Catalog No.
Product Name
Application
Product Information
Citations
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ADC/PROTAC Linker
Propargyl-PEG4-thiol is a PEG-based linker specifically designed for use in the synthesis of PROTACs and non-cleavable antibody-drug conjugates (ADCs). This compound features an alkyne functional group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating precise conjugation with azide-containing molecules. Propargyl-PEG4-thiol is essential for advancing research in targeted protein degradation and therapeutic antibody development. -
ADC/PROTAC Linker
m-PEG7-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates the development of targeted therapeutics by enabling controlled release of active compounds. Its versatile application supports research in targeted protein degradation and drug delivery systems, making it an essential reagent for advancing science in cancer therapy and other diseases. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NHS ester is a versatile linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG/alkyl/ether-based compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its cleavable nature enhances the functionality and targeting capabilities of therapeutic agents, making it essential for researchers involved in drug development and bioconjugation applications. -
ADC/PROTAC Linker
N-Boc-N-bis(PEG4-OH) is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This cleavable linker also serves as a versatile component for the development of antibody-drug conjugates (ADCs). Due to its unique structure, it facilitates targeted drug delivery and enhances the efficacy of therapeutic agents in various biological applications. -
PROTAC Linkers
Bis-PEG7-acid is a polyethylene glycol (PEG) based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and stability of the PROTAC molecules, facilitating targeted protein degradation. Its application in chemical biology supports research focused on developing novel therapeutics through targeted ubiquitination pathways. -
ADC/PROTAC Linker
Propargyl-PEG9-bromide is a PEG-based linker utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This non-cleavable linker facilitates the targeted delivery of therapeutics through its unique click chemistry capabilities, featuring an alkyne group suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its applications extend to enhancing drug efficacy and specificity in chemical biology and therapeutic development. -
PROTAC Linkers
m-PEG4-Boc is a cleavable polyethylene glycol (PEG) linker with four ethylene glycol units, designed for use in the synthesis of antibody-drug conjugates (ADCs) and Proteolysis Targeting Chimeras (PROTACs). This versatile linker facilitates the development of ADCs by enabling site-specific conjugation, while also serving as a crucial component in PROTAC design for targeted protein degradation. Its functional properties contribute to the effectiveness and stability of various bioconjugates in chemical biology research. -
PROTAC linker
Boc-gly-PEG3-endo-BCN is a cleavable PEG-based linker designed for targeted protein degradation applications through PROTAC technology. Its biocompatible structure facilitates the synthesis of antibody-drug conjugates (ADCs) by serving as a versatile linker. The presence of a bicyclo[6.1.0]nonyne (BCN) group allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, making it a valuable reagent for click chemistry in biological research. -
ADC/PROTAC Linker
m-PEG5-MS is a PEG-based linker designed for antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This cleavable linker facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins. Its key applications include drug development and cellular regulation studies, making it a versatile tool in therapeutic research and protein modulation. -
PROTAC Linker
Amino-PEG11-OH is a non-cleavable linker composed of an 11-unit polyethylene glycol (PEG) moiety designed for use in antibody-drug conjugates (ADCs) and PROTAC (Proteolysis Targeting Chimera) synthesis. This PEG-based linker facilitates the conjugation of drugs to antibodies, enhancing therapeutic efficacy while maintaining stability. Additionally, it serves as an effective component in the development of PROTACs, enabling targeted protein degradation for advanced molecular research applications. -
ADC/PROTAC Linker
Propargyl-PEG7-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatility and efficiency make it a valuable tool in the development of targeted therapeutics and bioconjugates for cancer research and drug delivery applications. -
ADC/PROTAC Linker
N-Boc-N-bis(PEG2-OH) is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This cleavable linker facilitates the precise attachment of therapeutic agents to antibodies, enhancing targeted drug delivery while minimizing off-target effects. Its structure allows for efficient conjugation and release of the active component, making it suitable for a variety of applications in drug development and molecular biology research. -
ADC/PROTAC Linker
Bis-PEG2-PFP ester is a non-cleavable linker that comprises two units of polyethylene glycol (PEG) and is essential for the synthesis of antibody-drug conjugates (ADCs). Its unique structure makes it suitable for use in peptide-based PROTACs (Proteolysis Targeting Chimeras), facilitating targeted degradation of specific proteins. This reagent supports advanced research in the fields of targeted therapy and protein regulation. -
ADC/PROTAC Linker
m-PEG9-Amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates the attachment of biomolecules, enabling targeted protein degradation and precise delivery of therapeutic agents. m-PEG9-Amine is essential for advancing research in targeted therapy and bioconjugation applications. -
ADC/PROTAC Linker
Bis-PEG17-NHS ester is a PEG-based linker designed for efficient conjugation in both PROTAC and antibody-drug conjugate (ADC) synthesis. Its NHS ester functionality allows for selective coupling to amine-containing molecules, facilitating the development of targeted therapies. This reagent is particularly useful in the development of PROTACs for targeted protein degradation and in the construction of ADCs that deliver cytotoxic agents to specific cancer cells. -
