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Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
Antitubercular agent-9 is a bacterial inhibitor that demonstrates effective antitubercular activity, with a minimum inhibitory concentration (MIC) ranging from 1.03 to 2.32 μM. This compound is suitable for research focused on tuberculosis treatment mechanisms and the development of new antitubercular therapies. It serves as a valuable tool for understanding bacterial resistance and evaluating potential drug candidates in infectious disease research. -
Bacterial Inhibitor
Antibacterial Agent 62 is a novel redox cycling compound that targets bacterial cells, demonstrating potent bactericidal activity against both growing and nutrient-starved phenotypically drug-resistant nongrowing bacteria. This reagent is particularly useful in research applications focused on tuberculosis and the development of new antibacterial therapies. Its unique mechanism of action may also aid in understanding resistance mechanisms in various bacterial strains. -
Bacterial Inhibitor
Antibacterial Agent 30 is a potent bacterial inhibitor, exhibiting significant in vitro activity against Xanthomonas oryzae pv. oryzae with an EC50 value of 1.9 μg/mL. This compound is suitable for research applications aimed at understanding bacterial pathogenesis and developing new antibacterial strategies. -
Bacterial Inhibitor
NDM-1 inhibitor-2 is a selective inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) that effectively inhibits NDM-1 enzymatic activity. This compound demonstrates significant antibacterial activity against drug-resistant bacterial strains that overexpress NDM-1, providing insights into overcoming resistance mechanisms. Additionally, NDM-1 inhibitor-2 can enhance the efficacy of the carbapenem antibiotic meropenem, resulting in a synergistic effect that supports research in antimicrobial therapy and resistance management. -
Bacterial Inhibitor
1-Amino-2,5-anhydro-1-deoxy-D-mannitol is a potent antibacterial agent targeting a range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Its significant antibacterial activity makes it a valuable candidate for addressing drug-resistant bacterial infections. Research applications may include investigations into its efficacy as a therapeutic tool against prevalent multidrug-resistant pathogens in clinical settings. -
Bacterial Inhibitor
Altertoxin III is a bacterial inhibitor known for its mutagenic effects on Salmonella typhimurium strains TA98, TA100, and TA1537. Derived from an extract of the A. alternata isolate, this compound exhibits significant mutagenicity as demonstrated in the Ames assay. It is valuable for studies focused on mutagenesis and the mechanisms of bacterial resistance. -
Bacterial Inhibitor
Heraclenol is a coumarin compound that targets bacterial pathogens. Isolated from the fruits of Angelica lucida, Heraclenol demonstrates notable antibacterial activity, making it valuable for research applications focused on combatting bacterial infections. Its mechanism of action contributes to the understanding of antimicrobial resistance and the development of new therapeutic strategies. -
Bacterial Inhibitor
L-689065 is a potent bacterial inhibitor that acts by targeting essential bacterial processes. It exhibits significant antimicrobial activity against a range of bacterial strains, making it a valuable reagent for studies on bacterial resistance and infection mechanisms. This compound is applicable in microbiological research focused on identifying new antibacterial agents and understanding the pathways of bacterial growth inhibition. -
Bacterial Inhibitor
FK-518 is a potent inhibitor of AmpC β-lactamase, targeting resistance mechanisms in bacteria. This compound exhibits strong antimicrobial activity against Pseudomonas aeruginosa strains that overexpress AmpC β-lactamase, making it a valuable tool in the study of bacterial infections. FK-518 is particularly useful for research investigating therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
RO7075573 is a bacterial inhibitor that targets the lipopolysaccharide (LPS) transport machinery in Acinetobacter species. This compound has demonstrated protective effects in preclinical models against Acinetobacter baumannii infections, highlighting its potential for therapeutic applications in combating antibiotic-resistant bacterial pathogens. Research applications may include studying bacterial pathogenesis and developing new antibiotic strategies. -
Bacterial Inhibitor
