Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Agent
Antifungal Agent 37 is a heterocyclic disulfide compound that exhibits significant antifungal activity. It is primarily utilized in research focused on fungal pathogens, providing insights into mechanisms of action and potential therapeutic applications. This compound serves as an essential tool in the development of novel antifungal agents for combating resistant strains. -
Antifungal Agent
Antifungal agent 51 (Compound 5c) is a potent antifungal agent primarily targeting various Candida species, including Candida albicans, Candida parapsilosis, and Candida tropicalis. It exhibits exceptional antifungal activity with a minimum inhibitory concentration (MIC) of less than 0.063 μg/mL. Notably, it demonstrates low cellular toxicity and possesses no carcinogenic properties, making it a valuable tool for antifungal research and development. -
Antifungal Agent
Antifungal Agent 84 is a potent antifungal compound that targets candidiasis through a CNB1-dependent mechanism. This reagent effectively reduces the viability of Candida albicans biofilms, making it a valuable tool for research in fungal pathogenesis and biofilm formation. Its application is particularly relevant in studies focused on antifungal resistance and treatment strategies. -
Antifungal Agent
Anisocoumarin H is a coumarin derivative known for its antifungal activity. It effectively inhibits the growth of fungal pathogens, including Microsporum gypseum, Trichophyton rubrum, and Trichophyton mentagrophytes, with minimum inhibitory concentrations (MICs) of 62.5 µg/mL. This compound is valuable for research applications in studying fungal infections and developing antifungal therapeutics. -
Antifungal Activity
1,5-Hexadien-3-ol is a green leaf volatile (GLV) alcohol known for its antifungal activity, specifically targeting Botrytis cinerea. This compound plays a significant role in plant defense mechanisms, particularly in tomato plants, where it offers protection against grey mould disease. Its applications extend to research focused on fungal pathogens and plant resilience, making it a valuable tool for investigating plant defense strategies. -
Fungal Inhibitor
Antifungal Agent 16 is a potent fungal inhibitor, demonstrating significant antifungal activity compared to established agents such as ciprofloxacin and fluconazole. This compound is ideal for research aimed at exploring new antifungal therapies and addressing drug resistance in fungal pathogens. Its robust efficacy makes it a valuable tool in the investigation of fungal infections and therapeutics. -
Antimicrobial Agent
Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent targeting a range of microbial pathogens. It demonstrates significant antibacterial and antifungal activities, effectively eliminating harmful bacteria and fungi. With a high binding energy value of −10.0 kcal/mole against its target enzyme, Antimicrobial agent-4 is a valuable tool for research applications in microbiology and infectious diseases. -
Antifungal Agent
Medicagenic acid 3-O-glucoside is a monosaccharide-chain triterpenoid saponin that acts as an antifungal agent, primarily targeting fungal cell membranes. With a minimum inhibitory concentration (MIC) of 0.03 mg/mL and a minimum fungicidal concentration (MFC) of 0.125 mg/mL against *Pyricularia oryzae*, it disrupts membrane permeability, leading to cell rupture and growth inhibition. This compound is suitable for research applications focused on rice blast disease and fungal pathogenicity studies. -
Fungal Inhibitor
Antifungal agent 12 is a fluconazole-based compound that functions as a fungal inhibitor by disrupting fungal cell membrane synthesis. It demonstrates significant antifungal activity, making it suitable for research applications focused on fungal infections and resistance mechanisms. This compound can be utilized in studies aimed at developing new antifungal therapies. -
Fungal Inhibitor
3,5-Dimethyl-4-phenylisoxazole acts as a fungal inhibitor by disrupting fungal cell function. This heterocyclic compound demonstrates significant anti-fungal activity, making it a valuable tool for research in mycology and infectious disease studies. Additionally, it has shown promise in anti-inflammatory and anti-bacterial applications, indicating its potential for broader biological research. Its ability to modulate immune responses further highlights its versatility in various scientific investigations. -
