Catalog No.
Product Name
Application
Product Information
Citations
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Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
Antiviral Agent
Antiviral Agent 64 is a diarylheptanoid derived from Alpinia officinarum, primarily targeting viral pathogens. This compound demonstrates notable cytotoxicity in human neuroblastoma cells (IMR-32) with an IC50 value of 0.23 μM. Additionally, Antiviral Agent 64 exhibits significant antiviral activity against respiratory syncytial virus (RSV), poliovirus, measles virus, herpes simplex virus type 1 (HSV-1), and influenza virus H1N1, with EC50 values of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively. This makes it a valuable tool for research in virology and therapeutic development. -
IMPDH Inhibitor
Mycophenolic acid-13C17 is a stable isotope-labeled form of Mycophenolic acid, acting as a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) with an EC50 of 0.24 μM. This compound exhibits significant antiviral activity against a variety of RNA viruses, including influenza, and serves as an immunosuppressive agent. Additionally, Mycophenolic acid-13C17 demonstrates antiangiogenic and antitumor properties, making it valuable for research in immunology, virology, and cancer biology. -
Clk1 Inhibitor
CLK1-IN-2 is a potent and metabolically stable inhibitor of CLK1, exhibiting a selectivity for its target with an IC50 value of 1.7 nM. This compound is valuable for research applications focusing on tumor biology, Duchenne muscular dystrophy, and viral infections, including HIV-1 and influenza. CLK1-IN-2 facilitates the study of cellular mechanisms and therapeutic interventions related to these diseases. -
CLK Inhibitor
KH-CB19 is a selective inhibitor of CLK (cdc2-like kinase) with an IC50 of 19.7 nM for CLK1 and 530 nM for CLK3. This compound exhibits antiviral properties, demonstrated by its ability to hinder influenza virus replication, with an IC50 value of 13.6 μM. KH-CB19 serves as a valuable tool for research into CLK-related pathways and antiviral drug development. -
M2 Channel Blocker
M2 Ion Channel Blocker-2 is a selective inhibitor of M2 ion channels, effectively targeting both wild-type and mutant variants (L27F and V27A). This compound exhibits significant antiviral activity against HCoV-229E, with an EC50 value of 4.7 μM in cytopathic effect assays, while showing no antiviral effects against influenza A virus. Additionally, M2 Ion Channel Blocker-2 demonstrates negligible inhibition of hERG and key cytochrome P450 enzymes (CYP1A2, CYP2C19, and CYP3A4), making it a useful tool for research in virology and ion channel modulation. -
AXL kinase Inhibitor
SLC-391 is an orally active AXL kinase inhibitor, demonstrating an IC50 of 9.6 nM against AXL kinase. It effectively inhibits Gas6-induced AXL-dependent phosphorylation of Akt and has shown potential in suppressing SARS-CoV-2 infection, entry, and replication within host cells. Additionally, SLC-391 has been found to inhibit cancer cell proliferation and tumor growth in mouse solid tumor xenograft models. This compound serves as a valuable tool for research in areas such as COVID-19, influenza virus infections, triple-negative breast cancer, chronic myeloid leukemia, and non-small cell lung cancer. -
Antiviral Agent
Kistamicin A is an antiviral agent with demonstrated efficacy against influenza virus and herpes simplex virus. Its inhibitory doses (ID50) are measured at 3.6 μg/mL for influenza virus in MDCK cells and 44 μg/mL for herpes simplex virus. In addition to its antiviral properties, Kistamicin A exhibits antibacterial activity against Gram-positive bacteria, making it a versatile compound for research applications in virology and microbiology. -
