Catalog No.
Product Name
Application
Product Information
Citations
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Impurity of Darifenacin
(±)-Darifenacin N-Oxide is an impurity of the selective M3 muscarinic receptor antagonist Darifenacin. This compound may serve as a reference standard in analytical chemistry and pharmacological studies involving Darifenacin. Its characterization is crucial for ensuring the purity and efficacy of Darifenacin in various research applications. -
MOF
4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis, specifically targeting the biosynthetic pathway of porphyrins. It exhibits biological activity by interfering with key enzymatic processes involved in heme formation. This compound is useful in studies related to iron metabolism, porphyrias, and the regulation of heme-dependent enzymes in various biological contexts. Its application in chemical research provides valuable insight into metabolic regulation and related disorders. -
Biochemical Reagent
Citrate synthase is an essential enzyme that catalyzes the initial step of the citric acid cycle, facilitating the condensation of acetyl-CoA and oxaloacetate to produce citrate. This enzyme is primarily located in the mitochondrial matrix of eukaryotic cells. Citrate synthase plays a crucial role in cellular metabolism and energy production, making it a valuable biochemical reagent for research applications related to metabolic pathways and mitochondrial function. -
Biochemical Assay Reagent
β-D-Glucose is a monosaccharide that serves as a primary energy source for cells and plays a crucial role in various metabolic pathways. Its chemical properties allow it to be a significant component in both plant and animal tissues, where it is easily metabolized to produce cellular energy. In research applications, β-D-Glucose is utilized as a biochemical assay reagent and serves essential roles in studying metabolic processes, cell culture, and energy production mechanisms. -
MOF
Glutaric acid, a C5 dicarboxylic acid, serves as a key intermediate in the catabolic pathways of lysine and tryptophan. It plays a critical role in influencing pericyte contractility and migration, thereby impacting vascular dynamics. In addition, glutaric acid is recognized as a biomarker in the diagnosis of glutaric aciduria type I, making it relevant for studies in metabolic disorders and related pathways. -
Biochemical Assay Reagent
Fumaric acid disodium, a biochemical assay reagent, serves as a crucial tool in various life science research applications. This compound is utilized for its role in metabolic processes, enabling investigations into biochemical pathways and cellular functions. Its ability to modulate enzymatic activity makes it an essential component for experimental setups aimed at understanding metabolic disorders and cellular metabolism. -
Biochemical Reagent
(S)-2-Aminohexanedioic acid is a biochemical reagent primarily utilized in life science research as a building block in the synthesis of peptides and other organic compounds. This compound plays a crucial role in studies involving amino acid metabolism and protein function. Its application extends to various biochemical assays and experimental models aimed at understanding metabolic pathways and cellular processes. -
Drug Intermediate
m-Tolylacetic acid, also known as 3-Methylbenzeneacetic acid, serves as a hydroaromatic dicarboxylic acid and is commonly found as a metabolite of tolueneacetic acid in urine. This compound is primarily utilized as a drug intermediate, facilitating the synthesis of more complex organic molecules in pharmaceutical research. Its unique structure makes it a valuable component in the development of various bioactive compounds. -
Eszopiclone Impurity
RP 48497 is a photodegradation product and impurity of Eszopiclone, a non-benzodiazepine compound utilized in the management of insomnia. This compound serves as a valuable tool in pharmaceutical research and quality control, aiding in the assessment of Eszopiclone's stability and purity. Its analysis can contribute to a deeper understanding of the drug's degradation pathways and potential effects on efficacy and safety. -
Fexofenadine Impurity
Meta-Fexofenadine is a known impurity of Fexofenadine, which serves as an antihistamine by targeting the H1 receptor (H1R) and is primarily utilized for the treatment of allergic conditions such as seasonal allergic rhinitis and chronic idiopathic urticarial. This compound can be critical for analytical research, particularly in the study of drug purity, metabolic pathways, and formulation development. Its presence is significant in ensuring the quality and safety of Fexofenadine-based therapeutic products. -
