Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC Linker
Benzyl-PEG2-azide is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds possessing DBCO or BCN groups. This reagent is instrumental in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Biotin-PEG5-amine functions as a biotin-labeled polyethylene glycol (PEG) linker for the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the synthesis of PROTACs by allowing for the precise conjugation of target proteins to E3 ligases, promoting targeted protein degradation. It is valuable in research focusing on protein regulation and therapeutic development. -
PROTAC Linkers
TCO-PEG3-alcohol is a PEG-based linker specifically designed for PROTAC synthesis, functioning primarily through the inverse electron demand Diels-Alder (iEDDA) reaction. This compound features a TCO moiety that enables efficient coupling with tetrazine-conjugated molecules, facilitating the development of targeted protein degradation strategies. Its use in research applications enhances the exploration of protein function and regulation in various biological pathways. -
PROTAC Linkers
DBCO-PEG4-triethoxysilane is a PEG-based PROTAC linker specifically designed for the synthesis of PROTACs. Its DBCO group facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. This compound is instrumental in the development of targeted protein degradation strategies, enhancing research in cancer therapy and other therapeutic areas. -
PROTAC Linkers
m-PEG11-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to E3 ligase recruiters, enabling the selective degradation of protein targets in cellular systems. Its versatile applications include drug discovery and the study of protein function and regulation through targeted protein degradation. -
PROTAC Linkers
PEG3-C4-OBn is a polyethylene glycol (PEG)-derived linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTAC SGK3 degrader-1, which effectively induces targeted degradation of SGK3, a serine/threonine protein kinase. PEG3-C4-OBn is instrumental in advancing research related to targeted protein degradation and cellular regulation mechanisms. -
PROTAC Linker
TCO4-PEG3-Maleimide is a PROTAC linker designed for targeted protein degradation applications. It features TCO and Maleimide functional groups, enabling precise "click" reactions with tetrazine and thiol compounds, or "mercapto-acrylamide" reactions. This compound facilitates the development of innovative therapeutic modalities by promoting effective protein-interaction dynamics in chemical biology research. -
PROTAC Linker
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC technology. This linker facilitates the synthesis of novel PROTAC compounds, notably the K-Ras Degrader-1, by promoting the degradation of specific target proteins via the ubiquitin-proteasome pathway. It is particularly useful in studies focused on targeted protein degradation for therapeutic applications. -
PROTAC Linker
Propargyl-PEG8-Boc is a PEG-based linker designed for use in the synthesis of PROTACs. It features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This versatile linker facilitates research in targeted protein degradation and can be employed in the development of innovative therapeutic strategies. -
PROTAC Linker
Propargyl-PEG12-OH is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. Propargyl-PEG12-OH is essential for developing targeted protein degradation systems and advancing chemical biology research applications. -
PROTAC Linker
N-Mal-N-bis(PEG2-NH-Boc) is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand and E3 ligase components, enhancing the efficacy of targeted protein degradation. Its unique structure supports optimized solubility and stability, making it suitable for a variety of chemical biology applications in protein research and drug discovery. -
PROTAC Linkers
Bis-Mal-PEG11 is a polyethylene glycol (PEG) based PROTAC linker that facilitates the development of targeted protein degradation agents. It enhances the solubility and stability of PROTACs while improving their overall pharmacological properties. This linker is crucial for synthesizing PROTACs that engage specific E3 ligases, enabling selective degradation of target proteins in various cellular contexts. -
PROTAC Linker
Azido-PEG4-Amido-Tris is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. This versatility makes Azido-PEG4-Amido-Tris a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
3,4-Dibromo-Mal-PEG2-amine TFA is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting targeted protein degradation. Its unique structure enhances the pharmacokinetic properties of PROTAC molecules, making it suitable for diverse applications in drug discovery and chemical biology. -
PROTAC Linker
Methylamino-PEG3-azide serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates. In addition, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a valuable tool for chemical biology applications, particularly in targeted protein degradation studies. -
PROTAC Linker
Amino-PEG1-C2-acid is a polyethylene glycol (PEG) linker designed for use in the development of proteolysis targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted protein degradation. Its biocompatibility and flexible structure make it an ideal choice for research applications focusing on targeted protein modulation and therapeutic strategies. -
PROTAC Linkers
Mal-amide-PEG2-oxyamine is a PEG-based linker specifically designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the targeted degradation of specific proteins by connecting E3 ligases with ligands that bind to the desired protein, enabling precise modulation of protein levels. Its application in PROTAC development supports research in targeted therapy, cellular signaling, and protein homeostasis. -
PROTAC linker