ADC/PROTAC Linker
N-Boc-PEG9-alcohol is a polyethylene glycol (PEG)-based linker utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of bioactive molecules, enhancing the pharmacokinetic properties of ADCs. Its application extends to the development of targeted degraders, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linkers
N-Succinimidyl 3-(Bromoacetamido)propionate is a versatile PEG-based linker designed for PROTAC (proteolysis-targeting chimeras) synthesis. This compound facilitates the effective conjugation of small molecules to target proteins, enabling targeted protein degradation. Additionally, it serves as a cleavable linker for the development of antibody-drug conjugates (ADCs), enhancing therapeutic efficacy in cancer research. This reagent is essential for studies focused on protein modulation and targeted therapies. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-acid is a PEG-based linker designed for application in antibody-drug conjugates (ADCs) and PROTAC synthesis. This linker features a DBCO group that participates in strain-promoted alkyne-azide cycloaddition (SPAAC), facilitating selective conjugation with azide-containing molecules. Its chemical properties make it ideal for developing targeted therapeutics that can modulate protein levels in biological research, enhancing experimental outcomes in drug discovery and development. -
PROTAC Linker
5-Hydroxypentanoic acid serves as a versatile PROTAC linker, playing a crucial role in targeted protein degradation technology. This compound facilitates the synthesis of PROTAC AR-V7 degrader-1, contributing to innovative research in protein regulation and therapeutic development. Its structural characteristics enhance the design of bifunctional molecules for selective protein degradation, making it a valuable reagent in life sciences research. -
ADC/PROTAC Linker
Amino-PEG10-OH is a non-cleavable, 10-unit polyethylene glycol (PEG) linker primarily utilized in the development of antibody-drug conjugates (ADCs). This versatile linker also serves a critical role in the synthesis of proteolysis-targeting chimeras (PROTACs). Its hydrophilic properties enhance solubility and stability, making it suitable for diverse applications in chemical biology and therapeutic development. -
PROTAC Linkers
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive DBCO moiety. This compound engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise conjugation in chemical biology applications. Its utility in targeted protein degradation research makes it a valuable tool for biochemists developing innovative therapeutic strategies. -
PROTAC Linkers
Carboxyfluorescein-PEG12-NHS is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It enables the formation of covalent bonds with target proteins, facilitating the selective degradation of unwanted intracellular proteins. This reagent is valuable for researchers exploring targeted protein degradation and developing novel therapeutics in cancer and other diseases. -
PROTAC Linker
(Rac)-Biotin-PEG3-oxyamine hydrochloride is a PEG-based linker specifically designed for the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the conjugation of biotin to target proteins, enhancing their degradation via the ubiquitin-proteasome pathway. It is valuable in research applications focused on targeted protein degradation and the study of protein-protein interactions. -
E3 Ligase Ligand and PROTAC Linker
(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc serves as an E3 ligase ligand and a PROTAC linker, facilitating targeted protein degradation. It is integral to the development of PROTAC K-Ras Degrader-3, demonstrating potential in cancer research. This compound is designed to help elucidate molecular mechanisms and therapeutic pathways involved in oncogenesis. -
PROTAC linker
Leukotriene B4 (LTB4) is a potent chemoattractant and activator of leukocytes, playing a critical role in mediating inflammatory responses. As an alkyl chain-based PROTAC linker, LTB4 is essential for the synthesis of PROTACs, enabling targeted protein degradation in research applications. This compound is valuable for studies focused on inflammation, immune response, and the development of therapeutic interventions in related diseases. -
PROTAC Linkers
DSPE-PEG-Biotin, MW 2000 is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of biotin to target proteins, enhancing their recognition and degradation by the cellular proteasome. Its application in PROTAC technology supports the development of novel therapeutics by enabling targeted protein modulation in cellular research. -
PROTAC linker
DSPE-PEG8-Mal is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of PROTACs by enhancing their solubility and stability. Its primary mechanism involves forming a covalent bond with target proteins, thus enabling targeted degradation. DSPE-PEG8-Mal is essential for researchers investigating novel therapeutic strategies via targeted protein degradation. -
PROTAC Linker
(2E,9Z)-Octadeca-2,9-dienoic acid serves as a PROTAC linker in chemical research applications. This polyunsaturated fatty acid plays a critical role in lipoxygenase-dependent metabolic processes, facilitating the study of enzyme-modulating pathways. Its unique structure enables the development of targeted protein degradation strategies in cellular systems. -
PROTAC Linkers
m-PEG-NHS ester (MW 5000) is a PEGylated linker that facilitates the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an N-hydroxysuccinimide (NHS) functional group, enabling efficient coupling to amine-containing substrates. Its hydrophilic nature enhances solubility and improves pharmacokinetic properties, making it an essential tool for researchers in targeted protein degradation and therapeutic development. -
PROTAC Linker
Ms-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a Boc-protected amine that facilitates conjugation to target proteins, enhancing the efficient recruitment of E3 ligases. Ms-PEG8-Boc plays a critical role in research applications focused on targeted protein degradation, enabling the study of protein function and therapeutic development in various disease models. -
PROTAC Linkers
