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Fig. 1 · Structure
Cat. No.
A19129
CAS No.
71184-20-8
Formula
C10H15N3O4
Mol. Weight
241.24

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Carbodine

Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent active against DNA viruses, (+)RNA viruses, (-)RNA viruses, paramyxo, rhabdo and (+/-)RNA viruses, targets CTP synthetase that converts UTP to CTP.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
MDCK IC50 > 414 μM Cytotoxicity against MDCK cells after 3 days by neutral red dye uptake assay [PMID: 20231094]
MDCK IC50 > 414 μM Cytotoxicity against MDCK cells after 3 days by neutral red dye uptake assay [PMID: 20231094]
MDCK EC50 0.6 μM Antiviral activity against Influenza A virus Solomon Islands/03/2006/H1N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay [PMID: 20231094]
MDCK EC50 0.6 μM Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 0.7 μM Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 0.7 μM Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 0.7 μM Antiviral activity against Influenza A virus Solomon Islands/03/2006/H1N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 0.8 μM Antiviral activity against Influenza A virus Hong Kong/213/2003/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay [PMID: 20231094]
MDCK EC50 0.8 μM Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay [PMID: 20231094]
MDCK EC50 0.8 μM Antiviral activity against Influenza A virus Gull/PA/4175/83/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 0.8 μM Antiviral activity against Influenza A virus Vietnam/1203/ 2004H/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 0.8 μM Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 1 μM Antiviral activity against Influenza A virus Gull/PA/4175/83/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay [PMID: 20231094]
MDCK EC50 1 μM Antiviral activity against Influenza A virus Vietnam/1203/ 2004H/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 1.1 μM Antiviral activity against Influenza A virus Gull/PA/4175/83/H5N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 1.3 μM Antiviral activity against Influenza B virus Malaysia/2506/2004 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay [PMID: 20231094]
MDCK EC50 1.3 μM Antiviral activity against Influenza A virus California/07/2009 /H1N1 infected MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days [PMID: 20231094]
MDCK EC50 1.4 μM Antiviral activity against Influenza A virus Gull/PA/4175/83/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay [PMID: 20231094]
MDCK EC50 1.5 μM Antiviral activity against Influenza A virus Vietnam/1203/ 2004H/H5N1 infected MDCK cells after 42 to 46 hrs by neutral red dye uptake assay [PMID: 20231094]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 71184-20-8
Formula C10H15N3O4
Molecular Weight 241.24
SMILES
O=C1N=C(N)C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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