Catalog No.
Product Name
Application
Product Information
Citations
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Neuropeptide Y Y1 Receptor Antagonist
Neuropeptide Y Y1 Receptor Antagonist 1 is a potent antagonist of the neuropeptide Y Y1 receptor (Y1R), exhibiting a Ki value of 0.19 nM. This compound serves as a valuable tool in neurobiology research, facilitating the investigation of neuropeptide signaling pathways and their roles in various physiological processes. Its applications include studying the effects of Y1R modulation on neuroendocrine responses, food intake, and anxiety-related behaviors. -
β-catenin/GSK-3β Activator
C-Peptide 1 (rat) is a peptide that functions as an activator of β-catenin and GSK-3β. Its primary mechanism involves the regulation of the Wnt/β-catenin signaling pathway, which plays a crucial role in cellular processes such as proliferation and differentiation. C-Peptide 1 (rat) is utilized in cancer research, contributing to studies aimed at understanding tumorigenesis and potential therapeutic interventions. -
GSK-3 Substrate
Phospho-Glycogen Synthase Peptide-2 is a specific substrate for glycogen synthase kinase-3 (GSK-3). This peptide facilitates the study of GSK-3 activity and its role in various signaling pathways. It is also suitable for affinity purification of protein-serine kinases, enabling researchers to investigate kinase interactions and functions in cellular processes. -
Antibiotic/Antimicrobial Peptide
Aurein 5.2 is an antimicrobial peptide with potent antibiotic properties. It exhibits broad-spectrum activity against various bacterial strains, making it a valuable tool in studies related to infection control and antibiotic resistance. Its mechanism of action involves disrupting bacterial cell membranes, leading to cell lysis. Aurein 5.2 is applicable in research focused on antimicrobial development and the understanding of peptide-based therapeutics. -
Bioactive Peptide
NRC-16 is a bioactive peptide that functions as a pleurocidin-like cationic antimicrobial peptide (AMP). It exhibits potent antimicrobial activity against a range of pathogens, making it a valuable tool for research in infectious diseases and host defense mechanisms. Its unique properties facilitate studies in peptide structural biology and the development of novel antimicrobial therapies. -
antimicrobial peptides
LZ1 peptide is an antimicrobial peptide that exhibits antimalarial activity. It demonstrates the ability to inhibit the growth of Plasmodium species, making it a valuable candidate for research in malaria treatment and prevention strategies. This peptide can be utilized in studies focusing on the development of novel antimicrobial agents and the mechanisms of host-pathogen interactions. -
Tool Peptide
SP2 is a 14-amino acid synthetic tool peptide that functions by inducing growth arrest in MTLa cells of Candida albicans through modulation of cell cycle regulation. This peptide is valuable for research applications focusing on fungal biology, specifically in understanding the mating type locus and associated regulatory mechanisms. Its unique properties make it an essential reagent for studies investigating cell growth and development in yeast models. -
Antibiotic/Antimicrobial Peptide
Aurein 2.3 is an antibiotic antimicrobial peptide targeting bacterial ATPases, primarily inhibiting E. coli ATPase activity. This compound demonstrates significant antibacterial activity, effectively suppressing cell growth in susceptible bacterial strains. Aurein 2.3 serves as a valuable tool in microbiological studies and the development of new antimicrobial therapies. -
Antibiotic Peptide
Aurein 1.1 is an antibiotic peptide derived from the skin of the Australian Bell Frog (Litoria raniformis). It demonstrates potent antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria. This peptide is valuable for research applications in the field of antimicrobial resistance and the development of new therapeutic agents targeting bacterial infections. -
Antibiotic Peptide
Aurein 2.1 is an antibiotic peptide derived from the skin secretions of Australian Bell Frogs, specifically Litoria aurea and Litoria raniformis. It exhibits significant antimicrobial activity against a range of bacterial strains, making it a valuable tool for research in antibiotic development and investigations into novel antimicrobial mechanisms. This peptide is of particular interest for studies related to infection control and the exploration of natural antimicrobial agents. -
Cationic antimicrobial peptide
