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Catalog No.
Product Name
Application
Product Information
Citations
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Dihydropyrimidinase Inhibitor
Dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) is a natural antioxidant with good prospects. -
NLRP3 inflammasome inhibitor
Isoliquiritigenin is a licorice chalconoid, a type of natural phenols that is currently under experimentation phase testing for use as a cancer treatment as well as an aide for cocaine addiction. -
RNA polymerase inhibitor
Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).- Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
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Hsp90 inhibitor
Geldanamycin binds to the ATP site of Hsp90 (Kd = 1.2 μM) and inhibits its chaperone activity.- Sunayn Cheku, .et al. , Fly (Austin), 2025, Apr 25;19(1):2497565 PMID: 40277072
- Michael Heider, .et al. , Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
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influenza virus neuraminidase inhibitor
Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses. -
influenza virus neuraminidase (NA) inhibitor
Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes. -
viral RNA polymerase inhibitor
T-705, a substituted pyrazine compound, has been found to exhibit potent anti-influenza virus activity in vitro and in vivo.
- Dylan M Johnson, .et al. , Viruses, 2024, Jul 9;16(7):1101 PMID: 39066263
- Steven B Tillis, .et al. , Microorganisms, 2023, May 24;11(6):1371 PMID: 37374873
- Hyeon-Min Cha, .et al. , ACS Infect Dis, 2023, Apr 14;9(4):1033-1045 PMID: 36912867
- Satoko Yamaoka, .et al. , Antiviral Res, 2022, Apr;200:105291 PMID: 35296419
- Crystal A Mendoza, .et al. , Antiviral Res, 2021, Jan;185:104993 PMID: 33296695
- Liva Checkmahomed, .et al. , Viruses, 2020, Oct; 12(10): 1139 PMID: 33049959
- JE Comer, .et al. , Viruses, 2019, Feb 3;11(2). pii: E137 PMID: 30717492
- Ma J, .et al. , Antiviral Res, 2018, Feb;150:112-122 PMID: 29253498
- Ji-Ae Kim, .et al. , Viruses, 2018, Feb; 10(2): 72 PMID: 29425176
- Haejin Chun, .et al. , Polym Chem, 2018, 9: 2116-2123
- Baz M, .et al. , Viruses, 2018, Nov 3;10(11) PMID: 30400276
- Sehee Park, .et al. , PLoS One., 2014, 9(7): e101325 PMID: 24992479
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NF-κB inhibitor
SC75741 is a potent NF-kB inhibitor with EC50 of 200 nM.- Yunshang Yang, .et al. , Biomed Pharmacother, 2023, Feb;158:114113 PMID: 36516692
- Yajun Li, .et al. , Cell Prolif, 2022, Oct;55(10) PMID: 35708050
- Crystal A Mendoza, .et al. , Antiviral Res, 2021, Jan;185:104993 PMID: 33296695
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Adenosine deaminase inhibitor
EHNA hydrochloride is a specific inhibitor of adenosine deaminase, prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts. -
neuraminidase (NA) inhibitor
Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. -
Influenza Virus Inhibitor
Dehydroandrographolide succinate acts as a potent inhibitor of the influenza virus. Extracted from the medicinal plant Andrographis paniculata, it exhibits immunostimulatory, anti-infective, and anti-inflammatory properties, making it valuable for research into viral pneumonia and upper respiratory tract infections. Additionally, it demonstrates antithrombotic effects by significantly reducing platelet aggregation, as evidenced by a calculated ED50 of 386.9 mg/kg. The compound also mitigates muscle atrophy through the Akt/GSK3β and MuRF-1 signaling pathways. -
NA Inhibitor
Urolithin M5 is an orally active inhibitor of influenza virus neuraminidase, exhibiting IC50 values of approximately 174.8 μM to 257.1 μM. It effectively suppresses influenza virus replication, including strains resistant to oseltamivir, while demonstrating neuroprotective properties by reducing reactive oxygen species and inhibiting neuronal apoptosis. Urolithin M5 also promotes neurite outgrowth and protects against lung edema in infected mammals. Additionally, it interacts with key signaling proteins such as IGF1R, MAPK14, AKT1, NFKB1, and EGFR, making it a valuable reagent for research into influenza and neurodegenerative diseases like Alzheimer's. -
IL-6 Inhibitor
Koaburaside is an IL-6 inhibitor known for its cytoprotective and anti-inflammatory properties. This natural compound exhibits significant antioxidant activity, with an IC50 value of 9.0 μM in the DPPH free radical scavenging assay. Additionally, Koaburaside effectively reduces histamine release and downregulates the expression of pro-inflammatory cytokines IL-6 and TNF-α in human mast cells. It also demonstrates inhibitory effects on influenza A neuraminidase, highlighting its potential applications in inflammatory and viral research. -
SCD1 Inhibitor
