Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC Linkers
Bis-PEG11-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic spacer that enhances solubility and stability. Its applications extend to targeted protein degradation studies and the development of novel therapeutic agents in chemical biology research. -
PROTAC Linker
Propargyl-PEG4-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing partners. Its application is pivotal in the development of targeted protein degradation strategies, facilitating the creation of bifunctional molecules for modulating protein levels in cellular studies. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. This compound is instrumental in the development of innovative research tools aimed at targeted protein degradation, enabling studies in cellular biology and therapeutic development. -
PROTAC Linkers
DBCO-PEG9-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring a DBCO moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound enables precise and efficient conjugation strategies, making it valuable for applications in targeted protein degradation research. -
PROTAC Linker
m-PEG3-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. This linker enhances the solubility and pharmacokinetic properties of PROTAC molecules, making it valuable in drug discovery and development within the context of targeted therapies. -
PROTAC Linkers
HO-PEG20-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its unique structure enhances solubility and flexibility, making it suitable for various biochemical applications in drug discovery and development. -
PROTAC Linkers
Propargyl-PEG3-methane is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne functional group, this compound facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction, enabling efficient conjugation with azide-containing molecules. It is a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
Benzyl-PEG4-acid is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras. This compound enhances the solubility and stability of PROTACs, enabling effective targeting and degradation of specific proteins within cellular environments. It is primarily utilized in research applications involving targeted protein degradation and the exploration of protein interactions. -
PROTAC Linkers
TCO-PEG3-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase, promoting ubiquitination and subsequent degradation. Its versatile structure makes it a valuable tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linker
NH-bis(PEG3-Boc) is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It enables efficient conjugation of target proteins and E3 ligases, facilitating selective degradation of unwanted proteins. This compound is particularly valuable in chemical biology and drug discovery research focusing on targeted protein degradation mechanisms. -
PROTAC Linkers
Propargyl-PEG2-beta-D-glucose is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by providing a suitable chemical scaffold for target protein degradation studies. Its unique structure enhances the versatility and efficacy of PROTACs in biochemical research, enabling targeted therapeutic approaches in fields such as oncology and drug discovery. -
PROTAC Linkers
Azido-PEG9-S-methyl ethanethioate is a PEG-based linker designed for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in targeted protein degradation research. -
PROTAC Linker
Tri-(PEG1-C2-acid) functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTAC molecules for targeted protein degradation. This compound enhances solubility and biocompatibility, making it an essential component in drug development and chemical biology research focusing on ubiquitin-proteasome pathways. Its utility in constructing effective PROTACs can aid in studies aimed at modulating protein levels in various biological systems. -
PROTAC Linker
Boc-NH-PEG10-CH2CH2NH2 is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure facilitates the effective conjugation of ligands and E3 ligase recruiters, enabling targeted protein degradation. This compound is instrumental in advancing research related to targeted therapies and compound development in cellular and molecular biology. -
PROTAC Linker
m-PEG2-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the development of PROTACs by providing a flexible and hydrophilic moiety that can enhance their solubility and bioavailability. Its application in chemical biology allows for targeted protein degradation studies, making it a valuable tool in drug discovery and therapeutic research. -
PROTAC Linkers
m-PEG7-4-nitrophenyl carbonate is a PEG-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the conjugation of protein ligands to E3 ligase recruiters, enabling targeted protein degradation. It is ideal for applications in drug discovery and development, particularly in the study of protein modulation and the regulation of cellular pathways. -
PROTAC Linker
OTs-C6-OBn is an alkyl chain-based PROTAC linker designed for the synthesis of PROTAC conjugates targeting the SGK3 protein. This compound facilitates targeted protein degradation by linking E3 ligases to specific protein substrates, thereby enhancing the efficacy of PROTACs in biological research. It is suitable for applications in drug development and proteostasis modulation studies. -
PROTAC Linkers
DBCO-PEG6-amine is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This versatile reagent facilitates the construction of bifunctional molecules for targeted protein degradation studies, enhancing research in cellular regulation and therapeutic development. -
PROTAC Linkers
