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Catalog No.
Product Name
Application
Product Information
Citations
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Furin Inhibitor
Furin-IN-3 is a potent and selective inhibitor of the proprotein convertase furin, exhibiting a Ki of 12.4 nM. Additionally, it demonstrates a Ki of 278 nM for PC7. This compound has been shown to exert significant antiviral activity against the furin-dependent H7N7 influenza A virus strain SC35M by inhibiting the cleavage and activation of the viral hemagglutinin (HA), thereby preventing viral membrane fusion with host cells and inhibiting viral replication. Furin-IN-3 is a valuable tool for research into viral infections, particularly those related to influenza. -
Influenza Inhibitor
6-Epi-albassitriol is a potent influenza inhibitor derived from Aspergillus sp. FH-A 6357. It effectively disrupts cholesterol synthesis, achieving an inhibition rate of 40% at a concentration of 10 nM in HepG2 cells. Additionally, 6-Epi-albassitriol demonstrates significant antiviral activity against both influenza A virus and parainfluenza virus, with a minimum inhibitory concentration (MIC) ranging from 44.4 to 133.3 µg/mL, making it a valuable compound for research in antiviral therapeutics. -
IAV Inhibitor
IAV replication-IN-1 is a potent inhibitor of influenza A virus (IAV) replication. This compound effectively reduces the upregulation of inflammatory factors and apoptosis associated with IAV infection, providing potential protective effects against lung injury induced by the virus. It is suitable for research applications focused on viral pathogenesis, inflammation, and therapeutic interventions in respiratory diseases. -
Influenza A Inhibitor
Pimodivir hydrochloride hemihydrate (VX-787) is an orally bioavailable inhibitor targeting the influenza A virus polymerase by specifically interfering with the PB2 subunit. This compound demonstrates significant antiviral activity against various strains of the influenza A virus, making it a valuable tool for research in virology and antiviral drug development. Its mechanism of action paves the way for studying the dynamics of viral replication and the efficacy of potential therapeutic interventions. -
Influenza Virus Inhibitor
M090 is a potent inhibitor of hemagglutinin, specifically targeting the influenza A virus. It effectively inhibits multiple strains of influenza, demonstrating an EC50 in the micromolar range. This compound is essential for research applications involving antiviral drug development and the study of influenza virus pathogenesis. -
Hemagglutinin Inhibitor
F0045(S) is an effective inhibitor of influenza hemagglutinin, demonstrating a KD value of 6.1 µM. This compound is utilized in biological research to investigate its protective effects against influenza virus infections in human cells, making it a valuable tool for antiviral studies and the development of therapeutic strategies. -
Influenza Virus Inhibitor
CEF6 is a 9-amino acid peptide derived from residues 418-426 of the nucleocapsid protein of influenza A virus (H1N1). It functions as an inhibitor of influenza virus, demonstrating key antiviral activity through interference with the viral life cycle. This peptide is valuable for research applications focused on studying viral replication mechanisms and the development of antiviral therapeutics targeting influenza infections. -
Influenza Virus Inhibitor
Sodium copper chlorophyllin B is a sodium-copper complex of chlorophyll with demonstrated antiviral activity against the Influenza virus, exhibiting IC50 values between 50 to 100 μM. It also shows potential activity against HIV. This compound is primarily utilized in research applications aimed at understanding antiviral mechanisms and developing therapeutic strategies for viral infections. -
Influenza Viru Inhibitor
(E/Z)-RA-0002034 is an inhibitor targeting the protease activity of the Chikungunya virus (CHIKV) nsP2, with an IC50 value of 58 nM. This compound covalently modifies the catalytic cysteine residue in a site-specific manner, leading to the inhibition of viral replication. It serves as a valuable tool for studying CHIKV biology and developing antiviral therapies against Chikungunya virus infections. -
Influenza Virus Inhibitor
Glabranine is a flavonoid compound recognized for its inhibitory effects against the influenza virus. Isolated from Tephrosia species, it demonstrates significant interaction with the soluble ectodomain of the dengue virus type 2 (DENV2) E protein, suggesting potential applications in antiviral research. This compound serves as a valuable tool for investigating the mechanisms of viral inhibition and offers insights into therapeutic strategies against influenza and related viral infections. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
