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Catalog No.
Product Name
Application
Product Information
Citations
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Cap-dependent Endonuclease Inhibitor
Cap-dependent endonuclease-IN-6 is a potent inhibitor of cap-dependent endonuclease (CEN), a critical enzyme required for the replication of certain viruses, including influenza. This compound exhibits substantial antiviral activity, demonstrating an effective EC50 of 38.21 nM against the influenza virus. It serves as a valuable tool for researchers investigating viral mechanisms and developing antiviral therapies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-20 is an inhibitor of cap-dependent endonuclease (CEN), targeting the viral replication process. It exhibits antiviral activity against the influenza virus A/Hanfang/359/95 (H3N2), with an IC50 of 4.82 μM. This compound is useful for research in virology, particularly in the study of influenza virus mechanisms and the development of antiviral therapeutics. -
Influenza Virus Growth Inhibitor
BMY-27709 is an influenza virus growth inhibitor that primarily targets hemagglutinin proteins. It demonstrates significant antiviral activity with an IC50 value of 3-8 μM against the A/WSN/33 strain. BMY-27709 effectively inhibits the growth of H1 and H2 subtype viruses early in the infection process, making it a valuable tool for research into influenza virus pathogenesis and therapeutic development. However, it does not inhibit H3 subtype viruses or influenza B/Lee/40 strains. -
CEN Inhibitor
Cap-dependent endonuclease-IN-9 is a selective inhibitor of cap-dependent endonuclease (CEN), demonstrating significant efficacy against influenza viruses. This compound exhibits low cytotoxicity and favorable pharmacokinetic and pharmacodynamic properties in vivo. Cap-dependent endonuclease-IN-9 effectively inhibits the RNA polymerase activity of A viruses, making it a valuable tool for research in antiviral therapeutics and molecular biology studies. -
Endonuclease Inhibitor
Flutimide is a selective endonuclease inhibitor that targets the influenza virus. Demonstrating an IC50 value of 3 μM, Flutimide exhibits significant antiviral activity in cell culture assays. This compound is valuable for research focused on acute contagious respiratory diseases, particularly influenza, and can aid in the investigation of therapeutic strategies against viral infections. -
Influenza A Virus Inhibitor
3-epi-Dihydroscandenolide is a sesquiterpene lactone that serves as an inhibitor of influenza A virus. Isolated from the dried aerial parts of Mikania micrantha, this compound effectively inhibits the cytopathic effects induced by the virus. 3-epi-Dihydroscandenolide is valuable for research applications focused on influenza A and may aid in the development of antiviral strategies. -
A/M2 Inhibitor
3-Azaspiro[5.5]undecane hydrochloride is an inhibitor of the wild-type influenza A virus M2 ion channel. It demonstrates potent biological activity with an IC50 value of 1 μM, making it a valuable tool for studying influenza virus function and host-pathogen interactions. This compound is applicable in viral research and can aid in the development of antiviral strategies targeting M2. -
Hemagglutinin Inhibitor
Influenza virus-IN-5 is a potent inhibitor of influenza virus hemagglutinin (HA), demonstrating an EC50 of 1 nM against the influenza A/H3N2 strain. This compound is valuable for research applications focused on viral entry and infection mechanisms. Its high selectivity and efficacy make it an important tool for studying influenza virus pathogenesis and developing antiviral strategies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-26 is a selective inhibitor of cap-dependent endonuclease (CEN), exhibiting an IC50 of 286 nM. This compound demonstrates significant antiviral activity against various strains of influenza A and B, making it a valuable tool for research in antiviral therapy and mechanisms of viral replication. Its use may advance the understanding of CEN's role in viral RNA processing and contribute to the development of new antiviral strategies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN), primarily targeting influenza A virus. This compound demonstrates significant inhibitory activity, making it a valuable tool for studying the mechanisms of influenza virus infection. Researchers can utilize Cap-dependent endonuclease-IN-13 to explore viral replication pathways and evaluate potential therapeutic interventions. -
PAN Endonuclease Inhibitor
