Catalog No.
Product Name
Application
Product Information
Citations
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Exenatide Impurity
(Des-Gly2)-Exenatide is a structural variant of Exenatide, acting as an impurity in this peptide-based drug. Its presence is significant for quality control and purity assessment in pharmaceutical formulations. Researchers utilize this compound to study the stability and degradation pathways of Exenatide, enhancing analytical methods within peptide characterization and drug development processes. -
Atorvastatin Impurity
O-Methyl Atorvastatin calcium serves as an impurity of Atorvastatin, a well-established 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This compound is primarily utilized in research to study the metabolic effects of HMG-CoA inhibitors and their role in lipid regulation. Its biological activity includes the effective reduction of cholesterol levels, making it significant for investigations into cardiovascular disease and dyslipidemia. -
Imatinib Impurity
Imatinib Impurity E is a specific impurity associated with the tyrosine kinase inhibitor Imatinib. Imatinib selectively targets BCR/ABL, PDGFR, and c-Kit kinases, inhibiting their activity by binding near the ATP binding site, thereby stabilizing a closed conformation and reducing enzyme activity. This compound is significant in research focused on cancer treatments and has also demonstrated inhibitory effects against viruses such as SARS-CoV and MERS-CoV. -
Impurity of Atorvastatin
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin, a potent HMG-CoA reductase inhibitor. This compound demonstrates the capacity to effectively lower blood lipid levels and has been shown to inhibit human smooth muscle cell proliferation and invasion with IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a valuable reference for studies involving atorvastatin's pharmacological properties and mechanisms of action. -
Atorvastatin Impurity
Desfluoro-atorvastatin is an impurity of Atorvastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This compound is primarily used in the evaluation and characterization of Atorvastatin's purity in pharmaceutical formulations. Its relevance in lipid-lowering research underscores the importance of monitoring impurities that may influence therapeutic efficacy and safety. -
Febuxostat Impurity
Febuxostat impurity 6 is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor with a Ki of 0.6 nM. This impurity is relevant for analytical studies and quality control during the synthesis of Febuxostat. Researchers may utilize Febuxostat impurity 6 to assess the purity of pharmaceutical formulations and investigate potential side effects linked to impurities in drug development. -
Drug Impurity
Quetiapine impurity 4 is a dimeric impurity associated with quetiapine. This compound is primarily investigated for its relevance in the analysis of the purity of quetiapine formulations. It serves as a useful reference standard for quality control and regulatory compliance in pharmaceutical research, particularly in studies assessing the safety and efficacy of antipsychotic medications. -
Glyphosate Impurity
N-Nitrosoglyphosate sodium is a nitrosamine degradation product and synthetic impurity of glyphosate, primarily targeting the glyphosate molecule. This compound is significant for researchers studying the safety and environmental impact of glyphosate herbicides, as it aids in understanding degradation pathways and potential toxicological effects. Its analysis is crucial for regulatory compliance and assessing impurity levels in glyphosate formulations. -
Atorvastatin Impurity
Atorvastatin acetonide is a known impurity of Atorvastatin, derived from patent WO2011131605A1, Compound 4. Atorvastatin functions primarily as an HMG-CoA reductase inhibitor, demonstrating significant efficacy in lowering blood lipid levels. This compound is useful for research applications focused on lipid metabolism and the evaluation of atorvastatin's synthetic pathways and purity. -
Pemetrexed Impurity
N-Methyl pemetrexed is a notable impurity of Pemetrexed, an antifolate cytotoxic agent. This compound exhibits key biological activity by inhibiting folate-dependent enzymes, making it relevant in cancer research. Its study aids in understanding the pharmacological properties and safety profiles of Pemetrexed in therapeutic applications against various malignancies. -
Drug Intermediate
Org-9768, a derivative of (2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine, serves as a chemical intermediate for the synthesis of mitochondrial permeability transition pore (mPTP) inhibitors. Its potential applications encompass investigations into neurological and cardiovascular disorders, particularly in the context of Parkinson's disease research. The compound is instrumental in exploring therapeutic strategies aimed at modulating mitochondrial function and mitigating disease progression. -
Ivabradine Impurity
Ivabradine impurity 2 is a known impurity of Ivabradine, a selective blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This compound serves as a valuable reference standard for evaluating the purity and quality of Ivabradine formulations. Its characterization is essential for research applications in pharmacology and quality control in pharmaceutical development, particularly in studies related to cardiac function and rhythm management. -
Atorvastatin Impurity
