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|Storage||at -20°C 2 years|
|Synonyms||Ubenimex, NK 421, NK-421, NK421, Bestatin, NSC 265489, NSC265489, NSC-265489|
|SMILES||CC(C)C[[email protected]@H](C(O)=O)NC([[email protected]@H](O)[[email protected]](N)CC1=CC=CC=C1)=O|
|Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells.|
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||32.43 mL||162.14 mL||324.28mL|
|0.5 mM||6.49 mL||32.43 mL||64.86 mL|
|1 mM||3.24 mL||16.21 mL||32.43 mL|
|5 mM||0.65 mL||3.24 mL||6.49 mL|
*The above data is based on the productmolecular weight 308.378. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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