Onradivir monohydrate is an orally active antiviral agent that targets the influenza A virus RNA polymerase PB2 subunit, exhibiting an IC50 value of 0.562 nM. This compound effectively inhibits cap binding to the PB2 subunit, leading to suppression of viral replication, reduction of viral titers, and decreased RNA loads. In murine models, Onradivir monohydrate demonstrates improved survival rates in influenza A virus-infected mice and is a valuable tool for studying influenza A virus infections in research applications.
Onradivir monohydrate is an orally active antiviral agent that targets the influenza A virus RNA polymerase PB2 subunit, exhibiting an IC50 value of 0.562 nM. This compound effectively inhibits cap binding to the PB2 subunit, leading to suppression of viral replication, reduction of viral titers, and decreased RNA loads. In murine models, Onradivir monohydrate demonstrates improved survival rates in influenza A virus-infected mice and is a valuable tool for studying influenza A virus infections in research applications.
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