N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring a propargyl group, this compound facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling efficient conjugation with azide-containing molecules. Its versatility supports research applications in targeted protein degradation and novel therapeutic development. -
PROTAC Linker
Biotin-PEG6-Mal is a biotinylated polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to E3 ligases, enabling selective degradation of intracellular proteins. Its unique structure allows for increased solubility and stability in biological systems, making it a valuable tool in chemical biology and targeted protein degradation research. -
PROTAC Linkers
Methyltetrazine-amido-PEG5-alkyne is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases. Its application in PROTAC development enables enhanced therapeutic strategies in the field of targeted protein degradation for various diseases, including cancer. -
PROTAC Linkers
Azido-PEG6-MS is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an azide functional group, it facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules or those labeled with DBCO or BCN groups. This reagent is particularly useful in the development of targeted protein degradation strategies, enabling precise control over the conjugation of various biologically active compounds for research applications. -
PROTAC Linker
Ac4GalNAl is an alkyl chain-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne functional group, it facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This reagent serves as a tool for developing targeted protein degradation systems and is valuable in chemical biology research focused on modulating protein levels within cells. -
PROTAC Linkers
m-PEG17-acid functions as a polyethylene glycol (PEG)-based linker for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the connection of the ligand and the target protein, enhancing the efficiency of targeted protein degradation. Its application is pivotal in chemical biology research aimed at understanding and manipulating cellular protein levels. -
PROTAC Linkers
m-PEG4-NH-DBCO is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a dibenzocyclooctyne (DBCO) moiety, enabling effective strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its properties facilitate the development of targeted protein degradation strategies in chemical biology research, positioning m-PEG4-NH-DBCO as a valuable tool for advancing PROTAC technology. -
PROTAC Linker
Amino-PEG13-amine is a polyethylene glycol (PEG) based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of drug conjugates that combine target proteins with E3 ubiquitin ligases, enabling selective degradation mechanisms. Its hydrophilic nature enhances solubility and bioavailability, making it a valuable tool for researchers exploring targeted protein degradation strategies in drug discovery and development. -
PROTAC Linker
Mal-NH-Boc is an alkyl/ether-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical component in the development of PROTACs, enabling targeted protein degradation. Its structural properties allow for efficient conjugation, enhancing the efficacy of therapeutic applications in the study of protein functions and cellular pathways. -
PROTAC Linker
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC K-Ras Degrader-1, enabling the selective degradation of the K-Ras protein. It is essential for research in therapeutic strategies aimed at modulating protein levels in various disease models. -
PROTAC Linker
Aldehyde-benzyl-PEG5-alkyne serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables its use in click chemistry reactions, specifically undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. Its utility in synthesizing novel PROTACs makes it valuable for biochemical research applications focused on protein modulation and degradation pathways. -
PROTAC Linker
N-(Boc-PEG3)-N-bis(PEG3-acid) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound enhances the solubility and cellular uptake of PROTACs while providing a flexible connection between the target protein and the E3 ligase. Its application in drug development allows for the targeted degradation of proteins, thereby facilitating innovative research in cancer therapy and beyond. -
PROTAC Linker
N-Mal-N-bis(PEG4-NHS ester) is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. It facilitates the synthesis of PROTACs by providing a flexible and effective means to conjugate targeting ligands to E3 ligase components. This reagent is essential for researchers aiming to explore targeted protein degradation pathways in various biological contexts. -
PROTAC Linker
N3-PEG5-C6-Cl is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of degradable protein-targeting molecules, enhancing the delivery and efficacy of targeted protein degradation strategies. It is ideal for applications in chemical biology, particularly in the development of novel therapeutic agents aimed at selective protein modulation. -
PROTAC Linkers
Tri(Amino-PEG5-amide)-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of diverse protein ligands for targeted protein degradation, enhancing the efficacy of PROTAC-based therapeutics. Its unique structural features allow for improved solubility and stability, making it suitable for various chemical biology and drug discovery applications. -
PROTAC Linker
endo-BCN-PEG3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. Featuring a BCN group, this compound enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating the formation of complex bioconjugates. Its application in chemical biology makes it a valuable tool for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