PAN endonuclease-IN-1 is a potent inhibitor of PAN endonuclease, showing Kd values of 277 μM, 384 μM, and 328 μM for wild-type, I38T, and E23K variants, respectively. Targeting the RNA-dependent RNA polymerase acidic N-terminal endonuclease, this compound plays a critical role in disrupting influenza viral replication. It is a valuable tool for studying antiviral strategies and the effects of PAN endonuclease inhibition on influenza virus biology. -
Influenza Virus Inhibitor
Influenza virus-IN-2 is a potent inhibitor of the influenza virus, demonstrating significant antiviral activity with an EC50 of 2.58 µM and a cytotoxicity threshold of CC50 at 150.85 µM. This compound exhibits concentration-dependent inhibition of PAN endonuclease, with an EC50 of 489.39 nM. Influenza virus-IN-2 is effective against influenza A virus, making it a valuable tool for research focused on antiviral drug development and the mechanisms of influenza virus replication. -
Neuraminidase Inhibitor
Ganoderic acid T-N is a triterpenoid compound that functions as a neuraminidase inhibitor, specifically targeting H5N1 and H1N1 influenza strains with IC50 values of 2.7 μM and 42 μM, respectively. In addition to its antiviral properties, Ganoderic acid T-N demonstrates cytotoxic effects against MCF7 cancer cells, exhibiting a CC50 value of 24.4 μM. This compound is relevant for research applications in virology and cancer biology, providing insights into influenza pathogenesis and potential therapeutic strategies. -
Influenza Viru Inhibitor
Tirfipiravir is a nucleoside analog with antiviral properties, primarily targeting influenza viruses. This compound exhibits potent activity against viral replication by inhibiting RNA polymerase, making it a valuable tool for research on viral infections. Tirfipiravir is particularly applicable in studies focusing on the mechanisms of antiviral resistance and developing therapeutic strategies against influenza. -
Neuraminidase Inhibitor
Influenza A virus-IN-4 is a potent neuraminidase inhibitor with significant antiviral activity against influenza A viruses. As an Oseltamivir derivative, it effectively impedes viral replication by blocking the enzymatic function of neuraminidase, thereby preventing the release of new viral particles. This compound is valuable for research focused on influenza virology and therapeutic intervention strategies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent endonuclease (CEN), targeting the enzymatic activity crucial for the replication of various viruses, including influenza. This compound demonstrates a strong inhibitory effect on RNA polymerase activity in A viruses, making it a valuable tool for virology research. Notably, Cap-dependent endonuclease-IN-2 exhibits lower cytotoxicity and favorable pharmacokinetic properties in vivo, supporting its potential as an effective antiviral agent for further investigation. -
Cap-dependent Endonuclease Inhibitor
Influenza virus-IN-7 is a potent cap-dependent endonuclease inhibitor designed for research into influenza viral infections. This compound exhibits oral bioavailability and can effectively modulate the viral lifecycle by hindering the endonuclease activity essential for viral RNA processing. Its application extends to studies focusing on influenza pathogenesis and the development of antiviral therapies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-5 is a selective inhibitor of cap-dependent endonuclease (CEN), a crucial enzyme in the lifecycle of the influenza virus. This compound demonstrates significant antiviral activity against influenza while exhibiting lower cytotoxicity compared to existing treatments. Additionally, Cap-dependent endonuclease-IN-5 shows improved pharmacokinetic and pharmacodynamic properties in vivo, making it a valuable tool for research on CEN-targeted antiviral therapies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). This pyridone polycyclic derivative is designed for research applications focusing on influenza, specifically targeting the viral replication process. Its inhibitory effects on CEN make it a valuable tool for studying the mechanisms of RNA transcription and development of antiviral strategies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN), crucial for the replication of influenza viruses. This compound specifically targets influenza A, demonstrating significant antiviral activity. It serves as a valuable tool for research focused on understanding influenza virus infection and developing therapeutic strategies against this pathogen. -
