Catalog No.
Product Name
Application
Product Information
Citations
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SMARCA4/SMARCA2 ATPase Inhibitor
FHT-1015 is a selective allosteric inhibitor of SMARCA4 (BRG1) and SMARCA2 (BRM), with IC₅₀ values of 4 nM and 5 nM, respectively. It binds to an allosteric site, inducing conformational changes that inhibit the ATPase activity of BRG1/BRM. FHT-1015 disrupts tumor cell growth and migration and is applicable in research on uveal melanoma and hematologic malignancies. -
Na+/K+-ATPase Inhibitor
Cryptanoside A is a potent Na+/K+-ATPase inhibitor derived from the stems of Cryptolepis dubia. This cardiac glycoside epoxide exhibits significant cytotoxic effects against various cancer cell lines. Additionally, Cryptanoside A enhances the expression of Akt and the p65 subunit of NF-κB, making it a valuable tool for studying cancer biology and the regulatory pathways involved in cell survival and proliferation. -
V-ATPase Inhibitor
Bafilomycin D is a specific inhibitor of vacuolar-type ATPase (V-ATPase), blocking proton translocation and disrupting acidic environments within cells. This compound exhibits significant antimicrobial, insecticidal, herbicidal, and cytotoxic activities, making it a valuable tool for biochemical research. It is useful in studies related to cellular metabolism, ion homeostasis, and the investigation of V-ATPase functions across various biological systems. -
Pma1p-ATPase Inhibitor
ATPase-IN-5 is a potent inhibitor of Pma1p-ATPase, exhibiting an IC50 value of 12.7 μM. This compound is critically important in the study of antifungal mechanisms, providing insights into yeast cell metabolism and enzyme regulation. ATPase-IN-5 offers valuable applications in antifungal research, enabling the exploration of new therapeutic strategies. -
H+, K+-ATPase Inhibitor
Esomeprazole hemistrontium is a potent H+, K+-ATPase inhibitor that functions as an effective proton pump inhibitor. It reduces gastric acid secretion by targeting the H+, K+-ATPase enzyme in parietal cells. This compound is particularly valuable for research applications related to symptomatic gastroesophageal reflux disease. -
Na+/K+ ATPase Inhibitor
Chamigrenol is an inhibitor of the Na+/K+ ATPase, exhibiting an IC50 value of 15.9 μg/mL. This compound demonstrates significant antibacterial activity against both Gram-positive and Gram-negative bacteria, with the exception of Escherichia coli, showing minimum inhibitory concentration (MIC) values of 50 µg/mL. Chamigrenol is valuable for research in microbiology and the development of novel antimicrobial agents. -
Na+/K+-ATPase Inhibitor
(-)-γ-Cuparenol is a sesquiterpene compound that acts as an inhibitor of Na+/K+-ATPase, with an IC50 value of 23.6 μg/mL in porcine models. It has demonstrated the ability to reduce phytohemagglutinin (PHA)-induced activation of NF-AT and NF-κB in Jurkat cells, indicating potential applications in immunoregulation. Additionally, (-)-γ-Cuparenol exhibits antibacterial activity against certain Gram-positive and some Gram-negative bacteria, as well as weak inhibitory effects on Candida albicans. This compound is relevant for research exploring cardiovascular diseases and bacterial infections. -
H+, K+-ATPase Inhibitor
Esomeprazole (S-Omeprazole) is a potent H+, K+-ATPase inhibitor that functions as an effective proton pump inhibitor. It reduces gastric acid secretion by specifically inhibiting the H+, K+-ATPase enzyme in parietal cells of the stomach lining. This compound is valuable in research related to gastroesophageal reflux disease and studies investigating acid secretion mechanisms. -
H+, K+-ATPase Inhibitor
Esomeprazole potassium salt is a potent H+, K+-ATPase inhibitor, primarily functioning as a proton pump inhibitor. It effectively reduces gastric acid secretion by targeting the H+, K+-ATPase enzyme in gastric parietal cells. This compound is valuable for research applications focusing on symptomatic gastroesophageal reflux disease and related gastrointestinal disorders. -
BRG1/BRM ATPase Inhibitor
BRM/BRG1 ATP Inhibitor-2 is a selective inhibitor of BRG1 and BRM ATPase activity, targeting the SWI/SNF chromatin remodeling complexes. This compound is valuable for investigating the molecular implications of BAF-related disorders, including cancer and developmental syndromes. Its mechanism of action enables researchers to explore the role of ATP-dependent chromatin remodeling in gene expression regulation and cellular differentiation. -
