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Ubenimex

reversible Protease inhibitor

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Catalog No. A10958

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Ubenimex 25mg A10958-25
$180.00
Ubenimex 100mg A10958-100
$580.00
Ubenimex 200mg A10958-200
$880.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells.

Ubenimex

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Chemical Information

Catalog Num A10958
Actions Inhibitor
M. Wt 308.378
Formula C16H24N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 58970-76-6
Synonyms Ubenimex, NK 421, NK-421, NK421, Bestatin, NSC 265489, NSC265489, NSC-265489
SMILES CC(C)C[[email protected]@H](C(O)=O)NC([[email protected]@H](O)[[email protected]](N)CC1=CC=CC=C1)=O

Biological Activity

Description
Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.43 mL 162.14 mL 324.28mL
0.5 mM 6.49 mL 32.43 mL 64.86 mL
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.378. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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