Catalog No.
Product Name
Application
Product Information
Citations
-
SDH Inhibitor
SDH-IN-29 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.0709 μM. This compound demonstrates broad-spectrum antifungal activity, with EC50 values of 0.356 μg/mL for Fusarium graminearum, 0.798 μg/mL for Sclerotinia sclerotiorum, and 0.146 μg/mL for Rhizoctonia solani. SDH-IN-29 also shows moderate to significant protective effects against rice blast, wheat scab, and cucumber powdery mildew, making it a valuable tool for agricultural research and fungal disease management. -
Anti-Fungal Agent
Chondramide A is a potent anti-fungal agent that specifically targets various fungal species, including Candida and several yeast types such as Henson yeast and ball-like yeast. It exhibits significant anti-fungal activity but does not affect Gram-positive or Gram-negative bacteria. This compound is valuable for research applications focused on fungal infections and the mechanisms underlying antifungal resistance. -
Antifungal Antibiotic
Phyllosinol is an antifungal antibiotic that targets fungal cell membranes, disrupting their integrity and leading to cell death. This compound exhibits potent antifungal activity against a variety of pathogenic fungi, making it a valuable tool for studying fungal infections. Phyllosinol is utilized in research applications focused on antifungal drug development and mechanisms of antifungal resistance. -
CYP51 Inhibitor
CYP51-IN-32 is a selective inhibitor of CYP51, demonstrating a potent antifungal activity with an IC50 of 0.331 μM against Candida albicans. This compound not only inhibits the growth of Candida albicans by disrupting hyphal formation and biofilm development, but it also releases hydrogen sulfide (H2S), contributing to its antifungal effects. CYP51-IN-32 is suitable for investigating Candida albicans infections and can be formulated into PEG-based nanovesicles for enhanced delivery in research applications. -
Antibacterial/Antifungal Agent
Geninthiocin is a thiopeptide that primarily targets bacterial and fungal pathogens, exhibiting significant antibacterial and antifungal activities. Its mechanism of action includes the inhibition of protein synthesis, making it a valuable tool for studying microbial resistance and potential therapeutic applications. Geninthiocin is used in research to investigate the efficacy of novel antimicrobial agents and to explore the underlying biochemical pathways involved in microbial infections. -
Anti-Fungal Agent
Cladospolide D is an anti-fungal agent derived from the strain of Cladosporium sp. FT-0012. This compound exhibits significant activity against various fungal species, making it a valuable tool in antifungal research. It is primarily utilized in studies aimed at understanding fungal pathogenicity and developing new antifungal therapies. -
Anti-Fungal Agent
Clavamycin C functions as a potent anti-fungal agent, demonstrating strong activity against Candida species. Its antifungal effects can be antagonized by dipeptides or tripeptides, while amino acids do not diminish its efficacy. Notably, Clavamycin C displays no antibacterial activity and does not inhibit β-lactamase enzymes, making it a specific agent for fungal research applications. -
Anti-Fungal Agent
Cispentacin is an anti-fungal agent that exhibits significant activity against Candida species and other fungi. This compound demonstrates a favorable safety profile, showing no toxicity at doses up to 1 g/kg. It is primarily utilized in research applications focused on the development of treatments for fungal infections. -
Fungal Inhibitor
Prumycin dihydrochloride is an antifungal compound that targets fungal pathogens, specifically demonstrating efficacy against cucumber powdery mildew. This reagent significantly inhibits disease progression while not inducing plant defense gene expression, suggesting its mechanism does not rely on host defensive responses. Additionally, it has shown effectiveness in preventing spore germination of P. fusca, making it valuable for research into fungal pathogenesis and disease management in agriculture. -
CYP51 Inhibitor
(Rac)-Ketoconazole is an imidazole antifungal agent that acts as a potent inhibitor of cytochrome P450-dependent 14α-sterol demethylase (CYP51). By disrupting ergosterol synthesis, it induces membrane dysfunction, thereby inhibiting the growth and reproduction of various fungi. This compound is primarily utilized in research relating to fungal infections and the mechanisms of antifungal resistance. -
Antifungal Compound
Malvone A is an antifungal compound derived from Malva sylvestris that exhibits significant activity against Verticillium dahliae with an ED50 of 24 µg/mL. This compound serves as a valuable tool for research into the development of anti-infective agents and the study of fungal pathogenesis. Its efficacy against pathogenic fungi makes it a noteworthy candidate for investigations focused on antifungal therapies. -
Fungicide Agent
Tecnazene is a dinitroaromatic fungicide that acts as a plant growth regulator. It effectively inhibits the sprouting of potato tuber buds while demonstrating strong antifungal activity against pathogens responsible for dry rot. Additionally, Tecnazene exhibits acute toxicity in Rattus norvegicus and possesses significant harmful effects on aquatic organisms, including freshwater fish and crustaceans. This compound is primarily utilized in agricultural settings for controlling sprouting and managing dry rot in stored potatoes. -