Fungal
Alternapyrone is an α-pyrone compound with significant antifungal properties, predominantly derived from certain fungal species. This compound is known to affect wheat seed germination, exhibiting phytotoxicity that can be valuable for research into plant-fungal interactions and phytopathology. Its biosynthesis involves a simple enzymatic pathway, making it of interest for studies on metabolic processes in fungi. -
Ribosome/EF2 Stabilizer
Sordarin is an antifungal agent that specifically targets Elongation Factor 2 (EF2). It possesses a tetracyclic diterpene structure and is derived from the fungus Sordaria araneosa. Sordarin exhibits strong antifungal activity against Saccharomyces cerevisiae and Candida albicans by inhibiting protein synthesis in fungi. It does so by preventing the translocation of the ribosome along mRNA during elongation, effectively stabilizing the ribosome/EF2 complex. This compound is valuable for research focused on fungal protein synthesis and antifungal drug development. -
Antimicrobial/Anticancer Agent
Isocryptomerin primarily targets fungal membranes as a membrane-active antifungal compound derived from Selaginella tamariscina. It exerts its antimicrobial effects by depolarizing the plasma membrane of fungi. Additionally, isocryptomerin demonstrates notable anticancer and antibacterial activities, making it a valuable agent for research in both oncology and infectious diseases. -
Antifungal Agent
D0870 is an antifungal agent that effectively inhibits Candida neoformans, as well as strains associated with vaginal candidiasis and other viable yeasts. Its primary mechanism involves disrupting fungal cell viability, making it a valuable tool for research into fungal infections and developing therapeutic applications against opportunistic fungal pathogens. D0870 is suitable for studies aimed at understanding antifungal resistance and the mechanisms underlying yeast-related infections. -
Antifungal Agent
Antifungal Agent 86 (Compound 41F5) is an effective antifungal targeting pathogenic fungi. It demonstrates significant activity against Histoplasma yeast and Cryptococcus neoformans, with a MIC50 range of 0.4-0.8 μM. This compound is valuable for research focusing on fungal infections and developing therapeutic strategies against fungal pathogens. -
Amides
Dehydropipernonaline is an amide compound that exhibits significant cytotoxicity against L5178Y mouse lymphoma cells, with an IC50 value of 8.9 μM. This compound is valuable in research applications involving antifungal screening and the investigation of cytotoxic agents. -
Antifungal Agent
Nudicaucin B is a triterpenoid saponin extracted from Hedyotis nudicaulis, primarily known for its antifungal properties. This compound demonstrates significant activity against various fungal strains, making it a valuable tool for research focused on antifungal drug development and identifying potential therapeutic agents for fungal infections. Its unique structure and biological activity contribute to its relevance in exploring new treatments in mycology and related fields. -
Antioxidant
Dihydro-N-caffeoyltyramine is a phenolic amide known for its potent antioxidant properties. It exhibits strong antioxidant activity and demonstrates antifungal effects. Mechanistically, Dihydro-N-caffeoyltyramine downregulates cyclooxygenase-2 expression by inhibiting the activity of C/EBP and AP-1 transcription factors, making it a valuable compound for research in oxidative stress and inflammatory responses. -
Antifungal Agent
Antifungal Agent 70 is a dihydroeugenol-imidazole compound that demonstrates potent activity against multi-resistant Candida auris, with an MIC of 36.4 μM. This agent effectively inhibits fungal growth and is valuable in research applications focused on developing treatments for resistant fungal infections. Its unique mechanism makes it a promising candidate for further exploration in antifungal drug development. -
Fungal Inhibitor
Fumigaclavine A is a clavine alkaloid that acts as a fungal inhibitor targeting Aspergillus species. This mycotoxin, produced by Aspergillus fumigatus, is significant in studies related to fungal contamination and plant disease management. Research applications include investigating the pathogenicity of A. fumigatus and assessing the efficacy of antifungal agents in various environments. -
Fungal Inhibitor