HO-PEG18-OH is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs by providing a flexible and biocompatible linker that enhances the efficiency of targeted protein degradation. Its key biological activity involves improving the solubility and stability of PROTAC constructs, making it valuable for research in targeted therapeutics. -
PROTAC Linkers
PEG8-Tos is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of high-performance PROTACs by enhancing solubility and stability, which are critical for effective protein degradation. Its use is essential in biochemical research focusing on targeted protein modulation and degradation studies, making it a valuable tool for drug discovery and development. -
PROTAC Linkers
Amino-PEG9-amine is a polyethylene glycol (PEG)-based linker designed for the development of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, enhancing the specificity and efficacy of PROTACs in targeting proteins for ubiquitination and subsequent degradation. Its applications are pivotal in the study of targeted protein degradation and the modulation of cellular pathways in various research fields, including cancer biology and drug discovery. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. This compound features an azide moiety that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzoazacyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the development of versatile bioconjugates in chemical biology research. -
PROTAC Linker
NH2-PEG2-methyl acetate hydrochloride is a polyethylene glycol-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of targeting ligands to E3 ubiquitin ligases, enabling the selective degradation of specific proteins in cellular systems. Its unique chemical structure enhances solubility and flexibility, making it a valuable tool for researchers investigating protein regulation and degradation pathways. -
PROTAC Linker
Bromoacetamido-PEG3-NH-Boc is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted degradation pathways. Its applications are essential in chemical biology and drug discovery, allowing for the development of innovative therapeutic strategies through selective protein modulation. -
PROTAC Linkers
Mal-PEG6-mal is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of PROTACs by facilitating the coupling of target proteins with E3 ligases to promote targeted degradation. Its applications span the development of novel therapeutics aimed at addressing difficult-to-treat diseases through targeted protein modulation. Mal-PEG6-mal is essential for researchers investigating innovative approaches in protein degradation technologies. -
PROTAC Linker
Methyltetrazine-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. It is suitable for applications in drug discovery and development, enabling researchers to investigate protein function and therapeutic potential in various biological contexts. -
PROTAC Linkers
(+) -Biotin-ONP is a biotinylated linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeting and degradation of proteins through the recruitment of E3 ligases, thereby enhancing the effectiveness of protein modulation studies. It is an essential tool for researchers exploring targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
Bromoacetamido-PEG5-DOTA is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bromacetamido moiety that facilitates covalent bonding with target proteins, thereby enhancing the efficacy of targeted protein degradation. Bromoacetamido-PEG5-DOTA is instrumental in the development of novel therapeutic strategies in oncology and other fields by allowing precise modulation of protein levels within cells. -
PROTAC Linkers
Boc-Aminoxy-PEG4-OH is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC molecules, facilitating the development of targeted protein degradation strategies. It is invaluable in research applications focusing on the design and optimization of PROTACs for therapeutic purposes. -
PROTAC Linkers
DBCO-PEG1-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring a DBCO moiety, this compound facilitates efficient click chemistry through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. DBCO-PEG1-acid is integral for developing targeted degradation strategies in protein research, enabling precise modulation of protein levels for various biological applications. -
PROTAC Linkers
HyNic-PEG2-DBCO is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its efficient click chemistry properties enable precise conjugation, making it valuable for studies in targeted protein degradation and therapeutic development. Applications of HyNic-PEG2-DBCO include the creation of custom PROTACs for probing biological pathways and evaluating protein interactions. -
PROTAC Linkers
N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that have DBCO or BCN functionalities. This versatility makes it suitable for various applications in chemical biology and targeted protein degradation research. -
PROTAC Linkers
Ms-PEG2-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by improving the binding efficiency between the protein of interest and the E3 ligase. It is suitable for applications in chemical biology and drug discovery, enabling researchers to develop novel therapeutic strategies for treating various diseases through targeted protein degradation. -
PROTAC Linkers
Benzyl-PEG2-CH2COOH is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by linking ligands to E3 ligases, thereby promoting the selective elimination of target proteins. It is an important tool for researchers exploring novel therapeutic strategies in cellular biology and drug development applications. -
PROTAC Linkers