Atorvastatin Epoxy Tetrahydrofuran Impurity is an oxidative degradation product of Atorvastatin, a potent HMG-CoA reductase inhibitor. This impurity may serve as a useful reference standard in quality control and analytical studies, particularly in assessing the integrity of Atorvastatin formulations. Its identification and quantification can provide insights into the stability and degradation pathways of statin compounds in pharmaceutical research. -
Candesartan Cilexetil Impurity
1H-1-Ethyl Candesartan Cilexetil is an impurity associated with the synthesis of Candesartan Cilexetil, an angiotensin II receptor antagonist. This compound may serve as a critical reference standard in the quality control of pharmaceutical formulations containing Candesartan Cilexetil. Its presence and characterization are essential for ensuring the safety and efficacy of products within the cardiovascular therapeutic landscape. -
Captopril Impurity
Captopril EP Impurity E is a known impurity of the antihypertensive agent Captopril, a thiol-containing competitive angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 0.025 μM. It serves as a valuable reference standard for analytical applications, including quality control and characterization of Captopril formulations. This reagent is essential for studies focusing on the synthesis, stability, and impurity profile of Captopril and its derivatives in pharmaceutical research. -
Captopril Impurity
Captopril EP Impurity B is an impurity associated with Captopril, a thiol-containing competitive angiotensin-converting enzyme (ACE) inhibitor. Captopril is utilized primarily as an antihypertensive agent, exhibiting a potent inhibitory activity with an IC50 of 0.025 μM. This impurity may be relevant in pharmacokinetic studies and impurity profiling in the development and quality control of Captopril formulations. -
Impurity
Zopiclone impurity-1 is a byproduct and degradation product associated with the synthesis of zopiclone. This compound is used primarily in analytical and quality control studies to ensure the purity and integrity of zopiclone formulations. Its identification and quantification can aid in understanding degradation pathways and improving manufacturing processes in pharmaceutical development. -
Captopril Impurity
Captopril EP Impurity C is a known impurity of the antihypertensive agent Captopril, a competitive angiotensin-converting enzyme (ACE) inhibitor. This compound is characterized by its thiol-containing structure and possesses a potent inhibitory effect on ACE, with an IC50 of 0.025 μM. Captopril EP Impurity C is primarily utilized in quality control and method validation for pharmaceutical formulations of Captopril, providing essential insights into purity and compound stability in research contexts. -
Drug Impurity
1,2-Diacetylhydrazine, also known as N,N'-Diacetylhydrazine, functions primarily as a drug impurity. This compound can be utilized in analytical and quality control studies to evaluate the purity of pharmaceutical products and to assess potential safety profiles. Its presence may also be significant in the context of metabolic studies and toxicological assessments related to hydrazine derivatives. -
Fluticasone Dimer Impurity
Fluticasone dimer impurity is a dimeric form of Fluticasone Propionate, a potent corticosteroid known for its high affinity for glucocorticoid receptors. This impurity may be of interest in investigations related to the stability, purity, and efficacy of Fluticasone formulations. Its assessment can be essential for ensuring quality control in pharmaceutical development and research on corticosteroid activity. -
Carbocisteine Impurity
Carbocysteine sulfoxide is a metabolite and an impurity associated with carbocisteine. This compound is primarily utilized in chemical research to study its effects and interactions within biological systems. Its role as an impurity may provide insights into the metabolic pathways and biochemical properties of carbocisteine, enhancing our understanding of this compound's pharmacological profile. -
Risperidone Impurity
Risperidone E-oxime is a recognized impurity of Risperidone, primarily targeting serotonin 5-HT2 receptors and dopamine D2 receptors. This compound acts as a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist, exhibiting inhibition constants (Kis) of 4.8 nM and 5.9 nM, respectively. It is particularly relevant for studies involving antipsychotic drug development, pharmacokinetics, and the assessment of metabolite profiles. -
MOF
4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis, specifically targeting the biosynthetic pathway of porphyrins. It exhibits biological activity by interfering with key enzymatic processes involved in heme formation. This compound is useful in studies related to iron metabolism, porphyrias, and the regulation of heme-dependent enzymes in various biological contexts. Its application in chemical research provides valuable insight into metabolic regulation and related disorders. -
Biochemical Reagent
Citrate synthase is an essential enzyme that catalyzes the initial step of the citric acid cycle, facilitating the condensation of acetyl-CoA and oxaloacetate to produce citrate. This enzyme is primarily located in the mitochondrial matrix of eukaryotic cells. Citrate synthase plays a crucial role in cellular metabolism and energy production, making it a valuable biochemical reagent for research applications related to metabolic pathways and mitochondrial function. -
Biochemical Assay Reagent
β-D-Glucose is a monosaccharide that serves as a primary energy source for cells and plays a crucial role in various metabolic pathways. Its chemical properties allow it to be a significant component in both plant and animal tissues, where it is easily metabolized to produce cellular energy. In research applications, β-D-Glucose is utilized as a biochemical assay reagent and serves essential roles in studying metabolic processes, cell culture, and energy production mechanisms. -