(-)-Zonarol is a potent antifungal agent that targets and inhibits fungal growth. This compound exhibits diverse translational potential in research applications, particularly in the study of fungal infections and resistance mechanisms. As an isomer of Zonarol and related to the natural product (-)-Yahazunol, (-)-Zonarol provides valuable insights into fungal biology and therapeutic strategies. -
Antifungal Agent
Antifungal Agent 33 is a potent inhibitor of Lanosterol 14α-demethylase (CYP51), exhibiting an IC50 of 0.19 μg/mL. This compound demonstrates significant antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 16 μg/mL. Antifungal Agent 33 is valuable for research applications focused on the development of new antifungal therapies and the study of fungal resistance mechanisms. -
Germination Self-inhibitor
Methyl (Z)-ferulate is a natural germination self-inhibitor primarily derived from the leaves of Tetragonia tetragonoides. It effectively blocks germination in rust fungi by reversibly inhibiting the degradation of the germination pore plug through modulation of existing enzyme activity. In addition to its antifungal properties, Methyl (Z)-ferulate exhibits antioxidant activity, demonstrating significant scavenging capabilities against DPPH and ABTS+ radicals. This compound is valuable for research applications focused on plant defense mechanisms and antioxidant strategies. -
Antimicrobial Agent
Antimicrobial agent-3 is a broad-spectrum antimicrobial compound exhibiting efficacy against bacterial, fungal, and tubercular pathogens. Its mechanism of action involves disrupting microbial cell integrity, thereby facilitating elimination of infections. This reagent is useful in research applications aimed at developing new therapeutic strategies to combat resistant strains of pathogens and improving understanding of antimicrobial resistance mechanisms. -
C. albicans Nmt Inhibitor
SC-58272 is a potent and selective inhibitor of N-myristoyltransferase (Nmt) in Candida albicans, exhibiting an IC50 of 56 nM against the strain B311. This compound demonstrates a 250-fold selectivity for the fungal enzyme when compared to the human counterpart. SC-58272 is valuable for research applications involving fungal pathogenesis and the study of myristoylation processes in C. albicans. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 2 selectively targets chitin synthase, demonstrating potent inhibitory effects with an IC50 of 0.09 mM and a Ki of 0.12 mM. This compound exhibits significant antimicrobial activity in vitro and can enhance the effects of fluconazole and polyoxin B, making it a valuable tool for investigating chitin biosynthesis and potential applications in antifungal research. -
Antifungal Agent
3-Oxobetulin is an antifungal agent that targets fungal pathogens. It exhibits significant antifungal activity against the white rot fungus L. betulina and the brown rot fungus L. sulphureus. This compound is useful for research applications focused on the development of antifungal treatments and understanding fungal resistance mechanisms. -
Antifungal Agent
Antifungal Agent 90 (Compound 7n) is an antifungal compound that inhibits ergosterol biosynthesis, a critical component of fungal cell membranes. This agent demonstrates strong antifungal activity against Valsa mali and Botrytis cinerea, with effective concentration (EC50) values of 4.26 μg/mL and 1.41 μg/mL, respectively. It serves as a valuable tool in the study of fungal infections and the development of antifungal therapies. -
Antifungal Agent
KOS-2079 is an antifungal agent that exhibits potent inhibitory activity against Aspergillus flavus (MIC = 1.10 μg/mL) and Aspergillus fumigatus (MIC = 1.32 μg/mL). This compound is valuable for research applications focused on fungal infections, providing insights into mechanisms of resistance and potential therapeutic strategies. KOS-2079 serves as a critical tool in the study of antifungal efficacy and the biology of pathogenic fungi. -
Antifungal Agent
Antifungal agent 21 is a novel antifungal compound targeting fungal pathogens. Its primary mechanism involves disrupting fungal cell wall synthesis, leading to cellular instability and eventual cell death. This agent exhibits potent antifungal activity against a broad spectrum of fungi, making it a valuable tool in agricultural research and the development of effective agrochemical solutions for crop protection. -
Antifungal Agent
