Metallo-β-lactamase-IN-6

Metallo-β-lactamase-IN-6 is a potent inhibitor of VIM-type metallo-β-lactamases, demonstrating IC50 values of 0.56 μM for VIM-2, 29.50 μM for VIM-1, and 5.78 μM for VIM-5. This compound exhibits significant antibacterial synergy with Meropenem against engineered Escherichia coli strains and clinically isolated Pseudomonas aeruginosa strains that produce VIM-2 metallo-β-lactamase. It serves as a valuable research tool for exploring resistance mechanisms in bacterial pathogens and for developing novel therapeutic strategies.