MOF
Glutaric acid, a C5 dicarboxylic acid, serves as a key intermediate in the catabolic pathways of lysine and tryptophan. It plays a critical role in influencing pericyte contractility and migration, thereby impacting vascular dynamics. In addition, glutaric acid is recognized as a biomarker in the diagnosis of glutaric aciduria type I, making it relevant for studies in metabolic disorders and related pathways. -
Biochemical Assay Reagent
Fumaric acid disodium, a biochemical assay reagent, serves as a crucial tool in various life science research applications. This compound is utilized for its role in metabolic processes, enabling investigations into biochemical pathways and cellular functions. Its ability to modulate enzymatic activity makes it an essential component for experimental setups aimed at understanding metabolic disorders and cellular metabolism. -
Biochemical Reagent
(S)-2-Aminohexanedioic acid is a biochemical reagent primarily utilized in life science research as a building block in the synthesis of peptides and other organic compounds. This compound plays a crucial role in studies involving amino acid metabolism and protein function. Its application extends to various biochemical assays and experimental models aimed at understanding metabolic pathways and cellular processes. -
Drug Intermediate
m-Tolylacetic acid, also known as 3-Methylbenzeneacetic acid, serves as a hydroaromatic dicarboxylic acid and is commonly found as a metabolite of tolueneacetic acid in urine. This compound is primarily utilized as a drug intermediate, facilitating the synthesis of more complex organic molecules in pharmaceutical research. Its unique structure makes it a valuable component in the development of various bioactive compounds. -
Eszopiclone Impurity
RP 48497 is a photodegradation product and impurity of Eszopiclone, a non-benzodiazepine compound utilized in the management of insomnia. This compound serves as a valuable tool in pharmaceutical research and quality control, aiding in the assessment of Eszopiclone's stability and purity. Its analysis can contribute to a deeper understanding of the drug's degradation pathways and potential effects on efficacy and safety. -
Fexofenadine Impurity
Meta-Fexofenadine is a known impurity of Fexofenadine, which serves as an antihistamine by targeting the H1 receptor (H1R) and is primarily utilized for the treatment of allergic conditions such as seasonal allergic rhinitis and chronic idiopathic urticarial. This compound can be critical for analytical research, particularly in the study of drug purity, metabolic pathways, and formulation development. Its presence is significant in ensuring the quality and safety of Fexofenadine-based therapeutic products. -
Nifedipine Impurity
m-Nifedipine is an impurity associated with Nifedipine, a well-known calcium channel blocker. Nifedipine primarily targets L-type calcium channels, resulting in the relaxation of vascular smooth muscle, which is beneficial in the treatment of cardiac insufficiencies and hypertension. The study of m-Nifedipine may provide insights into the stability, quality, and potential side effects of Nifedipine formulations in pharmaceutical research. -
Impurity of Methotrexate
1,1,3-Tribromoacetone is identified as an impurity of Methotrexate, an established antimetabolite and antifolate that targets dihydrofolate reductase. By inhibiting this enzyme, Methotrexate effectively disrupts the conversion of folic acid to tetrahydrofolate, leading to a significant reduction in DNA synthesis. This compound can be utilized in the study of Methotrexate's pharmacological profiles and potential impurities in biological research. -
Biochemical Assay Reagent
2-(Benzhydrylsulfinyl)acetic acid is a biochemical assay reagent and a known metabolite of modafinil. This compound serves as a useful tool for studying metabolic pathways and pharmacokinetics of modafinil and related compounds. Its unique chemical structure can aid in investigations related to neurotransmitter regulation and cognitive enhancement research. -
Impurity of Palbociclib
N-Methyl Palbociclib is an impurity of Palbociclib, a selective inhibitor of CDK4 and CDK6. This compound is primarily used in analytical studies to assess the purity and quality of Palbociclib formulations. Its relevance in research includes characterization of CDK inhibition and investigations into cell cycle regulation in cancer therapy. -
Impurity of Febuxostat
Febuxostat amide impurity is a known impurity associated with the compound Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. The presence of this impurity can be significant for analytical applications and the assessment of the purity in pharmaceutical formulations. It serves as an important reference material for researchers investigating the chemical integrity and efficacy of xanthine oxidase inhibitors in various biological contexts. -
Osimertinib Mesylate Impurity
Rezivertinib analogue 1 is recognized as a process impurity of osimertinib mesylate, a potent inhibitor of EGFR mutations. This compound serves as a valuable tool in the research of non-small cell lung cancer, facilitating the investigation of drug efficacy and safety profiles in therapeutic applications. Its role in characterizing impurities enhances understanding of the pharmacological landscape surrounding osimertinib-related treatments. -
Labetalol Impurity
