Catalog No.
Product Name
Application
Product Information
Citations
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NF-κB Pathway Inhibitor
Pterocenoid C is a potent inhibitor of the NF-κB signaling pathway. This compound demonstrates significant biological activity by modulating inflammatory responses and has potential applications in the study of diseases associated with NF-κB dysregulation, including cancer and autoimmune disorders. Pterocenoid C serves as a valuable tool for researchers investigating the intricate roles of NF-κB in various biological processes and disease mechanisms. -
NF-κB Inhibitor
mcIRBP-9 is an orally bioavailable NF-κB inhibitor that effectively reduces pro-inflammatory cytokines such as TNF-α, IL-1β, and TGF-β1 in renal tissues. Additionally, mcIRBP-9 decreases LPS-induced production of IL-1β, making it a valuable tool for studying inflammatory processes. This compound is relevant to research focused on diabetic nephropathy and type 2 diabetes mellitus, providing insights into the underlying mechanisms of these conditions. -
Anti-Inflammatory Agent
Goshonoside F5 is an anti-inflammatory agent derived from the unripe fruits of Rubus chingii. It demonstrates significant anti-inflammatory activity by inhibiting the NF-κB and MAPK signaling pathways. This compound is relevant for research applications focusing on inflammation-related conditions and the underlying molecular mechanisms. -
NF-κB Inhibitor
NF-κB-IN-17 is an NF-κB inhibitor that effectively suppresses TNF-α-induced NF-κB DNA binding activity in C2C12 cells. Its mechanistic action provides valuable insights into the modulation of inflammatory responses, making it a useful tool for research applications focused on immune regulation and cancer biology. This reagent is suitable for studies examining the NF-κB signaling pathway and its implications in various disease models. -
Amide Alkaloid
Coumaperine is an amide alkaloid known for its ability to inhibit NF-κB signaling pathways. This compound has demonstrated anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma, making it valuable for cancer research. Additionally, Coumaperine derivatives exhibit antibacterial properties, further expanding their potential applications in biomedical studies. -
NF-κB
ABD-350 is a selective inhibitor of NF-κB, primarily targeting the phosphorylation of the inhibitor of NF-κB. This compound demonstrates key antiresorptive activity by promoting osteoclast apoptosis while preserving osteoblast function, making it effective in preventing ovariectomy-induced bone loss. Its application includes studying osteoclast regulation and potential therapeutic strategies for osteoporosis without interfering with bone formation driven by parathyroid hormone. -
NF-κB Inhibitor
Avenanthramide-C methyl ester is an NF-κB inhibitor that exerts anti-inflammatory effects by inhibiting the secretion of pro-inflammatory factors. This compound blocks NF-κB activation through the inhibition of IKK and IκB phosphorylation, as well as by impairing proteasome activity. Avenanthramide-C methyl ester is valuable for research applications focused on inflammation and related signaling pathways. -
NF-κB Inhibitor
Coronalolic acid acts as an NF-κB inhibitor, derived from the apical bud of Gardenia sootepenesis Hutch. This compound effectively suppresses TNF-α-induced NF-κB activation and inhibits nitric oxide (NO) production. It serves as a valuable tool for research applications focused on inflammation and immune response modulation. -
NIK Inhibtior
AM-0561 is a potent NIK inhibitor with a Ki of 0.3 nM, effectively suppressing the activity of the non-canonical NF-κB signaling pathway. By inhibiting NIK, AM-0561 significantly reduces p52 protein levels, which may contribute to the regulation of various cellular processes. This reagent is useful for research applications aimed at understanding NF-κB signaling in inflammation, immune response, and cancer biology. -
Anticancer Agent
Antiproliferative Agent-76 is an 8-sulfonamidoquinoline derivative functioning as a selective anticancer agent. It effectively inhibits the NF-κB and WNT signaling pathways, promoting apoptosis in cancer cells. This compound demonstrates notable anticancer activity against colorectal cancer and leukemia, making it a valuable tool for cancer research and therapeutic applications. -
NF-κB Inhibitor
Myrcene-d6 functions as an NF-κB inhibitor through its deuterium labeling of the natural compound myrcene. With demonstrated efficacy in inhibiting TNFα and NF-κB activity, myrcene exhibits significant anti-invasive properties, mediates cell cycle arrest, and promotes apoptosis in cancer cells. Its biological activities also include robust blood protection and anti-inflammatory effects, making it a valuable reagent for research in cancer biology and inflammatory responses. -
