Catalog No.
Product Name
Application
Product Information
Citations
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Peptide for BH3 Profiling
MS1 peptide is a significant tool for BH3 profiling, designed to enhance the depolarization of mitochondrial membranes in melanoma cells, particularly those pre-treated with Encorafenib. This peptide serves as a valuable research reagent for investigating the mechanisms underlying BRAFV600E melanoma and its response to targeted therapies. Its application facilitates the exploration of apoptotic signaling pathways in cancer research, aiding in the development of novel therapeutic strategies. -
P53 Activating Peptide
PK7088 is a pyrazole-based compound that serves as a specific p53 activating peptide. It facilitates the reactivation of mutant p53, restoring its wild-type functionalities. Due to its ability to enhance p53 activity, PK7088 demonstrates significant anticancer properties, making it a valuable tool in cancer research aimed at targeting p53 mutations. -
Anticancer Peptide
PNC-27 is a chimeric anticancer peptide that targets HDM-2 through its p53-like structure. It induces selective membrane pore formation, leading to the lysis of cancer cells. This reagent is particularly applicable in research focused on acute myeloid leukemia and offers insights into mechanisms of apoptosis and tumor suppression. -
Bioactive Peptide
p53 CBS is a bioactive peptide that corresponds to the consensus binding sequence of the p53 tumor suppressor protein. This peptide is crucial for studying p53-DNA interactions and provides insights into the regulation of gene expression in response to cellular stress. Research applications include elucidating the mechanisms of p53-mediated transcriptional activation and investigating its role in tumorigenesis and apoptosis. -
Peptide
p53 (17-26) is a peptide derived from the MDM2 binding domain of the tumor suppressor p53, with a binding affinity (Kd) of 50 nM for MDM2. This peptide demonstrates significant biological activity by inducing necrosis in cancer cells through disruption of cellular integrity and nuclear membrane damage. Research applications for p53 (17-26) include studies focused on pancreatic cancer and the development of therapeutic strategies targeting MDM2-mediated pathways. -
Tumor Suppressor Peptide
p53 (232-240) is a peptide derived from the 232-240 amino acid sequence of the human tumor suppressor protein p53. This peptide enhances binding affinity to the Major Histocompatibility Complex (MHC), thus increasing its immunogenicity and bolstering the immune system's response to tumor antigens. p53 (232-240) is valuable in cancer vaccine development and studies focused on tumor cell recognition and clearance by immune cells. -
Inducing Peptide
Peptide 234CM is an inducing peptide that features isoleucine at position 3, reflecting a point mutation in p53 codon 234. This peptide is known to elicit strong cytotoxic T cell (CTL) responses and robust antitumor immune responses against the mutant form of p53. It is valuable in immunological research focusing on cancer therapy and the enhancement of immune response mechanisms. -
MDM2/p53 Inhibitor
Phage-derived 12/1 peptide is a potent inhibitor of the MDM2/p53 interaction, effectively disrupting the binding between MDM2 and p53, as well as MDMX and p53. This peptide demonstrates significant antitumor activity, exhibiting IC50 values of 0.15 μM for MDM2 and 1.25 μM for MDMX. It serves as a valuable tool for research investigating the modulation of p53 activity and the therapeutic potential in targeting MDM2/MDMX pathways in cancer. -
Polypeptide
N1-Glutathionyl-spermidine disulfide acts as a substrate for trypanothione reductase, an enzyme critical in the redox regulation of trypanothione in certain organisms. This compound plays a significant role in cellular antioxidant defense mechanisms and is relevant for studies involving oxidative stress and redox biology. Its use can enhance understanding of trypanosomatid parasites and the biochemical pathways they exploit, facilitating research in parasitology and drug development. -
Antiparasitic Agent
Cycloaspeptide A is an antiparasitic agent derived from the endophytic fungus Penicillium janczewskii. It exhibits potent biological activity against various parasitic organisms, making it a valuable tool in parasitology research. This compound holds promise for further exploration in the development of novel therapeutic strategies to combat parasitic infections. -