Fmoc-N-PEG36-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of PROTAC molecules, enabling targeted degradation of proteins within cellular contexts. Its unique structure enhances solubility and stability, making it a valuable tool for researchers exploring targeted protein degradation in drug discovery and development. -
PROTAC Linkers
Tos-PEG6-C2-Boc is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, enabling the selective degradation of specific proteins in cellular systems. Its application in PROTAC development supports advancements in targeted protein regulation and therapeutic discovery. -
PROTAC Linker
Fluorescein-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting moieties to E3 ligase ligands, promoting the targeted degradation of specific proteins. Its fluorescent properties enable visualization and tracking of the resulting PROTACs in biological assays and studies. Fluorescein-PEG6-NHS ester is suitable for applications in chemical biology, drug discovery, and protein degradation research. -
PROTAC Linkers
Fluorescein-PEG5-NHS ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a fluorescein moiety, enabling fluorescence-based detection and tracking of PROTACs in cellular assays. Its versatile structure facilitates the conjugation of ligands and the modulation of target protein degradation, supporting research in targeted protein degradation and drug discovery applications. -
PROTAC Linkers
Methyltetrazine-PEG8-NHS ester is a PEG-based linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound effectively connects a target protein and an E3 ligase for targeted degradation, enhancing the specific elimination of proteins in cellular systems. Its utility in PROTAC synthesis makes it an essential reagent for researchers exploring novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Lipoamide-PEG3-Mal is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of the resulting conjugates, promoting efficient protein degradation through the ubiquitin-proteasome system. Lipoamide-PEG3-Mal is instrumental in advancing research in targeted protein degradation and drug discovery applications. -
PROTAC Linker
Mal-amido-PEG3-acid is a polyethylene glycol (PEG) based linker utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This conjugate facilitates targeted protein degradation by connecting target proteins with E3 ligases, contributing to the modulation of specific biological pathways. Its application is pivotal in drug discovery and therapeutic research aimed at exploring novel mechanisms of action for varied diseases. -
PROTAC Linkers
N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTACs. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds, making it a versatile tool for targeted protein degradation research applications. -
PROTAC Linker
Biotin-PEG9-amine is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the modulation of targeted protein degradation by improving the solubility and biocompatibility of PROTAC constructs. Its biotin moiety enables affinity capture via streptavidin, enhancing the efficiency of target identification and validation in cellular studies. Biotin-PEG9-amine serves as a valuable tool in chemical biology and drug discovery research applications. -
PROTAC Linker
Cl-C6-PEG4-C3-COOH is a PROTAC linker designed for the synthesis of chloroalkane-based PROTACs, commonly referred to as HaloPROTACs. This compound facilitates the formation of targeted protein degradation systems by enabling specific interactions with target proteins. It is instrumental in studying protein dynamics and developing innovative therapeutic strategies that harness the ubiquitin-proteasome system for drug discovery and research applications. -
PROTAC Linkers
TCO-PEG4-biotin is a PEG-based PROTAC linker designed to facilitate the construction of PROTACs. This compound enhances the solubility and stability of the resulting bifunctional molecules, enabling targeted protein degradation. Its incorporation into PROTACs allows for selective modulation of target proteins, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
TCO-PEG2-Sulfo-NHS ester is a PEGylated PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables efficient conjugation of targeting ligands to E3 ligases, enhancing cellular degradation of specific proteins. Its utility in drug discovery and development makes it a valuable tool for researchers investigating targeted protein degradation strategies. -
PROTAC Linkers
Fmoc-aminooxy-PFP ester is a versatile PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an aminooxy group that promotes target protein degradation through the recruitment of E3 ubiquitin ligases. It is instrumental in exploring targeted protein modulation and advancing drug discovery efforts. -
PROTAC Linker
endo-BCN-PEG3-acid is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing target degradation by connecting ligands to E3 ligases. Its utility in protein modulation research positions it as a valuable tool for studies focusing on targeted protein degradation strategies in various diseases. -
PROTAC Linker
Boc-11-aminoundecanoic acid is an alkyl/ether-based PROTAC linker that facilitates the development of targeted protein degraders. This compound is essential for synthesizing bifunctional molecules that recruit E3 ligases for the selective degradation of proteins. It finds applications in protein engineering, drug discovery, and the study of protein function through targeted degradation. -
PROTAC Linkers
Benzyl-PEG5-amine functions as a PEG-based linker in the development of PROTACs (proteolysis-targeting chimeras). This reagent enhances solubility and offers flexibility in molecular design, facilitating targeted protein degradation. Its application is crucial in drug discovery and the exploration of targeted therapies for various diseases.