SSI-4 is a potent stearoyl-CoA desaturase (SCD1) inhibitor with an EC50 of 1.9 nM for mouse SCD1. By blocking the conversion of saturated fatty acids to monounsaturated fatty acids, SSI-4 effectively reduces oleic and palmitoleic acid production. It promotes lipid peroxidation, induces endoplasmic reticulum stress, and activates apoptotic pathways. Additionally, SSI-4 inhibits mTORC1 activity, suppresses B cell proliferation and antibody production, and induces autophagy. This compound is valuable for studies related to cancers such as acute myeloid leukemia and renal cell carcinoma, as well as influenza infections. -
IMPDH Inhibitor
Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), with an EC50 of 0.24 µM. This compound exhibits antiviral activity against various RNA viruses, including influenza, alongside its immunosuppressive properties. Additionally, Mycophenolic acid sodium demonstrates antiangiogenic and antitumor effects, making it valuable for research in immunology, virology, and cancer therapy. -
CMV Inhibitor
Soyasaponin II is a saponin known for its antiviral properties, particularly as an inhibitor of cytomegalovirus (CMV) replication. It demonstrates strong efficacy against various viruses, including HSV-1, HCMV, influenza, and HIV-1. Additionally, Soyasaponin II inhibits YB-1 phosphorylation and NLRP3 inflammasome priming, offering potential protective effects in models of acute liver failure induced by LPS/GalN. This compound is valuable for research in virology and inflammation. -
DNA Gyrase Inhibitor
DNA Gyrase-IN-11 is a selective inhibitor of DNA gyrase, targeting bacterial DNA replication and supercoiling mechanisms. It demonstrates a potent inhibitory effect on protein synthesis with an IC50 of 0.74 μM and effectively inhibits E. coli DNA gyrase with an IC50 of 11.9 μM. Additionally, DNA Gyrase-IN-11 possesses significant antibacterial activity against pathogens such as Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.25 μg/mL, making it a valuable tool for antimicrobial research. -
RdRP Inhibitor
RdRP-IN-3 is an inhibitor of RNA-dependent RNA polymerase (RdRp), providing a potent approach for antiviral research against influenza viruses. This compound effectively disrupts RdRp activity, thereby hindering viral replication and proliferation. It serves as a valuable tool in studying the mechanisms of influenza pathogenesis and evaluating potential antiviral therapies. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
LAL Inhibitor
Lalistat 1 is a selective and competitive inhibitor of lysosomal acid lipase (LAL), demonstrating an IC50 of 68 nM against purified human LAL. It also inhibits immunoglobulin A1 protease (IgA1P) from Haemophilus influenzae while exhibiting minimal effects on other serine hydrolases such as trypsin and β-lactamase. This compound is valuable for investigating Niemann-Pick type C (NPC) disease and related metabolic disorders. -
SCD Inhibitor
Elemicin is a potent inhibitor of Stearoyl-CoA Desaturase 1 (SCD1), acting through metabolic activation. This compound exhibits a range of biological activities, including anti-influenza, antimicrobial, antioxidant, and antiviral effects. Its mechanism and diverse applications make Elemicin a valuable reagent for research in metabolic studies and infectious disease treatment. Caution is advised, as Elemicin and its reactive metabolite, 1′-Hydroxyelemicin, may induce hepatotoxicity. -
Clk1 Inhibitor
CLK1-IN-2 is a potent and metabolically stable inhibitor of CLK1, exhibiting a selectivity for its target with an IC50 value of 1.7 nM. This compound is valuable for research applications focusing on tumor biology, Duchenne muscular dystrophy, and viral infections, including HIV-1 and influenza. CLK1-IN-2 facilitates the study of cellular mechanisms and therapeutic interventions related to these diseases. -
CLK Inhibitor
KH-CB19 is a selective inhibitor of CLK (cdc2-like kinase) with an IC50 of 19.7 nM for CLK1 and 530 nM for CLK3. This compound exhibits antiviral properties, demonstrated by its ability to hinder influenza virus replication, with an IC50 value of 13.6 μM. KH-CB19 serves as a valuable tool for research into CLK-related pathways and antiviral drug development. -
AXL kinase Inhibitor
SLC-391 is an orally active AXL kinase inhibitor, demonstrating an IC50 of 9.6 nM against AXL kinase. It effectively inhibits Gas6-induced AXL-dependent phosphorylation of Akt and has shown potential in suppressing SARS-CoV-2 infection, entry, and replication within host cells. Additionally, SLC-391 has been found to inhibit cancer cell proliferation and tumor growth in mouse solid tumor xenograft models. This compound serves as a valuable tool for research in areas such as COVID-19, influenza virus infections, triple-negative breast cancer, chronic myeloid leukemia, and non-small cell lung cancer. -
Endonuclease Inhibitor
AV5116 is a cap-dependent endonuclease inhibitor that specifically targets the active site of the cap-dependent endonuclease (CEN) within the N-terminal domain of polymerase acidic. This compound demonstrates potent inhibitory activity against various influenza viruses, including types A, B, and C. AV5116 is valuable for research investigating influenza virus infections and the mechanisms of antiviral action. -