SMARCA2 ATPase Inhibitor
SMARCA2-IN-10 is a selective inhibitor of the SMARCA2 ATPase domain, with an IC50 value of 17.676 μM. This compound has been shown to induce cell death in tumors lacking SMARCA4, making it a valuable tool for investigating SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma. Its targeting of the SMARCA2 ATPase offers significant potential for advancing research in these cancer types. -
V-ATPase/HIV-1 Inhibitor
Diphyllin is a potent inhibitor of vacuolar H+-ATPase (V-ATPase) with an IC50 of 17 nM, and also acts as an HIV-1 inhibitor with an IC50 of 0.38 μM. This compound effectively disrupts the acidification of osteoclast lysosomes, leading to significant inhibition of osteoclast-mediated bone resorption while leaving osteoblastic bone formation unaffected. Diphyllin is valuable for investigating bone metabolism-related diseases and exploring therapeutic avenues for conditions characterized by excessive bone resorption. -
ATPase/Bacterial Inhibitor
Dihydronovobiocin is a bacterial inhibitor that targets ATPase activity by binding to the GyrB subunit of DNA gyrase. This compound is useful for investigating the interactions between coumarin antibiotics, such as Novobiocin, Chlorobiocin, and Coumermycin, and their effects on DNA gyrase function. Dihydronovobiocin also has potential applications in the study of bacterial infections, facilitating research into the mechanisms of antibiotic action and resistance. -
ATPase Inhibitor
ATPase-IN-6 is a H+/K+-ATPase inhibitor and a prazole derivative. It exhibits significant antiviral activity against a range of viruses, including HIV-1 and SARS-CoV-2. This compound is useful for research investigating antiviral mechanisms and potential therapeutic strategies for viral infections. -
ATPase Inhibitor
Apicularen A is a macrolide that selectively inhibits vesicular ATPases, targeting ATPase activity in cellular processes. This compound has been isolated from the mucoid bacterium Chondrosporium spp. Its potent inhibitory effects make it a valuable tool for research applications focused on cellular transport mechanisms and metabolic regulation. -
CV-B3 2C ATPase Inhibitor
ATPase-IN-8 is a selective inhibitor of CV-B3 2C ATPase, exhibiting an IC50 of 1.4 μM. This compound demonstrates significant anti-enteroviral activity, particularly against coxsackievirus B3 (CV-B3) and enterovirus D68 (EV-D68). ATPase-IN-8 is suitable for research applications focusing on enteroviral infections and their molecular mechanisms. -
H+, K+-ATPase Inhibitor
Esomeprazole magnesium salt is a selective inhibitor of the H+, K+-ATPase enzyme in gastric parietal cells, functioning as an effective proton pump inhibitor. This compound demonstrates significant biological activity by reducing gastric acid secretion. It is primarily utilized in research related to gastroesophageal reflux disease, exploring its therapeutic potential and mechanisms of action in acid-related disorders. -
Na+-V-ATPase Inhibitor
V-161 is an orally active inhibitor of Na+-V-ATPase, exhibiting an IC50 of 144 nM. This compound effectively inhibits the growth of Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline conditions, with a minimum inhibitory concentration (MIC) of 4 µg/mL for both bacterial strains. In vivo studies demonstrate that V-161 significantly reduces VRE colonization in the mouse small intestine, making it a valuable tool for research into antimicrobial resistance and gut microbiota interactions. -
p97 ATPase Inhibitor
p97-IN-2 is a selective inhibitor of the p97 ATPase, with an IC50 of 0.6 μM. This compound effectively inhibits the proliferation of cancer cell lines, including HCT15 (IC50 = 1.1 μM) and SW403 (IC50 = 0.8 μM). p97-IN-2 serves as a valuable tool for investigating the role of p97 in cancer biology and therapeutic applications. -
Natural Products
Thevetin A is a cardiac glycoside derived from the plant Cascabela thevetioides. It exhibits potent biological activity by inhibiting Na+/K+ ATPase, leading to increased intracellular calcium levels and enhanced contractility of cardiac muscle. This compound is primarily utilized in cardiovascular research to study its effects on cardiac function and potential therapeutic applications in heart disease. -
Stable Isotope