Tetrapeptide
AGPV is a tetrapeptide that demonstrates potential for the prevention of schistosome parasite infections. This compound may be valuable in research focused on developing novel therapeutic strategies for schistosomiasis, a significant public health concern. Its biological activity warrants exploration in parasitology and drug development applications. -
Chromogenic Peptide Substrate
Bz-Pro-Phe-Arg-pNA is a chromogenic peptide substrate designed for the detection and study of plasma and glandular kallikrein, cysteine proteinase (Cruzipain), and trypsin. This substrate facilitates real-time monitoring of enzyme activity through colorimetric changes, making it a valuable tool in biochemical assays. Additionally, Bz-Pro-Phe-Arg-pNA is applicable in Factor XII assays, enhancing research in coagulation and protease activity. -
Antiplasmodial Peptide
Koshidacin B is an antiplasmodial cyclic tetrapeptide that exhibits potent activity against Plasmodium falciparum, with IC50 values of 0.89 μM for the FCR3 strain and 0.83 μM for the K1 strain. This compound effectively suppresses malaria parasites in vivo, making it a valuable tool for research in parasitic infections and the development of novel antimalarial therapies. -
Cyclodepsipeptide
Isariin D is a cyclodepsipeptide derived from the fungus Isaria felina, known for its potent insecticidal properties. This compound demonstrates significant biological activity against Galleria mellonella larvae, making it a valuable tool in entomological research and pest management studies. Its unique mechanism may provide insights into insect physiology and the development of natural insecticides. -
Cyclodepsipeptide
Isariin A is a cyclodepsipeptide derived from the fungus Isaria cretacea, known for its antimalarial properties. Research indicates its potential efficacy in inhibiting the proliferation of malaria parasites, making it a valuable compound for studies targeting malaria treatment and understanding related biological pathways. -
Cyclodepsipeptide
Isariin B is a cyclodepsipeptide derived from the fungus Isaria felina, recognized for its antimalarial properties. This compound demonstrates significant biological activity against Plasmodium species, making it a valuable tool in malaria research. Its unique structure and mechanism of action offer potential for the development of novel therapeutic agents in combating malaria. -
Retroviral Envelope Peptide
CKS-17 is a synthetic retroviral envelope peptide that targets the highly conserved amino acid sequences within the transmembrane envelope protein of various animal and human retroviruses. This peptide functions as an immunomodulatory epitope, exhibiting suppressive properties on numerous immune functions. CKS-17 is valuable for research applications focused on retroviral biology, immune modulation, and the development of therapeutic strategies against retroviral infections. -
HPV Epitope Peptides Fragment
Human Papillomavirus (HPV) E7 protein (49-57) is a fragment of the E7 protein, specifically the epitope spanning amino acid residues 49 to 57, which is restricted by the H-2d MHC class I molecule. This peptide is vital for studying HPV-induced tumorigenesis and immune response mechanisms. It is commonly utilized in research applications focusing on HPV vaccination, T cell recognition, and the understanding of viral oncogenesis. -
Polypeptide
HHV-2 Envelope Glycoprotein G (552-574) is a polypeptide derived from the glycoprotein G (gG-2) of herpes simplex virus type 2 (HSV-2). This immunodominant region elicits a robust immune response, making it a valuable target for serological studies and vaccine development related to HSV-2. It is critical for understanding the pathogenesis of herpes simplex virus infections and can be used in diagnostic assays to detect HSV-2 specific antibodies. -
FITC Labeled Peptide
FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a fluorescently labeled peptide that targets the immunodominant region of herpes simplex virus type 2 (HSV-2) glycoprotein G (gG-2). This reagent exhibits strong reactivity with HSV-2 sera, making it suitable for various research applications in virology, including antibody detection and vaccine development studies. Its fluorescent labeling facilitates visualization and analysis in cellular assays. -
Virus Replication Inhibitor
