Catalog No.
Product Name
Application
Product Information
Citations
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NF-κB Inhibitor
Rubiadin-1-methyl ether is a natural anthraquinone that acts as an NF-κB inhibitor. It demonstrates significant biological activity by inhibiting osteoclastic bone resorption through the suppression of NF-κB p65 phosphorylation and the degradation of IκBα, resulting in decreased nuclear translocation of p65. This compound is relevant for research applications focusing on bone metabolism and inflammatory responses. -
RelA/p65 PROTAC Degrader
JP-163-16 is a RelA/p65 PROTAC degrader that facilitates the selective degradation of RelA/p65 via the proteasome pathway. By inhibiting the NF-κB signaling pathway, JP-163-16 promotes apoptosis in cells, making it a valuable tool for investigating RelA/p65-dependent tumors, including chronic lymphocytic leukemia (CLL). This compound is instrumental for studies aimed at understanding the role of NF-κB in cancer progression and therapeutic resistance. -
NF-κB Inhibitor
Aristolochic acid A sodium is a potent NF-κB inhibitor derived from Aristolochia and Asarum species. This compound effectively diminishes the activity of both activator protein 1 (AP-1) and NF-κB, thereby modulating key signaling pathways involved in inflammation and cancer. Additionally, Aristolochic acid A sodium has been shown to reduce BLCAP gene expression in human cell lines, making it valuable for research in cell signaling and gene regulation. -
Anti-inflammatory Agent
Anti-inflammatory Agent 51 is an amide/sulfonamide derivative that functions primarily as an anti-inflammatory agent. This compound effectively inhibits the activation of NF-κB, making it a valuable tool for research into conditions such as acute lung injury and ulcerative colitis. Its ability to modulate inflammatory pathways positions it as a significant reagent for studying inflammatory diseases and therapeutic interventions. -
NF-κB Activator
Asatone is an NF-κB activator derived from Radix et Rhizoma Asari. It exhibits anti-inflammatory properties by activating the NF-κB signaling pathway while downregulating phosphorylated MAPK pathways, including ERK, JNK, and p38. This compound is valuable for research focused on inflammation, immune response modulation, and signaling pathways associated with these biological processes. -
NF-κB Inhibitor
Suberosin is a potent NF-κB inhibitor derived from Plumbago zeylanica. It demonstrates significant anti-inflammatory and anticoagulant properties by suppressing PHA-induced proliferation of peripheral blood mononuclear cells (PBMC) and inhibiting cell cycle progression from the G1 phase to the S phase. Due to its ability to modulate the transcription factors NF-AT and NF-κB, Suberosin serves as a valuable tool in studies of inflammation and thrombosis. -
NF- B Inhibitor
2,4,6-Trihydroxybenzaldehyde is an orally active inhibitor of NF-κB, a key transcription factor involved in inflammatory and immune responses. This compound exhibits notable anti-tumor activity, inhibits cancer cell proliferation, and demonstrates anti-obesity effects. Its applications in cancer research and metabolic studies make it a valuable reagent for exploring mechanisms of disease and potential therapeutic strategies. -
NF-κB Inhibitor
Lucyoside B is a potent NF-κB inhibitor that effectively modulates inflammatory responses. It inhibits the production of various inflammatory mediators through the NF-κB and activator protein-1 signaling pathways in activated macrophages. This compound is valuable for research applications focused on understanding inflammation and its modulation in various disease states. -
OST-A Inhibitor
NGI-235 is a selective inhibitor of the OST-A enzyme, effectively blocking the glycosylation of Toll-like receptor 4 (TLR4). This compound demonstrates potent inhibition of NF-κB inflammatory signaling, making it a valuable tool for investigating mechanisms of inflammation and immune response regulation. NGI-235 is suitable for research applications focused on inflammatory diseases and TLR4-mediated pathways. -
Diterpene alkaloid