Omiganan is a cationic antimicrobial peptide that exhibits potent activity against both gram-positive and gram-negative bacteria, as well as Candida species. As an analogue of indolicidin, Omiganan is valuable for studying its effects on microbial infections. Its applications extend to research on conditions such as acne and addressing issues related to alcohol-induced nasal problems. -
Skin-Antimicrobial Peptide
Human β-defensin-1 (HβD-1) is a cationic skin-antimicrobial peptide that targets a broad spectrum of bacteria. It is produced by various epithelial surfaces as well as circulatory and reproductive tract cells. This peptide exhibits significant antimicrobial activity, making it a valuable reagent for research applications focused on innate immunity and skin defense mechanisms. -
Polypeptide Antibiotic
Colistin is a polypeptide antibiotic primarily targeting Gram-negative bacteria. It demonstrates potent activity against multidrug-resistant strains such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. Due to its nephrotoxic potential, careful consideration is required during research. Colistin is valuable for studying infections caused by Gram-negative bacilli and exploring antibiotic resistance mechanisms. -
Lipoglycopeptide Antibiotic
Dalbavancin is a semisynthetic lipoglycopeptide antibiotic targeting Gram-positive bacteria. It exhibits potent bactericidal activity, with minimal inhibitory concentrations (MIC90) of 0.06 μg/mL against Staphylococcus aureus and 0.25 μg/mL against Bacillus anthracis. This compound is primarily utilized in research applications focused on bacterial infections and the development of novel antimicrobial therapies. -
Polypeptide Antibiotics
Polymyxin B2 is a polypeptide antibiotic that primarily targets the cell membrane of gram-negative bacteria. It exerts its antibacterial effect by binding to lipopolysaccharide components, leading to membrane disruption and subsequent cell lysis. This compound is relevant for antibiotic research and development, particularly in addressing drug-resistant bacterial strains. -
Antibiotic Peptide
Aurein 1.2 is an antibiotic peptide derived from amphibian sources, exhibiting potent antimicrobial and anticancer properties. This peptide targets bacterial membranes, leading to disruption and cell death, making it valuable in the study of antibiotic resistance and cancer therapeutics. Aurein 1.2 is ideal for research applications focused on the development of novel antimicrobial agents and exploring mechanisms of cancer cell apoptosis. -
Glycopeptide Antibiotic
A40926 is a glycopeptide antibiotic that targets the bacterial cell wall peptidoglycan precursor D-alanyl-D-alanine (D-Ala-D-Ala). It functions by irreversibly inhibiting cell wall synthesis through competitive binding, demonstrating significant bactericidal activity against Gram-positive bacteria, including Staphylococcus and Streptococcus, as well as Neisseria gonorrhoeae, with MIC values ranging from 0.06 to 2 μg/mL. Additionally, A40926 is effective against penicillin-resistant strains, disrupting peptidoglycan cross-linking and leading to bacterial lysis and death. The compound's fat-soluble fatty acid structure enhances serum concentrations and extends its duration of action, with a terminal half-life of 61.22 hours in rats. -
Antibiotic Peptide
Dermcidin-1L (human) is an antibiotic peptide that targets microbial pathogens with its inherent antimicrobial activity. Secreted by sweat glands, it plays a crucial role in skin defense mechanisms. Research applications include studies of inflammatory skin disorders and the investigation of innate immune responses. -
Lipopeptide Antibiotic
Globomycin is a lipopeptide antibiotic that acts as an irreversible inhibitor of signal peptidase II (LspA). By binding to the peptidase, Globomycin disrupts the processing of prolipoproteins, demonstrating significant antibacterial activity against the mollicute Spiroplasma melliferum with a minimum inhibitory concentration (MIC) of 6.25-12.5 μM. This compound is valuable for research applications focused on bacterial protein processing and antibiotic resistance mechanisms. -
Glycopeptide Antibiotic
Chloroorienticin A is a glycopeptide antibiotic that inhibits bacterial cell wall synthesis by targeting the transglycosylation activity in gram-positive bacteria. This compound demonstrates potent antibacterial activity against staphylococci and streptococci, making it a valuable tool for research on antibiotic resistance and bacterial pathogenesis. Its efficacy in inhibiting the growth of these pathogens supports its use in studying the mechanisms of antibiotic action and resistance development in clinical strains. -
Glycopeptide Antibiotic