Neorauflavene is a phenolic isoflavonoid derived from Neorautanenia edulis, functioning as a bacterial inhibitor. This compound exhibits significant antibacterial activity against various strains, including Enterococcus faecalis, Streptococcus suis, Streptococcus agalactiae, Pseudomonas aeruginosa, Bacillus subtilis, and Riemerella anatipestifer. Neorauflavene's antibacterial properties make it a valuable tool for research in microbiology and the development of therapeutic agents targeting bacterial infections. -
Bacterial Virulence Factor Inhibitor
Anti-virulence factor-IN-1 is a bacterial virulence factor inhibitor that disrupts the bacterial infection process. It demonstrates potent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo) with an EC50 value of 0.28 µg/mL. This compound is applicable for the management of rice bacterial leaf blight in vivo and offers significant potential for research related to plant bacterial diseases. -
Bacterial Peptide Deformylase Inhibitor
Lanopepden camsylate is a high-affinity inhibitor of bacterial peptide deformylase, an enzyme critical for protein maturation in bacteria. This compound exhibits potent activity against bacterial infections by disrupting essential protein processing. Lanopepden camsylate is primarily utilized in research applications focused on the development of new antibacterial agents and the study of bacterial pathogenicity. -
Bacterial Inhibitor
TP-271 is a bacterial inhibitor specifically designed to target pathogens associated with community-acquired pneumonia. This compound exhibits significant antimicrobial activity, making it suitable for research applications focused on bacterial infections and respiratory diseases. Its potential to disrupt bacterial growth presents promising avenues for further exploration in the development of effective therapeutics. -
Bacterial Inhibitor
Cefonicid is a broad-spectrum beta-lactam antibiotic targeting bacterial cell wall synthesis. It exhibits potent antibacterial activity against a variety of Gram-positive and Gram-negative bacteria, making it valuable in treating various infectious diseases. Pharmacokinetic studies indicate that high plasma concentrations are swiftly attained following intravenous or intramuscular administration, and its half-life may be extended with concomitant use of albendazole, leading to reduced renal clearance. Cefonicid serves as an essential tool in bacterial infection research and the development of therapeutic strategies. -
β-lactamase Inhibitor
β-Lactamase-IN-4 is a potent β-lactamase inhibitor that targets β-lactamase enzymes, effectively enhancing the efficacy of β-lactam antibiotics. This compound is critical for research applications focused on combating bacterial infections caused by β-lactamase-producing microorganisms. Its use may contribute to the development of novel therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
Penicillin N is a penicillin-type antibiotic that primarily targets bacterial cell wall synthesis. It exhibits potent antibacterial activity against enteric bacilli, making it effective for the treatment of infections caused by these pathogens. This compound is widely utilized in microbiological research to study antibacterial mechanisms and evaluate susceptibility of bacterial strains. -
Bacterial Inhibitor
Methyl sterculate is a potent bacterial inhibitor that targets Δ9 desaturase. This compound effectively inhibits the growth of Rhodococcus opacus at a concentration of 0.75 mM, demonstrating toxicity towards the bacteria. Furthermore, it alters the fatty acid profile by decreasing overall fatty acid content while increasing the palmitate ratio and reducing stearate and oleate levels at concentrations of 0.25 or 0.5 mM. Methyl sterculate also exhibits a synergistic effect on tumor growth induced by aflatoxin Q1 in rainbow trout at a concentration of 50 ppm. -
Bacterial Inhibitor
Quorum sensing-IN-2 is a potent quorum sensing inhibitor that targets bacterial communication mechanisms to diminish pathogenicity while preserving overall bacterial growth. This compound effectively reduces bacterial infections with minimal hemolytic activity. Additionally, Quorum sensing-IN-2 exhibits a synergistic effect when combined with Ciprofloxacin in models of Pseudomonas aeruginosa PAO1 bacteremia, making it a valuable tool for investigating bacterial virulence and developing novel therapeutic strategies. -
Bacterial Inhibitor
ORM-3819 is a bacterial inhibitor targeting Staphylococcus aureus. This compound exhibits broad-spectrum antimicrobial activity against both methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). Additionally, ORM-3819 reduces the phagocytosis of MRSA and MSSA strains by monocytic THP-1 cells, making it valuable for research related to bacterial infections and resistance mechanisms. Its efficacy in combatting staphylococcal infections positions it as a critical tool in antimicrobial studies. -