Karacoline is a diterpene alkaloid derived from the plant Aconitum kusnezoffii that modulates the NF-κB signaling pathway. This compound plays a significant role in reducing the degradation of the extracellular matrix (ECM), making it valuable for research into intervertebral disc degeneration (IDD) and related conditions. Its ability to influence ECM stability positions Karacoline as a candidate for studying therapeutic interventions in degenerative disc diseases. -
Isomer
(S)-NIK SMI1 is the isomer of NIK SMI1, serving as a useful experimental control in research applications. As a potent and selective inhibitor of NF-κB inducing kinase (NIK), it effectively inhibits the NIK-catalyzed hydrolysis of ATP to ADP, with an IC50 value of 0.23±0.17 nM. This compound is instrumental in studies investigating NF-κB signaling pathways and their implications in various biological processes. -
Immunotherapeutic Agent
Echinulin is a cyclic dipeptide characterized by a triprenylated indole structure, functioning as an immunotherapeutic agent. It promotes the activation of T cell subsets, which subsequently leads to the activation of the NF-κB signaling pathway. Echinulin's ability to modulate immune responses positions it as a promising candidate in cancer immunotherapy and other research applications focused on immune regulation. -
NIK Inhibitor
NIK-IN-2 is a potent inhibitor of NF-κB-inducing kinase (NIK), exhibiting an impressive pIC50 of 7.4. This compound serves as a valuable tool in cancer research, enabling the investigation of NIK's role in NF-κB signaling pathways and their implications in tumorigenesis. Its selective inhibition of NIK provides insights into therapeutic strategies targeting NF-κB-related diseases. -
NF-κB Inhibitor
9-Hydroxycanthin-6-one is an alkaloid that functions as an NF-κB inhibitor, exhibiting significant biological activity. With an IC50 value of 3.8 μM, this compound effectively modulates the NF-κB signaling pathway. It offers potential applications in research related to inflammation, cancer, and other diseases driven by NF-κB activation. -
Stable Isotope
(R)-(-)-Ibuprofen-d3 is a deuterium-labeled derivative of the R enantiomer of Ibuprofen. This compound is utilized as a stable isotope in pharmacokinetic and metabolic studies. While the (R)-(-)-Ibuprofen itself is inactive on COX and inhibits NF-κB activation, it is recognized for its anti-inflammatory and antinociceptive properties, making this isotope valuable for research applications focused on drug metabolism and efficacy. -
Naphthohydroquinone Dimer
Rubipodanone A is a naphthohydroquinone dimer known for its cytotoxic effects on various cancer cell lines, including A549, BEL-7402, HeLa, HepG2, SGC-7901, and U251. Additionally, Rubipodanone A exhibits significant activation of NF-κB at concentrations of 20 and 40 μM. This compound is valuable for research focused on cancer biology and cellular signaling pathways. -
NF-κB Inhibitor
NBD peptide is a selective inhibitor of the NF-κB signaling pathway, acting by disrupting the interaction between NEMO and the IKK complex. This inhibition leads to reduced production of pro-inflammatory cytokines, showcasing its anti-inflammatory properties. Additionally, NBD peptide demonstrates immunosuppressive effects through modulation of immune cell activity. The incorporation of the cell-penetrating HIV-TAT peptide enhances its cellular uptake, facilitating its application in various research contexts. -
BRD4 BD2 Inhibitor
BRD4-BD1/2-IN-3 is a selective inhibitor of the BRD4 bromodomain 2 (BD2), exhibiting an IC50 of 0.41 nM for BRD4 BD2 compared to BRD4 BD1. This compound effectively inhibits LPS-induced expression of IL-6, demonstrating significant anti-inflammatory properties through modulation of the TNF and NF-κB signaling pathways. BRD4-BD1/2-IN-3 is valuable for research focused on inflammatory diseases. -
Anti-ophthalmic Disorders Agent
BIZ 114 is a fatty acid derivative that actively inhibits the TNF-α activated NF-κB pathway. It demonstrates significant potential in the prevention and treatment of ophthalmic disorders, including retinal degenerative conditions and ocular inflammatory diseases. This compound is valuable for research investigating the molecular mechanisms underlying these disorders and developing targeted therapeutic strategies. -
NF-κB Activator
