Catalog No.
Product Name
Application
Product Information
Citations
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Febuxostat Impurity
Febuxostat sec-butoxy acid is a known impurity of Febuxostat, a selective inhibitor of xanthine oxidase with a Ki of 0.6 nM. This compound serves as a reference standard for analytical and quality control processes in pharmaceutical research. It is essential for investigating the purity and composition of Febuxostat formulations, as well as for understanding the implications of impurities in therapeutic contexts. -
Atorvastatin Impurity
Atorvastatin 3-Deoxyhept-2E-Enoic Acid, a known impurity of Atorvastatin, functions primarily as an HMG-CoA reductase inhibitor. This compound plays a critical role in lipid metabolism regulation and is utilized for analysis in pharmaceutical development and quality control of Atorvastatin formulations. Its presence and characterization are essential for ensuring the purity and efficacy of atorvastatin-based therapies to manage hyperlipidemia and cardiovascular diseases. -
Venetoclax Impurity
Venetoclax N-oxide is an impurity of the Bcl-2 inhibitor Venetoclax (ABT-199; GDC-0199), which exhibits exceptional potency with a Ki value lower than 0.01 nM. This compound serves as a valuable reference for the synthesis and characterization of Venetoclax, and is essential for ensuring the quality and consistency of research involving Bcl-2 modulation. Its analysis is relevant for studies investigating therapeutic applications in hematological malignancies and other conditions associated with dysregulated Bcl-2 activity. -
Cetirizine Impurity
Deschloro Cetirizine dihydrochloride is an impurity of Cetirizine, a second-generation antihistamine and a carboxylated metabolite of hydroxyzine. This compound acts as a selective and orally active histamine H1-receptor antagonist, exhibiting long-lasting antihistaminic effects. It is primarily used in biochemical research aimed at understanding the purity and composition of antihistamine formulations. -
Gefitinib Impurity
Gefitinib impurity 5 is a chemical impurity associated with Gefitinib, a selective EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. This compound effectively inhibits EGF-stimulated tumor cell proliferation (IC50 of 54 nM) and blocks EGFR autophosphorylation in tumor cells, contributing to its antitumor efficacy. Additionally, Gefitinib has been shown to induce autophagy, making it a valuable reagent for research in cancer biology and drug development. -
Acetaminophen Impurity
4-Hydroxyacetophenone oxime is recognized as an impurity of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic. This compound acts as an inhibitor of cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2), contributing to the pharmacological profile of Acetaminophen. It serves as a useful reference for analytical and quality control studies related to Acetaminophen formulations. -
Linezolid Impurity
(R)-Linezolid is an impurity associated with Linezolid (PNU-100766), the first oxazolidinone-synthetic antibiotic. It functions by inhibiting the initiation phase of bacterial protein synthesis, effectively targeting various gram-positive bacteria. This reagent is valuable for research focused on antibiotic characterization, development of new antibacterial agents, and understanding resistance mechanisms. -
Rapamycin Impurity
28-Epirapamycin is an impurity of Rapamycin, a well-characterized inhibitor of the mechanistic target of rapamycin (mTOR). It exhibits potent biological activity with an inhibitory concentration (IC50) of 0.1 nM in HEK293 cells. This compound is primarily utilized for research involving mTOR signaling pathways and cellular growth regulation. It is valuable for studies focused on cancer, metabolic disorders, and age-related diseases. -
Impurity of Febuxostat
Febuxostat dicarboxylic acid impurity is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor that exhibits a Ki of 0.6 nM. This impurity is utilized in chemical analysis and quality control processes in the pharmaceutical industry to ensure the purity and efficacy of Febuxostat formulations. Its characterization is crucial for compliance with regulatory standards and for optimizing drug development protocols. -
Impurity
Captopril EP Impurity D is identified as an impurity associated with Captopril, an angiotensin-converting enzyme (ACE) inhibitor. It serves as a reference standard in pharmaceutical quality control and analytical testing to ensure the purity and compliance of Captopril formulations. This compound is critical for researchers monitoring the chemical profile and safety of ACE inhibitors in drug development and therapeutic applications. -
