Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Bn-PEG8-OBn is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This versatile linker facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of proteins of interest. Its application is significant in small molecule drug discovery and biological research, particularly in the development of targeted therapies. -
PROTAC Linker
tert-Butyl 2-(piperidin-4-yl)acetate hydrochloride is a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to target proteins, enabling targeted degradation pathways. Its role in PROTAC development makes it essential for research applications in targeted protein modulation and therapeutic interventions. -
PROTAC Linker
OH-PEG3-Cl is a bifunctional linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This reagent facilitates the conjugation of target proteins to an E3 ligase, enabling the degradation of specific proteins through the ubiquitin-proteasome system. Its application is crucial in chemical biology for the development of targeted protein degradation strategies that can be used in therapeutic research and drug discovery. -
PROTAC Linker
Ethyl 7-oxoheptanoate serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in enhancing the degradation of specific target proteins through the recruitment of E3 ligases. Its application extends to research in targeted protein degradation, making it valuable for studies in cancer biology and other disease mechanisms. -
PROTAC Linker
1-Bromo-4-(4-bromobutyl)benzene acts as an effective PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enables the selective degradation of target proteins by bridging an E3 ligase and a protein of interest, thereby enhancing the efficiency of targeted protein degradation studies. Its utility in the development of novel therapeutic strategies makes it valuable for research in drug discovery and protein regulation. -
PROTAC Linker
3-Cyanocyclobutane-1-carboxylic acid serves as a synthetic linker for PROTAC (proteolysis-targeting chimera) development. This compound facilitates the formation of stable PROTACs, enabling targeted protein degradation by linking a target protein ligand to an E3 ligase ligand. Its unique structural properties make it valuable for research applications in protein modulation and therapeutics. -
PROTAC Linker
Ethyl hex-5-ynoate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for researchers aiming to create novel protein degraders that target specific proteins for degradation in cellular systems. Its versatility and effectiveness make it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine-1-carboxylate is a specialized linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the targeted degradation of specific proteins by bridging E3 ubiquitin ligases with the target protein, enhancing the recruitment and subsequent ubiquitination. It is valuable in research applications focused on protein regulation and therapeutic discovery, particularly in cancer and neurodegenerative diseases. -
PROTAC Linkers
HO-PEG8-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of ligand molecules, enhancing the stability and solubility of PROTACs. HO-PEG8-CH2COOH is essential in chemical biology studies aimed at targeted protein degradation and provides a versatile tool for researchers developing novel therapeutic agents. -
PROTAC Linker
2-Propargyl-(trans)-4-cyclohexanediamine functions as a versatile PROTAC linker, enabling the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases, thereby enhancing the modulation of biological pathways. It is an essential tool in drug discovery and protein regulation research applications. -
PROTAC Linker
3-Hydroxy-2,2,4,4-tetramethylcyclobutan-1-one oxime serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. It enables the efficient combination of target proteins with E3 ligases, enhancing the design of PROTAC molecules. This compound is pivotal in biochemical research focused on modulating protein levels and exploring therapeutic potentials in various diseases. -
PROTAC Linker
tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in targeted protein degradation, enhancing the efficacy of therapeutic agents by promoting the ubiquitin-proteasome system. Its unique structure allows for selective degradation of specific proteins, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
20-Bromoicosanoic acid is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the recruitment of E3 ligases to specific target proteins, promoting targeted protein degradation. Its unique structure allows for effective conjugation with various moieties, making it a valuable tool for researchers investigating targeted therapeutics and protein modulation. -
PROTAC Linker
2-(1-benzylpiperidin-4-yl)ethan-1-amine is a versatile PROTAC linker that plays a critical role in the design and synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds between E3 ligases and target proteins, enabling targeted degradation of specific proteins within cellular systems. Its application is essential in innovative drug discovery and the study of protein homeostasis and regulation. -
PROTAC Linker
tert-Butyl 6-iodohexanoate serves as a PROTAC linker, facilitating targeted protein degradation through the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of innovative therapeutics designed to selectively degrade unwanted proteins in various biological contexts, thereby advancing drug discovery and development efforts. Its chemical structure enhances conjugation and stability, making it a valuable tool in chemical biology research. -
PROTAC Linker
trans-4-Aminocyclohexanol hydrochloride is a versatile PROTAC linker that facilitates the development of Proteolysis Targeting Chimeras (PROTACs). This compound is instrumental in enabling targeted protein degradation, thereby providing valuable insights into protein function and regulation. Its application in synthetic biology enhances the efficiency of drug discovery and therapeutic development processes. -
PROTAC Linker
2-tert-Butyl 6-methyl 2-azaspiro[3.3]heptane-2,6-dicarboxylate serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in enhancing the selective degradation of target proteins via the ubiquitin-proteasome system. Its structural attributes support efficient conjugation to both ligands and E3 ligases, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