Influenza Virus Inhibitor
β-Cyclodextrin is a cyclic polysaccharide that targets influenza virus inhibition, specifically effective against the H1N1 strain. Its primary mechanism involves enhancing the solubility of various compounds, making it a valuable tool in virology research. Additionally, β-Cyclodextrin demonstrates significant antiviral activity, providing potential therapeutic applications in the treatment of influenza. -
Neuraminidase Inhibitor
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid is a potent inhibitor of neuraminidase enzymes, functioning primarily through competitive inhibition. This compound demonstrates significant inhibitory effects on human neuraminidase isoforms NEU1, NEU2, NEU3, and NEU4, with IC50 values of 143, 43, 61, and 74 μM, respectively. Its inhibitory activity positions it as a valuable tool for researching anti-influenza virus mechanisms and for studying sialidase-related biological processes. -
Influenza Viru Inhibitor
Desaminotyrosine is an influenza virus inhibitor that enhances type I interferon signaling. This microbial metabolite plays a crucial role in the immune response against influenza, offering protective effects by promoting antiviral activity. Its mechanism of action makes it valuable for research into antiviral therapies and immune modulation strategies. -
Influenza Viru Inhibitor
L-Norleucine, a derivative of leucine, primarily functions as an antiviral agent by inhibiting protein synthesis, particularly in the context of influenza virus infections. Its activity interferes with viral replication, making it a valuable reagent for research applications focused on viral biology and therapeutic interventions against influenza. L-Norleucine can be utilized in studies exploring mechanisms of protein synthesis modulation and the development of antiviral strategies. -
MTr1 Inhibitor
Trifluoromethyl-tubercidin (TFMT) is an inhibitor of the enzyme 2'-O-ribose methyltransferase 1 (MTr1). This compound effectively disrupts the cap-snatching mechanism utilized by influenza A and B viruses, thereby inhibiting viral replication. TFMT demonstrates notable antiviral activity with minimal toxicity, making it a valuable reagent for studies in virology and antiviral research. -
Influenza Virus Inhibitor
Epigoitrin is a natural alkaloid that exhibits antiviral activity against influenza viruses by inhibiting attachment and replication of the influenza A1 virus FM1 in vitro. This compound enhances the host's resistance to influenza infection, particularly under stress conditions. Additionally, Epigoitrin demonstrates lipid-lowering effects, making it a potential candidate for research in infectious diseases and metabolic health. -
Influenza Virus Inhibitor
2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that serves as a potent inhibitor of influenza viruses, exhibiting an effective concentration (EC90) of less than 0.35 μM against both influenza A and B strains. This compound disrupts the replication process of the influenza virus in the upper respiratory tract, resulting in reduced fever and alleviated nasal inflammation. Its antiviral properties make it a valuable tool for research on influenza virus pathogenesis and therapeutic intervention strategies. -
Influenza Virus Inhibitor
Rupestonic acid is a sesquiterpene that acts as an inhibitor of the influenza virus. This compound demonstrates significant antiviral activity, making it a valuable tool for research focused on influenza virus pathogenesis and therapeutic interventions. Its ability to disrupt viral replication holds potential for the development of novel antiviral strategies. -
Kinase Inhibitor
3-Deoxysappanchalcone is a potent kinase inhibitor that selectively targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, thrombin, FXa, and influenza virus neuraminidase, modulating key signaling pathways. This compound is known to induce cell cycle arrest, reactive oxygen species (ROS) production, and apoptosis, demonstrating significant biological activities. Its anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic properties make it valuable for research in gefitinib-resistant lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infections. -
Influenza Virus Inhibitor
Oseltamivir-d3 is a deuterium-labeled derivative of Oseltamivir, which functions as a neuraminidase inhibitor targeting the influenza virus. This compound demonstrates potent antiviral activity against various influenza strains, including A/H3N2, A/H1N2, A/H1N1, and B, with mean IC50 values of 0.67, 0.9, 1.34, and 13 nM, respectively. Oseltamivir-d3 is valuable for research applications focused on influenza virus studies, antiviral drug development, and mechanistic investigations of neuraminidase inhibition. -
CEN Inhibitor
AV5124 is an orally active cap-dependent endonuclease (CEN) inhibitor, functioning as a prodrug of AV5116. It exhibits potent antiviral activity by inhibiting the endonuclease function essential for influenza virus replication. This compound is primarily utilized in research focused on developing antiviral strategies against influenza and understanding viral RNA synthesis mechanisms. -
