits notable antifungal activity, making it a valuable tool for researchers studying fungal infections and developing antifungal therapies. Its mechanism of action and efficacy highlight its potential applications in both basic and applied microbiological research. -
Fungal Inhibitor
Etisazole is a potent antifungal agent primarily targeting fungal infections. It exhibits significant antifungal activity against various dermatophytes and yeast species, making it valuable in studying skin-related fungal infections. Its skin sensitizing properties also provide insight into dermal reactions and safety assessments for antifungal therapies. This compound is applicable in both in vitro and in vivo research settings to explore antifungal efficacy and skin interaction mechanisms. -
Antifungal Agent
Diamthazole is an antifungal agent that targets fungal infections by inhibiting cell wall synthesis and disrupting cellular processes. It demonstrates significant activity against a variety of pathogenic fungi, making it a valuable tool for studying fungal biology and developing antifungal therapies. Researchers can utilize Diamthazole in the investigation of antifungal resistance mechanisms and in the evaluation of new treatment strategies for fungal infections. -
Fungicide
Furametpyr is a fungicide that targets fungal pathogens to effectively control rice sheath blight. It demonstrates a broad spectrum of metabolic activity in rats, mediated by recombinant human cytochrome P450 enzymes. This compound is utilized in agricultural research to study mechanisms of fungal resistance and to optimize crop protection strategies. -
Antifungal Compound
Rimocidin is a polyene macrolide that exhibits potent antifungal activity. It demonstrates broad-spectrum effectiveness against various plant-pathogenic fungi, making it a valuable tool in agricultural research and plant protection studies. Its mechanism of action involves disrupting fungal cell membrane integrity, providing insights into antifungal strategies and potential applications in crop management. -
Fungal
Aspergillin PZ is a novel isoindole-alkaloid derived from Aspergillus awamori, targeting fungal pathogens. This compound exhibits significant biological activity by inducing moderate deformation of conidia in Penicillium oryzae. Aspergillin PZ is valuable for research applications focusing on fungal biology and the mechanisms of fungal morphology alteration. -
Fungal Inhibitor
Demethoxypiplartine is an amide alkaloid derived from Piper flaviflorum and Piper sarmentosum, exhibiting potent antifungal activity. It demonstrates efficacy against Cryptococcus neoformans, with an IC50 value of 18.1 μg/mL. This compound is valuable for researchers investigating antifungal mechanisms and developing therapeutic strategies for fungal infections. -
Volatile Compound
3,5-Dimethyl-4-octanone is a volatile compound primarily known for its occurrence in Lippia alba. This compound exhibits potential antifungal activity, making it a valuable candidate for studies related to fungal infections. Its unique properties support research in the development of antifungal agents and characterization of plant-derived substances. -
Anti-fungal Agent
Nifuroxime is an anti-fungal agent that operates through the inhibition of fungal growth by disrupting nucleic acid synthesis. It exhibits potent activity against various fungal pathogens, making it a valuable reagent in the study of fungal infections and the development of antifungal therapies. This compound is useful for researchers investigating the mechanisms of action and resistance in fungal biology. -
Antifungal Agent
Picarbutrazox is a potent antifungal agent targeting various fungal pathogens. It is effective against Pythium and Phytophthora, making it suitable for agricultural applications, particularly in the cultivation of corn and soybean. Picarbutrazox serves to enhance crop protection and promote healthy plant development by mitigating fungal infections.