Neuraminidase (NA) Inhibitor
Neuraminidase-IN-10 is a highly potent inhibitor of neuraminidase (NA), exhibiting significant anti-influenza activity. It demonstrates inhibitory effects against H1N1, H5N1, and H5N8 strains with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively. This compound is valuable for research applications focusing on viral pathogenesis and therapeutic development for influenza infections. -
CEN Inhibitor
Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN), which plays a critical role in viral RNA synthesis. This compound effectively inhibits multiple strains of the influenza virus while exhibiting lower cytotoxicity and favorable in vivo pharmacokinetic and pharmacodynamic profiles. Additionally, Cap-dependent endonuclease-IN-10 demonstrates enhanced hepatic microsomal stability, making it valuable for research applications focused on viral infections, including influenza A, B, and C. -
HA Inhibitor
RO5487624 is an orally active hemagglutinin (HA) inhibitor that targets the influenza H1N1 virus. It functions by disrupting HA conformational changes necessary for viral fusion in acidic environments, effectively preventing virus entry into host cells. In preclinical studies, RO5487624 has demonstrated protective effects in mice challenged with lethal doses of the influenza H1N1 virus, highlighting its potential applications in antiviral research and therapeutic development. -
CEN Inhibitor
Cap-dependent endonuclease-IN-14 is a selective inhibitor of cap-dependent endonuclease (CEN), a key enzyme involved in the replication of influenza viruses. By disrupting the function of CEN, this compound effectively inhibits viral replication, making it a valuable tool for studying influenza virus infections. Its application extends to virology research focused on antiviral drug development and understanding the mechanisms of influenza pathogeneses. -
Neuraminidase Inhibitor
Neuraminidase-IN-8 is a potent inhibitor of neuraminidase, demonstrating an IC50 of 0.027 µM. This compound exhibits significant anti-influenza activity, making it a valuable tool for research into antiviral therapies targeting influenza virus replication and spread. Its effectiveness in inhibiting neuraminidase enzymes supports its use in studies aimed at developing new strategies for influenza treatment. -
Neuraminidase Inhibitor
Neuraminidase-IN-11 is a highly potent and selective inhibitor of neuraminidase with IC50 values of 4.7 nM, 8.46 nM, and 1.5 nM against H1N1, H5N1, and H5N8 neuraminidases, respectively. This compound plays a crucial role in the study of viral pathogenesis and therapeutic interventions for influenza. Its selective inhibition of neuraminidase makes it an important tool for understanding antiviral drug efficacy and the modulation of viral replication dynamics. -
Influenza Virus Inhibitor
Antiviral agent 35 is a potent inhibitor of influenza virus replication, functioning effectively during the early stages of the viral life cycle. It reduces reactive oxygen species (ROS) accumulation, as well as autophagy and apoptosis induced by the virus, while also mitigating the inflammatory response mediated by the RIG-1 pathway in mouse models of pulmonary infection. This compound exhibits low cytotoxicity, with a CC50 greater than 800 μM in MDCK cells, and demonstrates anti-H1N1 activity with an EC50 of 2.28 μM, making it a valuable tool for research on influenza virus inhibition. -
Influenza A Virus Inhibitor
Influenza A virus-IN-18 (Compound C2e) is an orally active inhibitor specifically targeting the Influenza A virus. It demonstrates significant antiviral activity, with an IC50 value of 2.5 μM against PR8/H1N1 and 6.42 μM against H3N2 strains. Influenza A virus-IN-18 exhibits a high affinity for the H1N1/PR8 hemagglutinin protein, with a KD of 0.25 μM. This compound is valuable for research in Influenza A virus infection and therapeutic development. -
H5N1 Inhibitor
Yadanziolide B is a natural quassinoid that functions as an inhibitor of H5N1 neuraminidase, an essential enzyme for the viral life cycle. Its inhibitory activity makes it a valuable candidate for research applications focusing on antiviral therapies targeting H5N1 influenza. Studies exploring its properties may contribute to the development of effective treatments for influenza virus infections. -
RdRP Inhibitor
RdRP-IN-5 is a potent inhibitor of influenza virus RNA-dependent RNA polymerase (RdRP). This compound exhibits significant antiviral activity, making it a valuable tool for the study of influenza virus replication and pathogenesis. Researchers can utilize RdRP-IN-5 to investigate therapeutic strategies targeting RNA polymerase in viral infections. -
