Fig. 1 · Structure
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FR-167356
V ATPase Inhibitor
FR-167356 is a selective inhibitor of vacuolar ATPase, exhibiting potent activity with IC50 values of 170 nM for osteoclast plasma membranes, 220 nM for macrophage microsomes, and higher values for renal brush border and liver lysosomal membranes. This compound inhibits bone resorption and effectively addresses ovariectomy-induced bone loss. It serves as a valuable tool for research into osteoporosis and related bone disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 174185-16-1 |
| Applications | V ATPase Inhibitor |
| Formula | C19H17Cl2NO3 |
| Molecular Weight | 378.25 |
| SMILES | O=C(NC1=C(OC(C)=C2C(C)(O)C)C2=CC=C1)C3=C(Cl)C=CC=C3Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.