4-Ethoxycarbonylmethylphenylboronic acid pinacol ester serves as a versatile linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs). By facilitating the assembly of target proteins and E3 ligases, this compound enhances the selective degradation of specific proteins within cellular environments. Its application is crucial in drug discovery and development, particularly for targeting disease-related proteins in cancer and other disorders. -
PROTAC Linker
22-Methoxy-22-oxodocosanoic acid is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by engaging the E3 ubiquitin ligase pathway. It is instrumental in constructing novel therapeutic agents for the modulation of protein levels in various biological research applications. -
PROTAC Linker
Boc-pyrrolidine-cyclopentanamine is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for the construction of bifunctional molecules that selectively induce the degradation of target proteins via the ubiquitin-proteasome pathway. Its structural features enable optimal interaction with E3 ligases, making it suitable for various research applications in targeted protein degradation studies. -
PROTAC Linker
Methyl 3-cyanopropanoate serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the recruitment of E3 ligases, proving essential for targeted protein modulation studies. Its chemical structure supports efficient synthesis and functional application in cellular research, making it valuable for studies in targeted therapy and protein homeostasis. -
PROTAC Linker
N-(3-Hydroxypropyl)carbamic acid benzyl ester serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the recruitment of E3 ligases to specific proteins of interest, thus promoting their ubiquitination and subsequent degradation. Its application is crucial in research focused on targeted protein degradation, providing a strategic approach to modulating protein levels for therapeutic investigation. -
PROTAC Linker
tert-Butyl 4-(4-cyanophenyl)piperazine-1-carboxylate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound is essential in directing protein degradation pathways, enabling targeted modulation of protein levels within biological systems. Its application is valuable in drug discovery and development, especially for the study of protein interactions and cellular processes. -
PROTAC Linker
1,16-Dibromohexadecane is a versatile PROTAC linker that facilitates the design and synthesis of Protein Targeting Chimeras (PROTACs). Its structural properties allow for effective conjugation to target proteins, enhancing the degradation of unwanted proteins in cellular systems. This compound is essential for researchers focused on targeted protein degradation and drug discovery applications. -
PROTAC Linker
3-Benzyloxy-propionic acid methyl ester serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in creating bifunctional molecules that can selectively induce the degradation of target proteins via the ubiquitin-proteasome system. Its applications span various fields, including drug discovery and cellular signaling research, enabling advancements in targeted protein modulation. -
PROTAC Linker
11-Methoxy-11-oxoundecanoic acid serves as a PROTAC linker, facilitating the development of targeted protein degradation compounds. This reagent is utilized in the synthesis of PROTACs to selectively degrade specific proteins within cellular systems. Its unique structure enhances the binding efficiency and stability of PROTAC constructs, making it an essential tool for research in targeted therapeutics and protein modulation. -
PROTAC Linker
SCO-PEG3-NHS is a polyethylene glycol (PEG) linker featuring a terminal imine (NH) group, specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This linker facilitates the formation of stable PROTAC molecules, enhancing their effectiveness by promoting targeted protein degradation. SCO-PEG3-NHS is suitable for a variety of research applications, including drug discovery and the study of cellular protein regulation and turnover. -
PROTAC Linker
2-Boc-2-Azaspiro[3.3]heptane-6-methanesulfonate is a linker compound designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the degradation of specific proteins through the ubiquitin-proteasome pathway. Its application is significant in the advancement of targeted protein degradation research and therapeutic development. -
PROTAC Linker
tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate hydrochloride is a versatile PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ubiquitin ligases to substrates, enabling targeted protein modulation. Its application is essential for advancing research in targeted therapy, particularly in the fields of cancer and other diseases characterized by dysfunctional protein expression. -
PROTAC Linker
1,4-Diisocyanatobutane is a versatile PROTAC linker that facilitates the development of proteolysis targeting chimeras (PROTACs). Its unique structure enables efficient conjugation to both ligand and E3 ligase moieties, enhancing targeted protein degradation. This compound is essential for researchers focusing on targeted therapy and drug development in the fields of cancer research and other diseases. -
PROTAC Linker
Benzyl 4-hydroxybutanoate is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the selective degradation of target proteins by promoting the formation of ternary complexes between E3 ligases and substrate proteins. Its application is significant in the field of drug discovery, particularly in the development of innovative therapeutics for various diseases by harnessing the cellular ubiquitin-proteasome system. -
PROTAC Linker
4-Piperidineacetic acid hydrochloride serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound is instrumental in the synthesis of custom PROTACs, enabling researchers to probe biological pathways and investigate protein function with enhanced specificity. Its versatile structure supports various applications in drug discovery and therapeutic development, particularly in the field of targeted therapies. -
PROTAC Linker
Rel-(1R,4R)-4-Aminocyclohexane-1-carbonitrile hydrochloride serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial in connecting targeting and E3 ligase components, thereby promoting ubiquitination and degradation of specific proteins. Its application in research enhances the study of protein modulation and targeted therapy strategies. -
PROTAC Linker