Bacterial Inhibitor
4-Glycidyloxycarbazole is an antimicrobial agent that targets bacterial biofilm formation. It exhibits significant inhibitory activity against various bacterial strains, making it a valuable tool for studying bacterial behavior and infection control. This compound is useful in research applications focused on biofilm-related challenges in microbiology and infectious disease. -
CcrM Inhibitor
NSC177365 is a potent CcrM inhibitor that acts by competitively disrupting DNA binding. It demonstrates significant antibacterial activity, displaying IC50 values of 2.3 μM and 14.6 μM against C. crescentus and M. lincolnii, respectively. Furthermore, NSC177365 has potential applications in reversing neurodegenerative disorders and shows promise as an anticancer agent, making it a valuable tool for chemical research. -
Bacterial Inhibitor
KSK120 is a potent bacterial inhibitor targeting Chlamydia trachomatis (C. trachomatis). It disrupts the developmental cycle of the bacteria, leading to a reduction in the infectivity of progeny by targeting the glucose-6-phosphate metabolic pathway. KSK120 is particularly relevant for research into antimicrobial strategies, as its mechanism may involve inhibition of transcriptional processes, offering a novel approach for the development of targeted therapies against C. trachomatis infections. -
Bacterial Inhibitor
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a bacterial inhibitor derived from Inula helenium and Inula royleana root cultures, exhibiting moderate antimicrobial activity. This compound demonstrates efficacy against various pathogens, including Staphylococcus aureus, Enterococcus faecalis, Candida albicans, and Pseudomonas aeruginosa, with MIC values of 50, 250, 250, 250, and 1000 μg/mL, respectively. It serves as a valuable tool for research in antibacterial studies and the exploration of potential therapeutic agents. -
VIM-Type Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-6 is a potent inhibitor of VIM-type metallo-β-lactamases, demonstrating IC50 values of 0.56 μM for VIM-2, 29.50 μM for VIM-1, and 5.78 μM for VIM-5. This compound exhibits significant antibacterial synergy with Meropenem against engineered Escherichia coli strains and clinically isolated Pseudomonas aeruginosa strains that produce VIM-2 metallo-β-lactamase. It serves as a valuable research tool for exploring resistance mechanisms in bacterial pathogens and for developing novel therapeutic strategies. -
Bacterial Inhibitor
LolCDE-IN-3 is an inhibitor targeting the LolCDE complex, which plays a critical role in bacterial lipid A transport. This compound exhibits potent antibacterial activity, making it a valuable tool for studying bacterial physiology and pathogen resistance mechanisms. It is suitable for research applications focused on antibiotic development and the exploration of novel antibacterial strategies. -
Bacterial Inhibitor
OV-1, sheep is an alpha-helical antimicrobial peptide derived from the SMAP29 peptide of sheep, specifically designed to target and inhibit a range of antibiotic-resistant bacterial strains. This compound demonstrates significant efficacy against both mucoid and nonmucoid strains of Pseudomonas aeruginosa. OV-1, sheep is a valuable tool for research applications focusing on antimicrobial resistance and the development of peptide-based therapeutics. -
Bacterial Inhibitor
GSK729 is a selective inhibitor of EchA6, a critical enzyme involved in the fatty acid biosynthesis pathway of Mycobacterium tuberculosis. By specifically targeting and inhibiting EchA6, GSK729 demonstrates significant bactericidal activity, effectively obstructing the growth of the bacterium. This compound is valuable for research applications focused on the development of new therapeutic strategies against tuberculosis and exploring the role of fatty acid synthesis in bacterial pathogenesis. -
β-lactamase Inhibitor
FPI-1602 is a β-lactamase inhibitor that enhances the efficacy of β-lactam antibiotics. It exhibits significant antimicrobial activity against pathogens such as Pseudomonas aeruginosa, Escherichia coli, and Enterobacter spp. This compound is valuable for research applications aimed at overcoming antibiotic resistance mediated by β-lactamase enzymes. -
Parasite Inhibitor
