Target & Activity
| Target | Activity | Value |
|---|---|---|
| CYP51 |
Cellular Effect
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| Hepatocyte | IC50 | 79 μM | Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method | [PMID: 24948565] |
Fig. 1 · Structure
Documents & Downloads
Quilseconazole
Cat. No.
A19305
CAS
1340593-70-5
fungal Cyp51 inhibitor
Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1340593-70-5 |
| Applications | fungal Cyp51 inhibitor |
| Formula | C22H14F7N5O2 |
| Molecular Weight | 513.37 |
| Synonyms | VT-1129 |
| SMILES | O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=N3)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.