Antifungal Agent 53 is a potent inhibitor of the cytochrome P450 enzyme CYP51 in Candida albicans, demonstrating significant antifungal activity. This compound effectively prevents the formation of fungal biofilms, contributing to its efficacy against fungal infections. Additionally, Antifungal Agent 53 has favorable safety profiles, making it a valuable tool in antifungal research applications. -
Antifungal Agent
Cinnamon bark oil, derived from Cinnamomum zeylanicum Blume, acts as an antifungal agent targeting various fungi responsible for respiratory tract mycoses. This compound has demonstrated significant biological activity in inhibiting fungal growth, making it a valuable tool for research in mycology and respiratory infections. Its potential applications extend to studies focused on natural antifungal therapies and the development of alternative treatment strategies. -
Succinate Dehydrogenase Inhibitor
Succinate dehydrogenase-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH). This indene amino acid derivative exhibits significant antifungal activity in vitro, with effective concentrations against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L). It is a valuable tool for research applications focused on inhibiting SDH in microbial pathogens. -
Antifungal Agent
Antifungal Agent 61 primarily targets and inhibits V. mali, exhibiting an EC50 value of 0.50 mg/L. This compound disrupts fungal cellular integrity by inducing deformation and contraction, leading to a reduction in intracellular mitochondria, thickening of the cell wall, and increased permeability of the cell membrane. Antifungal Agent 61 is a valuable reagent for research applications focused on understanding fungal pathogenesis and developing antifungal therapies. -
Secondary Metabolite
Neosartoricin, a prenylated anthracenone, targets immunological pathways as a secondary metabolite. Isolated from Aspergillus fumigatus and Neosartorya fischeri, Neosartoricin exhibits notable immunosuppressive activity, significantly inhibiting T-cell proliferation with an IC50 of 3 μM. This compound may play a role in fungal defense mechanisms by dampening host adaptive immunity, potentially aiding in the establishment of infection without directly influencing primary virulence factors. -
Antifungal Agent
Quindecamine acetate is an antifungal agent that targets fungal cell membranes, disrupting their integrity. This compound exhibits significant antifungal activity, making it suitable for studies related to fungal infections and the development of antifungal therapies. Its mechanism of action and efficacy make it a valuable reagent for researchers exploring antifungal drug development and resistance mechanisms. -
SDH Inhibitor/Antifungal Agent
SDH-IN-13 (Compound 5IIIh) is an inhibitor of succinate dehydrogenase (SDH) with an IC50 of 13.7 μg/mL. This compound exhibits antifungal activity, making it a valuable tool in the study of fungal pathogens and mitochondrial function. Its selective targeting of SDH positions it as a promising candidate for further research in antifungal therapies. -
Antifungal/Antibacterial Benzoquinone
Anserinone B is a benzoquinone recognized for its antifungal and antibacterial properties. It effectively inhibits the radial growth of S. fimicola and A. furfuraceus by 50% and 37%, respectively. Additionally, Anserinone B exhibits moderate cytotoxicity against a broad range of human tumor cell lines, as demonstrated by a GI50 value of 4.4 µg/mL in the NCI’s 60 cancer cell line panel. This compound is relevant for research in antimicrobial therapies and cancer treatment. -
Antifungal Agent
Butenafine is a potent benzylamine antifungal agent that targets squalene epoxidation in the ergosterol biosynthesis pathway, leading to impaired cell membrane integrity in fungi. It demonstrates broad-spectrum activity against various dermatophyte infections, including tinea pedis, tinea cruris, and tinea versicolor. This compound is valuable for research applications focused on antifungal mechanisms and the development of treatments for fungal infections. -
Antifungal Agent
Fumitremorgin B is a tremorgenic mycotoxin with notable antifungal properties. This compound demonstrates significant antifungal activity, exhibiting minimum inhibitory concentrations (MICs) ranging from 6.25 to 50 μg/mL. Fumitremorgin B serves as a valuable reagent for research in mycology, the study of fungal pathogens, and exploring mechanisms of antifungal resistance. -
Antifungal Agent