Melilotigenin C is a natural product derived from the genus Erythrina, primarily acting as a parasite inhibitor. It exhibits significant antiplasmodial activity, making it a candidate for studies focused on malaria treatment. Additionally, Melilotigenin C demonstrates antimycobacterial properties and presents potential for cytotoxicity research, contributing to the exploration of new therapeutic agents against infectious diseases. -
Bacterial Inhibitor
NBTIs-IN-4 is a potent bacterial inhibitor targeting DNA gyrase and topoisomerase IV in Gram-positive pathogens. It exhibits significant antibacterial activity while maintaining a low frequency of resistance. This compound is valuable for research applications aimed at understanding bacterial resistance mechanisms and developing new antibacterial therapies. -
Bacterial Inhibitor
BPH-1358 free base is a potent inhibitor of human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS), exhibiting IC50 values of 1.8 μM and 110 nM, respectively. This compound demonstrates significant antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of approximately 250 ng/mL. BPH-1358 free base is suitable for research applications aimed at understanding bacterial resistance mechanisms and developing novel antibacterial strategies. -
Bacterial Inhibitor
Lankacidin C 8-acetate is an antibiotic that targets bacterial pathogens through its antibacterial activity. This compound, part of the Lankacidin antibiotic group, exhibits significant inhibitory effects against specific bacterial strains. Additionally, Lankacidin C 8-acetate can react with various acyl donors to generate ester derivatives, highlighting its relevance in antibiotic synthesis and development for research applications. -
Bacterial Inhibitor
Macranthoside A is a triterpene glycoside that acts as a bacterial inhibitor. It demonstrates significant antimicrobial activity, making it a useful compound for research applications aimed at studying bacterial infections and evaluating potential therapeutic agents against microbial resistance. -
Bacterial Inhibitor
I-A09 is a bacterial inhibitor that demonstrates significant antitubercular activity against Mycobacterium tuberculosis H37Rv. This compound and its derivatives, particularly the 1,2,3-triazole-adamantylacetamide hybrids synthesized via copper-catalyzed click chemistry, display enhanced efficacy with a minimum inhibitory concentration (MIC) as low as 3.12 μg/mL. These novel analogues, particularly N-(1-adamantan-1-yl)-2-(4-(phenanthren-2-yl)-1H-1,2,3-triazol-1-yl)acetamide (5t), have applications in research focused on tuberculosis treatment and the development of new antitubercular agents. -
Bacterial Inhibitor
Antibacterial Agent 95 is a potent bacterial inhibitor with a primary target of Mycobacterium tuberculosis. Demonstrating a minimum inhibitory concentration (MIC) as low as 0.3 μM against the reference strain H37Rv, this 2-(quinoline-4-methoxy)acetamide compound effectively inhibits the growth of Mycobacterium tuberculosis in macrophage models of tuberculosis infection. Its exceptional activity makes it a valuable tool for research in antitubercular drug development. -
β-lactamase Inhibitor
Brobactam is a potent synthetic β-lactamase inhibitor designed to combat antibiotic resistance by inhibiting β-lactamase enzymes. It exhibits broad-spectrum antibacterial activity, making it valuable in the study and treatment of β-lactamase-mediated resistance in various bacterial infections. Research applications include the evaluation of combination therapies and the development of novel antibacterial agents. -
Bacterial Inhibitor
Pelagiomicin A is a phenazine antibiotic with a primary mechanism targeting bacterial cell functions. This compound demonstrates significant antibacterial activity against both Gram-positive and Gram-negative bacteria, making it a valuable tool for research in microbial resistance. Additionally, Pelagiomicin A has shown promising antitumor effects in vitro and in vivo, underscoring its potential applications in cancer research. Its structure has been elucidated through a combination of spectroscopic data and synthesis techniques, contributing to the understanding of its biological properties. -
DHPS Inhibitor
Dihydropteroate synthase-IN-1 is a potent inhibitor of dihydropteroate synthase (DHPS), primarily targeting the folate biosynthesis pathway. This compound exhibits significant antimicrobial and antifungal properties, making it valuable for research in microbial resistance and pathogenicity studies. Additionally, Dihydropteroate synthase-IN-1 has implications in diagnostics as a potential radio imaging agent, advancing the exploration of therapeutic interventions. -
β-Lactamase Inhibitor