Nifedipine Impurity
m-Nifedipine is an impurity associated with Nifedipine, a well-known calcium channel blocker. Nifedipine primarily targets L-type calcium channels, resulting in the relaxation of vascular smooth muscle, which is beneficial in the treatment of cardiac insufficiencies and hypertension. The study of m-Nifedipine may provide insights into the stability, quality, and potential side effects of Nifedipine formulations in pharmaceutical research. -
Impurity of Methotrexate
1,1,3-Tribromoacetone is identified as an impurity of Methotrexate, an established antimetabolite and antifolate that targets dihydrofolate reductase. By inhibiting this enzyme, Methotrexate effectively disrupts the conversion of folic acid to tetrahydrofolate, leading to a significant reduction in DNA synthesis. This compound can be utilized in the study of Methotrexate's pharmacological profiles and potential impurities in biological research. -
Biochemical Assay Reagent
2-(Benzhydrylsulfinyl)acetic acid is a biochemical assay reagent and a known metabolite of modafinil. This compound serves as a useful tool for studying metabolic pathways and pharmacokinetics of modafinil and related compounds. Its unique chemical structure can aid in investigations related to neurotransmitter regulation and cognitive enhancement research. -
Impurity of Palbociclib
N-Methyl Palbociclib is an impurity of Palbociclib, a selective inhibitor of CDK4 and CDK6. This compound is primarily used in analytical studies to assess the purity and quality of Palbociclib formulations. Its relevance in research includes characterization of CDK inhibition and investigations into cell cycle regulation in cancer therapy. -
Impurity of Febuxostat
Febuxostat amide impurity is a known impurity associated with the compound Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. The presence of this impurity can be significant for analytical applications and the assessment of the purity in pharmaceutical formulations. It serves as an important reference material for researchers investigating the chemical integrity and efficacy of xanthine oxidase inhibitors in various biological contexts. -
Osimertinib Mesylate Impurity
Rezivertinib analogue 1 is recognized as a process impurity of osimertinib mesylate, a potent inhibitor of EGFR mutations. This compound serves as a valuable tool in the research of non-small cell lung cancer, facilitating the investigation of drug efficacy and safety profiles in therapeutic applications. Its role in characterizing impurities enhances understanding of the pharmacological landscape surrounding osimertinib-related treatments. -
Labetalol Impurity
Labetalone hydrochloride is an impurity of Labetalol, an orally active adrenoceptor blocking agent. It functions as a competitive antagonist at both alpha- and beta-adrenoceptor sites, contributing to the pharmacological profile of Labetalol. This compound is primarily used in research applications related to cardiovascular pharmacology and the study of adrenoceptor interactions. -
Febuxostat Impurity
Febuxostat sec-butoxy acid is a known impurity of Febuxostat, a selective inhibitor of xanthine oxidase with a Ki of 0.6 nM. This compound serves as a reference standard for analytical and quality control processes in pharmaceutical research. It is essential for investigating the purity and composition of Febuxostat formulations, as well as for understanding the implications of impurities in therapeutic contexts. -
Atorvastatin Impurity
Atorvastatin 3-Deoxyhept-2E-Enoic Acid, a known impurity of Atorvastatin, functions primarily as an HMG-CoA reductase inhibitor. This compound plays a critical role in lipid metabolism regulation and is utilized for analysis in pharmaceutical development and quality control of Atorvastatin formulations. Its presence and characterization are essential for ensuring the purity and efficacy of atorvastatin-based therapies to manage hyperlipidemia and cardiovascular diseases. -
Venetoclax Impurity
Venetoclax N-oxide is an impurity of the Bcl-2 inhibitor Venetoclax (ABT-199; GDC-0199), which exhibits exceptional potency with a Ki value lower than 0.01 nM. This compound serves as a valuable reference for the synthesis and characterization of Venetoclax, and is essential for ensuring the quality and consistency of research involving Bcl-2 modulation. Its analysis is relevant for studies investigating therapeutic applications in hematological malignancies and other conditions associated with dysregulated Bcl-2 activity. -