Pantoprazole-d4 is a deuterated derivative of Pantoprazole, a potent proton pump inhibitor that targets the H+/K+-ATPase enzyme with an IC50 of 6.8 μM. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research to enhance the accuracy of drug absorption and distribution analysis. Pantoprazole exhibits anti-secretory and anti-ulcer properties, while its combination with Doxorubicin has been shown to significantly increase tumor growth delay, underscoring its potential utility in cancer research. -
Isotope-Labeled Compounds
Digitoxin-d3 is a deuterated derivative of digitoxin, a cardiac glycoside that primarily targets the Na+/K+ ATPase enzyme, enhancing intracellular calcium levels and improving myocardial contractility. This isotope-labeled compound is utilized in pharmacokinetic studies, providing insights into the metabolism and distribution of digitoxin in biological systems. It serves as a valuable tool for researchers examining heart function and the therapeutic mechanisms of cardiac glycosides. -
H+, K+-ATPase Inhibitor
Esomeprazole magnesium, a potent H+, K+-ATPase inhibitor, is utilized in research related to upper intestinal disorders and gastroesophageal reflux disease. Its primary mechanism involves the inhibition of proton pumps, leading to decreased gastric acid secretion. Additionally, Esomeprazole magnesium exhibits properties as an exosome inhibitor by blocking exosome release through the inhibition of vacuolar H+-ATPases, making it valuable for studies on cellular communication and disease progression. -
SERCA Inhibitor
2,5-Di-tert-butylhydroquinone is a potent inhibitor of Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), demonstrating an IC50 of 400 nM. This compound disrupts the gating function of Glu309, thereby preventing calcium ions from accessing their binding site. Additionally, 2,5-Di-tert-butylhydroquinone influences the activity of key enzymes such as 5-lipoxygenase and COX-2, with IC50 values of 1.8 μM and 14.1 μM, respectively. It is utilized in research focused on cellular calcium regulation and inflammatory processes. -
Proton Pump Inhibitor
Ilaprazole sodium is a potent proton pump inhibitor that irreversibly targets H+/K+-ATPase, demonstrating a dose-dependent inhibition with an IC50 of 6 μM in rabbit parietal cell assays. This compound is primarily utilized in research focused on gastric ulcers, providing insights into gastric acid secretion regulation. Additionally, Ilaprazole sodium acts as an effective inhibitor of TOPK (T-lymphokine-activated killer cell-originated protein kinase), facilitating studies related to immune responses and cancer therapeutics. -
Antidepressant
Depramine, a tricyclic antidepressant, primarily targets neurotransmitter reuptake mechanisms, elevating levels of norepinephrine and serotonin in the synaptic cleft. It exhibits significant biological activity through the inhibition of acetylcholinesterase, Mg2+-ATPase, and Na+/K+ ATPase. Depramine is utilized in research focused on depression and related mood disorders, facilitating studies on neurotransmitter dynamics and cellular signaling pathways involved in antidepressant efficacy. -
Stable Isotope
Cyclopiazonic acid-13C20 is a stable isotope-labeled derivative of Cyclopiazonic acid, a selective inhibitor of endoplasmic reticulum calcium ATPases (ECAs) and has demonstrated efficacy against human respiratory syncytial virus (RSV) with an EC50 value of 4.13 μM. This compound is shown to inhibit the antagonistic effects of serotonin receptors in rat thoracic aorta, induce p53-dependent apoptosis, and exhibit reproductive toxicity in mouse testes, as well as inhibit the biological activation of aflatoxin B. Cyclopiazonic acid-13C20 is valuable for research applications in calcium signaling, viral infections, and toxicology studies. -
H+/K+-ATPase Inhibitor
DBM-819 is a reversible inhibitor of H⁺/K⁺-ATPase, exhibiting an IC50 value of 5 µM. This compound effectively inhibits gastric acid secretion by blocking the proton pump in the gastric mucosa, demonstrating significant protective effects against duodenal ulcers induced by Cysteamine, and gastric ulcers induced by Indomethacin and Aspirin, with EC50 values of 6, 3.1, and 4 mg/kg, respectively. DBM-819 serves as a valuable tool in research focused on ulcer prevention and gastroprotection. -
H+/K+-ATPase Inhibitor
ATPase-IN-7 is a potent inhibitor of H+/K+-ATPase, which plays a crucial role in regulating gastric acid secretion. This compound is primarily utilized in research focused on gastrointestinal inflammatory diseases and conditions related to gastric acidity. Its inhibitory effect makes it a valuable tool for studying acid-related pathologies and potential therapeutic interventions. -