IMPDH Inhibitor
Mycophenolic acid-13C17 is a stable isotope-labeled form of Mycophenolic acid, acting as a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH) with an EC50 of 0.24 μM. This compound exhibits significant antiviral activity against a variety of RNA viruses, including influenza, and serves as an immunosuppressive agent. Additionally, Mycophenolic acid-13C17 demonstrates antiangiogenic and antitumor properties, making it valuable for research in immunology, virology, and cancer biology. -
Clk1 Inhibitor
CLK1-IN-2 is a potent and metabolically stable inhibitor of CLK1, exhibiting a selectivity for its target with an IC50 value of 1.7 nM. This compound is valuable for research applications focusing on tumor biology, Duchenne muscular dystrophy, and viral infections, including HIV-1 and influenza. CLK1-IN-2 facilitates the study of cellular mechanisms and therapeutic interventions related to these diseases. -
CLK Inhibitor
KH-CB19 is a selective inhibitor of CLK (cdc2-like kinase) with an IC50 of 19.7 nM for CLK1 and 530 nM for CLK3. This compound exhibits antiviral properties, demonstrated by its ability to hinder influenza virus replication, with an IC50 value of 13.6 μM. KH-CB19 serves as a valuable tool for research into CLK-related pathways and antiviral drug development. -
AXL kinase Inhibitor
SLC-391 is an orally active AXL kinase inhibitor, demonstrating an IC50 of 9.6 nM against AXL kinase. It effectively inhibits Gas6-induced AXL-dependent phosphorylation of Akt and has shown potential in suppressing SARS-CoV-2 infection, entry, and replication within host cells. Additionally, SLC-391 has been found to inhibit cancer cell proliferation and tumor growth in mouse solid tumor xenograft models. This compound serves as a valuable tool for research in areas such as COVID-19, influenza virus infections, triple-negative breast cancer, chronic myeloid leukemia, and non-small cell lung cancer. -
influenza virus neuraminidase inhibitor
Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses. -
influenza virus neuraminidase (NA) inhibitor
Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes. -
Adenosine deaminase inhibitor
EHNA hydrochloride is a specific inhibitor of adenosine deaminase, prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts. -
neuraminidase (NA) inhibitor
Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. -
IMPDH Inhibitor
Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), with an EC50 of 0.24 µM. This compound exhibits antiviral activity against various RNA viruses, including influenza, alongside its immunosuppressive properties. Additionally, Mycophenolic acid sodium demonstrates antiangiogenic and antitumor effects, making it valuable for research in immunology, virology, and cancer therapy. -
DNA Gyrase Inhibitor
DNA Gyrase-IN-11 is a selective inhibitor of DNA gyrase, targeting bacterial DNA replication and supercoiling mechanisms. It demonstrates a potent inhibitory effect on protein synthesis with an IC50 of 0.74 μM and effectively inhibits E. coli DNA gyrase with an IC50 of 11.9 μM. Additionally, DNA Gyrase-IN-11 possesses significant antibacterial activity against pathogens such as Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.25 μg/mL, making it a valuable tool for antimicrobial research. -
RdRP Inhibitor
RdRP-IN-3 is an inhibitor of RNA-dependent RNA polymerase (RdRp), providing a potent approach for antiviral research against influenza viruses. This compound effectively disrupts RdRp activity, thereby hindering viral replication and proliferation. It serves as a valuable tool in studying the mechanisms of influenza pathogenesis and evaluating potential antiviral therapies. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
CMV Inhibitor
Soyasaponin II is a saponin known for its antiviral properties, particularly as an inhibitor of cytomegalovirus (CMV) replication. It demonstrates strong efficacy against various viruses, including HSV-1, HCMV, influenza, and HIV-1. Additionally, Soyasaponin II inhibits YB-1 phosphorylation and NLRP3 inflammasome priming, offering potential protective effects in models of acute liver failure induced by LPS/GalN. This compound is valuable for research in virology and inflammation. -
Influenza Virus Inhibitor
Oseltamivir is an orally active neuraminidase inhibitor targeting the influenza virus. It demonstrably inhibits various strains of influenza, including A/H3N2, A/H1N2, A/H1N1, and B, with mean IC50 values of 0.67 nM, 0.9 nM, 1.34 nM, and 13 nM, respectively. This compound is essential for studying antiviral strategies and evaluating the efficacy of flu treatments in laboratory settings.