Chlorthalidone Impurity
Chlorthalidone impurity is a metabolite of the thiazide-like diuretic Chlorthalidone, primarily targeting sodium reabsorption in the renal tubules. This impurity is important for studies involving metabolic pathways and pharmacokinetics of Chlorthalidone. It is particularly relevant for research into hypertension treatment and the identification of potential off-target effects or interactions. -
Drug intermediate
4-Methoxybenzenecarbothioamide is a synthetic intermediate primarily employed in pharmaceutical synthesis. This compound is synthesized through the reaction of 4-methoxybenzamide with phosphorus pentasulfide, facilitating the creation of various thioamide derivatives. Its unique structure and reactivity make it a valuable building block for the development of biologically active molecules in chemical research. -
Vardenafil Impurity
Vardenafil N-oxide is an N-Oxide impurity of Vardenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor. This compound serves as an important analytical standard for quality control and characterization of Vardenafil formulations in pharmaceutical research. Its presence may impact the pharmacokinetics and efficacy of Vardenafil, making it relevant for studies on drug metabolism and safety assessments. -
Simvastatin Impurity
Anhydrosimvastatin is an impurity of Simvastatin, a known competitive inhibitor of HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis. This compound is primarily used in research to assess the purity and quality of Simvastatin preparations. Its characterization is essential for studies evaluating the pharmaceutical formulations and metabolic pathways influenced by cholesterol-lowering therapies. -
Trityl olmesartan medoxomil Impurity
Trityl olmesartan medoxomil impurity III is a characterized impurity of Trityl olmesartan medoxomil, which itself serves as an intermediate in the synthesis of Olmesartan medoxomil. This compound is utilized in chemical research to evaluate the purity of olmesartan formulations and assess related synthesis methods. Its presence as an impurity is crucial for understanding the intricacies of drug development and quality control processes within the pharmaceutical industry. -
Atorvastatin Impurity
Difluoro atorvastatin is an impurity of the HMG-CoA reductase inhibitor atorvastatin. This compound demonstrates significant activity by effectively reducing blood lipid levels. Additionally, difluoro atorvastatin is known to inhibit the proliferation and invasion of human smooth muscle cells, exhibiting IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a useful reference compound in the evaluation of atorvastatin purity and related studies in cholesterol management and cardiovascular research. -
Febuxostat Impurity
Febuxostat impurity 7 is a chemical impurity related to Febuxostat, a selective xanthine oxidase inhibitor with a Ki value of 0.6 nM. This impurity is important for quality control and characterization in drug development and analytical chemistry applications involving Febuxostat. Understanding its properties can aid in assessing the purity and stability of formulations containing Febuxostat. -
Daclatasvir Impurity
Daclatasvir Impurity C is a chemical impurity associated with Daclatasvir, a potent inhibitor of the Hepatitis C virus (HCV) NS5A protein. Its characterization is essential for assessing the purity and quality of Daclatasvir in pharmaceutical formulations. This reagent is valuable for researchers focusing on the pharmacological properties of antiviral compounds and for ensuring compliance in drug development processes. -
Hydroxychloroquine Impurity
Hydroxychloroquine Impurity F is a structural impurity associated with Hydroxychloroquine, a synthetic antimalarial agent. This compound demonstrates the ability to inhibit Toll-like receptor 7/9 (TLR7/9) signaling pathways. Hydroxychloroquine has also been shown to effectively inhibit SARS-CoV-2 infection in vitro, making it a significant focus of research in virology and immunology. -
Prasugrel Impurity
Prasugrel chloride impurity is a chemical impurity associated with Prasugrel, extracted from patent US20130345428A1, line 0053. Prasugrel serves as a potent and orally active antagonist of the P2Y12 receptor, effectively inhibiting ADP-induced platelet aggregation. This reagent is useful for research applications related to platelet function and thrombotic disorders, aiding in the assessment of drug purity and compliance in pharmaceutical formulations. -