NF-κB Modulator
IMD-vanillin is an NF-κB modulator that functions as a novel immunomodulatory compound derived from imidazoquinolinone dimers. This reagent has demonstrated the ability to inhibit NF-κB activation, thereby modulating inflammatory responses and influencing cell survival. IMD-vanillin is suitable for research applications focused on inflammation, autoimmune diseases, and cancer, where NF-κB pathways play a crucial role. -
Chlorinated Alkaloid
Dauricumine is a chlorinated alkaloid that functions as an inhibitor of NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. This compound is significant in research applications focused on bone metabolism and osteoclastogenesis, providing insights into the regulation of inflammatory responses and potential therapeutic approaches for bone-related disorders. -
Chromone Derivative
7-O-Methylaloesinol is a chromone derivative that exhibits notable inhibitory activity against TNFα-induced NF-κB transcriptional activation, with an IC50 value of 29.07 μM. This compound serves as a valuable tool for studying inflammatory pathways and the modulation of NF-κB signaling, contributing to research in cellular responses and potential therapeutic strategies for inflammatory diseases. -
NF-κB Inhibitor
NF-κB-IN-9 is a potent inhibitor of nuclear factor kappa B (NF-κB), functioning as a sonosensitizer with an excitation/emission wavelength of 489/628 nm. This compound exhibits significant inhibition of NF-κB signaling pathways, attributed to its dual resveratrol units. NF-κB-IN-9 demonstrates effective anti-tumor activity and exhibits pronounced sonocytotoxicity against various cancer cell lines. Additionally, NF-κB-IN-9 has shown favorable biosafety profiles in xenograft mouse models, making it a valuable tool for cancer research. -
NF-κB decoy oligonucleotide
Cupabimod is a decoy oligonucleotide designed to inhibit the transcription factor NF-κB. By sequestering NF-κB, it effectively modulates inflammatory responses and regulates gene expression associated with various diseases. This compound is utilized in research focused on inflammation, autoimmune disorders, and cancer, providing valuable insights into the role of NF-κB signaling pathways. -
NF-κB Inhibitor
Licoagrochalcone C is a flavonoid that serves as an effective inhibitor of NF-κB transcription. It demonstrates significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production. This compound is valuable for research applications focused on inflammatory responses and NF-κB-related signaling pathways. -
Anti-inflammatory Agent
Catalposide is an iridoid glycoside derived from Catalpa ovata G. Don (Bignoniaceae) that acts as an anti-inflammatory agent. It effectively inhibits the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, as well as the activation of NF-κB (p65) in lipopolysaccharide-stimulated RAW 264.7 macrophages. This compound is valuable for research in inflammatory pathways and potential therapeutic interventions in inflammatory diseases. -
NF-κB Activator
oxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) is an NF-κB activator that functions as a key ligand for β-glycoprotein I (β(2)-GPI), derived from oxidized low-density lipoprotein (oxLDL). By promoting nuclear translocation, oxLig-1 initiates the NF-κB signaling pathway, which plays a significant role in various inflammatory processes. This compound is instrumental in research on atherosclerosis and offers insights into the mechanisms underlying lipid metabolism and cardiovascular diseases. -
NF-κB Inhibitor
(R)-SEMBL is a potent inhibitor of the NF-κB signaling pathway. This compound exhibits significant biological activity in the modulation of inflammatory responses and has potential applications in cancer research, autoimmune diseases, and metabolic disorders such as diabetes. Additionally, (R)-SEMBL may be useful in investigating therapeutic strategies for cardiovascular diseases and complications associated with defective reperfusion injury. -
NF-κB Inhibitor
(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene that acts as a nuclear factor kappa B (NF-κB) inhibitor. It effectively inhibits TNFα-triggered NF-κB activity with an IC50 of 8.7 μg/mL, demonstrating significant anti-inflammatory properties. Additionally, this compound reduces nitric oxide (NO) production and exhibits notable cytotoxic effects against tumor cells, making it a valuable tool for cancer and inflammation research. -