Influenza Viru Inhibitor
NSC-65847 is a dual inhibitor that targets both viral neuraminidase and Streptococcus pneumoniae neuraminidase, disrupting essential enzymatic functions. Its unique mechanism of action impedes the replication and spread of Influenza viruses, making it a valuable tool in antiviral research. Research applications include studying viral infections and developing therapeutic interventions for influenza and associated bacterial co-infections. -
Influenza A Virus Inhibitor
Influenza virus-IN-1 is a potent inhibitor of Influenza A virus, exhibiting an EC50 of 2.46 µM and a CC50 exceeding 200 µM. This compound demonstrates concentration-dependent inhibition of the PAN endonuclease, with an EC50 of 312.36 nM. Influenza virus-IN-1 is valuable for research focused on evaluating anti-influenza A virus therapies and elucidating viral mechanisms. -
Neuraminidase Inhibitor
Neuraminidase-IN-5 is a potent neuraminidase inhibitor, demonstrating an IC50 of 0.02 μM. Targeting the neuraminidase enzyme makes this compound a promising candidate for the development of novel anti-influenza therapies. As a dihydrofurocoumarin derivative, Neuraminidase-IN-5 offers significant potential for research applications in virology and antiviral drug discovery. -
Influenza Virus Inhibitor
Influenza virus-IN-4 is a potent inhibitor of the influenza virus neuraminidase, exhibiting IC50 values of 3.4 µM, 0.094 µM, 0.79 µM, and 0.077 µM against H5N1, H5N2, H5N6, and H5N8, respectively. This compound demonstrates effective NA-inhibitory activity, contributing to its role in antiviral research. Additionally, Influenza virus-IN-4 exhibits low cytotoxicity, with a CC50 greater than 200 µM, and displays no significant toxicity at doses of 1500 mg/kg in murine models. Its safety profile and efficacy in inhibiting neuraminidase make it a valuable tool for studying influenza virus pathogenesis and developing therapeutic strategies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-8 is a potent inhibitor of cap-dependent endonuclease (CEN), a crucial enzyme in the replication of orthomyxoviruses. This compound effectively demonstrates antiviral activity against diverse strains, including influenza A, B, and C. It serves as a valuable tool for research investigating the molecular mechanisms of viral replication and the development of novel antiviral therapies. -
Neuraminidase Inhibitor
Neuraminidase-IN-6 is a potent inhibitor of neuraminidase, exhibiting an IC50 of 0.11 μM. As a 1,3,4-triazole-3-acetamide derivative, it demonstrates effective inhibition of viral neuraminidase, an essential target for anti-influenza drug development. This compound is valuable for research focused on influenza virus mechanisms and potential therapeutic strategies. -
Influenza A Viruses Inhibitor
Antiviral agent 43 is a potent entry inhibitor targeting influenza A viruses. This compound effectively inhibits the replication of various influenza A strains, including VH04-H5N1 and PR8-H1N1, with EC50 values of 240 nM and 72 nM, respectively. Its oral bioavailability makes it a valuable tool for research into antiviral therapies against influenza A virus infections. -
CEN Inhibitor
Sebaloxavir marboxil is a potent inhibitor of cap-dependent endonuclease (CEN). This compound effectively suppresses the replication of influenza viruses, making it a valuable tool in the investigation of viral infections associated with these pathogens. Its mechanism of action highlights its potential applications in antiviral research and the development of therapeutic strategies against influenza. -
Neuraminidase Inhibitor
Massarilactone H is a polyketide that acts as a neuraminidase inhibitor, exhibiting an IC50 value of 8.18 µM. This compound demonstrates significant biological activity in modulating viral replication and has potential research applications in virology and therapeutic development against influenza and other neuraminidase-dependent pathogens. -
NS1 inhibitor
NS1-IN-1 is a potent inhibitor of the NS1 protein, a critical virulence factor for the influenza A virus that disrupts host gene expression. By targeting the NS1 protein, NS1-IN-1 effectively reduces viral protein levels and inhibits virus replication. Its antiviral activity is mediated through the repression of mTORC1 signaling in a TSC1-TSC2-dependent manner, making it a valuable tool for research into influenza virus pathogenesis and potential therapeutic strategies. -
