Catalog No.
Product Name
Application
Product Information
Citations
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Chitin synthase Inhibitor
Chitin Synthase Inhibitor 1 is a potent and selective inhibitor of chitin synthase (CHS) with an IC50 value of 0.12 mM. This compound exhibits significant antifungal activity against drug-resistant fungal variants, making it a valuable tool for research in antifungal drug development and fungal pathogenesis studies. Its mechanism of action provides insight into chitin metabolism and its role in fungal cell wall synthesis. -
Fungicide
Propamocarb hydrochloride is a systemic fungicide that targets various fungal pathogens. It is primarily utilized in agricultural settings to protect crops such as cucumbers and tomatoes from disease, thereby enhancing plant health and yield. Its mechanism of action involves inhibiting fungal growth, making it a valuable tool in crop management and plant protection research. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 9 is a selective inhibitor of chitin synthase (CHS), which plays a critical role in fungal cell wall synthesis. This compound exhibits broad-spectrum antifungal activity, making it suitable for investigating fungal infections. It serves as a valuable tool in research aimed at understanding the mechanisms of fungal pathogenesis and evaluating potential therapeutic strategies against fungal diseases. -
Antibacterial Agent, Antifungal Agent, Cell Proliferation Inhibitor
Deacetylnomilin, derived from Citrus reticulata, exhibits significant antibacterial and antifungal properties. Additionally, it serves as a potent inhibitor of cell proliferation, demonstrating an IC50 value of 0.005 µg/mL against estrogen receptor-positive (ER+) cells. This compound is valuable for research in microbiological studies and cancer biology. -
Antifungal Agent
Voriconazole camphorsulfonate is a second-generation broad-spectrum triazole antifungal agent that primarily targets fungal ergosterol biosynthesis. It exerts its antifungal activity by inhibiting 14-α-lanosterol demethylation, a process that is mediated by fungal cytochrome P450 enzymes. This compound is widely used in research applications to study fungal infections and evaluate therapeutic strategies against a range of pathogenic fungi. -
Succinate Dehydrogenase Inhibitor
Siccanin is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.9 μM with selective activity across species. In addition to its role as an SDH inhibitor, Siccanin demonstrates antimicrobial properties against pathogenic fungi. This compound is valuable for research applications focused on metabolic processes and the treatment of fungal infections. -
Antifungal Agent
Antibiofilm agent-12 is a carbazate derivative with a primary mechanism as an antifungal agent targeting Candida auris. It exhibits significant antifungal activity, demonstrated by a minimum inhibitory concentration (MIC90) of 237.9 μM, and functions by disrupting drug efflux pump activity and promoting ergosterol depletion. This effectively hinders biofilm formation and decreases the metabolic flexibility of Candida auris. Furthermore, Antibiofilm agent-12 has shown efficacy in a C. elegans model infected with Candida auris, highlighting its potential for addressing fungal infections and biofilm-related complications. -
Bassiatin Enantiomer
(3R,6S)-Bassiatin is an enantiomer of the fungal metabolite Bassiatin, known for its ability to inhibit ATPase activity in erythrocyte membranes, leading to cell lysis. This compound's mechanism suggests that its effects are linked to disruptions in membrane integrity. (3R,6S)-Bassiatin is useful in studies exploring erythrocyte physiology and the biochemical pathways involved in cell membrane interactions and integrity. -
Antifungal Agent
9-OxoOTrE (9-KOTrE) functions as an antifungal agent targeting multiple fungal species, including Botrytis cinerea, Cladosporium herbarum, Phytophthora infestans, and Phytophthora parasitica. Its electrophilic mechanism enables effective disruption of fungal cellular processes. This compound is valuable in research aimed at understanding fungal pathogenicity and developing potential therapeutic strategies against fungal infections. -
Succinate Dehydrogenase Inhibitor
SDH-IN-7 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 26 nM against porcine SDH. This compound demonstrates significant fungicidal activity, making it a valuable tool for research applications focused on mitochondrial metabolism and fungal pathogenicity. Its inhibitory effect on SDH suggests potential implications in cancer research and metabolic studies. -