Antimicrobial Agent
Cyclogregatin is an antimicrobial agent with demonstrated antibacterial and antifungal activity. It effectively inhibits the growth of airy ascites carcinoma with a minimum inhibitory concentration (MIC) of 10 μg/mL. This compound is applicable in research settings focusing on microbial resistance and cancer biology. -
Anti-Fungal Agent
Orchinol is an aromatic derivative with potent antifungal activity. This compound targets fungal cell membrane integrity, disrupting the synthesis of ergosterol and ultimately leading to cell death. Orchinol is utilized in research to explore antifungal mechanisms and develop new therapeutic strategies against fungal infections. -
Anti-Fungal Agent
Crocacin D is an anti-fungal agent that exhibits significant activity against both yeast and filamentous fungi. This compound demonstrates the ability to inhibit mouse fibroblast cell line L929, indicating its potential cytotoxic effects. Additionally, Crocacin D disrupts the bc1 segment of the electron transport chain in calf heart microsomes, resulting in a redshift of the 569 nm peak in the cytochrome B reduction spectrum, which highlights its role in mitochondrial function studies. -
Anti-Fungal Agent
Chainin is an anti-fungal agent that exhibits significant activity against yeast and Aspergillus niger. This compound is utilized in research focused on fungal infections and provides valuable insights into the mechanisms of antifungal resistance and therapeutic efficacy. Its effectiveness makes it a critical tool for the study of fungal pathogenesis and potential treatments. -
OSBP Inhibitor
Antifungal agent 107 is an oxysterol-binding protein (OSBP) inhibitor that exhibits antifungal activity. This compound is effective in managing cucumber downy mildew and potato late blight in greenhouse settings, making it a valuable tool for researchers investigating plant pathology and disease control strategies. Its targeted mechanism of action provides a means to explore the role of OSBP in fungal biology. -
Antifungal Agent
Cavipetin C is a diterpene derived from B. cavipes, known for its antifungal properties. This compound effectively inhibits spore formation in Cladosporium cucumericum, making it a valuable tool for studying fungal biology and developing antifungal strategies. Its biological activity supports research in mycology and potential therapeutic applications. -
Macrolide Compound
Dunaimycin A1 is a 24-membered macrolide compound that exhibits immunosuppressive activity. It demonstrates antifungal properties specifically against Aspergillus niger. This compound is valuable for research in the field of autoimmune diseases and can contribute to understanding immune system modulation. -
Antifungal Antibiotic
Pradimicin T1 is an antifungal antibiotic that targets a wide range of filamentous fungi and yeast-like fungi. It exhibits potent antifungal activity, making it a valuable tool in the study of fungal infections and the development of antifungal therapies. Pradimicin T1 is commonly utilized in research applications focusing on fungal biology and mechanisms of resistance. -
Anti-Fungal Agent
Chandrananimycin B acts as an anti-fungal agent with specific activity against Mucor species. In addition, it demonstrates anti-tumor cell effects on various cancer cell lines, including HT29, MFXF 529L, and MCF-7. This compound is valuable for research applications focused on fungal infections and cancer therapeutics. -
Antifungal Agent
NC-1175 hydrochloride is an antifungal agent that targets cell membrane H+-ATPase, disrupting essential ion homeostasis in fungi. This compound demonstrates significant antifungal activity and is employed in research focused on fungal infections and potential therapeutic strategies. Its mechanism may provide insights into treatment options for various fungal diseases. -
Cer1 Inhibitor
Cs-2d is a selective inhibitor of ceramide synthase 1 (Cer1) with notable potency against C. neoformans. This compound demonstrates significant antifungal activity, effectively inhibiting growth while exhibiting minimal off-target effects on human ceramide synthase 1 (hCerS1). Cs-2d is a valuable tool for research focused on invasive fungal infections, facilitating the study of therapeutic strategies targeting ceramide metabolism. -
Fungal Inhibitor
Griseofulvic acid is a metabolite of the antifungal agent Griseofulvin, acting as a potent fungal inhibitor. It is known to induce protein aggregation and facilitate tubulin polymerization in cell-free assays, making it a valuable tool in the study of fungal biology and cell dynamics. This compound can be utilized in research applications focusing on the mechanisms of antifungal activity and cytoskeletal interactions. -
Antitumor Agent
PD 113270 is an antitumor agent that functions primarily through the inhibition of specific cellular pathways. This compound has demonstrated notable inhibitory effects on yeast, indicating its potential use in studying antifungal mechanisms and tumor cell proliferation. PD 113270 is of particular interest for research applications in cancer biology and pharmacology, aiding in the exploration of new therapeutic strategies. -
Antimicrobial Agent