Na+/K+ ATPase Inhibitor
Acevaltrate is a selective inhibitor of Na+/K+ ATPase, demonstrating IC50 values of 22.8 μM in rat kidney tissues and 42.3 μM in brain hemispheres. This compound is valuable for studying ion transport mechanisms and the physiological roles of Na+/K+ ATPase in renal and neurological contexts. Its inhibitory effects make it a suitable tool for exploring potential therapeutic applications in conditions related to dysregulated ion homeostasis. -
Na, K-ATPase Inhibitor
Digoxigenin monodigitoxoside is an inhibitor of Na,K-ATPase and a metabolite of Digoxin. It modulates cardiac function by affecting ion transport, making it valuable for studying cardiovascular diseases, including congestive heart failure and cardiac arrhythmias. This reagent is essential for researchers investigating the mechanisms of cardiac glycosides and their therapeutic potential. -
Na+/K+-ATPase Inhibitor
Gitoxin is a potent Na+/K+-ATPase inhibitor that significantly alters cellular ion homeostasis. It is a metabolite derived from the degradation of Digitoxin, featuring a hydroxyl (ZOH) group at the C-17β position, which impacts its pharmacokinetic and pharmacodynamic properties. Gitoxin's inhibitory effect on Na+/K+-ATPase makes it a valuable tool in cardiovascular research and studies involving ion transport mechanisms. -
Na+/K+ ATPase Inhibitor
Marinobufogenin is a potent Na+/K+ ATPase inhibitor found in mammalian plasma. It exhibits significant biological activity by modulating electrolyte balance and influencing cellular signaling pathways. Research applications include studies on cardiovascular function, renal physiology, and the exploration of cellular mechanisms related to ion transport. -
Na+/K+ ATPase Inhibitor
Transdermal Peptide Disulfide is a synthetic 11-amino acid peptide that serves as an inhibitor of the Na+/K+-ATPase by binding to the beta-subunit (ATP1B1) and specifically interacting with its C-terminus. This compound enhances the transdermal delivery of various macromolecules, making it a valuable tool in drug formulation and transdermal research applications. Its ability to facilitate the transport of biologically relevant molecules may have significant implications for improving therapeutic delivery in clinical settings. -
Na, K-ATPase Inhibitor
Prilocaine hydrochloride is an amino amide that functions as an inhibitor of Na+/K+-ATPase. This compound exhibits neurotoxic properties, making it relevant for studies involving neuronal function and toxicity. Research applications include exploring membrane transport mechanisms and assessing the impacts of ion channel modulation on cellular activity. -
Na+/K+ ATPase Inhibitor
Stauntosaponin A is a steroid glycoside that serves as a potent inhibitor of Na+/K+ ATPase, demonstrating an IC50 value of 21 nM. Isolated from Carnation, this compound exhibits significant biological activity that may be leveraged in anti-cancer research. Its ability to modulate ion transport makes it a valuable tool for exploring cellular mechanisms and therapeutic interventions in cancer biology. -
Na+/K+ ATPase Inhibitor
Suloctidil hydrochloride is a potent Na+/K+ ATPase inhibitor that modulates membrane fluidity in rat brain synaptosomes. It demonstrates significant biological activity relevant to neurological research and is under investigation in clinical trials for potential therapeutic applications in dementia and thrombotic disorders. -
ATPase Inhibitor
16-HETE is an arachidonic acid metabolite that functions primarily as an ATPase inhibitor. It demonstrates vasodilatory effects and inhibits polymorphonuclear leukocyte (PMN) activity, making it valuable in studying inflammatory processes. Additionally, 16-HETE serves as a biomarker in the early detection of non-alcoholic fatty liver disease, facilitating research into metabolic disorders and their progression. -
H⁺/K⁺ ATPase Inhibitor
AU-461 is a reversible inhibitor of the gastric H⁺/K⁺ ATPase, exhibiting IC₅₀ values of 12.15 μM for rabbit-derived enzymes and 4.20 μM for pig-derived enzymes. By competing with activated cationic K⁺ (Kᵢ = 1.64 μM), AU-461 effectively reduces both histamine-stimulated and basal gastric acid secretion in rat models. This compound demonstrates protective effects against ulcer formation induced by ethanol or sodium hydroxide and normalizes plasma gastrin levels. AU-461 is valuable for research into the mechanisms of peptic ulcers and gastric acid regulation. -