Fungicide
Vinclozolin is a non-systemic dicarboximide fungicide that primarily targets fungal spores, effectively inhibiting germination and controlling fungal growth in various crops, including fruits and vegetables. Additionally, Vinclozolin functions as an androgen receptor antagonist, exerting anti-androgenic effects via its metabolites. Studies have indicated its reproductive toxicity in rat models and its potential anti-tumor properties, making it valuable for research in toxicology and cancer biology. -
Fungal Inhibitor
NSC-670224 is a potent fungal inhibitor that demonstrates toxicity to Saccharomyces cerevisiae with an LC50 of 3.2 μM. This compound is useful for studying the effects of fungal inhibition and can serve as a vital tool in antifungal research and the exploration of yeast biology. -
Phytotoxic Metabolite
Altiloxin A is a drimane-type sesquiterpenoid derived from fungal metabolism, exhibiting significant phytotoxic activity. It has been reported to inhibit the growth of lettuce seedlings, making it a valuable tool for studying plant-fungal interactions and herbicide mechanisms. This compound is useful in research applications aimed at understanding phytotoxic effects and their implications in agriculture. -
Fungicide
Propamocarb is a systemic fungicide that targets various fungal pathogens in agricultural settings. It is effective in the control of diseases affecting crops such as cucumbers and tomatoes, thereby enhancing plant health and yield. Its broad-spectrum efficacy makes it a valuable tool for researchers studying plant disease management and fungicide resistance. -
Anti-Fungal Agent
Phoslactomycin C is an anti-fungal agent that exhibits potent activity against various fungal pathogens. While it demonstrates a weak effect against Gram-positive bacteria, its primary efficacy lies in combating fungal infections. This compound is valuable for research focusing on antifungal mechanisms and the development of new therapeutic strategies against fungal diseases. -
Antifungal Agent
(25RS)-Schidigera-saponin E1 is a steroidal saponin known for its antifungal properties, isolated from the stems of Yucca schidigera. It demonstrates weak antifungal activity by compromising microbial cell membrane integrity, with a minimum inhibitory concentration (MIC) of ≥100 μg/mL against various food spoilage yeasts. This compound is suitable for applications in food preservation, aiding in the extension of shelf life for products such as cooked rice, beans, and fermented condiments. -
Cyclic AMP Phosphodiesterase Inhibitor, Antifungal Agent
Sequosempervirin B is a norlignan that acts as an inhibitor of cyclic AMP phosphodiesterase, demonstrating notable antifungal activity. Isolated from the branches and leaves of Sequoia sempervirens, this compound is significant in the study of fungal infections and the modulation of intracellular signaling pathways. Its ability to inhibit cyclic AMP degradation positions it as a valuable tool for research in both pharmacology and mycology. -
Antifungal Agent
Antifungal Agent 39 (Compound 9h) is a broad-spectrum antifungal compound that targets fungal cell membranes and disrupts their integrity. This agent exhibits significant inhibitory activity against various pathogenic fungi, making it suitable for applications in antifungal drug discovery and research. Its efficacy in combating fungal infections positions it as a valuable tool in studying antifungal resistance and therapeutics. -
Antifungal Agent
Topazolin is a flavone that exhibits antifungal activity, primarily targeting Cladosporium herbarum AHU 9262. This compound demonstrates weak fungi-toxic properties, making it a valuable tool for studying fungal pathogenesis and evaluating potential antifungal therapies in research applications. -
Antifungal Agent
Aszonapyrone A is a secondary metabolite derived from Aspergillus zonatus, functioning primarily as an antifungal agent. This compound exhibits significant antifungal activity, making it a valuable tool for studying fungal infections and their treatments. Its diverse biological properties support research in mycology and infectious disease, providing insights into antifungal mechanisms and potential therapeutic applications. -
Antifungal Agent
4-O-Methylsappanol is a natural isoflavonoid recognized for its antifungal properties. It exhibits significant activity against Beauveria bassiana, providing potential for applications in fungal research. Notably, 4-O-Methylsappanol has been shown to inhibit melanin synthesis in HMV-II cells with an EC50 of 4.6 μM, making it a valuable tool for studies involving melanin-related processes. -
