Thujopsene is a potent inhibitor of cytochrome P450 enzymes, specifically targeting CYP2B6, CYP3A4, CYP2C19, CYP2C8, and CYP2C9, with IC50 values of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. In addition to its role as a metabolic inhibitor, thujopsene binds to PKM2, disrupting cancer cell metabolic pathways and inducing apoptosis in MKN45 cells, thereby demonstrating significant antitumor activity. This compound also exhibits notable anti-termite and antifungal properties through its autoxidation process, broadening its potential applications in both cancer research and pest control.
Thujopsene is a potent inhibitor of cytochrome P450 enzymes, specifically targeting CYP2B6, CYP3A4, CYP2C19, CYP2C8, and CYP2C9, with IC50 values of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. In addition to its role as a metabolic inhibitor, thujopsene binds to PKM2, disrupting cancer cell metabolic pathways and inducing apoptosis in MKN45 cells, thereby demonstrating significant antitumor activity. This compound also exhibits notable anti-termite and antifungal properties through its autoxidation process, broadening its potential applications in both cancer research and pest control.
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