Phleomycin D1 is a glycopeptide antibiotic that targets DNA. It exerts its biological activity by binding to and cleaving DNA, leading to cell death. Additionally, Phleomycin D1 induces cell cycle arrest at the S phase, making it a valuable reagent for research applications in cancer biology and molecular genetics. -
Antifungal Peptide
Pezadeftide is a potent antifungal peptide that targets fungal cells by inducing a rapid mitochondrial response. This mechanism leads to hyperpolarization of the mitochondrial membrane, disrupting cellular function and contributing to antifungal activity. Pezadeftide is valuable for studying antifungal resistance and developing therapeutic strategies against fungal infections. -
Antibacterial Peptide
D2A21 is an antibacterial peptide derived from cecropins that exhibits potent antimicrobial activity. It has a minimum cidal concentration of 21.69 μg/mL against Chlamydia trachomatis, demonstrating its effectiveness in combating bacterial infections. This peptide is valuable for research applications aimed at developing novel antimicrobial therapies and studying bacterial resistance mechanisms. -
αvβ6-integrin-specific Peptide
Cyclic αvβ6 (c(FRGDLAFp(NMe)K)) is a cyclic nonapeptide that specifically targets the αvβ6-integrin. It demonstrates significant potential in the field of positron emission tomography (PET) imaging, particularly for detecting malignancies such as head and neck cancer and pancreatic cancer. By coupling with 68Ga-labeled monomeric triazacyclononane-triphosphinate (TRAP), Cyclic αvβ6 can enhance imaging specificity and accuracy in oncological research applications. -
Peptide-PEG2 Conjugate of Unlabeled FXX489
FAP targeting peptide-PEG2 conjugate is a peptide-PEG2 linker conjugate of Unlabeled FXX489, a ligand specifically targeting fibroblast activation protein (FAP). This conjugate facilitates targeted delivery and enhances bioavailability in therapeutic applications. It is primarily employed in research focusing on FAP-related diseases, offering valuable insights into cancer progression and tissue remodeling. -
MAPK Substrate
EGF-R (661-681) T669 peptide serves as a substrate for Mitogen-Activated Protein Kinase (MAPK). This peptide is instrumental in evaluating MAPK catalytic activity in various biological contexts. It is particularly useful in studies focusing on cell signaling pathways, proliferation, and differentiation associated with EGF receptor signaling. -
Substrate Peptide
Nictide is a peptide substrate for LRRK2 (leucine-rich repeat kinase 2), specifically phosphorylated by the activated LRRK2[G2019S] variant. Its Km value of 10 μM indicates a moderate affinity, making it suitable for assessing LRRK2 activity in biological research. Nictide can be effectively utilized in studies exploring LRRK2-related signaling pathways and neurodegenerative disease mechanisms. -
Antimicrobial Peptides
Bac5(1-25) is an N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5, targeting bacterial membranes. This peptide exhibits significant antibacterial activity against a broad spectrum of pathogens, making it a valuable tool for antimicrobial research. Bac5(1-25) is suitable for studies focused on the mechanisms of antimicrobial action and the development of novel antimicrobial therapies. -
RDC Peptide
DOTA-GPC3 targeting peptide 2 is an RDC peptide specifically designed to target glypican-3 (GPC3) with a dissociation constant (Kd) of 0.3 nM. This compound features a DOTA moiety, enabling labeling with radioactive elements for imaging and therapeutic applications. It is utilized in cancer research, particularly for the study of GPC3-expressing tumors, making it a valuable tool for targeted radiotherapy and diagnostic imaging strategies. -
CXCR4 Targeting Peptide
Pentixafor is a synthetic peptide that targets the CXCR4 receptor, playing a critical role in various cellular processes, including cell migration and signaling. This compound can be labeled with 68Gallium (68Ga), enabling its application in positron emission tomography (PET) imaging for assessing CXCR4 expression in vivo. Additionally, Pentixafor serves as a vital component in the development of Radionuclide-Drug Conjugates (RDCs) for targeted cancer therapies. -
CAIX-targeting Cyclic Peptide
DPI-4452 is a CAIX-targeting cyclic peptide incorporating a DOTA cage, designed for chelation with radionuclides for positron emission tomography-computed tomography (PET-CT) imaging of CAIX-expressing tumors. This compound exhibits high specificity by binding to the carbonic anhydrase IX (CAIX) with an IC50 of 130 nM, while showing no significant interactions with a panel of 55 off-target receptors. In preclinical studies, radiolabeled DPI-4452 effectively inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. Additionally, it serves as a valuable reagent for the research and development of Radionuclide-Drug Conjugates (RDCs). -