Antifungal Agent
Toonaciliatin M is a pmaradiene-type diterpenoid derived from Toona ciliate, exhibiting potent antifungal activity primarily against Trichophyton rubrum. With a minimum inhibitory concentration (MIC) of 12.5 µg/mL, it is a valuable compound for investigating antifungal mechanisms and exploring potential therapeutic applications in fungal infections. Researchers can utilize Toonaciliatin M to better understand its efficacy and broader applications in antifungal drug development. -
Chitin Deacetylase Inhibitor
CDA-IN-2 is a potent inhibitor of chitin deacetylase (CDA), effectively targeting the enzymes PxCDA1 and PxCDA2 in the pathogen P. xanthii. At a concentration of 100 μM, CDA-IN-2 demonstrates significant antifungal activity, achieving inhibition rates of 83.7% and 74.5%, respectively. This compound is valuable for research into managing agricultural fungal diseases, particularly against resistant strains of powdery mildew and Botrytis cinerea. -
Antifungal Agent
Sulconazole is a potent antifungal agent belonging to the imidazole class, primarily known for its ability to inhibit fungal growth. It exerts its effects by blocking the NF-κB/IL-8 signaling pathway, which is implicated in cancer stem cell formation and tumor progression. Additionally, Sulconazole shows potential for applications in breast cancer research, highlighting its dual role as both an antifungal and an anti-tumor compound. -
Fungicide
Zarilamid is a fungicide targeting Oomycete fungi, demonstrated to inhibit nuclear division in germinating zoospore cysts of Phytophthora capsici. This compound disrupts microtubule cytoskeleton integrity, leading to impaired mitosis and abnormal swelling of root tips in tobacco. Zarilamid is valuable for research on fungal growth inhibition and cellular mechanisms associated with Oomycete pathogens. -
Fungal
Phlebiakauranol aldehyde is a potent antifungal and cytotoxic metabolite, primarily targeting fungal pathogens. It demonstrates significant antibacterial and cytotoxic effects against various plant pathogens, attributed to its aldehyde group and multiple hydroxyl groups. This compound serves as a valuable tool for research in fungal biology and antimicrobial activity, providing insight into its mechanisms of action and potential applications in plant protection. The related acetic acid derivatives exhibit only minimal biological activities, highlighting the unique efficacy of Phlebiakauranol aldehyde. -
1,3-β-glucan Synthase Inhibitor
Arborcandin D is a potent inhibitor of 1,3-β-glucan synthase, functioning as an effective antifungal antibiotic. It demonstrates notable inhibitory activity with IC50 values of 3 μg/mL against Candida albicans and 0.35 μg/mL against Aspergillus fumigatus. Furthermore, Arborcandin D exhibits a minimal inhibitory concentration (MIC) of 4 μg/mL against the Candida genus, making it a valuable tool for research on fungal infections and treatment development. -
Antifungal Agent
Sporothriolide, a potent antifungal agent derived from the metabolite of Nodulisporium sp. A21, exhibits strong inhibitory effects against various fungal pathogens, specifically R. solani and S. sclerotiorum, with EC50 values of 11.6 μM and 10.7 μM, respectively. Additionally, Sporothriolide effectively inhibits the conidium germination of Magnaporthe oryzae, both in vitro and in vivo, making it a valuable tool for research in antifungal activity and plant disease management. -
Antifungal Agent
13-Epimanool is a potent antifungal agent derived from the bark of the Taiwan hemlock. This compound exhibits significant inhibitory activity against various fungal pathogens, making it a valuable tool for research into antifungal treatments and mechanisms. Its unique properties facilitate investigations into the biosynthetic pathways of natural products and the development of novel antifungal therapies. -
Secondary Metabolite
Strevertene A is a pentaene macrolide classified as a secondary metabolite with notable antibiotic properties. This compound exhibits potent antifungal activity, effectively inhibiting the mycelial growth of various phytopathogenic fungi, including Alternaria mali, Aspergillus oryzae, and Cylindrocarpon destructans, with IC50 values ranging from 4 to 16 μg/mL. Additionally, Strevertene A demonstrates the ability to significantly mitigate the development of Fusarium wilt in tomato plants, making it a valuable reagent for agricultural and fungal research applications. -