Cetirizine Impurity
Deschloro Cetirizine dihydrochloride is an impurity of Cetirizine, a second-generation antihistamine and a carboxylated metabolite of hydroxyzine. This compound acts as a selective and orally active histamine H1-receptor antagonist, exhibiting long-lasting antihistaminic effects. It is primarily used in biochemical research aimed at understanding the purity and composition of antihistamine formulations. -
Gefitinib Impurity
Gefitinib impurity 5 is a chemical impurity associated with Gefitinib, a selective EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. This compound effectively inhibits EGF-stimulated tumor cell proliferation (IC50 of 54 nM) and blocks EGFR autophosphorylation in tumor cells, contributing to its antitumor efficacy. Additionally, Gefitinib has been shown to induce autophagy, making it a valuable reagent for research in cancer biology and drug development. -
Acetaminophen Impurity
4-Hydroxyacetophenone oxime is recognized as an impurity of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic. This compound acts as an inhibitor of cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2), contributing to the pharmacological profile of Acetaminophen. It serves as a useful reference for analytical and quality control studies related to Acetaminophen formulations. -
Linezolid Impurity
(R)-Linezolid is an impurity associated with Linezolid (PNU-100766), the first oxazolidinone-synthetic antibiotic. It functions by inhibiting the initiation phase of bacterial protein synthesis, effectively targeting various gram-positive bacteria. This reagent is valuable for research focused on antibiotic characterization, development of new antibacterial agents, and understanding resistance mechanisms. -
Rapamycin Impurity
28-Epirapamycin is an impurity of Rapamycin, a well-characterized inhibitor of the mechanistic target of rapamycin (mTOR). It exhibits potent biological activity with an inhibitory concentration (IC50) of 0.1 nM in HEK293 cells. This compound is primarily utilized for research involving mTOR signaling pathways and cellular growth regulation. It is valuable for studies focused on cancer, metabolic disorders, and age-related diseases. -
Impurity of Febuxostat
Febuxostat dicarboxylic acid impurity is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. This impurity is utilized in chemical analysis and quality control processes in the pharmaceutical industry to ensure the purity and efficacy of Febuxostat formulations. Its characterization is crucial for compliance with regulatory standards and for optimizing drug development protocols. -
Impurity
Captopril EP Impurity D is identified as an impurity associated with Captopril, an angiotensin-converting enzyme (ACE) inhibitor. It serves as a reference standard in pharmaceutical quality control and analytical testing to ensure the purity and compliance of Captopril formulations. This compound is critical for researchers monitoring the chemical profile and safety of ACE inhibitors in drug development and therapeutic applications. -
Chlorthalidone Impurity
Chlorthalidone impurity is a metabolite of the thiazide-like diuretic Chlorthalidone, primarily targeting sodium reabsorption in the renal tubules. This impurity is important for studies involving metabolic pathways and pharmacokinetics of Chlorthalidone. It is particularly relevant for research into hypertension treatment and the identification of potential off-target effects or interactions. -
Drug intermediate
4-Methoxybenzenecarbothioamide is a synthetic intermediate primarily employed in pharmaceutical synthesis. This compound is synthesized through the reaction of 4-methoxybenzamide with phosphorus pentasulfide, facilitating the creation of various thioamide derivatives. Its unique structure and reactivity make it a valuable building block for the development of biologically active molecules in chemical research. -
Vardenafil Impurity
Vardenafil N-oxide is an N-Oxide impurity of Vardenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor. This compound serves as an important analytical standard for quality control and characterization of Vardenafil formulations in pharmaceutical research. Its presence may impact the pharmacokinetics and efficacy of Vardenafil, making it relevant for studies on drug metabolism and safety assessments. -
Simvastatin Impurity
