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Catalog No.
Product Name
Application
Product Information
Citations
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Aminopeptidase inhibitor
CHR-2797 (Tosedostat) is a novel metalloenzyme inhibitor that exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity. -
reversible Protease inhibitor
Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells. -
Aminopeptidase inhibitor
Bestatin methyl ester is a cell-permeable derivative of Bestatin which displays slightly stronger inhibition of neutral aminopeptidase than Bestatin, but has much weaker activity against basic aminopeptidase. -
Aminopeptidase inhibitor
Fumagillin is a complex natural product antibiotic which covalently binds a key histidine residue of methionine aminopeptidase type II (MetAP-2), inhibiting endothelial cell proliferation and angiogenesis. -
Aminopeptidase Inhibitor
Amastatin hydrochloride is a potent competitive inhibitor of aminopeptidases, exhibiting slow, tight binding kinetics. It demonstrates Ki values of 0.26 nM, 30 nM, and 52 nM against Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, and microsomal aminopeptidase, respectively. This compound is valuable for research applications focusing on protein metabolism and post-translational modifications, as well as in studies exploring the role of aminopeptidases in various physiological and pathological processes. -
Aminopeptidase N/Leukotriene A4 Hydrolase Inhibitor
Bestatin trifluoroacetate is a potent inhibitor of CD13 (Aminopeptidase N) and leukotriene A4 hydrolase. It plays a significant role in cancer research by modulating enzymatic activity associated with tumor progression and inflammation. With its capability to interfere with amino acid metabolism, Bestatin trifluoroacetate is valuable for studying the biological processes linked to these targets. -
Aminopeptidase N/Leukotriene A4 Hydrolase Inhibitor
Bestatin hydrochloride is an inhibitor of aminopeptidase N (CD13) and leukotriene A4 hydrolase. It plays a significant role in cancer research by modulating the enzymatic activities associated with tumor progression and inflammatory processes. This compound is valuable for studies investigating the implications of aminopeptidases in tumor microenvironments and immune responses. -
Aminopeptidase B Inhibitor
Arphamenine B is a selective inhibitor of aminopeptidase B, a Zn2+-dependent exopeptidase that cleaves arginine and lysine residues from the amino terminus of peptide substrates. This compound enhances immune responses and serves as a valuable tool for the characterization of novel proteases in biochemical research. Its unique mechanism provides insights into protein metabolism and potential therapeutic applications. -
Aminopeptidase B Inhibitor
Arphamenine B hemisulfate is a selective inhibitor of aminopeptidase B, a Zn2+-dependent exopeptidase that primarily cleaves arginine and lysine residues from the N-terminus of peptide substrates. This compound is derived from bacterial sources and has been shown to enhance immune responses. Arphamenine B hemisulfate is utilized in research for characterizing novel proteases and investigating their biological roles. -
Aminopeptidase P2 Inhibitor
ST-115 is a potent inhibitor of aminopeptidase P2, a target involved in the regulation of various physiological processes. Its high specificity makes it an invaluable tool for studying the role of aminopeptidase P2 in ischemic stroke and related conditions. Researchers may utilize ST-115 to explore its potential therapeutic implications in neuroprotection and recovery following cerebral ischemia. -
Aminopeptidase A Inhibitor
Firibastat is a potent inhibitor of aminopeptidase A (APA), exhibiting a Ki value of 200 nM. This first-in-class compound effectively inhibits the conversion of brain angiotensin-II to angiotensin-III, resulting in reduced blood pressure in hypertensive models. Firibastat is particularly valuable in exploring the role of APA in neurophysiological processes and hypertension research. -
Aminopeptidase Inhibitor
L-Leucinol is a competitive inhibitor of aminopeptidase, exhibiting a Ki value of 17 μM. This reagent is primarily utilized in in vitro enzymatic assays to study enzymatic activity and inhibition. Additionally, L-Leucinol serves as a valuable tool in peptide synthesis applications, facilitating the exploration of peptide structure and function in biochemical research. -
Aminopeptidase/Epoxide Hydrolase Inhibitor
ARM1 (4BSA) is a potent inhibitor of aminopeptidase and epoxide hydrolase. It exhibits aminopeptidase inhibitory activity with an IC50 of 7.61 µM and demonstrates epoxide hydrolase inhibitory activity with an IC50 of 12.4 µM. This compound is valuable for research applications targeting metabolic pathways involving peptide and epoxide metabolism. -
Anti-inflammatory Agent, Aminopeptidase Inhibitor
2-(2'-Pyridyl)benzimidazole is an effective anti-inflammatory agent and a potent inhibitor of methionine aminopeptidase in Escherichia coli. This compound exhibits tridentate ligand properties, capable of forming stable complexes with various transition metal ions. Its applications extend to biochemical research focused on inflammatory processes and amino acid metabolism, making it a valuable reagent for studies in these areas. -
Leucine Aminopeptidase Inhibitor
Adamantanine is a potent inhibitor of leucine aminopeptidase, demonstrating an I/S0.5 value of 10.5. It effectively impairs the transport of methionine and leucine in Ehrlich ascites carcinoma cells, with a Ki value of 0.76 mM. Additionally, Adamantanine displays inhibitory effects on the proliferation of P388 lymphocytic leukemia cells, exhibiting an IC50 of greater than 1 mM. This compound serves as a valuable tool for researchers investigating amino acid transport and cancer cell proliferation. -
