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Urumin

Catalog No.: A52178
Antiviral Peptide
Urumin is an antiviral peptide that targets the conserved stalk of H1 hemagglutinin, exhibiting potent antiviral activity against human influenza A virus. With an IC50 value of 3.8 μM against the PR8 strain, Urumin effectively inhibits the growth of both drug-sensitive and drug-resistant H1 influenza viruses. In preclinical studies, Urumin has demonstrated protective effects in naive mice against lethal influenza infection, highlighting its potential for therapeutic applications in influenza management.
Urumin 2215863-74-2 Antiviral Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionUrumin is an antiviral peptide that targets the conserved stalk of H1 hemagglutinin, exhibiting potent antiviral activity against human influenza A virus. With an IC50 value of 3.8 μM against the PR8 strain, Urumin effectively inhibits the growth of both drug-sensitive and drug-resistant H1 influenza viruses. In preclinical studies, Urumin has demonstrated protective effects in naive mice against lethal influenza infection, highlighting its potential for therapeutic applications in influenza management.
Product Information
Catalog NumA52178
FormulaC129H198N42O35S2
Molecular Weight2961.34
CAS Number2215863-74-2
SequenceIle-Pro-Leu-Arg-Gly-Ala-Phe-Ile-Asn-Gly-Arg-Trp-Asp-Ser-Gln-Cys-His-Arg-Phe-Ser-Asn-Gly-Ala-Ile-Ala-Cys-Ala
Sequence shorteningIPLRGAFINGRWDSQCHRFSNGAIACA
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CS)=O)C)=O)[C@H](CC)C)=O)C)=O)=O)CC(N)=O)=O)CO)=O)=O)CCCNC(=N)N)=O)=O)CS)=O)CCC(N)=O)=O)CO)=O)CC(O)=O)=O)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(=O)[C@H]4N(C([C@H]([C@H](CC)C)N)=O)CCC4)CC(C)C)=O)CCCNC(=N)N)=O)=O)C)=O)=O)[C@H](CC)C)=O)CC(N)=O)=O)=O)CCCNC(=N)N)=O)C=5C=6C(NC5)=CC=CC6
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