Bactericide
HMR-3787 is a 2-fluoroketolide that functions as a bactericide. It exhibits potent bactericidal activity against multiple strains of Haemophilus influenzae, making it a valuable tool for microbiological research. HMR-3787 is particularly useful for studies focused on bacterial resistance and the development of novel therapeutic agents. -
ClpP Activator
ACP1b is an activator of the ClpP protease, exhibiting a binding affinity with a Kd of 3.2 μM. This compound demonstrates significant antibacterial activity, effectively inhibiting Neisseria meningitidis and Haemophilus influenzae, with minimum bactericidal concentrations (MBC) of 16 μg/mL and 8 μg/mL, respectively. ACP1b serves as a valuable tool in microbiological research, particularly in studies focused on bacterial protease function and antibiotic resistance mechanisms. -
Cephalosporin
Cefdaloxime is an orally active cephalosporin that functions by inhibiting bacterial cell wall synthesis. It demonstrates a broad spectrum of antimicrobial activity against various pathogens, including Enterobacteriaceae, staphylococci, Streptococcus spp., Neisseria gonorrhoeae, Moraxella catarrhalis, and Haemophilus influenzae. This compound is utilized in research applications related to antibiotic efficacy and resistance mechanisms among Gram-negative and Gram-positive bacteria. -
Active Metabolite
Oseltamivir acid hydrochloride is the active metabolite of the antiviral agent Oseltamivir. This compound primarily functions as a neuraminidase inhibitor, effectively limiting the spread of influenza virus within the host. It is commonly utilized in pharmaceutical research for the assessment of antiviral efficacy and toxicity ratio analysis. -
influenza virus neuraminidase inhibitor
Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses. -
influenza virus neuraminidase (NA) inhibitor
Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes. - Oseltamivir is an antiviral drug, which may slow the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.
- Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM)
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antiviral agent
Baloxavir marboxil is an antiviral agent. CAS: 1985605-59-1 (Baloxavir) 1985606-14-1 (Baloxavir marboxil) -
interferon inducer
Tilorone Dihydrochloride is an antiviral, antineoplastic, and anti-inflammatory agent; Orally active interferon inducer, inhibiting Ebola virus (EBOV). -
antiviral drug
Rimantadine is an orally administered antiviral drug used to treat, and in rare cases prevent, influenzavirus A infection. -
Adenosine deaminase inhibitor
EHNA hydrochloride is a specific inhibitor of adenosine deaminase, prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts. -
broad-spectrum antiviral activity
Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. -
neuraminidase (NA) inhibitor
Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. -
anti-human influenza virus efficacy
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 ?g/ml. Antiviral and anti-inflammatory activities. -
anti-tumor agent
Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. - RIG-1 modulator 1 is an anti-viral compound which can be useful for the treatment of viral infections including influenza virus, HBV, HCV and HIV extracted from patent WO 2015172099 A1.
- 3,4'-Dihydroxyflavone (3,4'-DHF) is an oral active flavonoid with antiviral activity against Influenza A virus.
- Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim.
- N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs).
- Influenza Hemagglutinin (HA) Peptide is a tag peptide derived from an epitope of the influenza hemagglutinin protein.
