Catalog No.
Product Name
Application
Product Information
Citations
-
Conjugate Of VHL Ligand And Linker
(S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker. This compound facilitates the synthesis of PROTAC ERα Degrader-12, a highly selective degrader targeting estrogen receptor alpha (ERα). It serves as a valuable tool for research applications focusing on protein degradation mechanisms and targeted therapy development in hormone-responsive cancers. -
E3 Ligase Ligand-Linker Conjugates
Pomalidomide 4'-alkylC2-azide is an E3 ligase ligand-linker conjugate that incorporates a Pomalidomide-based cereblon (CRBN) ligand. This reagent is designed for use in synthesizing proteolysis-targeting chimeras (PROTACs), facilitating targeted protein degradation. Its selective binding to E3 ligases enables the development of innovative therapeutic strategies in cellular biology and drug discovery research. -
E3 ligase ligand-Linker Conjugate
Thalidomide-4-O-C8-Br is an E3 ligase ligand-linker conjugate that integrates the Thalidomide-derived CRBN ligand with a linear linker designed for PROTAC applications. This reagent facilitates the targeted degradation of proteins, exemplified by its use in the synthesis of PROTAC EZH2 Degrader-15. Thalidomide-4-O-C8-Br is an essential tool for researchers exploring protein regulation and degradation pathways in cellular processes. -
E3 Ligase Ligand-Linker Conjugate
6-(2,6-Dioxopiperidin-3-yl)-2-(piperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidine-5,7(6H)-dione hydrochloride is a ligand-linker conjugate targeting E3 ligases, specifically designed for the synthesis of PROTACs. It features a CRBN-based ligand that facilitates targeted degradation of intracellular proteins. This compound is essential for researchers exploring targeted therapeutic strategies and studying the role of protein degradation in cellular processes. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-AHPC-Amide-PEG2-C2-NH2 is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTACs, specifically targeting the degradation of PI3K/110β. This compound facilitates targeted protein degradation by enhancing the recruitment of E3 ligases to specific substrates, enabling the selective modulation of protein levels within cells. Its utilization expands research applications in cancer biology and other areas where protein degradation plays a critical role. -
E3 Ligase Ligand-Linker Conjugate
3-Azathalidomide-piperazine is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand alongside a versatile linker. This compound is primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras), facilitating targeted protein degradation in research applications. Its effectiveness in modulating protein interactions makes it a valuable tool for studying various cellular processes and disease mechanisms. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-6-F-5-Pip-COOH is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand for targeted protein degradation. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating precise modulation of protein levels in cellular systems. It is a valuable tool for researchers studying targeted therapeutics and protein degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-Pip-CH2-piperazine is an E3 ligase ligand-linker conjugate featuring a CRBN-based ligand. This compound facilitates the synthesis of PROTAC (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins within cellular contexts. Its application in chemical biology allows for the exploration of novel therapeutic strategies by modulating protein levels and functions. -
E3 ligase ligand-Linker Conjugate
(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that targets the VHL E3 ligase, which plays a crucial role in cellular protein degradation. This compound facilitates the formation of PROTACs, such as the EZH2 Degrader-28, by linking to specific ligands for protein degradation studies. Its application in PROTAC technology makes it valuable for researchers investigating targeted protein modulation and degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-amido-C3-COOH TFA functions as an E3 ligase ligand-linker conjugate, incorporating a CRBN-based ligand and a flexible linker. This compound serves as a valuable building block for synthesizing PROTACs (Proteolysis Targeting Chimeras). It enables targeted protein degradation, thus facilitating the study of protein functions and interactions in various biological contexts. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride functions as an E3 ligase ligand-linker conjugate, incorporating a VHL ligand with a (S,R,S)-AHPC-based linker. This compound is designed for use in PROTAC synthesis, facilitating targeted protein degradation in various research applications. Its unique structure allows for the selective recruitment of E3 ligases, making it valuable for studies in protein regulation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
(S)-Thalidomide-piperazin besylate is an E3 ligase ligand-linker conjugate that features a cereblon (CRBN)-based ligand. This compound facilitates the synthesis of proteolysis-targeting chimeras (PROTACs) and is significant in research focused on targeted protein degradation. Its unique structure enables selective interaction with E3 ligases, offering valuable insights into protein regulation processes in cellular environments. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperidin-C-piperidin hydrochloride is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN)-based ligand. This compound is used in the synthesis of proteolysis-targeting chimeras (PROTACs), which harness the protein degradation machinery to selectively target proteins for ubiquitin-mediated degradation. Its application is pivotal in studying protein regulation and discovery of novel therapeutic strategies in various diseases. -
E3 ligase ligand-Linker Conjugate
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is an E3 ligase ligand-linker conjugate designed for applications in PROTAC (proteolysis targeting chimera) technology. This compound features the (4R,5S)-Nutlin carboxylic acid, a potent MDM2 inhibitor, facilitating targeted degradation of proteins by linking to an E3 ligase. It is essential for developing PROTACs aimed at directing specific therapeutic pathways for proteins such as EZH2. -
E3 Ligase Ligand-Linker Conjugates
DCAF11 ligand-Linker Conjugate 1 is a conjugate designed to facilitate targeted protein degradation through the DCAF11 E3 ubiquitin ligase. This compound serves as a key component for synthesizing PROTAC LGF308, enabling the selective degradation of specific proteins within cellular systems. Its utility in research applications includes the exploration of protein degradation pathways and investigating therapeutic targets in cancer and other diseases.