Quadrilineatin is an antimicrobial agent that exhibits significant antifungal and antibacterial activity. It disrupts microbial cell function, making it effective against a broad spectrum of pathogens. This reagent is applicable in research focused on infectious diseases and the development of antimicrobial therapies. -
Antifungal Agent
Antifungal Agent 134 primarily targets fungal pathogens by disrupting cellular membranes and mitochondrial function, resulting in substantial reactive oxygen species (ROS) accumulation. It exhibits potent antifungal activity with EC50 values of 3.24 μg/mL against Botrytis cinerea and varying efficacy against other fungi, including Alternaria and Fusarium species. In addition to its antifungal properties, Antifungal Agent 134 also demonstrates significant herbicidal activity against common field weeds such as Amaranthus retroflexus and Abutilon theophrasti. This compound is suitable for research focused on crop disease management and weed control strategies. -
Antifungal Agent
Bullatenone is a volatile bioactive compound sourced from Lophomyrtus bullata, primarily functioning as an antifungal agent. It exhibits significant inhibitory effects against fungal pathogens, including Candida albicans and Cladosporium resinae. Due to its multifaceted biological activities, Bullatenone is valuable in researching inflammatory conditions and infectious diseases. -
PXR Agonist
Tolindate is a potent PXR agonist, exhibiting an EC50 value of 8.3 μM. This compound demonstrates significant antifungal activity, making it a valuable tool for research in pharmacology and toxicology. Its ability to modulate the pregnane X receptor (PXR) may provide insights into drug metabolism and interactions with xenobiotics. -
Insect toxin
3-GlcA-28-AraRhaxyl-medicagenate is an insect toxin classified within the saponin family. This compound demonstrates notable antifungal properties and has been shown to induce mortality in rice weevils at concentrations as low as 0.1 mg/mL. It serves as a valuable tool for research into insecticidal agents and pest management strategies. -
Anthraquinone Derivative
Neobulgarone E is an anthraquinone derivative isolated from Neobulgaria pura HA A07-97, an ascomycete fungus. This compound effectively inhibits the formation of appressoria in Magnaporthe grisea, making it a valuable tool for research on fungal development and pathogenesis. Notably, Neobulgarone E exhibits minimal cytotoxicity and lacks antifungal, antibacterial, or phytotoxic effects, highlighting its specificity in targeting fungal processes without adversely affecting other biological systems. -
Lactone
Feigrisolide B is a lactone derived from Streptomyces griseus, exhibiting notable antiviral properties against Coxsackie virus B3 and antifungal activity against Sporobolomyces ochreata. Additionally, it demonstrates moderate inhibitory effects on the enzyme 3α-hydroxysterol dehydrogenase, making it a valuable compound for research into lipid metabolism and infectious diseases. This compound is suitable for studies involving fungal resistance mechanisms and viral pathogenesis. -
Fungi Inhibitor
Acremine I is a potent fungi inhibitor derived from the endophytic fungus Acremonium byssoides. It has demonstrated effective inhibition of Plasmopara viticola, making it a valuable tool for research on plant diseases, particularly grape downy mildew. This compound is useful for studying the mechanisms of fungal resistance and developing strategies for disease management in agriculture. -
Anti-Fungal Agent
Chondramide D is an anti-fungal agent that specifically targets Candida species, including various yeast forms such as Henson yeast and lipids yeast. This compound demonstrates significant antifungal activity but does not exhibit antibacterial properties against Gram-positive or Gram-negative bacteria. Chondramide D is valuable for research applications focused on fungal infection treatment and understanding yeast-related pathologies. -
Fungicide
Imazalil sulfate is a potent fungicide that primarily targets fungal pathogens in agricultural settings. It exhibits strong activation of the mouse pregnane X receptor (mPXR) while showing minimal interaction with the mouse constitutive androstane receptor (mCAR), indicating its specific metabolic effects. Research indicates that Imazalil sulfate can induce developmental abnormalities, disrupt gut microbiota, and impair hepatic metabolism, making it significant for studies on environmental and toxicological impacts of fungicides. -
Anti-Fungal Agent
Crocacin C functions as an anti-fungal agent, exhibiting significant activity against both yeast and filamentous fungi. In studies, it has been shown to inhibit mouse fibroblast L929 cells, highlighting its potential cytotoxic effects. Additionally, Crocacin C disrupts the bc1 segment of electronic transmission in calf heart microsomes, resulting in a redshift of the 569 nm peak in the cytochrome B reduction spectrum. These properties make it a valuable reagent for research in fungal pathogenesis and cellular bioenergetics. -
Fungal Inhibitor
Mollugogenol A is a potent fungal inhibitor that disrupts cellular integrity in fungal cells. It induces lipid peroxidation, leading to damage to sperm membranes, demonstrating significant sperm-killing activity. This compound is valuable for research applications focused on antifungal mechanisms and reproductive toxicity studies. -
Bc1 Complex Inhibitor