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH) is a potent inhibitor of viral replication, targeting and disrupting the membrane fusion activity of viral glycoproteins. This compound is essential for studying viral pathogenesis and developing antiviral therapies, as it effectively impedes the entry of viruses into host cells. Its applications extend to research focused on the mechanisms of viral infections and the exploration of therapeutic strategies to prevent viral replication. -
Peptide
Bursin is a peptide targeting B precursor cells, promoting their phenotypic differentiation in both mammalian and avian systems. This compound is known to enhance cyclic guanosine monophosphate (cGMP) levels in human B-cell lines, such as Daudi. Additionally, Bursin exhibits immunomodulatory properties, which bolster the immune response against infections, including those caused by H9N2. Its applications in immunology and cellular biology research make it a valuable tool for investigating immune mechanisms and enhancing vaccine efficacy. -
Peptide Fragment
NS2 (114-121), Influenza is a peptide fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This influenza epitope is primarily utilized in research focused on CD8+ cytotoxic T lymphocyte (CTL) responses during antiviral immune reactions. NS2 (114-121) serves as an important tool for studying the mechanisms of T cell-mediated immunity against influenza infections. -
HA Peptide Segment
Influenza HA (529-537) is a peptide segment derived from positions 529-537 of hemagglutinin (HA) of the influenza A virus, consisting of the amino acid sequence IYATVAGSL. This peptide is recognized by various specificities of CD8+ cytotoxic T-lymphocyte (CTL) clones, including H1-specific, H2-specific, and H1/H2 cross-reactive responses. Influenza HA (529-537) is instrumental in studying T-cell immune specificity and has potential applications in the design of novel vaccines against influenza. -
Hemagglutinin Peptide
Influenza HA (126-138) is a peptide derived from the hemagglutinin (HA) of the influenza virus, consisting of amino acids 126-138. This peptide induces apoptosis in thymic and peripheral T-cells, making it a valuable tool for investigating T-cell responses to influenza virus infection. It serves as an important reagent for studies in immunology and virology, particularly in the development of vaccines and therapies targeting influenza. -
Peptide
PA (224-233), Influenza is a 10-amino acid peptide derived from the polymerase 2 protein of the influenza A virus. This peptide plays a crucial role in viral RNA synthesis and is important for understanding influenza pathogenesis. It can be utilized in research applications aimed at studying viral replication mechanisms, developing vaccines, and evaluating antiviral drug candidates. -
Bioactive Peptide
Influenza NP (311-325) is a bioactive peptide derived from the nucleoprotein (NP) of the influenza virus, acting as an MHC class II restricted epitope to stimulate host immune responses. This peptide is known for its ability to induce substantial interferon gamma (IFN-γ) production while avoiding activation of CD8 T cells in murine models. Its unique properties make Influenza NP (311-325) a valuable tool for research in immunology and vaccine development. -
Antiviral Peptide
Urumin is an antiviral peptide that targets the conserved stalk of H1 hemagglutinin, exhibiting potent antiviral activity against human influenza A virus. With an IC50 value of 3.8 μM against the PR8 strain, Urumin effectively inhibits the growth of both drug-sensitive and drug-resistant H1 influenza viruses. In preclinical studies, Urumin has demonstrated protective effects in naive mice against lethal influenza infection, highlighting its potential for therapeutic applications in influenza management. -
Antiviral Peptide
Cyclo(-Met-Pro) is a cyclic dipeptide comprised of methionine and proline, serving as an antiviral peptide. It demonstrates weak inhibitory activity against the influenza A virus (H3N2), achieving 2.1% inhibition at a concentration of 5 mM. This compound may be useful in studies targeting viral infections and exploring the structure-activity relationships of peptide-based antivirals. -
Antiparasitic Peptide
LL-37 FK-13 is an antimicrobial peptide that targets Trichomonas vaginalis, demonstrating significant antiparasitic activity. It has been characterized by low cytotoxicity in human fibroblasts and only mild hemolytic effects on human erythrocytes, making it a valuable candidate for research applications involving parasitic infections and related therapeutic strategies. -