Neuraminidase Inhibitor
Neuraminidase-IN-18 is a potent neuraminidase inhibitor designed to target the neuraminidase enzyme in influenza viruses. It exhibits significant inhibitory activity against H5N1 neuraminidase, with IC50 values of 0.14 μM for the wild-type strain and 0.27 μM for the H5N1-H274Y mutant. This compound effectively inhibits influenza virus replication at the cellular level, making it a valuable tool for research in antiviral drug development and the study of influenza pathogenicity. -
CEN Inhibitor
Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN), a critical enzyme involved in viral RNA synthesis. As a macrocyclic pyridotriazine derivative, it exhibits significant potential for research focused on viral infections, particularly those caused by the Orthomyxoviridae family, including influenza viruses. This compound serves as a valuable tool in studying the mechanisms of viral replication and may aid in the development of antiviral therapeutics. -
Endonuclease Inhibitor
Suraxavir marboxil is an endonuclease inhibitor specifically targeting the PA subunit of cap-dependent endonucleases, demonstrating significant antiviral activity against influenza A and B viruses. By inhibiting the PA subunit, Suraxavir marboxil effectively disrupts viral replication. This reagent can be utilized in research to explore therapeutic strategies for preventing influenza A and B infections, both as a standalone treatment and in combination with other antiviral agents. -
Influenza Virus Inhibitor
Influenza virus-IN-8 is a potent inhibitor targeting the influenza virus by inducing the aggregation of viral nucleoprotein (NP) and blocking its nuclear accumulation. This compound demonstrates broad-spectrum anti-influenza activity, effectively inhibiting both the replication and transcription of influenza A viruses. Additionally, Influenza virus-IN-8 is effective against Oseltamivir-resistant H1N1/pdm09 strains, making it a valuable tool for research in combating influenza virus variants. -
CEN Inhibitor
Cap-dependent endonuclease-IN-17 is a highly selective inhibitor of cap-dependent endonuclease (CEN). This compound exhibits significant antiviral activity against influenza virus A/Hanfang/359/95 (H3N2), with an IC50 value of 1.29 μM. It serves as a valuable tool for research focused on antiviral therapies and the inhibition of viral replication mechanisms. -
Influenza Neuraminidase Inhibitor
Neuraminidase-IN-9 is a highly effective inhibitor of influenza neuraminidase, exhibiting IC50 values of 0.12 µM for H5N1, 0.049 µM for H5N2, and 0.16 µM for H5N6. This compound demonstrates significant antiviral activity, making it a valuable tool in influenza research. Neuraminidase-IN-9 can be utilized in studies aimed at understanding and combating influenza virus infections. -
CEN Inhibitor
Cap-dependent endonuclease-IN-7 is a potent inhibitor of cap-dependent endonuclease (CEN), disrupting the synthesis of viral mRNA. This inhibition subsequently hampers viral proliferation. Cap-dependent endonuclease-IN-7 is valuable for research into viral infections, including strains of influenza A, B, and C. -
Neuraminidase Inhibitor
DS-22-inf-021 is a neuraminidase inhibitor that exhibits antiviral activity against influenza viruses. By inhibiting neuraminidase, this compound disrupts viral replication and spread, making it a valuable tool for research in virology and antiviral drug development. Its effectiveness against influenza strains positions DS-22-inf-021 as a potential candidate for further exploration in therapeutic applications. -
Influenza Virus Inhibitor
Zanamivir-Cholesterol Conjugate is a long-acting neuraminidase inhibitor targeting the influenza virus. This compound exhibits potent efficacy against both drug-sensitive and drug-resistant strains of the virus, making it valuable for studying influenza pathogenesis and developing therapeutic strategies. Its unique conjugation to cholesterol enhances membrane association, potentially improving bioavailability and antiviral activity in cellular systems. -
Neuraminidase Inhibitor
4-O-Methylepisappanol is a potent neuraminidase inhibitor derived from the heartwood of Caesalpinia sappan. It effectively inhibits neuraminidase activity in various strains of influenza viruses, demonstrating IC50 values of 42.8 µM for A/Chicken/Korea/MS96/96 [H9N2] and 63.2 µM for both A/PR/8/34 [H1N1] and A/Hong Kong/8/68 [H3N2]. This compound is valuable for studying viral pathogenesis and developing antiviral therapies targeting influenza neuraminidase.
