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N-(Tos-PEG4)-N-bis(PEG4-Boc)

PROTAC Linker

N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the development of PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the conjugation of ligand-recruiting components to E3 ligase adapters, enabling targeted protein degradation mechanisms. Its flexible PEG structure enhances solubility and biocompatibility, making it suitable for various biochemical and pharmacological investigations in drug discovery and development.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2112737-74-1
Applications	PROTAC Linker
Formula	C₄₅H₈₁NO₁₈S
Molecular Weight	956.19
SMILES	O=C(OC(C)(C)C)CCOCCOCCOCCOCCN(CCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O)CCOCCOCCOCCOCCC(OC(C)(C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.