bc1 Complex-IN-1 is a potent inhibitor of the bc1 complex, demonstrating significant antifungal activity. This compound effectively exhibits fungicidal properties against Cucumber downy mildew (CDM), making it a valuable tool for studying fungal pathogenesis and potential therapeutic interventions. Its application in research can aid in understanding the mechanisms underlying fungal resistance and the development of effective fungicides. -
Antifungal Agent
Vermistatin is an antifungal agent derived from the fungal strain Guignardia. It exhibits potent cytotoxic and antifungal activities, making it a valuable tool for studying fungal infections and testing antifungal efficacy. This reagent is useful in various research applications, including drug development and the investigation of fungal pathogenesis. -
Anti-Fungal Agent
Cyclothiazomycin is an antifungal agent that selectively inhibits renin activity while sparing other proteases such as pepsin, aspartic acid, serine, mercaptan protease, and metalloproteinases. Although it demonstrates weak antifungal activity, it serves as a valuable tool in research settings focused on elucidating renin-related pathways and their implications in fungal infections. Its specific inhibition profile makes it a candidate for studies exploring renin's role in various biological processes. -
Fungal CYP51A1 Inh
Becliconazole functions as an inhibitor of the fungal cytochrome P450 51A1 (CYP51A1) enzyme. This compound exhibits significant antifungal activity and is primarily utilized in research related to fungal infections, offering insights into the mechanisms of action and potential therapeutic interventions against fungal pathogens. -
Antifungal Agents
Pradimicin L is an antifungal agent derived from the Streptomyces madurensis species. This homolog of pradimicin A exhibits potent antifungal activity, making it a valuable tool for research in mycology and fungal infection studies. Its efficacy in disrupting fungal cell integrity highlights its potential for further investigation in the development of antifungal therapies. -
Anti-Fungal Agent
Haliangicin C is an anti-fungal agent targeting filamentous fungi and oomycetes. It exhibits potent activity against a range of filamentous fungal pathogens, making it a valuable tool for studying fungal infections and their mechanisms. However, it does not demonstrate antibacterial activity, highlighting its specificity for fungal applications in research and therapeutic investigations. -
Anti-Fungal Agent
Ramulosin is an antifungal agent that effectively inhibits the germination of fungal meristems. Its primary mechanism involves disrupting fungal growth, making it a valuable tool for research in mycology and antifungal drug discovery. Ramulosin's activity can aid in understanding fungal pathogenesis and developing targeted therapies against fungal infections. -
Macrocyclic dilactone
De-N-methylpamamycin-593A is a macrocyclic dilactone that effectively induces aerial mycelium formation in fungi. This compound serves as a valuable tool in the study of fungal biology, particularly in understanding the mechanisms behind mycelial growth and development. Its unique structure and bioactivity make it pertinent for research in mycology and related fields. -
Chitin Synthase Inhibitor
Asulam potassium is a potent chitin synthase inhibitor that targets the biosynthesis of chitin in fungal cell walls. By disrupting the structural integrity of fungal cells, Asulam potassium effectively impedes normal growth and reproduction, demonstrating significant antifungal activity. This compound is valuable for research applications focused on managing fungal diseases, including downy mildew and gray mold, particularly in crops such as spinach, tulips, daffodils, and lilies. -
Fungicide
PPm is a potent succinate dehydrogenase inhibitor with demonstrated fungicidal activity. It effectively targets fungal respiratory pathways, disrupting energy production and leading to cell death. This compound is widely utilized in agricultural research and studies aimed at understanding fungal resistance mechanisms and developing novel fungicidal strategies. -
Antifungal Agent
SPK-843 is a potent antifungal agent that demonstrates significant inhibitory activity against Aspergillus fumigatus (MIC 0.5 μg/mL), Aspergillus flavus (MIC 0.25 μg/mL), and Aspergillus niger (MIC 0.0625 μg/mL). This compound exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis, making it valuable for studying therapeutic strategies for fungal infections. SPK-843 can be employed in various research applications related to antifungal drug development and fungal pathogenesis. -
Anti-Fungal Agent
1,6-Dihydroxy-2-chlorophenazine is a compound that exhibits weak anti-fungal and anti-yeast activity. Its mechanism involves interference with cellular processes in fungi, making it a candidate for research in antifungal drug development. This compound may be utilized in studies investigating the mechanisms of fungal infection and resistance, as well as in screening assays for new therapeutic agents. -
Antifungal Agent
O-Acetylbenzeneamidinocarboxylic acid serves as an antifungal agent targeting various plant pathogenic fungi. This compound exhibits notable inhibitory activity, making it suited for research applications focused on understanding fungal infections and developing antifungal strategies in agricultural settings. Its effectiveness as a fungal metabolite positions it as a valuable tool in the study of plant pathology.