FAP-Targeting Peptide
3BP-3940 is a highly potent and selective peptide inhibitor targeting fibroblast activation protein (FAP) in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. This reagent exhibits significant potential for tumor imaging when labeled with radionuclides such as Ga-68 and for targeted anticancer therapies using Lu-177. 3BP-3940 selectively accumulates in tumor lesions, making it valuable for the diagnosis and treatment of various solid tumors and conditions related to CAFs. -
RDC Peptide
FAP targeting peptide for FXX489 is a polypeptide that specifically targets fibroblast activation protein (FAP). This ligand plays a crucial role in the development of therapeutic agents aimed at modulating FAP-related pathways. It is particularly applicable in cancer research, where FAP is associated with tumor stroma and cancer progression, facilitating targeted delivery of therapeutic compounds. -
Peptide Drug Conjugate
DOTA-EB-TATE is a peptide drug conjugate composed of a somatostatin (SST) peptide derivative, DOTA-octreotate, conjugated to an Evans blue analog. This compound enhances the pharmacokinetics of somatostatin receptor subtype 2 (SSTR2) analogs while decreasing associated toxicity in peptide receptor radionuclide therapy (PRRT). DOTA-EB-TATE is also applicable in the synthesis and research of radionuclide-drug conjugates (RDCs), making it valuable for investigations in targeted cancer therapies. -
GRPR-targeting Peptide
GB-6 is a GRPR-targeting peptide that selectively binds to the gastrin releasing peptide receptor, which is frequently overexpressed in pancreatic cancer. This peptide demonstrates excellent in vivo stability and efficacy in tumor targeting and imaging when conjugated with near-infrared fluorescent dyes or the radionuclide technetium-99m (99mTc). In SW1990 subcutaneous xenograft models, GB-6 exhibited tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, facilitating precise tumor boundary delineation. This high-contrast imaging capability positions GB-6 as a promising tool for cancer imaging applications. -
FPR-specific Peptide
cFLFLF is a FPR-specific peptide designed for targeted imaging applications. When conjugated with a bifunctional polyethylene glycol moiety (PEG, 3.4 kD) and a DOTA through a lysine spacer, it forms cFLFLFKPEG-64Cu, which is subsequently labeled with 64Cu-CuCl2. This compound serves as a neutrophil-specific PET imaging agent, enabling visualization and assessment of inflammatory responses in various research contexts. -
HPV Epitope Peptides Fragment
Human Papillomavirus (HPV) E7 protein (49-57) is a fragment of the E7 protein, specifically the epitope spanning amino acid residues 49 to 57, which is restricted by the H-2d MHC class I molecule. This peptide is vital for studying HPV-induced tumorigenesis and immune response mechanisms. It is commonly utilized in research applications focusing on HPV vaccination, T cell recognition, and the understanding of viral oncogenesis. -
Polypeptide
HHV-2 Envelope Glycoprotein G (552-574) is a polypeptide derived from the glycoprotein G (gG-2) of herpes simplex virus type 2 (HSV-2). This immunodominant region elicits a robust immune response, making it a valuable target for serological studies and vaccine development related to HSV-2. It is critical for understanding the pathogenesis of herpes simplex virus infections and can be used in diagnostic assays to detect HSV-2 specific antibodies. -
FITC Labeled Peptide
FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a fluorescently labeled peptide that targets the immunodominant region of herpes simplex virus type 2 (HSV-2) glycoprotein G (gG-2). This reagent exhibits strong reactivity with HSV-2 sera, making it suitable for various research applications in virology, including antibody detection and vaccine development studies. Its fluorescent labeling facilitates visualization and analysis in cellular assays. -
Virus Replication Inhibitor
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH) is a potent inhibitor of viral replication, targeting and disrupting the membrane fusion activity of viral glycoproteins. This compound is essential for studying viral pathogenesis and developing antiviral therapies, as it effectively impedes the entry of viruses into host cells. Its applications extend to research focused on the mechanisms of viral infections and the exploration of therapeutic strategies to prevent viral replication. -