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antiviral agent
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst. -
IMPDH Inhibitor
Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), with an EC50 of 0.24 µM. This compound exhibits antiviral activity against various RNA viruses, including influenza, alongside its immunosuppressive properties. Additionally, Mycophenolic acid sodium demonstrates antiangiogenic and antitumor effects, making it valuable for research in immunology, virology, and cancer therapy. -
Antioxidant Agent
Clovamide is a natural phenolic compound that functions as a potent antioxidant agent. It effectively scavenges reactive oxygen species (ROS) and oxygen radicals, demonstrating significant anti-inflammatory and neuroprotective properties. Additionally, Clovamide exhibits antimicrobial activity against human pathogens such as influenza A subtype H5N1, Trypanosoma evansi, and Helicobacter pylori, making it valuable for various biological research applications. -
PPAR-γ Activator
Glabrone, a PPAR-γ activator derived from the roots of Glycyrrhiza glabra, demonstrates notable ligand binding activity to this nuclear receptor. In addition to its role as a specific probe substrate for UGT1A9, Glabrone's metabolites inhibit neuraminidase, thus preventing influenza virus release. This compound is suitable for research applications focused on herb-drug interactions and the evaluation of anti-influenza viral activity. -
Antiviral Agent
Onradivir is an orally active antiviral agent that specifically targets the PB2 subunit of influenza A virus RNA polymerase, exhibiting an IC50 of 0.562 nM. By inhibiting cap binding, Onradivir effectively suppresses viral replication, lowers viral titers, and mitigates influenza A virus infection. In preclinical studies, Onradivir demonstrated enhanced survival rates in mice infected with influenza A virus and significantly reduced viral loads. This compound is valuable for researching influenza A virus infections and developing potential therapeutic strategies. -
Larvicide/Antiviral
Cappariloside A is a potent larvicide primarily targeting Aedes aegypti larvae, demonstrating significant larvicidal activity while inhibiting larval glutathione-S-transferase activity. Additionally, it exhibits antiviral effects by decreasing phosphorylated STAT1 levels, inhibiting the replication of various influenza viruses, including H1N1 and H3N2, and downregulating key pro-inflammatory cytokines such as IL-6 and IFN-β. Cappariloside A is valuable for research involving larvicidal strategies and the investigation of antiviral responses in influenza virus infections. -
Antiviral Agent
Onradivir monohydrate is an orally active antiviral agent that targets the influenza A virus RNA polymerase PB2 subunit, exhibiting an IC50 value of 0.562 nM. This compound effectively inhibits cap binding to the PB2 subunit, leading to suppression of viral replication, reduction of viral titers, and decreased RNA loads. In murine models, Onradivir monohydrate demonstrates improved survival rates in influenza A virus-infected mice and is a valuable tool for studying influenza A virus infections in research applications. -
DNA Gyrase Inhibitor
DNA Gyrase-IN-11 is a selective inhibitor of DNA gyrase, targeting bacterial DNA replication and supercoiling mechanisms. It demonstrates a potent inhibitory effect on protein synthesis with an IC50 of 0.74 μM and effectively inhibits E. coli DNA gyrase with an IC50 of 11.9 μM. Additionally, DNA Gyrase-IN-11 possesses significant antibacterial activity against pathogens such as Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.25 μg/mL, making it a valuable tool for antimicrobial research. -
RdRP Inhibitor
RdRP-IN-3 is an inhibitor of RNA-dependent RNA polymerase (RdRp), providing a potent approach for antiviral research against influenza viruses. This compound effectively disrupts RdRp activity, thereby hindering viral replication and proliferation. It serves as a valuable tool in studying the mechanisms of influenza pathogenesis and evaluating potential antiviral therapies. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
CMV Inhibitor
Soyasaponin II is a saponin known for its antiviral properties, particularly as an inhibitor of cytomegalovirus (CMV) replication. It demonstrates strong efficacy against various viruses, including HSV-1, HCMV, influenza, and HIV-1. Additionally, Soyasaponin II inhibits YB-1 phosphorylation and NLRP3 inflammasome priming, offering potential protective effects in models of acute liver failure induced by LPS/GalN. This compound is valuable for research in virology and inflammation. -
Antiviral/Immunomodulator
HEP-1 is a synthetic peptide derived from human ezrin (324 - 337) that exhibits potent antiviral and immunomodulatory properties. It demonstrates efficacy against a range of viral infections, including HIV, HCV, herpes viruses, HPV, and influenza. Additionally, HEP-1 enhances adaptive immunity by promoting B cell and T cell responses, and it has been shown to increase antibody titers following hepatitis B vaccination. This reagent is suitable for research applications focused on viral infections and inflammation-related disorders. -
Surface Glycans of EVs
6′SLN is a sialic acid derivative that targets surface glycans of extracellular vesicles (EVs). It plays a crucial role in protein glycosylation within EVs and is known to interact with hemagglutinins from both human and avian influenza virus strains. Research applications include the investigation of anti-influenza drug mechanisms and the study of EV-mediated communication in cancer biology.