Neutral Endopeptidase Inhibitor, Aminopeptidase N Inhibitor
RB 101 is a mixed inhibitor of neutral endopeptidase and aminopeptidase N, enzymes that metabolize enkephalins. This compound exhibits long-lasting antinociceptive effects and inhibits in vivo [3H]DPN binding in mice under both basal conditions and after swim stress. RB 101 is particularly useful for studying the in vivo localization of enkephalinergic pathways activated by various stimuli, making it a valuable tool for pain research and neuropharmacology. -
Aminopeptidase B Inhibitor
Arphamenine A is a potent inhibitor of aminopeptidase B, derived from Chromobacterium violaceum HMG361-CF4. This compound has demonstrated the ability to inhibit aminopeptidase B activity, contributing to its potential anticancer effects. Research indicates that Arphamenine A may suppress the growth of sarcoma 180 and invasive micropapillary carcinoma (IMC), making it a valuable tool for studying cancer biology and therapeutic strategies targeting aminopeptidase B. -
Aminopeptidase N Inhibitor
Aminopeptidase N Inhibitor 1 is a potent inhibitor targeting aminopeptidase N, demonstrating an IC50 of 25 μM. It plays a significant role in research related to tumor angiogenesis, providing valuable insights into the mechanisms of cancer progression and the development of therapeutic strategies. Its application in studies of angiogenesis makes it a crucial tool for researchers investigating tumor microenvironment interactions. -
Leukotriene A4 Hydrolase Inhibitor
JNJ-26993135 is a selective inhibitor of leukotriene A4 hydrolase (LTA4H), demonstrating an IC50 value of 11 nM. This compound is valuable for research applications focusing on inflammatory processes and leukotriene metabolism. Its ability to modulate leukotriene synthesis suggests potential use in studying various inflammatory diseases and related therapeutic interventions. -
Aminopeptidase N Inhibitor
Probestin is a potent inhibitor of aminopeptidase N (APN), derived from the bacterium Streptomyces cyanogens MH663-2F6. This compound exhibits significant biological activity by selectively blocking APN activity, leading to the modulation of various physiological processes. Probestin is valuable for research applications focused on studying the role of APN in cancer, inflammation, and immune response pathways. -
Aminopeptidase-M Inhibitor
Leuhistin is an aminopeptidase-M (AP-M) inhibitor, targeting the enzymatic degradation of bioactive peptides within cerebral membranes. By inhibiting AP-M, Leuhistin enhances the availability and activity of these peptides, making it a valuable reagent for studies focused on neurobiology and peptide research. It is derived from Bacillus laterosporus BMI156-14F1, highlighting its natural origins in biochemical applications. -
Leukotriene A4 Hydrolase Inhibitor
LTA4H-IN-2 is a potent inhibitor of Leukotriene A4 Hydrolase, demonstrating an IC50 of less than 3 nM. This compound plays a crucial role in modulating inflammatory responses by inhibiting the biosynthesis of leukotrienes, which are key mediators in various inflammatory diseases. LTA4H-IN-2 is valuable for research applications focused on understanding leukotriene signaling pathways and developing therapeutics for conditions such as asthma and other inflammatory disorders. -
Aminopeptidase Inhibitor
Matlystatin A is a potent inhibitor of aminopeptidases, exhibiting IC50 values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. This compound is valuable for investigating proteolytic processes in cancer research. Its ability to modulate enzymatic activity provides insights into tumor progression and metastasis mechanisms. -
Aminopeptidase Inhibitor
Ketomethylenebestatin is a selective inhibitor of aminopeptidases, showcasing notable activity against AP-B, AP-M, and Leu-AP with IC50 values of 56 μM, 752 μM, and 0.39 μM, respectively. This compound serves as an analog of the natural aminopeptidase inhibitor Bestatin, and is valuable in research applications focused on the regulation of peptide metabolism and potential therapeutic targets in various diseases. Its specificity towards aminopeptidases makes it a useful tool for investigating enzymatic pathways and the role of these enzymes in physiological processes. -
Aminopeptidase Inhibitor
Lys-psi(CH2NH)-Trp(Nps)-OMe is a pseudodipeptide analog of lysine and tryptophan designed to inhibit aminopeptidase activity. This compound exhibits significant analgesic properties, demonstrated through dose-dependent and naloxone-reversible responses following intracerebroventricular administration in murine models. It not only prolongs analgesic effects compared to its parent compound but also offers protection against the degradation of methionine enkephalin in rat striatal slices. Lys-psi(CH2NH)-Trp(Nps)-OMe's enhanced resistance to proteolysis contributes to its sustained analgesic activity, making it a valuable tool for studying pain mechanisms and the role of aminopeptidases in neuromodulation. -
Leucine Aminopeptidase Inhibitor
L-Val-P is a selective inhibitor of leucine aminopeptidase (LAP), exhibiting a Ki value of 0.15 μM. This compound demonstrates significant potential in studies related to HIV infection, inflammatory processes, lens cataract formation, and various types of cancer. Its ability to modulate LAP activity makes L-Val-P a valuable tool for researchers investigating associated biological pathways and therapeutic targets.