Anhydrosimvastatin is an impurity of Simvastatin, a known competitive inhibitor of HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis. This compound is primarily used in research to assess the purity and quality of Simvastatin preparations. Its characterization is essential for studies evaluating the pharmaceutical formulations and metabolic pathways influenced by cholesterol-lowering therapies. -
Trityl olmesartan medoxomil Impurity
Trityl olmesartan medoxomil impurity III is a characterized impurity of Trityl olmesartan medoxomil, which itself serves as an intermediate in the synthesis of Olmesartan medoxomil. This compound is utilized in chemical research to evaluate the purity of olmesartan formulations and assess related synthesis methods. Its presence as an impurity is crucial for understanding the intricacies of drug development and quality control processes within the pharmaceutical industry. -
Atorvastatin Impurity
Difluoro atorvastatin is an impurity of the HMG-CoA reductase inhibitor atorvastatin. This compound demonstrates significant activity by effectively reducing blood lipid levels. Additionally, difluoro atorvastatin is known to inhibit the proliferation and invasion of human smooth muscle cells, exhibiting IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a useful reference compound in the evaluation of atorvastatin purity and related studies in cholesterol management and cardiovascular research. -
Febuxostat Impurity
Febuxostat impurity 7 is a chemical impurity related to Febuxostat, a selective xanthine oxidase inhibitor with a Ki value of 0.6 nM. This impurity is important for quality control and characterization in drug development and analytical chemistry applications involving Febuxostat. Understanding its properties can aid in assessing the purity and stability of formulations containing Febuxostat. -
Daclatasvir Impurity
Daclatasvir Impurity C is a chemical impurity associated with Daclatasvir, a potent inhibitor of the Hepatitis C virus (HCV) NS5A protein. Its characterization is essential for assessing the purity and quality of Daclatasvir in pharmaceutical formulations. This reagent is valuable for researchers focusing on the pharmacological properties of antiviral compounds and for ensuring compliance in drug development processes. -
Hydroxychloroquine Impurity
Hydroxychloroquine Impurity F is a structural impurity associated with Hydroxychloroquine, a synthetic antimalarial agent. This compound demonstrates the ability to inhibit Toll-like receptor 7/9 (TLR7/9) signaling pathways. Hydroxychloroquine has also been shown to effectively inhibit SARS-CoV-2 infection in vitro, making it a significant focus of research in virology and immunology. -
Prasugrel Impurity
Prasugrel chloride impurity is a chemical impurity associated with Prasugrel, extracted from patent US20130345428A1, line 0053. Prasugrel serves as a potent and orally active antagonist of the P2Y12 receptor, effectively inhibiting ADP-induced platelet aggregation. This reagent is useful for research applications related to platelet function and thrombotic disorders, aiding in the assessment of drug purity and compliance in pharmaceutical formulations. -
Impurity of Cetirizine 3-chloro
Cetirizine 3-chloro impurity is a structural variant of Cetirizine 3-chloro, primarily analyzed for its potential effects on pharmacological activity. As an impurity, it is relevant in various quality control and analytical chemistry applications when assessing the purity of Cetirizine formulations. The characterization of this impurity is essential for ensuring the safety and efficacy of related pharmaceutical products. -
Atorvastatin Impurity
3-Oxo Atorvastatin is an impurity of atorvastatin, which acts as an HMG-CoA reductase inhibitor. This compound is critical in studying the metabolic pathways associated with cholesterol synthesis and lipid regulation. Its role as an impurity is essential for accurately assessing the purity and efficacy of atorvastatin in pharmaceutical formulations and research applications. -
Remdesivir Impurity
Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of the antiviral agent Remdesivir, a nucleoside analogue primarily targeting viral RNA synthesis. This compound is relevant in assessing the purity and efficacy of Remdesivir, which has demonstrated potent antiviral activity against SARS-CoV and MERS-CoV, with EC50 values of 74 nM in human airway epithelial cells and 30 nM against murine hepatitis virus in delayed brain tumor cells. Research involving this impurity can aid in the development and validation of antiviral therapeutics, particularly in the context of COVID-19. -