Methylchloroisothiazolinone is a potent NF-κB activator known for its pro-inflammatory properties. It induces the expression of pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6, through the activation of the NF-κB signaling pathway and upregulation of TLR4. This compound is utilized in research focusing on allergic contact dermatitis and immunotoxicity mechanisms. Additionally, Methylchloroisothiazolinone demonstrates neurotoxic effects and has been shown to impair cholinesterase activity, leading to increased oxidative stress and detrimental impacts on aquatic organisms, specifically Mediterranean mussels. -
NF-κB Inhibitor
HSR1304 is a potent NF-κB inhibitor that targets the multifunctional transcription factor involved in various human diseases, including cancer and chronic inflammation. This compound demonstrates significant biological activity in modulating NF-κB signaling pathways. HSR1304 is intended for research applications focused on cancer biology and the development of anti-inflammatory strategies. -
NF-κB Inhibitor
Rubioncolin C is a potent NF-κB inhibitor that demonstrates significant anti-tumor activity. It promotes apoptotic and autophagic cell death in human cancer cells while effectively suppressing the NF-κB and Akt/mTOR/P70S6K signaling pathways. This compound is valuable for research focused on cancer biology and therapeutic development. -
NF-κB Inhibitor
(−)-N-Hydroxyapiosporamide is a potent NF-κB inhibitor known for its significant antitumor activity both in vitro and in vivo. Its biological properties make it particularly relevant for research applications targeting colorectal cancer (CRC). This alkaloid serves as a valuable tool for studying the mechanisms of NF-κB signaling and its role in tumor progression. -
Anti-inflammatory Agent
Ageconyflavone B is a flavonoid that functions as an anti-inflammatory agent. It effectively reduces inflammation through the inhibition of IκBα phosphorylation, thereby modulating the NF-κB signaling pathway. This compound is relevant for research applications focused on inflammatory diseases and the underlying molecular mechanisms of inflammation. -
NF-κB
NF-κB-IN-2 is a selective inhibitor of NF-κB signaling. It effectively suppresses TNF-α-induced canonical NF-κB pathway activation in PC-3 cells, demonstrating significant potential in studies related to inflammation, cell survival, and cancer research. This compound is valuable for investigating the role of NF-κB in various biological processes and therapeutic applications. -
NF-κB Modulator
IMD-biphenylC is an imidazoquinolinone-NF-κB modulator that functions through the inhibition of NF-κB signaling pathways. It exhibits significant biological activity by suppressing tumor proliferation while promoting a favorable inflammatory response. This compound is valuable for research applications focused on cancer biology and the modulation of immune responses, particularly in evaluating therapies that minimize systemic inflammation and adjuvant toxicity. -
Protein Complex Stabilizer
ADHPE is a protein complex stabilizer that targets the 14-3-3σ and p65 proteins. It effectively inhibits the NF-κB (p65) signaling pathway, leading to a reduction in inflammatory responses. This reagent is suitable for research applications focusing on pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome. -
NF-κB Inhibitor
NF-κB-IN-3 is a potent NF-κB inhibitor with an IC50 of 0.70 µM. It exhibits significant biological activity by disrupting the NF-κB signaling pathway, which is crucial in various cellular processes including inflammation and cancer progression. This compound is utilized in research applications focused on cancer biology and therapeutic interventions targeting NF-κB-related pathways. -
NF-κB Inhibitor
Stipuleanoside R2 is a potent inhibitor of NF-κB activation, specifically blocking the pathway triggered by TNFα. This compound demonstrates dose-dependent inhibitory activity, with an IC50 value of 4.1 μM. Stipuleanoside R2 can be utilized in research focused on inflammatory response, cancer biology, and other diseases associated with NF-κB signaling. -
Anti-inflammatory Agent
BS-153 is a synthetic oxazolidinone compound that functions as an anti-inflammatory agent by inhibiting the activation of the NF-κB/PKCθ signaling pathway. It effectively reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, in LPS-stimulated RAW264.7 macrophage cells. This reagent is suitable for research applications focused on inflammation and immune response modulation. -
NF-κB Inhibitor