Impurity of Cetirizine 3-chloro
Cetirizine 3-chloro impurity is a structural variant of Cetirizine 3-chloro, primarily analyzed for its potential effects on pharmacological activity. As an impurity, it is relevant in various quality control and analytical chemistry applications when assessing the purity of Cetirizine formulations. The characterization of this impurity is essential for ensuring the safety and efficacy of related pharmaceutical products. -
Atorvastatin Impurity
3-Oxo Atorvastatin is an impurity of atorvastatin, which acts as an HMG-CoA reductase inhibitor. This compound is critical in studying the metabolic pathways associated with cholesterol synthesis and lipid regulation. Its role as an impurity is essential for accurately assessing the purity and efficacy of atorvastatin in pharmaceutical formulations and research applications. -
Remdesivir Impurity
Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of the antiviral agent Remdesivir, a nucleoside analogue primarily targeting viral RNA synthesis. This compound is relevant in assessing the purity and efficacy of Remdesivir, which has demonstrated potent antiviral activity against SARS-CoV and MERS-CoV, with EC50 values of 74 nM in human airway epithelial cells and 30 nM against murine hepatitis virus in delayed brain tumor cells. Research involving this impurity can aid in the development and validation of antiviral therapeutics, particularly in the context of COVID-19. -
Gefitinib Impurity
Gefitinib impurity 1 is a known impurity associated with the tyrosine kinase inhibitor gefitinib, which specifically targets the epidermal growth factor receptor (EGFR). This compound plays a role in research applications aimed at understanding gefitinib's mechanism of action and its effects on EGF-stimulated tumor cell proliferation. Gefitinib demonstrates a potent inhibitory effect on EGFR autophosphorylation and tumor cell growth, making it valuable for studies related to cancer therapeutics and the exploration of resistance mechanisms in oncological research. -
Macamide Impurity
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide is a known impurity of Macamide, primarily utilized in the study of lipid metabolism and signaling pathways. This compound can be valuable for researchers investigating the biological effects of macamide derivatives and their potential role in modulating cellular processes. Its distinct chemical structure allows for the exploration of its impacts on various biological systems. -
Drug Impurity
Clozapine impurity 3 is a known impurity associated with the antipsychotic agent Clozapine. It serves as a critical reference material for assessing the purity and quality of Clozapine formulations. This reagent is essential for research and analytical applications focused on drug development, impurity profiling, and safety assessments of pharmaceutical compounds. -
Cetilistat Impurity
Cetilistat impurity 1 is a known impurity of the anti-obesity agent Cetilistat, which inhibits pancreatic lipase. This compound demonstrates significant biological activity, inhibiting both rat and human pancreatic lipase with IC50 values of 54.8 nM and 5.95 nM, respectively. It is primarily utilized in research to assess the purity and efficacy of Cetilistat and related formulations in obesity-related studies. -
Daclatasvir Impurity
Daclatasvir Impurity B is an impurity of the antiviral agent Daclatasvir, which targets the HCV NS5A protein. This compound is significant for quality control and analytical purposes in the synthesis and formulation of Daclatasvir. It may also be utilized in research applications aimed at understanding the pharmacological properties and stability of Daclatasvir. -
Diagnostic Imaging Agent
Etarfolatide is a noninvasive diagnostic imaging agent that targets folate receptor expression. Upon radiolabeling, it facilitates the visualization of tumors, making it particularly valuable in research related to ovarian cancer and disease diagnosis. Its application in imaging studies allows for better assessment of folate receptor status in various malignancies. -
Impurity of DM1
DM1 Impurity is a byproduct associated with the synthesis of Mertansine (DM1), a potent linker drug used in antibody-drug conjugates. This impurity is critical for analytical purposes, enabling researchers to assess the purity and stability of Mertansine formulations. Its identification and quantification are essential in ensuring the quality control of therapeutic agents that utilize DM1 in clinical applications. -