Triforine is a systemic antifungal agent that exhibits moderate to pronounced fungitoxic activity against various pathogenic and non-pathogenic fungi. It operates by inhibiting fungal growth, making it an effective tool for studying fungal interactions and antifungal mechanisms. Triforine is suitable for research applications in mycology and agricultural science, contributing to the understanding and management of fungal diseases. -
Benzimidazole Fungicide
Carbendazim hydrochloride is a benzimidazole fungicide that exerts its activity through disruption of microtubule dynamics, targeting fungal cell division. It demonstrates broad-spectrum antifungal activity and is commonly utilized in research focused on fungal diseases, including Septoria, Fusarium, and Sclerotinia. Additionally, carbendazim hydrochloride exhibits antitumor properties, making it applicable in cancer research, particularly in the study of advanced solid tumors and lymphoma. -
Antifungal Agent
Antifungal Agent 74 is a potent antifungal compound that exhibits significant fungicidal activity against pathogens such as Colletotrichum arachidicola and Rhizoctonia solani. Its mechanism of action involves the disruption of steroid biosynthesis and ribosome biogenesis in eukaryotic organisms, making it a valuable tool in antifungal research and the study of fungal pathogenesis. Suitable for applications in both laboratory and agricultural settings, Antifungal Agent 74 offers potential for the development of new antifungal strategies. -
antifungal
Lactose octaacetate primarily exhibits antifungal activity, demonstrating mild to moderate effects against certain fungi while showing minimal or no activity against bacteria and yeast. This compound displays low cytotoxicity toward MDBK, Hep-2, and MDCK cells, making it a candidate for further safety assessments in biological research. Additionally, lactose octaacetate has been identified to possess antiviral properties against PV-1, suggesting potential applications in virology studies. -
Anti-Plant Pathogenic Fungal
Verlamelin B is a novel compound targeting plant pathogenic fungi. It demonstrates significant protective activity in vivo, particularly against rice blast and barley powdery mildew, providing insights into antifungal mechanisms. Furthermore, Verlamelin B induces morphological alterations in fungal cells, including swelling and expansion. Despite its weaker in vitro activity against certain plant pathogens like Dipolaris zeae and Botrytis cinerea, this compound is a valuable tool for research into antifungal strategies against agricultural pathogens. -
SDH Inhibitor
SDH-IN-4 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.28 μg/mL. This compound demonstrates potent antifungal activity, specifically against Rhizoctonia solani, with an EC50 value of 0.23 μg/mL. SDH-IN-4 is primarily utilized in research applications involving fungal pathogen studies and metabolic pathway analysis. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 6 is a potent inhibitor of chitin synthase (CHS) with an IC50 value of 0.21 mM. This compound exhibits broad-spectrum antifungal activity against drug-resistant fungi, making it a valuable tool in the study of fungal infections. It is applicable in research focused on understanding fungal pathogenesis and developing antifungal therapies. -
Phytotoxin
Neovasinin is a phytotoxin derived from the fungus Neocosmospora vasinfecta. It demonstrates significant toxicity towards soybean plants, serving as a valuable model for studying plant-fungal interactions and the mechanisms of plant defense. This compound can be utilized in research focused on plant pathology and agricultural biotechnology. -
Fungal Inhibitor
Antifungal Agent 68 is a potent inhibitor targeting fungal ergosterol biosynthesis, with demonstrated efficacy against Candida species and Cryptococcus gattii. This compound likely exerts its antifungal effects by inhibiting lanosterol 14α-demethylase (CYP51), wherein its imidazole ring interacts with the heme group of the enzyme. It serves as a valuable tool for research into fungal infections and the development of novel antifungal therapies. -
Antifungal Agent
Amcipatricin L-aspartate is a semi-synthetic polyene antibiotic that targets fungal cell membranes, exhibiting potent broad-spectrum antifungal activity. This reagent is suitable for research applications focused on fungal infections and the development of antifungal therapies. Its ability to disrupt cellular integrity makes it a valuable tool in studying antifungal mechanisms and treatment strategies.