Andrographolide-lipoic acid is an NF-κB inhibitor that combines Andrographolide and Lipoic acid. This compound exhibits significant anti-diabetic properties and provides protective effects on pancreatic β-cells. Its ability to modulate inflammatory pathways makes it a valuable tool for research in diabetes and related metabolic disorders. -
NF-κB Inhibitor
6-O-p-Hydroxybenzoylglutinoside is a selective NF-κB inhibitor that effectively suppresses TNF-α-activated NF-κB transcriptional activity, with an IC50 of 52.78 μM. This compound demonstrates targeted biological activity without significantly inhibiting soluble epoxide hydrolase (sEH), acetylcholinesterase (AChE), or butyrylcholinesterase (BChE). Isolated from the seeds of Catalpa bungei (Manchurian catalpa), 6-O-p-Hydroxybenzoylglutinoside is valuable for research applications focused on inflammation and signal transduction pathways. -
NF-κB Inhibitor
NF-κB-IN-10 is a potent inhibitor of the NF-κB signaling pathway, primarily targeting NF-κB activation. This compound has demonstrated the ability to alleviate heart failure by mitigating oxidative stress and inflammation through the modulation of the Nrf2/NF-κB axis. In RAW264.7 cells, NF-κB-IN-10 effectively inhibits lipopolysaccharide-induced nitric oxide production, as well as the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This reagent is invaluable for research into cardiovascular diseases and related inflammatory processes. -
NF-κB Inhibitor
IKKγ NBD Inhibitory Peptide is a selective inhibitor of NF-κB signaling. It functions by disrupting the interaction between the IKKγ/NEMO-binding domain and IKKα/IKKβ, effectively blocking TNF-α-induced NF-κB activation. This peptide exhibits significant anti-inflammatory properties and has potential applications in studying cerebral ischemia and its associated neurological deficits. -
NF-κB Inhibitor
(Rac)-Myrislignan is a potent NF-κB inhibitor derived from Myristica fragrans Houtt. This compound demonstrates significant anti-inflammatory properties by effectively reducing LPS-induced inflammatory responses in murine macrophage cells. Its ability to inhibit the NF-κB signaling pathway makes (Rac)-Myrislignan a valuable tool for research into inflammation and related diseases. -
Antineuropathic Pain Agent
Lemnalol is a ylangene-type sesquiterpenoid compound that serves as a potent antineuropathic pain agent. It exhibits significant anti-inflammatory, analgesic, and antitumor activities, effectively attenuating hyperalgesia and allodynia through the modulation of neuroinflammatory processes associated with neuropathic conditions. Additionally, Lemnalol influences LPS-induced alterations in left atrial calcium homeostasis and inhibits NF-κB pathways, potentially mitigating LPS-induced arrhythmogenic effects and neuropathic pain. These properties make Lemnalol a valuable tool for pain research and the study of neuroinflammatory mechanisms. -
NF-κB Inhibitor
Helenalin isobutyrate is an NF-κB (p65 subunit) inhibitor known for its anti-inflammatory properties. It functions by irreversibly alkylating cysteine sulfhydryl groups within the p65 subunit, effectively diminishing the DNA binding activity of the NF-κB complex. This compound is valuable in research focused on understanding inflammation pathways and potential therapeutic interventions in related diseases. -
NF-κB Inhibito
Pratol is a potent inhibitor of NF-κB, effectively attenuating the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 cells without exhibiting cytotoxic effects. By inhibiting NF-κB, Pratol also reduces the levels of proinflammatory cytokines. This compound is valuable for research applications focused on inflammatory diseases and cancer. -
Anti-Inflammatory Agent
8α-Hydroxyhirsutinolide is a sesquiterpene lactone that acts as an anti-inflammatory agent by inhibiting TNF-α-induced NF-κB activity with an IC50 of 1.9 μM. Additionally, it reduces nitric oxide production, indicating a potential role in modulating inflammatory pathways. This compound can be isolated from the plant Vernonia cinerea and is useful for research in inflammation and related cellular signaling mechanisms. -
NF-κB Modulator
IMD-catechol is a dimeric imidazoquinolinone that functions as a modulator of NF-κB signaling. This compound enhances therapeutic efficacy in models of CT26 colon carcinoma while demonstrating minimal adjuvant toxicity. Its unique mechanism makes it a valuable tool for investigating immune modulation and therapeutic strategies in cancer research. -