Na+/K+ ATPase inhibitor
Ro 18-5364 is a selective inhibitor of gastric H+/K+ ATPase, primarily targeting the enzyme's activity. It demonstrates significant inhibition, particularly at lower pH levels, making it a valuable tool for studying gastric physiology. The compound's effects on enzyme activity, proton transport, and binding interactions can be assessed through various experimental methodologies, providing insights into its mechanism of action and potential therapeutic applications in conditions related to proton pump regulation. -
Na+/K+ ATPase Inhibitor
AR-HO47108 is a reversible inhibitor of the Na+/K+ ATPase, primarily targeting the potassium ion binding site within gastric wall cells. By competitively blocking this site, AR-HO47108 effectively reduces gastric acid secretion, making it a valuable tool for investigating conditions associated with excessive gastric acid, such as peptic ulcers. This compound is particularly useful for research into gastric physiology and related gastrointestinal disorders. -
Cation ATPases Inhibitor
SPAI-1 is a specific inhibitor of monovalent cation transporting ATPases, targeting Na+, K+-ATPase and H+, K+-ATPase to provide valuable insights into ionic transport mechanisms. Isolated from porcine duodenum, SPAI-1 demonstrates the ability to inhibit these ATPases in vitro while also stimulating Mg2+-ATPase activity. This compound is essential for research applications involving cellular ion homeostasis and ATPase-related signaling pathways. -
Na+/K+-ATPase Inhibitor
14-Anhydrodigitoxigenin is a potent inhibitor of Na+/K+-ATPase, a crucial enzyme involved in maintaining ion gradients across cell membranes. Derived from the leaves of Acokanthera oblongifolia, this cardenolide exhibits significant biological activity relevant to cardiovascular research and cellular physiology. Its application in studies of cardiac function and electrolyte balance makes it a valuable reagent for investigating the roles of Na+/K+-ATPase in various physiological and pathological processes. -
Na+/K+ ATPase Inhibitor
LND 623 is a Na+/K+ ATPase inhibitor known for its positive inotropic effects. This aminosteroid compound effectively inhibits Na+/K+ ATPase activity, making it a valuable tool in cardiovascular research. With an LD50 of approximately 45 mg/kg when administered intravenously, LND 623 presents a significantly higher tolerance compared to ouabain, facilitating studies in cardiac function and related therapies. -
Na+/K+ ATPase Inhibitor
Laurinterol is a potent inhibitor of the Na+/K+-ATPase sodium-potassium ion pump. Isolated from Laurencia johnstonii, Laurinterol disrupts ion transport, influencing cellular homeostasis and signaling pathways. This compound is useful in research related to electrolyte balance, cellular physiology, and neurobiology, providing insights into the role of ion pumps in various biological processes. -
Na+/K+ ATPase Inhibitor
Istaroxime oxalate is a Na+/K+ ATPase inhibitor, functioning as an inotropic agent with an IC50 of 0.11 μM. This reagent enhances the force of contraction in guinea pig atria and increases twitch amplitude in isolated guinea pig myocytes, demonstrating significant potential for cardiac function studies. Its ability to exert these effects without inducing lethal arrhythmias makes it valuable for research in cardiovascular physiology and pharmacology. -
H+/K+ ATPase Inhibitor
SK&F 97574 hydrochloride is a reversible inhibitor of the H+/K+ ATPase enzyme, demonstrating significant efficacy in reducing gastric acid secretion. Its primary biological activity supports the healing of acid-related upper gastrointestinal ulcers, making it valuable for research into gastrointestinal disorders and acid secretion regulation. This reagent is essential for studies focused on the pharmacological modulation of gastric acid dynamics. -
Na+/K+ ATPase Inhibitor
Rs-029 is a selective inhibitor of Na+/K+ ATPase and an activator of Mg2+ ATPase. It effectively reduces ATP levels in red blood cells, which can be critical for studying energy metabolism and ion balance in cellular systems. This compound is valuable for research applications focused on membrane transport mechanisms and investigating cellular responses to altered energy states.