Phosphoramidite Derivative
DMT-2′Fluoro-dU Phosphoramidite is a phosphoramidite derivative of uridine with a fluorine atom at the 2' position. This reagent is designed for nucleoside modification, enabling the synthesis of modified DNA sequences. It is particularly useful in the development of oligonucleotides for applications in molecular biology and genetic research. -
Phosphoramidite Monomer
2'-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer designed for oligonucleotide synthesis. This compound incorporates a 2'-O-methyl group, which enhances the stability and hybridization properties of RNA oligonucleotides. It is particularly useful in studies involving RNA structure, function, and therapeutics, enabling researchers to create modified nucleic acids with improved pharmacological profiles. -
5-Fluoro-2'-deoxycytidine Phosphoramidite
DMTr-5-fluoro-2'-deoxycytidine-phosphoramidite functions as a phosphoramidite derivative of 5-fluoro-2'-deoxycytidine, specifically designed for use in solid-phase oligonucleotide synthesis. This reagent enables the incorporation of the nucleoside analogue into DNA sequences, facilitating studies of nucleotide metabolism, DNA repair mechanisms, and the effects of fluorinated nucleotides on enzyme activity. Its chemical structure allows for efficient coupling and enhances the stability of synthesized oligonucleotides, contributing to a range of molecular biology applications. -
Ibuprofen Impurity
p-Ethylhydratropic acid is identified as a notable impurity found in ibuprofen, which functions as a potent and selective inhibitor of cyclooxygenase-1 (COX-1). Its presence in pharmaceutical formulations is significant for quality control and analytical studies. Research applications may include the characterization of ibuprofen derivatives and the investigation of their respective pharmacological profiles. -
Impurity
11β-Misoprostol is an impurity derived from the synthesis of Misoprostol, a 15-deoxy-16-hydroxy-16-methyl analog of prostaglandin E1 (PGE1). Its structural characteristics may be important in assessing the quality and purity of Misoprostol preparations. Researchers may utilize 11β-Misoprostol in analytical studies focused on impurity profiling and quality control within pharmaceutical formulations. -
Impurity
Isopropyl 5-(diphenylphosphoryl)pentanoate is an impurity associated with Latanoprost, a prostaglandin analog used in the treatment of glaucoma. This compound serves as a reference material for assessing the purity and quality of Latanoprost formulations. Its presence and characterization are critical for regulatory compliance and ensuring product safety in pharmaceutical research and development. -
Exenatide Impurity
(Des-Gly2)-Exenatide is a structural variant of Exenatide, acting as an impurity in this peptide-based drug. Its presence is significant for quality control and purity assessment in pharmaceutical formulations. Researchers utilize this compound to study the stability and degradation pathways of Exenatide, enhancing analytical methods within peptide characterization and drug development processes. -
Atorvastatin Impurity
O-Methyl Atorvastatin calcium serves as an impurity of Atorvastatin, a well-established 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This compound is primarily utilized in research to study the metabolic effects of HMG-CoA inhibitors and their role in lipid regulation. Its biological activity includes the effective reduction of cholesterol levels, making it significant for investigations into cardiovascular disease and dyslipidemia. -
Imatinib Impurity
Imatinib Impurity E is a specific impurity associated with the tyrosine kinase inhibitor Imatinib. Imatinib selectively targets BCR/ABL, PDGFR, and c-Kit kinases, inhibiting their activity by binding near the ATP binding site, thereby stabilizing a closed conformation and reducing enzyme activity. This compound is significant in research focused on cancer treatments and has also demonstrated inhibitory effects against viruses such as SARS-CoV and MERS-CoV. -
Impurity of Atorvastatin
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin, a potent HMG-CoA reductase inhibitor. This compound demonstrates the capacity to effectively lower blood lipid levels and has been shown to inhibit human smooth muscle cell proliferation and invasion with IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a valuable reference for studies involving atorvastatin's pharmacological properties and mechanisms of action. -