NF-κB Inhibitor
Sul-121 hydrochloride is a potent NF-κB inhibitor that effectively reduces airway inflammation and hyperresponsiveness in models of chronic obstructive pulmonary disease (COPD). This compound demonstrates a dose-dependent inhibition of lipopolysaccharide-induced airway neutrophilia and attenuates oxidative stress markers in human airway smooth muscle cells. By preventing the nuclear translocation of the NF-κB subunit p65, Sul-121 hydrochloride decreases the release of pro-inflammatory cytokines, making it a valuable tool for investigating inflammatory pathways in respiratory diseases. -
NF-κB Inhibitor
OT-551 is a selective NF-κB inhibitor that exhibits both antioxidant and anti-inflammatory properties. This compound is utilized in research focused on retinal diseases, providing a valuable tool for exploring the mechanisms of inflammation and oxidative stress in these conditions. Its ability to modulate NF-κB signaling pathways positions OT-551 as a promising candidate for therapeutic development in ocular research. -
NF-κB Inhibitor
9,10-Dimethoxycanthin-6-one is an alkaloid compound that functions as an inhibitor of NF-κB. It demonstrates significant inhibitory activity with an IC50 value of 19.5 μM. This compound is primarily utilized in research pertaining to inflammatory responses and cancer pathways, making it relevant for studies investigating NF-κB signaling modulation. -
Anti-Inflammatory Agent
Catalpalactone is an anti-inflammatory agent that functions by inhibiting LPS-induced nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) in RAW264.7 macrophage cells. Additionally, it suppresses the activation of key signaling pathways, including IRF3, NF-κB, and IFN-β/STAT-1. Furthermore, Catalpalactone demonstrates the ability to reduce dopamine biosynthesis through the inhibition of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities, making it valuable for investigations into inflammatory processes and neurochemical pathways. -
Triterpenoid Saponin
Elatoside F is a triterpenoid saponin that exhibits significant anti-inflammatory activity. It effectively inhibits lipopolysaccharide-induced production of nitric oxide and the activation of the nuclear factor NF-κB. Elatoside F can be isolated in a single step from the plant Aralia elata, making it a valuable compound for research into inflammation and related pathways. -
NF-κB Inhibitor
Teuclatriol is an NF-κB inhibitor derived from Salvia mirzayanii, exhibiting notable anti-inflammatory properties. It effectively inhibits TNF-α secretion in a dose-dependent manner, making it valuable for research involving inflammatory pathways and the modulation of NF-κB activity. This compound is essential for studies focused on chronic inflammation, autoimmune diseases, and related therapeutic developments. -
NF-κB Inhibitor
NF-κB-IN-13 is a selective inhibitor of the NF-κB signaling pathway. This compound effectively suppresses lipopolysaccharide (LPS)-induced NF-κB activation and nitric oxide (NO) production in RAW264.7 macrophages, demonstrating its potential anti-inflammatory properties. NF-κB-IN-13 is valuable for research applications focusing on inflammation, immune response modulation, and potential therapeutic strategies for related diseases. -
NF-κB Inhibitor
APC0576 is an NF-κB inhibitor that effectively disrupts the activation of the NF-κB signaling pathway, demonstrating an IC50 of 1.0 μM for β-galactosidase. This compound significantly inhibits the release of IL-1-induced chemokines, making it a valuable tool for research related to diseases involving pathological endothelial cell activation. Its targeted action allows for the exploration of therapeutic strategies aimed at modulating inflammatory responses. -
NF-κB Inhibitor
CAY10657 is a potent NF-κB inhibitor that effectively downregulates the expression of proinflammatory cytokines, including IL-6, and chemokines such as MCP-1. This compound demonstrates significant anti-inflammatory activity, particularly in the context of meningitis induced by Streptococcus suis. CAY10657 is a valuable tool for researchers investigating inflammation and associated signaling pathways. -
NF-κB Inhibitor
Icariside F2 is a selective NF-κB inhibitor with an IC50 value of 16.25 μM. This aromatic glycoside, extracted from the leaves of E. ulmoides Oliver, exhibits significant anti-inflammatory activity. It is utilized in biomedical research to explore therapeutic strategies for conditions mediated by NF-κB signaling. -
Stable Isotope