Labetalone hydrochloride is an impurity of Labetalol, an orally active adrenoceptor blocking agent. It functions as a competitive antagonist at both alpha- and beta-adrenoceptor sites, contributing to the pharmacological profile of Labetalol. This compound is primarily used in research applications related to cardiovascular pharmacology and the study of adrenoceptor interactions. -
Febuxostat Impurity
Febuxostat sec-butoxy acid is a known impurity of Febuxostat, a selective inhibitor of xanthine oxidase with a Ki of 0.6 nM. This compound serves as a reference standard for analytical and quality control processes in pharmaceutical research. It is essential for investigating the purity and composition of Febuxostat formulations, as well as for understanding the implications of impurities in therapeutic contexts. -
Atorvastatin Impurity
Atorvastatin 3-Deoxyhept-2E-Enoic Acid, a known impurity of Atorvastatin, functions primarily as an HMG-CoA reductase inhibitor. This compound plays a critical role in lipid metabolism regulation and is utilized for analysis in pharmaceutical development and quality control of Atorvastatin formulations. Its presence and characterization are essential for ensuring the purity and efficacy of atorvastatin-based therapies to manage hyperlipidemia and cardiovascular diseases. -
Venetoclax Impurity
Venetoclax N-oxide is an impurity of the Bcl-2 inhibitor Venetoclax (ABT-199; GDC-0199), which exhibits exceptional potency with a Ki value lower than 0.01 nM. This compound serves as a valuable reference for the synthesis and characterization of Venetoclax, and is essential for ensuring the quality and consistency of research involving Bcl-2 modulation. Its analysis is relevant for studies investigating therapeutic applications in hematological malignancies and other conditions associated with dysregulated Bcl-2 activity. -
Cetirizine Impurity
Deschloro Cetirizine dihydrochloride is an impurity of Cetirizine, a second-generation antihistamine and a carboxylated metabolite of hydroxyzine. This compound acts as a selective and orally active histamine H1-receptor antagonist, exhibiting long-lasting antihistaminic effects. It is primarily used in biochemical research aimed at understanding the purity and composition of antihistamine formulations. -
Gefitinib Impurity
Gefitinib impurity 5 is a chemical impurity associated with Gefitinib, a selective EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. This compound effectively inhibits EGF-stimulated tumor cell proliferation (IC50 of 54 nM) and blocks EGFR autophosphorylation in tumor cells, contributing to its antitumor efficacy. Additionally, Gefitinib has been shown to induce autophagy, making it a valuable reagent for research in cancer biology and drug development. -
Acetaminophen Impurity
4-Hydroxyacetophenone oxime is recognized as an impurity of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic. This compound acts as an inhibitor of cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2), contributing to the pharmacological profile of Acetaminophen. It serves as a useful reference for analytical and quality control studies related to Acetaminophen formulations. -
Linezolid Impurity
(R)-Linezolid is an impurity associated with Linezolid (PNU-100766), the first oxazolidinone-synthetic antibiotic. It functions by inhibiting the initiation phase of bacterial protein synthesis, effectively targeting various gram-positive bacteria. This reagent is valuable for research focused on antibiotic characterization, development of new antibacterial agents, and understanding resistance mechanisms. -
Rapamycin Impurity
28-Epirapamycin is an impurity of Rapamycin, a well-characterized inhibitor of the mechanistic target of rapamycin (mTOR). It exhibits potent biological activity with an inhibitory concentration (IC50) of 0.1 nM in HEK293 cells. This compound is primarily utilized for research involving mTOR signaling pathways and cellular growth regulation. It is valuable for studies focused on cancer, metabolic disorders, and age-related diseases. -
Impurity of Febuxostat
Febuxostat dicarboxylic acid impurity is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. This impurity is utilized in chemical analysis and quality control processes in the pharmaceutical industry to ensure the purity and efficacy of Febuxostat formulations. Its characterization is crucial for compliance with regulatory standards and for optimizing drug development protocols. -
Impurity
Captopril EP Impurity D is identified as an impurity associated with Captopril, an angiotensin-converting enzyme (ACE) inhibitor. It serves as a reference standard in pharmaceutical quality control and analytical testing to ensure the purity and compliance of Captopril formulations. This compound is critical for researchers monitoring the chemical profile and safety of ACE inhibitors in drug development and therapeutic applications. -
Chlorthalidone Impurity
Chlorthalidone impurity is a metabolite of the thiazide-like diuretic Chlorthalidone, primarily targeting sodium reabsorption in the renal tubules. This impurity is important for studies involving metabolic pathways and pharmacokinetics of Chlorthalidone. It is particularly relevant for research into hypertension treatment and the identification of potential off-target effects or interactions. -
Drug intermediate
4-Methoxybenzenecarbothioamide is a synthetic intermediate primarily employed in pharmaceutical synthesis. This compound is synthesized through the reaction of 4-methoxybenzamide with phosphorus pentasulfide, facilitating the creation of various thioamide derivatives. Its unique structure and reactivity make it a valuable building block for the development of biologically active molecules in chemical research.