Atorvastatin Impurity
Desfluoro-atorvastatin is an impurity of Atorvastatin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. This compound is primarily used in the evaluation and characterization of Atorvastatin's purity in pharmaceutical formulations. Its relevance in lipid-lowering research underscores the importance of monitoring impurities that may influence therapeutic efficacy and safety. -
Febuxostat Impurity
Febuxostat impurity 6 is a known impurity associated with Febuxostat, a selective xanthine oxidase inhibitor with a Ki of 0.6 nM. This impurity is relevant for analytical studies and quality control during the synthesis of Febuxostat. Researchers may utilize Febuxostat impurity 6 to assess the purity of pharmaceutical formulations and investigate potential side effects linked to impurities in drug development. -
Drug Impurity
Quetiapine impurity 4 is a dimeric impurity associated with quetiapine. This compound is primarily investigated for its relevance in the analysis of the purity of quetiapine formulations. It serves as a useful reference standard for quality control and regulatory compliance in pharmaceutical research, particularly in studies assessing the safety and efficacy of antipsychotic medications. -
Glyphosate Impurity
N-Nitrosoglyphosate sodium is a nitrosamine degradation product and synthetic impurity of glyphosate, primarily targeting the glyphosate molecule. This compound is significant for researchers studying the safety and environmental impact of glyphosate herbicides, as it aids in understanding degradation pathways and potential toxicological effects. Its analysis is crucial for regulatory compliance and assessing impurity levels in glyphosate formulations. -
Atorvastatin Impurity
Atorvastatin acetonide is a known impurity of Atorvastatin, derived from patent WO2011131605A1, Compound 4. Atorvastatin functions primarily as an HMG-CoA reductase inhibitor, demonstrating significant efficacy in lowering blood lipid levels. This compound is useful for research applications focused on lipid metabolism and the evaluation of atorvastatin's synthetic pathways and purity. -
Pemetrexed Impurity
N-Methyl pemetrexed is a notable impurity of Pemetrexed, an antifolate cytotoxic agent. This compound exhibits key biological activity by inhibiting folate-dependent enzymes, making it relevant in cancer research. Its study aids in understanding the pharmacological properties and safety profiles of Pemetrexed in therapeutic applications against various malignancies. -
Drug Intermediate
Org-9768, a derivative of (2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine, serves as a chemical intermediate for the synthesis of mitochondrial permeability transition pore (mPTP) inhibitors. Its potential applications encompass investigations into neurological and cardiovascular disorders, particularly in the context of Parkinson's disease research. The compound is instrumental in exploring therapeutic strategies aimed at modulating mitochondrial function and mitigating disease progression. -
Ivabradine Impurity
Ivabradine impurity 2 is a known impurity of Ivabradine, a selective blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This compound serves as a valuable reference standard for evaluating the purity and quality of Ivabradine formulations. Its characterization is essential for research applications in pharmacology and quality control in pharmaceutical development, particularly in studies related to cardiac function and rhythm management. -
Atorvastatin Impurity
Atorvastatin Epoxy Tetrahydrofuran Impurity is an oxidative degradation product of Atorvastatin, a potent HMG-CoA reductase inhibitor. This impurity may serve as a useful reference standard in quality control and analytical studies, particularly in assessing the integrity of Atorvastatin formulations. Its identification and quantification can provide insights into the stability and degradation pathways of statin compounds in pharmaceutical research. -
Candesartan Cilexetil Impurity
1H-1-Ethyl Candesartan Cilexetil is an impurity associated with the synthesis of Candesartan Cilexetil, an angiotensin II receptor antagonist. This compound may serve as a critical reference standard in the quality control of pharmaceutical formulations containing Candesartan Cilexetil. Its presence and characterization are essential for ensuring the safety and efficacy of products within the cardiovascular therapeutic landscape.