Gefitinib Impurity
Gefitinib impurity 1 is a known impurity associated with the tyrosine kinase inhibitor gefitinib, which specifically targets the epidermal growth factor receptor (EGFR). This compound plays a role in research applications aimed at understanding gefitinib's mechanism of action and its effects on EGF-stimulated tumor cell proliferation. Gefitinib demonstrates a potent inhibitory effect on EGFR autophosphorylation and tumor cell growth, making it valuable for studies related to cancer therapeutics and the exploration of resistance mechanisms in oncological research. -
Macamide Impurity
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide is a known impurity of Macamide, primarily utilized in the study of lipid metabolism and signaling pathways. This compound can be valuable for researchers investigating the biological effects of macamide derivatives and their potential role in modulating cellular processes. Its distinct chemical structure allows for the exploration of its impacts on various biological systems. -
Drug Impurity
Clozapine impurity 3 is a known impurity associated with the antipsychotic agent Clozapine. It serves as a critical reference material for assessing the purity and quality of Clozapine formulations. This reagent is essential for research and analytical applications focused on drug development, impurity profiling, and safety assessments of pharmaceutical compounds. -
Cetilistat Impurity
Cetilistat impurity 1 is a known impurity of the anti-obesity agent Cetilistat, which inhibits pancreatic lipase. This compound demonstrates significant biological activity, inhibiting both rat and human pancreatic lipase with IC50 values of 54.8 nM and 5.95 nM, respectively. It is primarily utilized in research to assess the purity and efficacy of Cetilistat and related formulations in obesity-related studies. -
Daclatasvir Impurity
Daclatasvir Impurity B is an impurity of the antiviral agent Daclatasvir, which targets the HCV NS5A protein. This compound is significant for quality control and analytical purposes in the synthesis and formulation of Daclatasvir. It may also be utilized in research applications aimed at understanding the pharmacological properties and stability of Daclatasvir. -
Biochemical Assay Reagent
N-Isobutyryl-L-cysteine is a chiral derivatizing agent that facilitates the separation of amino acid enantiomers in biochemical assays. Its ability to react with amino acids enhances chromatographic resolution, making it an essential reagent in stereochemical analysis and purity assessment of chiral compounds. This reagent is valuable for researchers studying enantiomeric differences in various biological processes. -
Ester Product
Nervonate sodium is an ester compound known for its role in biochemical research. It serves as a valuable reagent for studies involving lipid metabolism and cellular signaling pathways. Its capacity to influence cellular functions makes it applicable in investigations of neurological processes and disorders. -
Biochemical Assay Reagent
[1,4-Bis(diphenylphosphino)butane](1,5-cyclooctadiene)rhodium(I) tetrafluoroborate is a rhodium-containing catalyst primarily utilized for regioselective hydrogenation and enantioselective reductive amination reactions. Its unique ligand framework allows for enhanced selectivity in various biochemical assays. This reagent is valuable for synthesizing chiral compounds and studying reaction mechanisms in organic chemistry. -
Biochemical Assay Reagent
5,10,15,20-Tetrakis(4-methoxyphenyl)-21H,23H-porphine iron(III) chloride is a metalloporphyrin complex centered around iron(III). It is primarily employed as a biochemical assay reagent, facilitating studies on metalloproteins and their interactions. This compound showcases significant biological activity, making it suitable for various research applications including sensor development, catalytic studies, and photodynamic therapy. -
Biochemical Assay Reagent
P(o-tol)3 Pd G2 ChemBeads is a stable and air-tolerant catalyst that incorporates a bulky, electron-rich dialkylbiaryl phosphine designed for palladium-catalyzed cross-coupling reactions. This reagent demonstrates excellent catalytic activity, facilitating the formation of carbon-carbon bonds in various biochemical assays. It is particularly useful in synthetic organic chemistry, enabling researchers to efficiently explore complex molecular architectures.