KSP-1007 is a bicyclic boronate compound functioning as a broad-spectrum β-lactamase inhibitor. It effectively targets class A, B, C, and D β-lactamases, including serine-type and metallo-type enzymes such as NDM, VIM, and IMP, in addition to Acinetobacter baumannii OXA-type enzymes. KSP-1007 enhances the antibacterial activity of Meropenem, decreasing its minimum inhibitory concentration (MIC) against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. This reagent is suitable for research on bacterial infections and antibiotic resistance mechanisms. -
Bacterial Inhibitor
2'-Hydroxy-2-methoxychalcone acts as a bacterial inhibitor, demonstrating significant antimicrobial activity against various bacterial strains. This synthetic chalcone derivative is valuable for research in understanding bacterial resistance mechanisms and developing new antimicrobial agents. Its structural properties facilitate the exploration of structure-activity relationships in the field of medicinal chemistry. -
Bacterial Inhibitor
Chinfloxacin is a bacterial inhibitor that exerts antibacterial activity against a range of clinical isolates in vitro. Demonstrating a concentration-dependent bactericidal effect, Chinfloxacin shares antibacterial efficacy comparable to that of moxifloxacin. This compound is suitable for research applications focused on bacterial pathogenicity and the development of new antimicrobial agents. -
Bacterial Inhibitor
Phenethicillin potassium is a β-lactam antibiotic that targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins. It demonstrates significant antibacterial activity against a range of Gram-positive bacteria, making it valuable in research applications focused on antimicrobial resistance and the mechanistic understanding of bacterial susceptibility. Its characteristic action profile facilitates studies in microbiology and pharmacology, providing insights into antibiotic efficacy and resistance mechanisms. -
Bacterial Inhibitor
Hikizimycin is a potent antibacterial agent that targets bacterial cell growth and division. This natural product exhibits significant antibacterial activity, making it a valuable tool for research focused on bacterial infections and their treatment. Its unique mechanism of action offers insights into new therapeutic strategies for combating antibiotic resistance. -
Bacterial Inhibitor
Antibacterial Agent 28 is a bacterial inhibitor with a mechanism targeting the growth and proliferation of pathogens such as Methicillin-resistant Staphylococcus aureus (MRSA). It exhibits antimicrobial activity with minimum inhibitory concentrations (MICs) ranging from 0.5 to 2 μg/mL. This reagent holds promise for research applications aimed at developing new treatments against resistant bacterial infections. -
MabA (FabG1) Inhibitor
FabG1-IN-1 is a selective inhibitor of MabA (FabG1), exhibiting an IC50 of 38 µM. This compound effectively impedes the enzymatic activity of FabG1, playing a crucial role in fatty acid biosynthesis. FabG1-IN-1 is applicable in research focusing on metabolic pathways and the development of antifungal therapies targeting lipid synthesis. -
β-Lactamase Inhibitor
Ledaborbactam etzadroxil is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes. It is designed to provide enhanced protection for β-lactam antibiotics from hydrolysis by these enzymes, thereby improving their efficacy. This compound is particularly relevant in research applications focused on combating antibiotic resistance and expanding the therapeutic options for bacterial infections. -
Bacterial Inhibitor
β-L-Gulopyranosyl-caldarchaetidyl-glycerol (GuCGp) is a polar lipid compound targeting bacterial membranes. Its role in the lipid composition of thermoacidophilic bacteria is crucial for understanding bacterial adaptation to varying environmental conditions. This compound is valuable for research applications focused on microbial physiology and membrane biochemistry. -
Bacterial Inhibitor
Ceratotoxin B is an antibacterial peptide derived from the sexually mature females of Ceratitis capitata. It exhibits lytic and antibacterial activity, making it a valuable research tool for studying bacterial inhibition and antimicrobial mechanisms. This peptide can be utilized in studies aimed at understanding bacterial resistance and the development of novel antibacterial agents. -
Bacterial Inhibitor
TP0586352 is a potent LpxC inhibitor specifically designed to target bacterial pathogens, including carbapenem-resistant Klebsiella pneumoniae. This compound exhibits significant antibacterial activity while maintaining a favorable safety profile, as it does not pose cardiovascular risks. Additionally, TP0586352 features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions for further chemical modifications.