IAV Inhibitor
VNT-101 is an orally active inhibitor of influenza A virus (IAV) that targets the nucleoprotein (NP) and disrupts NP-NP protein-protein interactions, leading to the destabilization of the viral ribonucleoprotein complex. This compound demonstrates potent antiviral activity across various IAV subtypes, with EC50 values ranging from 4-5 nM in cellular cytopathic effect assays, 4-8 nM in neuraminidase assays, and 21-45 nM in ribonucleoprotein assays. Additionally, VNT-101 shows significant in vivo antiviral efficacy in mice infected with lethal H1N1 virus, making it a valuable tool for studying influenza A infection and potential therapeutic interventions. -
PA endonuclease Inhibitor
L-742001 hydrochloride is an inhibitor of the influenza virus PA endonuclease, specifically targeting the viral RNA polymerase complex. It demonstrates an effective EC90 of 4.3 μM for vRNP activity in HEK293T cells. This compound is valuable for research applications focused on antiviral drug development and understanding viral replication mechanisms. -
H1N1 Inhibitor
CBS1117 is a potent inhibitor of the H1N1 influenza A virus, exhibiting an IC50 of 70 nM. It specifically targets the hemagglutinin (HA) protein, disrupting the viral entry process by interfering with HA-mediated fusion. This compound is valuable for research applications focused on understanding influenza virus entry mechanisms and developing antiviral strategies. -
Cap-dependent Endonuclease Inhibitor
Pixavir marboxilo is a potent orally active cap-dependent endonuclease inhibitor that targets the viral polymerase complex. This compound is primarily utilized in influenza research to investigate viral replication mechanisms and evaluate potential therapeutic strategies. Its high efficacy makes it a valuable tool for studying the pathogenesis of influenza and developing antiviral treatments. -
Influenza A Virus Inhibitor
Influenza A virus-IN-1 is a dihydropyrrolidone derivative that serves as a potent inhibitor of various subtypes of influenza A virus (IAV), exhibiting IC50 values ranging from 3.11 μM to 7.13 μM. This compound effectively inhibits IAV replication and enhances the expression of key antiviral cytokines, including IFN-β, as well as the antiviral protein MxA. Its mechanisms make it a valuable tool for research in antiviral drug development and the study of host immune responses to viral infections. -
NA Inhibitor
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a reversible noncompetitive neuraminidase (NA) inhibitor with significant antiviral activity. It demonstrates potent inhibitory effects against influenza virus strains, with IC50 values of 34.6 µM for H1N1, 39.5 µM for H3N2, and 50.5 µM for H9N2. This compound, derived from the dried heartwood of Caesalpinia sappan L., serves as a valuable reagent for research applications focusing on influenza virus inhibition and related studies in virology. -
Neuraminidase Inhibitor
AV-5080 is an orally active neuraminidase inhibitor that targets the enzyme involved in the life cycle of influenza viruses. By inhibiting neuraminidase, AV-5080 effectively reduces viral replication and spread, making it a valuable tool in the study of influenza A and B viruses. This compound is suitable for research applications aimed at understanding viral pathogenesis and developing antiviral strategies. -
Influenza Neuraminidase Enzymes Inhibitor
Ganoderic acid TR is an inhibitor of influenza neuraminidase enzymes (NAs), demonstrating significant antiviral activity. It exhibits IC50 values of 10.9 μM and 4.6 μM against H5N1 and H1N1 strains, respectively, making it a promising candidate for further research in influenza treatment. However, Ganoderic acid TR is associated with cytotoxicity and shows limited efficacy against Oseltamivir-resistant H1N1 and influenza B viruses. -
Influenza A Virus Inhibitor
MBX2546 is an inhibitor of the Influenza A virus, specifically targeting H1 and H3 Hemagglutinin with Kd values of 5.3 μM and greater than 100 μM, respectively. This compound demonstrates potential for antiviral research and therapeutic development aimed at combating Influenza A infections. Its selective mechanism of action makes it a valuable tool for studying hemagglutinin-mediated viral entry and host cell interactions. -
Influenza Virus Inhibitor
Amizon is an orally effective antiviral agent targeting the influenza virus. It inhibits viral replication and restricts RNA synthesis, while simultaneously reducing the mRNA expression of pro-inflammatory mediators such as COX-1, COX-2, NF-κB, TGF-β1, IL-1, and IL-6. Additionally, Amizon enhances the secretion and mRNA expression of the anti-inflammatory cytokine IL-10 and exhibits antioxidant properties, inhibiting the oxidative activity of macrophages. This compound is of interest in research focused on influenza and acute respiratory viral infections.