TML-6-d3 is a deuterated derivative of the curcumin compound TML-6, demonstrating stability as a labeled isotope. This reagent primarily inhibits the synthesis of β-amyloid precursor protein and β-amyloid (Aβ), contributing to research in neurodegenerative diseases. TML-6-d3 upregulates ApoE, suppresses NF-κB and mTOR signaling pathways, and enhances activities related to neuroprotection. It serves as a valuable tool for studying the molecular mechanisms of Alzheimer's disease and related disorders. -
ROR-γ Inhibitor
CID 7309015 is a selective inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). This compound demonstrates significant potential in modulating inflammatory pathways, particularly in the context of NF-κB signaling and inflammatory arthritis research. CID 7309015 serves as a valuable tool for investigating the roles of ROR-γ in immune response and inflammatory diseases. -
Trx/TrxR System Inhibitor
PMX464 is a thiol-reactive quinol that acts as an inhibitor of the thioredoxin-thioredoxin reductase (Trx/TrxR) system. This compound has been shown to inhibit NF-κB-mediated pro-inflammatory activation in human type II alveolar epithelial cells, making it a valuable tool for research focused on inflammation and oxidative stress. PMX464 is particularly useful in studies examining the role of redox signaling in various pathophysiological conditions. -
Tyrosinase Inhibitor
MHY884 is a potent tyrosinase inhibitor that effectively mitigates UVB-induced activation of the NF-κB signaling pathway by downregulating oxidative stress. This compound demonstrates a reduction in oxidative stress within melanoma cells, leading to diminished NF-κB activity in irradiated models. MHY884 holds significant promise for investigations into the mechanisms of UVB-induced skin damage and its potential therapeutic applications. -
Aβ Inhibitor
TML-6 is an orally active curcumin derivative that functions as a β-amyloid (Aβ) inhibitor by impeding the synthesis of β-amyloid precursor protein. It demonstrates key biological activities including the upregulation of Apo E, suppression of NF-κB and mTOR pathways, and enhancement of the anti-oxidative Nrf2 response. TML-6 is positioned as a promising candidate for research in Alzheimer's disease (AD) mechanisms and therapeutic developments. -
Chalcone
4'-Hydroxychalcone is a chalcone derivative known for its hepatoprotective properties. It exerts its biological activity by inhibiting TNFα-induced NF-κB activation through the modulation of the proteasome. Additionally, 4'-Hydroxychalcone has been shown to induce rapid potassium release from mitochondrial vesicles, adversely affecting respiratory control and oxidative phosphorylation in isolated rat liver mitochondria. This compound is valuable for research focused on liver protection and mitochondrial function. -
Stable Isotope
Metaxalone-d3 is a deuterium-labeled form of Metaxalone, an FDA-approved muscle relaxant primarily acting on the central nervous system. Its primary mechanism involves inhibition of polysynaptic reflex arcs, promoting muscle relaxation. Additionally, Metaxalone demonstrates inhibitory effects on MAO-A, contributing to its anti-inflammatory and antioxidant properties. This reagent is useful for research applications investigating inflammatory responses, as it modulation of IL-1β-induced phenotypes impacts NF-κB and related signaling pathways in microglia. -
Stable Isotope
Metaxalone-d6 is a deuterium-labeled analog of Metaxalone, an FDA-approved muscle relaxant primarily targeting the central nervous system. It promotes muscle relaxation by inhibiting polysynaptic reflex arcs and also exhibits activity as an inhibitor of MAO-A, contributing to anti-inflammatory and antioxidant effects. Metaxalone effectively reduces the IL-1β-induced inflammatory phenotype, modulates NF-κB signaling pathways, and lowers both expression and activity of MAO-A in IL-1β-treated microglia, making it a valuable tool for research in neurobiology and inflammation. -
20S Proteasome Inhibitor
5-Amino-8-hydroxyquinoline is a non-competitive inhibitor of the 20S proteasome, demonstrating potent inhibitory effects on NF-κB activity. This compound induces apoptosis in cancer cells while exhibiting minimal cytotoxicity towards normal hematopoietic cells. It is valuable for research applications in cancer biology, particularly in the study of leukemia and related malignancies. -
Immunoproteasome β5i Subunit Inhibitor
DPLG3 is a selective inhibitor of the immunoproteasome β5i subunit, demonstrating an IC50 of 4.5 nM. It effectively inhibits the mouse i-20S proteasome with an IC50 value of 9.4 nM. DPLG3 is capable of downregulating the protein levels of NF-κB p50 and p65, highlighting its potential in the study of immune-related diseases and therapeutic applications. -
