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p53 CBS

Catalog No.: A53857
Bioactive Peptide
p53 CBS is a bioactive peptide that corresponds to the consensus binding sequence of the p53 tumor suppressor protein. This peptide is crucial for studying p53-DNA interactions and provides insights into the regulation of gene expression in response to cellular stress. Research applications include elucidating the mechanisms of p53-mediated transcriptional activation and investigating its role in tumorigenesis and apoptosis.
p53 CBS 721963-21-9 Bioactive Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptionp53 CBS is a bioactive peptide that corresponds to the consensus binding sequence of the p53 tumor suppressor protein. This peptide is crucial for studying p53-DNA interactions and provides insights into the regulation of gene expression in response to cellular stress. Research applications include elucidating the mechanisms of p53-mediated transcriptional activation and investigating its role in tumorigenesis and apoptosis.
Product Information
Catalog NumA53857
FormulaC144H184N42O27S2
Molecular Weight2999.40
CAS Number721963-21-9
SequenceArg-Arg-Arg-Cys-Trp-Trp-Gly-Tyr-Tyr-Tyr-Arg-Arg-Arg-Cys-Trp-Trp-Gly-Tyr-Tyr-Tyr
Sequence shorteningRRRCWWGYYYRRRCWWGYYY
SMILESC([C@@H](C(N[C@@H](CC=1C=2C(NC1)=CC=CC2)C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CC=C(O)C=C5)C(O)=O)=O)=O)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CC7=CC=C(O)C=C7)NC([C@H](CC8=CC=C(O)C=C8)NC(CNC([C@H](CC=9C=%10C(NC9)=CC=CC%10)NC([C@H](CC=%11C=%12C(NC%11)=CC=CC%12)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CS)=O)=O)=O)=O)=O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CS)=O)C=%13C=%14C(NC%13)=CC=CC%14
Synonymsp53 Consensus binding sequence
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