Antimicrobial Peptide
Halictine 2 is an antimicrobial peptide that exhibits significant anti-parasitic activity against Leishmania species. It effectively targets both extracellular infective metacyclic promastigotes and intracellular amastigotes, making it a valuable tool for investigating leishmaniasis. This compound is suitable for research focused on the mechanisms of leishmaniasis and potential therapeutic strategies against this parasitic infection. -
Antiviral Peptide
Antiviral agent 76 is an antiviral peptide featuring azide functional groups, specifically designed to inhibit the hepatitis C virus (HCV). This compound demonstrates significant antiviral activity, making it a valuable tool for researching HCV interactions and potential therapeutic strategies. Its unique structure allows for investigations into peptide-based antiviral mechanisms and applications in virology. -
Peptide Substrate
Hepatitis C Virus S5A/5B is a synthetic peptide substrate designed to mimic the NS5A/5B junction of the nonstructural protein (NS) in the Hepatitis C virus. This peptide serves as an effective substrate for studying the activity of HCV NS3 protease, facilitating research on viral replication and proteolytic processing. It is valuable for investigations into antiviral drug development and the molecular mechanisms of HCV pathology. -
HIV-1 TAT Peptide
TAT (YGRKKRRQRRR) is a cell-penetrating peptide derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1). It enhances the solubility and yield of heterologous proteins, making it a valuable tool in research applications related to protein expression and purification. TAT's ability to facilitate cellular uptake has made it a useful reagent in studies exploring intracellular delivery mechanisms and molecular therapeutics. -
HIV-1 Polypeptide
HIV-1 TAT (48-60) is a cell-penetrating peptide derived from residues 48-60 of the HIV-1 Tat protein, functioning as a facilitator for cellular uptake. This peptide enables the effective delivery of exogenous macromolecules into cells without causing disruption to cellular integrity. Its unique mechanism enhances research applications in drug delivery, gene therapy, and the study of intracellular processes associated with HIV-1. -
CD4 Receptor Ligand
Peptide T is an octapeptide derived from the V2 region of the HIV-1 gp120 protein. It functions as a ligand for the CD4 receptor, effectively blocking the interaction between HIV and CD4, thereby inhibiting viral entry into host cells. This compound is essential for research in HIV pathogenesis and therapeutic development targeting CD4 receptor interactions. -
HIV-1 Polypeptide
TAT (48-57) is a cell-permeable peptide derived from the HIV-1 transactivator of transcription (Tat) protein, specifically residues 48 to 57. This peptide facilitates the study of viral gene expression and replication by interacting with intracellular targets to enhance the transcriptional activity of HIV-1. TAT (48-57) is utilized in research applications focused on HIV pathogenesis, viral life cycle analysis, and the development of antiviral strategies. -
Competitive Peptide Against HiBiT
DrkBiT is a competitive peptide that targets HiBiT and is membrane-impermeable. It effectively binds to LgBiT, facilitating studies in the context of HIV-1 infection research. This peptide serves as a valuable tool for understanding viral dynamics and developing potential therapeutic strategies. -
Cell-penetrating Peptide/Delivery Carrier
TAT (47-57) GGG-Cys (Npys) is a cell-penetrating peptide that functions as an effective delivery carrier for therapeutic agents. This peptide facilitates the transport of conjugated drug molecules across biological membranes, enhancing their bioavailability. It is particularly suited for delivering MT1-MMP inhibitors and serves as a valuable tool in research on diseases linked to MT1-MMP activity, including cancer, arthritis, heart disease, and vascular disorders. -
Polypeptide
HIV-1 gag Protein p24 (194-210) is a polypeptide that serves as a critical target for immunoassays in HIV research. This peptide is essential for studying protein interactions and conducting functional analyses, particularly in the context of epitope mapping and agent development. Its application in peptide screening facilitates the identification of active peptides, aiding researchers in advancing their understanding of HIV biology and potential therapeutic strategies. -