m-PEG2-Amino is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by providing a flexible and hydrophilic backbone. Its application in the construction of PROTACs enables researchers to enhance the selectivity and efficacy of targeted therapies. -
PROTAC Linker
Succinamic acid functions primarily as a linker in the construction of PROTAC molecules. This compound has been characterized as a weak inhibitor of human LL-xylose reductase, exhibiting an IC50 value of 1.45 mM. Its structural properties make it instrumental in synthesizing compounds such as CQ-16, facilitating advancements in targeted protein degradation research. -
PROTAC Linker
Azido-PEG9-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation of alkyne- or DBCO/BCN-containing molecules, respectively. Its versatility makes Azido-PEG9-Boc a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
(+)-Biotin-PEG2-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its application is critical in the development of novel therapeutic strategies for various diseases, particularly in the field of targeted protein degradation research. -
PROTAC linker
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based linker designed for PROTAC synthesis. It features an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds. This versatile linker is valuable for optimizing PROTAC constructs in chemical biology research. -
PROTAC Linker
Boc-NHCH2-Ph-pyrimidine-NH2 serves as a versatile linker for PROTAC (Proteolysis Targeting Chimeras) applications. By facilitating the conjugation of target proteins with E3 ligases, this compound enhances the selective degradation of proteins of interest. Its unique structure allows for improved target engagement and therapeutic potency, making it an essential tool for drug discovery and chemical biology research focused on targeted protein degradation. -
PROTAC Linker
N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that facilitates the synthesis of targeted protein degraders. This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for researchers in the field of protein degradation and chemical biology. -
PROTAC Linkers
N-Me-N-bis-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing the targeted degradation of specific proteins in cellular studies. Its application is crucial in the development of innovative therapeutics that modulate protein levels to investigate biological pathways and disease mechanisms. -
PROTAC linker
Boc-N-Amido-PEG5-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, enhancing targeted therapeutic strategies in chemical biology. Its application extends to various fields including drug discovery and the development of novel therapeutic agents aimed at specific molecular targets. -
PROTAC Linkers
Propargyl-PEG11-methane serves as a versatile PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC design makes it a valuable reagent for targeted protein degradation studies and drug discovery research. -
PROTAC Linker
m-PEG4-propargyl is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring an alkyne group, this compound serves as a click chemistry reagent, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is instrumental in the development of targeted protein degradation strategies and can be utilized in various research applications focusing on protein modulation and therapeutic discovery. -
PROTAC Linker
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the development of PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the conjugation of ligand-recruiting components to E3 ligase adapters, enabling targeted protein degradation mechanisms. Its flexible PEG structure enhances solubility and biocompatibility, making it suitable for various biochemical and pharmacological investigations in drug discovery and development. -
PROTAC Linker
Boc-Aminooxy-PEG1-C2-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins within cellular systems. It is an essential tool for researchers investigating targeted protein modulation and ubiquitin-proteasome system dynamics. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of targeted protein degradation strategies by linking proteins of interest to E3 ligases, enhancing their ubiquitination and subsequent degradation. Its unique trifluoroethyl moiety provides distinct chemical properties that may improve solubility and linker stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based linker designed for the synthesis of PROTACs. This reagent features a DBCO group that allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances labeling and purification processes, making it valuable in target protein degradation studies and other biochemical applications. -
PROTAC Linkers
Boc-NH-PEG10-CH2CH2COOH is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and pharmacokinetic properties of PROTACs, promoting efficient protein degradation and targeted therapeutic efficacy. Its carboxylic acid functionality facilitates conjugation to target ligands, making it a valuable tool in chemical biology and drug discovery research focused on novel therapeutics. -
PROTAC Linkers
Benzyl-PEG24-MS is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the precise conjugation of target protein ligands and ubiquitin E3 ligase binding domains, enhancing the design of bifunctional molecules for targeted protein degradation. Its unique structure allows for increased solubility and improved biocompatibility, making it suitable for various applications in the study of targeted therapies and protein modulation. -
PROTAC Linkers
Amino-PEG23-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligand and E3 ligase components, enhancing the selective degradation of target proteins. Its unique structural properties make it suitable for various applications in target protein modulation and therapeutic development. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linkers
6-Maleimidocaproic acid-PFP ester is a versatile PROTAC linker that features an alkyl chain structure. It facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs) by enabling the conjugation of target proteins to E3 ligases. This reagent is essential for applications in targeted protein degradation studies and can enhance the development of novel therapeutics in cancer research and other diseases.