Cl-C6-PEG3-C3-acid is a PROTAC linker designed for the efficient synthesis of PROTAC molecules. This compound facilitates the formation of targeted protein degradation approaches by connecting E3 ligases with target proteins. Its structure enhances solubility and flexibility, making it optimal for use in drug discovery and development aimed at manipulating intracellular protein levels. -
PROTAC Linker
tert-Butyl 5-iodopentanoate is a PROTAC linker designed to facilitate the construction of Proteolysis Targeting Chimeras (PROTACs). This compound enables the selective degradation of target proteins by linking E3 ubiquitin ligases to specific ligands, promoting targeted protein elimination. It serves as a crucial component in the development of therapeutic agents aimed at modulating protein levels in various research applications, including cancer and other diseases. -
PROTAC Linker
N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 is a PEG-based PROTAC linker designed for synthesizing proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by linking target proteins to E3 ligases, thereby promoting targeted degradation. Its unique structure allows for effective conjugation with various biomolecules, enabling advanced research into protein regulation and targeted therapeutics. -
PROTAC Linker
Propane-1,3-diyl bis(4-methylbenzenesulfonate) is a specialized PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enables the formation of a stable connection between a target protein and an E3 ligase, promoting targeted degradation via the ubiquitin-proteasome pathway. It is valuable in biochemical research for developing therapeutic strategies that modulate protein levels and functions. -
PROTAC Linker
tert-Butyl (2-(2-bromoethoxy)ethyl)(methyl)carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound serves as a critical component in the synthesis of PROTACs, enabling targeted protein degradation. It allows researchers to explore novel therapeutic strategies by selectively eliminating specific proteins within cellular contexts. -
PROTAC Linker
tert-Butyl (4-aminobicyclo[2.2.2]octan-1-yl)carbamate serves as a valuable PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in enhancing the degradation of specific proteins, allowing for targeted therapeutic interventions in various biological pathways. Its application in research includes the synthesis of PROTACs for studying protein dynamics and therapeutic efficacy. -
PROTAC Linker
5-Hydroxypentanenitrile serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the development of targeted protein degradation strategies, enhancing the degradation of specific proteins within cellular systems. Its application is vital in various areas of drug discovery and therapeutic development, particularly in targeting disease-relevant proteins for selective degradation. -
PROTAC Linker
1,8-Diiodooctane is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By providing a stable connection between an E3 ligase ligand and a target protein ligand, this compound enhances the selective degradation of specific proteins in cellular assays. It is particularly useful in the development of targeted protein degradation strategies in biochemical and pharmacological research. -
PROTAC Linker
Trans-4-(Aminomethyl)cyclohexanemethanol is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the synthesis of PROTACs by connecting target proteins to E3 ligases, thus promoting targeted protein degradation. It is valuable for researchers investigating selective protein modulation and degradation pathways. -
PROTAC Linker
Di-tert-butyl succinate is a PROTAC linker utilized in the development of proteolysis targeting chimeras (PROTACs). This compound enables the efficient synthesis of PROTACs by facilitating the conjugation of target ligands to E3 ligase ligands. Its application enhances the selective degradation of target proteins, making it valuable for chemical biology studies and therapeutic development. -
PROTAC Linker
3,3'-Thiodipropanoic acid is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the efficient conjugation of target proteins to E3 ligases, thereby promoting targeted protein degradation. Its unique structure enhances the stability and efficacy of PROTACs, making it valuable in drug development and pharmacological research aimed at modulating protein levels in various biological systems. -
PROTAC Linker
HO-PEG14-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of proteins or small molecules to enhance targeted protein degradation pathways. Its unique structure allows for increased solubility and flexibility, making it suitable for a variety of cellular and molecular biology applications, particularly in drug discovery and therapeutic development. -
PROTAC Linkers
Bis-aminooxy-PEG2 is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the formation of PROTACs, enabling targeted protein degradation. Its unique structure enhances solubility and provides flexibility, making it valuable for exploring novel therapeutic strategies in the field of targeted protein degradation research. -
PROTAC Linkers
t-Boc-Aminooxy-PEG5-azide is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This linker is valuable for researchers developing targeted protein degradation strategies in chemical biology and therapeutic applications. -
PROTAC Linker
N-Mal-N-bis(PEG2-acid) is a PEG-derived PROTAC linker designed for the construction of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the effective ubiquitination and degradation of target proteins, enhancing the study of protein homeostasis and regulation. It serves as a valuable tool in drug discovery and development, particularly in exploring targeted protein degradation pathways. -
PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG4-acid is a PEG-based linker designed for PROTAC synthesis, functioning effectively in targeted protein degradation applications. Featuring an azide functional group, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its robust reactivity makes it a valuable tool in chemical biology for the development of innovative therapeutics and advanced research applications. -
PROTAC Linkers
Pyrroline-5-carboxylate is a versatile PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkyl/ether backbone that enhances connectivity between target proteins and E3 ligases, facilitating selective protein degradation. This compound is essential for researchers investigating targeted protein modulation and degradation pathways in various biological systems.