HIV Inhibitor
(D-Ala)-Peptide T is an octapeptide that acts as an HIV inhibitor by targeting the HIV-1 envelope glycoprotein gp120. This compound has been shown to release chemokines and protect against neuronal death induced by gp120. It is a valuable reagent for research into infectious diseases and neurological disorders, particularly AIDS-related dementia. -
Polypeptide
HIV-2 Peptide is a polypeptide utilized in research focusing on HIV-2. It serves as a valuable tool for protein interaction studies, functional analysis, and epitope screening, particularly in the context of agent research and development. This peptide facilitates the understanding of immune responses and the development of therapeutic strategies related to HIV-2 infections. -
Peptide
(Cys47)-HIV-1 tat Protein (47-57) is a peptide known for its ability to facilitate membrane translocation. This peptide can be utilized to modify the surface of magnetic pharmaceuticals, significantly enhancing their uptake into target cells. It serves as a valuable tool in drug delivery systems and cellular uptake studies in research applications. -
Cell-Penetrating Peptide
TAT (47-57), FAM-labeled is a cell-penetrating peptide (CPP) that enhances the delivery of therapeutic agents into cells. This peptide facilitates the transport of various cargoes, making it a valuable tool for intracellular drug delivery studies. Its FAM labeling allows for easy monitoring and tracking in biological systems, enabling researchers to explore applications in drug formulation and cellular uptake mechanisms. -
Antimicrobial Peptides
Siamycin III is an antimicrobial peptide that exhibits activity against HIV-1. It is primarily used in research applications focusing on antiviral mechanisms and the development of therapies targeting viral infections. The compound's ability to interfere with viral replication makes it a valuable tool for studies in HIV-1 biology and treatment strategies. -
HIV Entry Inhibitor
T-peptide is an HIV entry inhibitor that functions as a Tuftsin analog, effectively targeting HIV infection. This compound is known to mitigate cellular immunosuppression and enhance survival rates in septic mouse models. Additionally, T-peptide demonstrates the ability to inhibit the growth of residual tumor cells following surgical resection, making it a valuable tool for oncological and infectious disease research applications. -
HIV-1 gp120 Peptide
Peptide T TFA is an octapeptide derived from the V2 region of the HIV-1 gp120 protein. It functions as a ligand for the CD4 receptor, effectively inhibiting the binding of HIV to this receptor. This compound is valuable in research applications focused on HIV-1 infection mechanisms and the development of potential therapeutic interventions. -
HIV Peptide Epitope
HIV gp120 (318-327) is a peptide epitope derived from the C-terminal region of the HIV-1 strain IIIB envelope glycoprotein. This sequence, known as the I10 peptide, is involved in the immune response and is part of the V3 peptide epitope relevant for HIV vaccine research. Although HIV gp120 (318-327) does not contain the A2 anchor residues recognized by cytotoxic T lymphocytes, it possesses structural characteristics that facilitate promiscuous binding to A2, making it valuable for studying HIV immunogenicity and vaccine development. -
HIV-1 Polypeptide
Cys-TAT(47-57) is a cell-penetrating peptide derived from the HIV-1 transactivating protein, specifically comprising the sequence Cys-[HIV-Tat (47-57)]. This arginine-rich peptide facilitates the delivery of therapeutic agents across cellular membranes. It is primarily utilized in research focused on HIV biology and the development of peptide-based drug delivery systems. -
Bioactive Peptide
DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a bioactive peptide that functions as a fluorogenic substrate for HIV-1 protease. This compound is crucial for advancing research in HIV pathology, as it enables continuous monitoring of protease activity through fluorescence resonance energy transfer (FRET) assays. Upon interaction with recombinant HIV-1 protease, cleavage occurs specifically at the Tyr-Pro bond, resulting in a notable increase in fluorescence that correlates with substrate hydrolysis. This substrate provides a reliable alternative to traditional HPLC or electrophoresis techniques for kinetic analysis of retroviral proteases, enhancing the study of HIV maturation and the development of targeted antiviral strategies.