Peptide
Bursin is a peptide targeting B precursor cells, promoting their phenotypic differentiation in both mammalian and avian systems. This compound is known to enhance cyclic guanosine monophosphate (cGMP) levels in human B-cell lines, such as Daudi. Additionally, Bursin exhibits immunomodulatory properties, which bolster the immune response against infections, including those caused by H9N2. Its applications in immunology and cellular biology research make it a valuable tool for investigating immune mechanisms and enhancing vaccine efficacy. -
Peptide Fragment
NS2 (114-121), Influenza is a peptide fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This influenza epitope is primarily utilized in research focused on CD8+ cytotoxic T lymphocyte (CTL) responses during antiviral immune reactions. NS2 (114-121) serves as an important tool for studying the mechanisms of T cell-mediated immunity against influenza infections. -
HA Peptide Segment
Influenza HA (529-537) is a peptide segment derived from positions 529-537 of hemagglutinin (HA) of the influenza A virus, consisting of the amino acid sequence IYATVAGSL. This peptide is recognized by various specificities of CD8+ cytotoxic T-lymphocyte (CTL) clones, including H1-specific, H2-specific, and H1/H2 cross-reactive responses. Influenza HA (529-537) is instrumental in studying T-cell immune specificity and has potential applications in the design of novel vaccines against influenza. -
Hemagglutinin Peptide
Influenza HA (126-138) is a peptide derived from the hemagglutinin (HA) of the influenza virus, consisting of amino acids 126-138. This peptide induces apoptosis in thymic and peripheral T-cells, making it a valuable tool for investigating T-cell responses to influenza virus infection. It serves as an important reagent for studies in immunology and virology, particularly in the development of vaccines and therapies targeting influenza. -
Peptide
PA (224-233), Influenza is a 10-amino acid peptide derived from the polymerase 2 protein of the influenza A virus. This peptide plays a crucial role in viral RNA synthesis and is important for understanding influenza pathogenesis. It can be utilized in research applications aimed at studying viral replication mechanisms, developing vaccines, and evaluating antiviral drug candidates. -
Bioactive Peptide
Influenza NP (311-325) is a bioactive peptide derived from the nucleoprotein (NP) of the influenza virus, acting as an MHC class II restricted epitope to stimulate host immune responses. This peptide is known for its ability to induce substantial interferon gamma (IFN-γ) production while avoiding activation of CD8 T cells in murine models. Its unique properties make Influenza NP (311-325) a valuable tool for research in immunology and vaccine development. -
Antiviral Peptide
Urumin is an antiviral peptide that targets the conserved stalk of H1 hemagglutinin, exhibiting potent antiviral activity against human influenza A virus. With an IC50 value of 3.8 μM against the PR8 strain, Urumin effectively inhibits the growth of both drug-sensitive and drug-resistant H1 influenza viruses. In preclinical studies, Urumin has demonstrated protective effects in naive mice against lethal influenza infection, highlighting its potential for therapeutic applications in influenza management. -
Antiviral Peptide
Cyclo(-Met-Pro) is a cyclic dipeptide comprised of methionine and proline, serving as an antiviral peptide. It demonstrates weak inhibitory activity against the influenza A virus (H3N2), achieving 2.1% inhibition at a concentration of 5 mM. This compound may be useful in studies targeting viral infections and exploring the structure-activity relationships of peptide-based antivirals. -
Antiparasitic Peptide
LL-37 FK-13 is an antimicrobial peptide that targets Trichomonas vaginalis, demonstrating significant antiparasitic activity. It has been characterized by low cytotoxicity in human fibroblasts and only mild hemolytic effects on human erythrocytes, making it a valuable candidate for research applications involving parasitic infections and related therapeutic strategies. -
Antimicrobial Peptide
Halictine 2 is an antimicrobial peptide that exhibits significant anti-parasitic activity against Leishmania species. It effectively targets both extracellular infective metacyclic promastigotes and intracellular amastigotes, making it a valuable tool for investigating leishmaniasis. This compound is suitable for research focused on the mechanisms of leishmaniasis and potential therapeutic strategies against this parasitic infection.