Br-PEG4-THP is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the selective degradation of target proteins by bridging an E3 ligase and the target protein, enhancing the efficacy of PROTACs. It is ideal for research applications focused on targeted protein degradation and therapeutic development in various disease models. -
PROTAC Linker
16-Aminohexadecanoic acid functions as a PROTAC linker, featuring a long alkane chain with terminal carboxylic acid and amine groups. Its amino group (NH2) readily reacts with carboxylic acids, activated NHS esters, and carbonyls, facilitating the formation of stable amide bonds. This biochemical property makes it a valuable component in the synthesis of PROTACs, enhancing their efficacy in targeted protein degradation studies and drug discovery applications. -
PROTAC Linkers
Bromo-PEG7-alcohol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bromine functionality that facilitates the conjugation of target ligands to E3 ligase recognition elements. It is employed in various research applications to enable targeted protein degradation, thereby providing valuable insights into cellular mechanisms and therapeutic potential. -
PROTAC Linkers
BocNH-PEG4-CH2CHO is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the selective degradation of target proteins by connecting a ligand that recruits an E3 ubiquitin ligase with a protein of interest. Its versatility makes it suitable for various applications in protein degradation research and drug discovery. -
PROTAC Linkers
N-(PEG3-acid)-N-bis(PEG3-amine) is a polyethylene glycol (PEG)-derived linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound enhances the solubility and stability of PROTACs, facilitating efficient target protein degradation. It serves as a vital component in the development of bifunctional molecules for targeted protein modulation and therapeutic applications. -
PROTAC Linker
Mal-Amido-PEG4-Boc is a PEG-derived linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins within cellular systems. Its incorporation in PROTAC development is crucial for investigating protein homeostasis and therapeutic applications in targeted cancer therapies. -
PROTAC Linker
Monoethyl pimelate acts as a key PROTAC linker, characterized by its alkyl/ether structure. This compound facilitates the synthesis of (S,R,S)-AHPC-Me-C7 ester, a targeted BCL-XL PROTAC degrader. Its application is crucial in the development of molecular degraders for therapeutic research, enabling the selective modulation of protein levels within biological systems. -
PROTAC Linker
Propargyl-PEG4-sulfonic acid serves as a versatile PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). Its alkyne functional group enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating the conjugation of azide-containing molecules. This compound is crucial for applications in targeted protein degradation research and functional proteomics, enhancing the development of innovative therapeutic strategies. -
PROTAC Linkers
(10-BRomodecyl)phosphonic acid is a versatile alkyl chain-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the recruitment of E3 ligases, promoting targeted protein degradation. This compound is essential for advancing research in targeted therapeutics and protein modulation studies. -
PROTAC Linkers
Mal-PEG8-alcohol functions as a PEG-based linker for the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligands to target proteins, enhancing the specificity and efficacy of targeted protein degradation. It is instrumental in research aimed at elucidating protein functions and therapeutic development in various diseases, including cancer. -
PROTAC Linker
Mal-PEG6-PFP ester is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of PROTAC molecules, enabling targeted protein degradation studies. Its molecular structure enhances solubility and improves the overall efficacy of PROTAC conjugates in research applications focused on targeted protein modulation and therapeutic interventions. -
PROTAC Linkers
1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane serves as a PEG-based linker for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the selective degradation of target proteins through targeted ubiquitin-proteasome system engagement. It is crucial for researchers developing novel PROTAC molecules to explore therapeutic avenues in targeted protein degradation. -
PROTAC Linker
N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTACs. This compound features an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it a valuable tool for researchers studying targeted protein degradation and expanding the capabilities of PROTAC technology in various biological applications. -
PROTAC Linkers
Propargyl-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. Propargyl-PEG2-MS serves as a critical tool for researchers exploring targeted protein degradation and other innovative therapeutic strategies. Its versatility in click chemistry makes it suitable for a variety of biological applications in chemical biology and drug development. -
PROTAC Linker
endo-BCN-PEG2-acid is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique chemoselectivity enhances the development of targeted protein degradation applications in various biological research contexts. -
PROTAC Linkers
m-PEG24-alcohol is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound provides the necessary flexibility and solubility for effective assembly of targeted protein degraders. Its application in PROTAC development enables researchers to investigate the selective degradation of specific proteins, facilitating studies in areas such as cancer treatment and protein homeostasis. -
PROTAC Linker
Bis-Mal-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins, thereby promoting ubiquitination and subsequent degradation. Bis-Mal-PEG3 is essential for researchers developing targeted protein degradation strategies to manipulate cellular pathways and study protein function.