Fungal Inhibitor
Antifungal agent 20 is a potent fungal inhibitor that demonstrates significant antifungal activity against a range of pathogens, including Colletotrichum gloeosporioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum. This compound is utilized in research applications focusing on fungal diseases, providing a valuable tool for studying plant pathology and developing effective control measures. -
Anti-Fungal Agent
Fusacandin A is an antifungal agent that targets (1,3)-β-glucan synthetase, an enzyme critical for fungal cell wall synthesis. By inhibiting this enzyme, Fusacandin A effectively disrupts fungal growth and division. This compound is useful in research applications focused on antifungal drug development and the investigation of fungal cell wall integrity. -
Antifungal Agent
Amorolfine is an antifungal agent that targets the biosynthesis of ergosterol. It effectively combats onychomycosis by inhibiting fungal growth, particularly against Candida albicans, exhibiting a minimum inhibitory concentration (MIC) of 0.404 µg/mL. This compound is valuable in research applications focused on antifungal mechanisms and the treatment of fungal infections. -
Fungal Inhibitor
Apigeninidin chloride is a 3-deoxyanthocyanidin that serves as a potent fungal growth inhibitor. Its unique structure imparts bioactive properties, making it useful as a red biocolorant in various applications. This compound is valuable for studying fungal biology and exploring potential antifungal strategies in research settings. -
1,3-β-glucan Synthase Inhibitor
Arborcandin E is a potent inhibitor of 1,3-β-glucan synthase, functioning as an effective antifungal antibiotic. It demonstrates remarkable inhibitory activity with IC50 values of 0.1 μg/mL for Candida albicans and 0.012 μg/mL for Aspergillus fumigatus. Arborcandin E also shows a minimum inhibitory concentration (MIC) range of 0.5-2 μg/mL against various Candida species, making it a valuable tool for studying fungal infections and potential therapeutic applications. -
Anti-Fungal Agent
S-F24 is an antifungal agent that targets CYP3A4, exhibiting an IC50 value of 0.4 μM. It demonstrates broad-spectrum antifungal activity with a favorable safety profile, including high selectivity, minimal hemolytic effects, and a low propensity for resistance development. S-F24 is suitable for research into fungal infections and may aid in the exploration of potential therapeutic strategies. -
Fungal Inhibitor
Isohemigossylic acid lactone 2-methyl ether is a sesquiterpene lactone that acts as a fungal inhibitor, specifically targeting Verticillium dahliae. It demonstrates significant antifungal activity, inhibiting conidial growth with an ED50 of 7.8 μg/mL. Sourced from the roots of Bombax malbaricum, this compound is particularly useful for research applications focused on Verticillium dahliae infections and related fungal pathogenicity studies. -
Antifungal Agent
Antifungal Agent 22 (compound D16) is an orally active antifungal agent targeting cryptococcal meningitis, exhibiting a potent IC50 of 0.5 μg/mL. This compound effectively penetrates the blood-brain barrier and exerts its antifungal activity by compromising the integrity of fungal cell membranes in Cryptococcus neoformans H99. Antifungal Agent 22 demonstrates selective anti-Cryptococcus efficacy, characterized by good metabolic stability and low cytotoxicity, making it a promising candidate for therapeutic applications in fungal infections. -
Antifungal Agent
Senkyunolide B is a naturally occurring phthalide derived from Angelica sinensis, exhibiting potent antifungal activity. It effectively inhibits the spore germination and hyphal growth of Aspergillus fumigatus by down-regulating the phosphatidylinositol-PKC-calcineurin signaling pathway and the expression of ENG genes. This compound is a valuable tool for research in antifungal drug development and pathogenic fungal biology. -
1,3-β-glucan Synthase Inhibitor
Arborcandin B is a potent inhibitor of 1,3-β-glucan synthase, functioning as an antifungal agent. It demonstrates notable biological activity with IC50 values of 0.30 μg/mL against Candida albicans and 0.025 μg/mL against Aspergillus fumigatus. Arborcandin B also reveals a minimum inhibitory concentration (MIC) of 2-4 μg/mL against various species within the genus Candida, making it a valuable tool for research in antifungal mechanisms and therapies. -
Pdr5p Inhibitor