NF-κB Inhibitor
Sootepin D is a triterpene that serves as an NF-κB inhibitor. It effectively suppresses TNF-α-induced NF-κB activity with an IC50 of 8.3 μM, demonstrating significant anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
NIK Inhibitor
AM-0216 is a potent inhibitor of NF-κB-inducing kinase (NIK), exhibiting a Ki value of 2 nM. This compound selectively modulates NF-κB signaling pathways, making it valuable for investigating NF-κB-dependent hematologic malignancies, such as multiple myeloma, as well as autoimmune disorders. The specificity and efficacy of AM-0216 position it as a significant tool in the study of related therapeutic targets and disease mechanisms. -
NF-κB Inhibitor
NF-κB-IN-8 is a selective NF-κB inhibitor that competitively antagonizes lipopolysaccharide (LPS) binding to MD-2. This compound effectively reduces the expression of inflammatory mediators, making it a valuable tool for studying inflammatory responses. Additionally, NF-κB-IN-8 has been shown to inhibit alkaline phosphatase (ALP) activity. It is particularly relevant for research into inflammation-related conditions, such as acute lung injury (ALI). -
NF-κB Modulator
IMD-biphenylA is a novel imidazoquinolinone compound that functions as a modulator of NF-κB activity. This dimeric structure enhances the adjuvanticity of small molecule immune potentiators, making it valuable for research in immunology and therapeutic applications targeting immune responses. Its ability to influence NF-κB signaling pathways positions it as a significant reagent for exploring immune modulation and adjuvant mechanisms. -
NF-κB p65 Inhibitor
Ratutrelvir is an NF-κB p65 inhibitor that targets the translocation of NF-κB p65 from the cytoplasm to the nucleus. By reducing phosphorylation levels of NF-κB p65 and IκBα, Ratutrelvir effectively inhibits the DNA-binding activity of NF-κB p65. This compound has been demonstrated to impair migration and invasion capabilities of breast cancer cells, as well as decrease their viability and colony-forming potential, making it a valuable tool for research in luminal A breast cancer. -
Anti-atherosclerosis Agent
Paeonolsilate sodium is an anti-atherosclerosis agent that effectively inhibits oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and associated inflammation. This compound suppresses NF-κB activation and the oxidative stress response triggered by ox-LDL. Paeonolsilate sodium is a valuable reagent for studying mechanisms underlying atherosclerosis and exploring potential therapeutic strategies. -
NF-κB Inhibitor
Laurotetanine is a potent isoquinoline alkaloid functioning as an NF-κB inhibitor. It exhibits anti-asthmatic properties by modulating immune responses, specifically inhibiting IgE and histamine release, alongside reducing inflammatory reactions. Laurotetanine's mechanism involves the downregulation of MUC5AC and NF-κB signaling pathways, making it a valuable tool for research in inflammatory diseases and asthma therapy. -
NF-κB Inhibitor
Dauricinoline is a potent orally active inhibitor of NF-κB, effectively blocking NF-κB activation induced by TNF-α. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for investigating inflammatory diseases, particularly in the context of lung inflammation. Researchers may utilize Dauricinoline to explore the mechanisms underlying NF-κB-mediated signaling pathways and their role in various inflammatory conditions. -
NIK Inhibitor
NIK-IN-1 is a potent inhibitor of NF-κB-inducing kinase (NIK), a critical regulator in the NF-κB signaling pathway. This compound demonstrates significant anti-inflammatory activity and is utilized in research focused on hepatic inflammatory diseases and acute liver injury. Its application helps elucidate the role of NIK in liver pathology and potential therapeutic interventions. -
NF-κB Modulator
IMD-biphenylB is a potent NF-κB modulator known for its ability to inhibit tumor proliferation. This imidazoquinolinone dimer also demonstrates a capacity to induce low systemic inflammation and minimize adjuvant toxicity. It serves as a valuable tool for research focused on immune response modulation and cancer therapy development.