Proteasome Inhibitor
Biotin-(Oaa)3-epoxomicin is a biotinylated proteasome inhibitor derived from Epoxomicin, connected through three hydrophilic oxaacetyl amino acid linkers. This compound is utilized primarily in proteomic research for the capture and identification of proteasome complexes, facilitating target validation and elucidation of intracellular targets. Epoxomicin effectively inhibits proteasome activity through covalent binding to catalytic subunits such as LMP7, X, MECL1, and Z, with a pronounced effect on chymotrypsin-like activity, while sparing non-proteasomal proteases like trypsin and papain. Additionally, it serves as an NF-κB inhibitor, demonstrating potential in studies of inflammatory responses. -
20S Proteasome Inhibitor
5-Amino-8-hydroxyquinoline dihydrochloride is a potent non-competitive inhibitor of the 20S proteasome. This compound effectively inhibits NF-κB activity, leading to apoptosis in cancer cells while exhibiting minimal cytotoxicity towards normal hematopoietic cells. Its unique properties make it a valuable tool for cancer research, particularly in studies related to leukemia and other malignancies. -
Proteasome Inhibitor
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the proteasome, exhibiting an inhibition constant (Ki) of 460 nM. This compound also functions as an inhibitor of NF-κB nuclear translocation, making it valuable for studies involving immune response and inflammation. Research applications include investigations into proteolytic processes and the role of cytokines in various disease models. -
Proteasome Inhibitor
4-Nitrochalcone serves as a proteasome inhibitor, specifically targeting the proteasomal degradation pathway. It effectively inhibits the activity of NF-κB induced by TNFα, making it a valuable tool for studying inflammatory processes and signaling pathways. This compound is utilized in research focused on cancer, neurodegenerative diseases, and other conditions where proteasome activity plays a critical role. -
Stable Isotope
17-Epiestriol-d5-1 is a deuterated form of 17-Epiestriol, a selective estrogen receptor (ER) β agonist. This compound functions as an effective inhibitor of vascular cell adhesion molecule VCAM-1 expression induced by tumor necrosis factor α (TNFα) and prevents the nuclear translocation of NF-κB. Additionally, 17-Epiestriol-d5-1 promotes the expression of endothelial nitric oxide synthase at both mRNA and protein levels. It serves as a valuable tool in research exploring estrogen receptor signaling and its implications in cardiovascular and inflammatory responses. -
Estrogen Receptor Agonist
Dehydrodiconiferyl alcohol is an estrogen receptor agonist that plays a significant role in promoting BMP-2-induced osteoblastogenesis. Additionally, this compound exhibits anti-inflammatory properties by inactivating NF-κB pathways. It is relevant for research in bone metabolism and inflammatory response modulation. -
ER Agonist
17-Epiestriol is an estrogen metabolite that acts as a selective estrogen receptor (ER) β agonist. It is known to inhibit the mRNA and protein expression of vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα), thereby preventing NF-κB migration to the nucleus. Additionally, 17-epiestriol promotes the expression of endothelial nitric oxide synthase at both mRNA and protein levels. This compound is useful in research related to vascular inflammation and endothelial function. -
HDAC8 Modulator
LG190119 is a selective modulator of HDAC8, primarily targeting Schistosoma mansoni with reduced affinity for human HDAC8. This compound has been shown to induce apoptosis in schistosome cells, making it a valuable tool for research in anti-parasitic agents. Its ability to selectively affect parasitic cells underscores its potential in developing effective treatments against schistosomiasis. -
Ophthalmic Preservative
Polyquaternium-1 (Polidronium chloride; PQ-1) is an effective ophthalmic preservative with antimicrobial properties, which activates the NF-κB signaling pathway. It acts by targeting bacterial cell membranes, utilizing its polycationic nature to disrupt membrane integrity, inducing potassium ion leakage, and resulting in bacterial cell death. At a concentration of 0.001%, Polyquaternium-1 exhibits low toxicity towards mammalian cells, making it suitable for various formulations including glaucoma eye drops, artificial tears, and contact lens solutions. Its use helps to mitigate the ocular surface toxicity associated with conventional preservatives like benzalkonium chloride.