Norbatzelladine L is a selective inhibitor of the Pdr5p transporter, demonstrating significant inhibition of its catalytic and functional activities. With an IC50 of 3.8 µM, Norbatzelladine L effectively suppresses Pdr5p ATPase activity. This compound exhibits a broad spectrum of biological activities, including antifungal, antiparasitic, antiviral, antibacterial, and antitumoral effects, making it a valuable tool for diverse research applications in microbiology and cancer studies. -
Antifungal Agent
Leotiomycene C is an isoprenylated bisresorcinol derivative derived from the freshwater fungus Helotiales sp., functioning primarily as an antifungal agent. This compound effectively disrupts the quorum sensing mechanisms of methicillin-resistant Staphylococcus aureus (MRSA), exhibiting an IC₅₀ value between 6.3 and 12.5 μM. Leotiomycene C is relevant for research focused on combating MRSA infections and understanding quorum sensing pathways in pathogenic bacteria. -
Antifungal Agent
2,5-Dimethylhexane-3,4-diol is an antifungal agent with demonstrated in vitro efficacy against various fungal pathogens. This compound, derived from Mansoa hirsuta, serves as a valuable tool for research into the mechanisms of fungal infections and potential treatments. Its biological activity makes it suitable for studies focused on antifungal drug development and resistance. -
Antifungal Agent
Antifungal Agent 54 is a potent antifungal compound that targets resistant strains of Candida albicans, exhibiting superior efficacy compared to traditional antifungal drugs. With minimal inhibitory concentration (MIC) values ranging from 0.25 to 1 μg/mL, it demonstrates significant activity against Fluconazole-resistant strains. This reagent is suitable for research applications focused on tackling antifungal resistance and evaluating new therapeutic options for fungal infections. -
Fungal Inhibitor
Hexamide is a potent fungal inhibitor primarily targeting Trichophyton species. Its efficacy makes it a valuable compound for studying fungal infections and evaluating antifungal therapies. This reagent can be utilized in various research applications involving mycology and the development of antifungal agents. -
Antifungal/Antibacterial Agent
2-Deethoxy-2-hydroxyphantomolin is a germacranolide known for its antifungal and antibacterial properties. Isolated from the whole plant of Elephantopus tomentosus and leaves of E. mollis, it exhibits moderate activity against Candida albicans, with a clearing zone of 14 mm, and slight activity against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis (12-14 mm clearing zones). Additionally, it shows some efficacy against Trichophyton mentagrophytes, making it a compound of interest for research in microbial infections. -
Microbial Antagonist
3-Methyl-1-hexanol is a microbial antagonist with antifungal properties, derived from the fungus Aureobasidium pullulans. This volatile organic compound exhibits effective inhibitory activity against pathogens such as Alternaria alternate and Botrytis cinerea. It serves as a valuable tool for research focused on microbial infections and fungal disease management. -
Fungal Inhibitor
Aleurodiscal is a fungal inhibitor derived from Aleurodiscus mirabilis. It demonstrates significant antifungal activity, making it a valuable tool in the study of fungal infections. This compound can be utilized in research applications focused on understanding fungal pathogenesis and developing antifungal therapies. -
Antioxidant Compound
Sclerotioramine, an antioxidant compound, is derived from the endolichenic fungus Penicillium sp.-strain 1322P. This compound demonstrates strong antibacterial activity, with minimum inhibitory concentrations (MICs) of 3.125 μg/mL against Bacillus subtilis and Bacillus megaterium, and 6.25 μg/mL against Shigella dysentery. In addition, sclerotioramine exhibits considerable antifungal efficacy against various pathogens, including Pestalotiopsis theae, Cochliobolus miyabeanus, and Exserohilum turcicum, making it a valuable reagent for research in microbiology and antimicrobial studies. -
Fungal Inhibitor
Stilbamidine is a diamidine compound that targets fungal infections by inhibiting fungal growth. Primarily utilized in its crystalline isethionate salt form, this reagent is effective against a range of fungi, making it valuable for research applications involving fungal pathology and treatment mechanisms. Its biochemical properties support studies focused on antifungal activity and resistance mechanisms in various fungal species.
